Details for: DVL2

Gene ID: 1856

Symbol: DVL2

Ensembl ID: ENSG00000004975

Description: dishevelled segment polarity protein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 94.9563
    Cell Significance Index: -14.7700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 58.2905
    Cell Significance Index: -14.7900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 45.0057
    Cell Significance Index: -18.5400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 37.3208
    Cell Significance Index: -17.6200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 33.0686
    Cell Significance Index: -17.0100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.9097
    Cell Significance Index: -17.1500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.2373
    Cell Significance Index: -14.0300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.4247
    Cell Significance Index: -17.4600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.8809
    Cell Significance Index: -11.9200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.3586
    Cell Significance Index: 37.8400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.3440
    Cell Significance Index: -5.1300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1881
    Cell Significance Index: 16.2100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1583
    Cell Significance Index: 114.5900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.1455
    Cell Significance Index: 133.5000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.8767
    Cell Significance Index: 18.3500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8249
    Cell Significance Index: 744.7800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.7568
    Cell Significance Index: 26.3000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7447
    Cell Significance Index: 44.7100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7057
    Cell Significance Index: 76.7600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.6982
    Cell Significance Index: 5.5800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6977
    Cell Significance Index: 18.9900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5946
    Cell Significance Index: 96.7100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.5905
    Cell Significance Index: 6.4200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5638
    Cell Significance Index: 29.2900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5380
    Cell Significance Index: 14.4200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4765
    Cell Significance Index: 21.6000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3746
    Cell Significance Index: 51.4400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3565
    Cell Significance Index: 71.5100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3411
    Cell Significance Index: 23.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3086
    Cell Significance Index: 8.8900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3058
    Cell Significance Index: 60.6900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2963
    Cell Significance Index: 8.2800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.2802
    Cell Significance Index: 3.3400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2772
    Cell Significance Index: 52.7500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2699
    Cell Significance Index: 14.1700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2647
    Cell Significance Index: 47.7300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2580
    Cell Significance Index: 5.5900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2544
    Cell Significance Index: 6.6900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2520
    Cell Significance Index: 15.8800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2437
    Cell Significance Index: 29.9600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2261
    Cell Significance Index: 123.4800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2148
    Cell Significance Index: 94.9700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1814
    Cell Significance Index: 23.2500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1725
    Cell Significance Index: 20.3400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.1671
    Cell Significance Index: 2.1400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1544
    Cell Significance Index: 9.9600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1516
    Cell Significance Index: 54.3800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1212
    Cell Significance Index: 5.6500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1030
    Cell Significance Index: 4.8400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0968
    Cell Significance Index: 12.5000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0965
    Cell Significance Index: 2.5800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0723
    Cell Significance Index: 5.3900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0574
    Cell Significance Index: 4.0600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0509
    Cell Significance Index: 35.2300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0474
    Cell Significance Index: 1.6700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0133
    Cell Significance Index: 25.0700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0122
    Cell Significance Index: 0.2600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0105
    Cell Significance Index: 0.1800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0038
    Cell Significance Index: -6.9200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0053
    Cell Significance Index: -8.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0073
    Cell Significance Index: -4.6100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0073
    Cell Significance Index: -9.8700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0106
    Cell Significance Index: -8.0300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0112
    Cell Significance Index: -0.2800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0132
    Cell Significance Index: -9.6900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0201
    Cell Significance Index: -14.9200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0215
    Cell Significance Index: -9.7500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0284
    Cell Significance Index: -16.0000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0315
    Cell Significance Index: -4.5800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0321
    Cell Significance Index: -20.0200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0377
    Cell Significance Index: -0.3900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0406
    Cell Significance Index: -4.1500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0457
    Cell Significance Index: -7.8000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0512
    Cell Significance Index: -14.7400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0599
    Cell Significance Index: -1.9200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0607
    Cell Significance Index: -1.5500
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0693
    Cell Significance Index: -0.4600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0783
    Cell Significance Index: -4.8100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0815
    Cell Significance Index: -2.1800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0835
    Cell Significance Index: -9.5700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0850
    Cell Significance Index: -4.7700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0885
    Cell Significance Index: -5.9500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0929
    Cell Significance Index: -19.5600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1013
    Cell Significance Index: -7.7800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1122
    Cell Significance Index: -1.7800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1455
    Cell Significance Index: -2.1800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1486
    Cell Significance Index: -15.4700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1624
    Cell Significance Index: -7.1900
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.1804
    Cell Significance Index: -2.5300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1891
    Cell Significance Index: -14.9800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2027
    Cell Significance Index: -5.8100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2250
    Cell Significance Index: -8.5200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2813
    Cell Significance Index: -2.5900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2856
    Cell Significance Index: -17.5100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2896
    Cell Significance Index: -3.2900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3071
    Cell Significance Index: -9.0200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3085
    Cell Significance Index: -7.9300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3290
    Cell Significance Index: -9.6900
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.3362
    Cell Significance Index: -2.0800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3390
    Cell Significance Index: -5.8100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** DVL2 is a cytoplasmic protein that belongs to the dishevelled family of proteins, which are known for their involvement in Wnt signaling. The protein exhibits a highly conserved structure, with multiple domains that facilitate its interactions with other signaling molecules. DVL2's most notable feature is its ability to bind to Frizzled receptors and beta-catenin, which is essential for the proper functioning of the Wnt signaling pathway. Additionally, DVL2 has been shown to interact with other proteins, such as Axin, to regulate the degradation of beta-catenin and the assembly of the destruction complex. **Pathways and Functions** DVL2's involvement in the Wnt signaling pathway is well-established, and it plays a critical role in regulating various cellular processes, including: 1. **Canonical Wnt Signaling**: DVL2 interacts with Frizzled receptors and beta-catenin to modulate the canonical Wnt signaling pathway, which is involved in cell proliferation, differentiation, and survival. 2. **Non-canonical Wnt Signaling**: DVL2 also participates in the non-canonical Wnt signaling pathway, which is involved in cell migration, polarity, and planar cell polarity. 3. **Regulation of Actin Cytoskeleton Organization**: DVL2 has been shown to regulate the organization of the actin cytoskeleton, which is essential for cell migration, differentiation, and survival. 4. **Regulation of Cell Population Proliferation**: DVL2's involvement in the Wnt signaling pathway enables it to regulate cell population proliferation, which is critical for tissue development and homeostasis. **Clinical Significance** DVL2's dysregulation has been implicated in various diseases, including: 1. **Heart Development**: Mutations in the DVL2 gene have been associated with congenital heart defects, highlighting the protein's critical role in heart development. 2. **Cancer**: DVL2's involvement in the Wnt signaling pathway has led to its association with various types of cancer, including colorectal, breast, and prostate cancer. 3. **Neurological Disorders**: DVL2's dysregulation has been implicated in neurological disorders, such as autism and schizophrenia, highlighting the protein's role in brain development and function. In conclusion, DVL2 is a critical component of the Wnt signaling pathway, playing a significant role in regulating various cellular processes, including cell migration, differentiation, and proliferation. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the molecular mechanisms underlying DVL2's functions.

Genular Protein ID: 3022503047

Symbol: DVL2_HUMAN

Name: Segment polarity protein dishevelled homolog DVL-2

UniProtKB Accession Codes:

O14641 D3DTN3 Q53XM0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 38 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 13 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 13 PRINTS 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 13 RefSeq 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9192851

Title: Human dishevelled genes constitute a DHR-containing multigene family.

PubMed ID: 9192851

DOI: 10.1006/geno.1997.4713

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11742073

Title: beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins.

PubMed ID: 11742073

DOI: 10.1073/pnas.211572798

PubMed ID: 15262978

Title: The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms.

PubMed ID: 15262978

DOI: 10.1074/jbc.m404598200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21422228

Title: Casein kinase 1 delta functions at the centrosome to mediate Wnt-3a-dependent neurite outgrowth.

PubMed ID: 21422228

DOI: 10.1083/jcb.201011111

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22610794

Title: Identification of novel rare mutations of DACT1 in human neural tube defects.

PubMed ID: 22610794

DOI: 10.1002/humu.22121

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23708998

Title: The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis.

PubMed ID: 23708998

DOI: 10.1038/nature12296

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25557784

Title: DCDC2 mutations cause a renal-hepatic ciliopathy by disrupting Wnt signaling.

PubMed ID: 25557784

DOI: 10.1016/j.ajhg.2014.12.002

PubMed ID: 25805136

Title: FOXKs promote Wnt/beta-catenin signaling by translocating DVL into the nucleus.

PubMed ID: 25805136

DOI: 10.1016/j.devcel.2015.01.031

PubMed ID: 27214281

Title: The polycystin complex mediates Wnt/Ca(2+) signalling.

PubMed ID: 27214281

DOI: 10.1038/ncb3363

PubMed ID: 19252499

Title: Inhibition of Wnt signaling by Dishevelled PDZ peptides.

PubMed ID: 19252499

DOI: 10.1038/nchembio.152

PubMed ID: 21248752

Title: Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.

PubMed ID: 21248752

DOI: 10.1038/nature09639

Sequence Information:

  • Length: 736
  • Mass: 78948
  • Checksum: 4BAD95B6C3FE531B
  • Sequence:
    • MAGSSTGGGG VGETKVIYHL DEEETPYLVK IPVPAERITL GDFKSVLQRP AGAKYFFKSM 
DQDFGVVKEE ISDDNARLPC FNGRVVSWLV SSDNPQPEMA PPVHEPRAEL APPAPPLPPL 
PPERTSGIGD SRPPSFHPNV SSSHENLEPE TETESVVSLR RERPRRRDSS EHGAGGHRTG 
GPSRLERHLA GYESSSTLMT SELESTSLGD SDEEDTMSRF SSSTEQSSAS RLLKRHRRRR 
KQRPPRLERT SSFSSVTDST MSLNIITVTL NMEKYNFLGI SIVGQSNERG DGGIYIGSIM 
KGGAVAADGR IEPGDMLLQV NDMNFENMSN DDAVRVLRDI VHKPGPIVLT VAKCWDPSPQ 
AYFTLPRNEP IQPIDPAAWV SHSAALTGTF PAYPGSSSMS TITSGSSLPD GCEGRGLSVH 
TDMASVTKAM AAPESGLEVR DRMWLKITIP NAFLGSDVVD WLYHHVEGFP ERREARKYAS 
GLLKAGLIRH TVNKITFSEQ CYYVFGDLSG GCESYLVNLS LNDNDGSSGA SDQDTLAPLP 
GATPWPLLPT FSYQYPAPHP YSPQPPPYHE LSSYTYGGGS ASSQHSEGSR SSGSTRSDGG 
AGRTGRPEER APESKSGSGS ESEPSSRGGS LRRGGEASGT SDGGPPPSRG STGGAPNLRA 
HPGLHPYGPP PGMALPYNPM MVVMMPPPPP PVPPAVQPPG APPVRDLGSV PPELTASRQS 
FHMAMGNPSE FFVDVM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.