Details for: DVL2

Gene ID: 1856

Symbol: DVL2

Ensembl ID: ENSG00000004975

Description: dishevelled segment polarity protein 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.15
    Marker Score: 2173
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.1
    Marker Score: 1863
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.09
    Marker Score: 2281
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.06
    Marker Score: 16607
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71735
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47960
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30398
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 478
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 433
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2708
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.9
    Marker Score: 603
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.87
    Marker Score: 3227
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5243
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 305
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.84
    Marker Score: 896
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.83
    Marker Score: 501
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.82
    Marker Score: 452
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.79
    Marker Score: 741
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.78
    Marker Score: 834
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.78
    Marker Score: 1581
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.76
    Marker Score: 1784.5
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.75
    Marker Score: 1153
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.73
    Marker Score: 920.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.73
    Marker Score: 294
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.73
    Marker Score: 4745
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.72
    Marker Score: 170
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.72
    Marker Score: 553
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.71
    Marker Score: 370
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.71
    Marker Score: 768
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.7
    Marker Score: 1910
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.69
    Marker Score: 630
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.69
    Marker Score: 9069
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.68
    Marker Score: 6889
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.68
    Marker Score: 689
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2858
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.66
    Marker Score: 186.5
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.66
    Marker Score: 1787.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 168
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.65
    Marker Score: 689
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.64
    Marker Score: 185
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.64
    Marker Score: 306
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.63
    Marker Score: 431
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.63
    Marker Score: 581
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.63
    Marker Score: 424
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.62
    Marker Score: 2431
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.62
    Marker Score: 157
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.59
    Marker Score: 206
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.58
    Marker Score: 486
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.58
    Marker Score: 372
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.58
    Marker Score: 4979
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.58
    Marker Score: 886
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.57
    Marker Score: 306
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.57
    Marker Score: 2315
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.56
    Marker Score: 2411
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.56
    Marker Score: 5298
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.55
    Marker Score: 2143
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.55
    Marker Score: 811
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.55
    Marker Score: 1115
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.55
    Marker Score: 223
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.54
    Marker Score: 610
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.54
    Marker Score: 33265
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.54
    Marker Score: 3226
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.53
    Marker Score: 401
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.53
    Marker Score: 424
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.53
    Marker Score: 351
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.53
    Marker Score: 762
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.52
    Marker Score: 102
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.52
    Marker Score: 326
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.52
    Marker Score: 851
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.52
    Marker Score: 622
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.51
    Marker Score: 136
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.51
    Marker Score: 482
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.5
    Marker Score: 651
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5
    Marker Score: 5659
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.5
    Marker Score: 2937.5
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.49
    Marker Score: 875
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.49
    Marker Score: 205
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.49
    Marker Score: 203
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.49
    Marker Score: 356
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.49
    Marker Score: 687
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.48
    Marker Score: 155
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.48
    Marker Score: 234
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.48
    Marker Score: 218
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.48
    Marker Score: 1120
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.47
    Marker Score: 209
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.47
    Marker Score: 495
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.47
    Marker Score: 248
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.47
    Marker Score: 2288
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.46
    Marker Score: 482
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.46
    Marker Score: 291.5
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.46
    Marker Score: 101
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.46
    Marker Score: 160
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.46
    Marker Score: 158
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.46
    Marker Score: 105
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.45
    Marker Score: 1285
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.45
    Marker Score: 554
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.45
    Marker Score: 261

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Other Information

**Key characteristics:** - DVL2 is a transmembrane protein with a predicted extracellular domain and a cytoplasmic domain. - It is expressed in a variety of cell types, including cardiac endothelial cells, mesenchymal cells, epithelial cells of the nephron, cardiac muscle myoblasts, cerebral cortex GABAergic interneurons, forebrain radial glial cells, absorptive cells, intestinal crypt stem cells of colon, tuft cells of colon, and BEST4+ intestinal epithelial cells. - It is a key regulator of epithelial cell migration and polarity, as it is involved in the regulation of cell migration, adhesion, and signaling. **Pathways and functions:** - DVL2 is a key regulator of the beta-catenin-independent wnt signaling pathway. - It is involved in the regulation of epithelial cell migration and polarity by interacting with the beta-catenin-TCF complex. - It acts as a negative regulator of the wnt signaling pathway by interacting with the TCF complex and inhibiting its activity. - It is involved in the regulation of epithelial cell migration by promoting the disassembly of the destruction complex, which is a complex that is responsible for the degradation of the epithelial cell adhesion molecule cadherin. - It is also involved in the regulation of cell adhesion by promoting the recruitment of axin to the plasma membrane. **Clinical significance:** - Mutations in DVL2 have been linked to a number of human diseases, including cardiovascular disease, cancer, and developmental disorders. - In particular, mutations in DVL2 have been linked to the development of heart failure, stroke, and other cardiovascular diseases. - Targeting DVL2 has been investigated as a potential therapeutic strategy for these diseases.

Genular Protein ID: 3022503047

Symbol: DVL2_HUMAN

Name: Segment polarity protein dishevelled homolog DVL-2

UniProtKB Accession Codes:

O14641 D3DTN3 Q53XM0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 39 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 13 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 15 PDBsum 11 PRINTS 2 PRO 1 PROSITE 3 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 13 RefSeq 1 SAM 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9192851

Title: Human dishevelled genes constitute a DHR-containing multigene family.

PubMed ID: 9192851

DOI: 10.1006/geno.1997.4713

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11742073

Title: beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins.

PubMed ID: 11742073

DOI: 10.1073/pnas.211572798

PubMed ID: 15262978

Title: The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms.

PubMed ID: 15262978

DOI: 10.1074/jbc.m404598200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21422228

Title: Casein kinase 1 delta functions at the centrosome to mediate Wnt-3a-dependent neurite outgrowth.

PubMed ID: 21422228

DOI: 10.1083/jcb.201011111

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22610794

Title: Identification of novel rare mutations of DACT1 in human neural tube defects.

PubMed ID: 22610794

DOI: 10.1002/humu.22121

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23708998

Title: The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis.

PubMed ID: 23708998

DOI: 10.1038/nature12296

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25557784

Title: DCDC2 mutations cause a renal-hepatic ciliopathy by disrupting Wnt signaling.

PubMed ID: 25557784

DOI: 10.1016/j.ajhg.2014.12.002

PubMed ID: 25805136

Title: FOXKs promote Wnt/beta-catenin signaling by translocating DVL into the nucleus.

PubMed ID: 25805136

DOI: 10.1016/j.devcel.2015.01.031

PubMed ID: 27214281

Title: The polycystin complex mediates Wnt/Ca(2+) signalling.

PubMed ID: 27214281

DOI: 10.1038/ncb3363

PubMed ID: 19252499

Title: Inhibition of Wnt signaling by Dishevelled PDZ peptides.

PubMed ID: 19252499

DOI: 10.1038/nchembio.152

PubMed ID: 21248752

Title: Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.

PubMed ID: 21248752

DOI: 10.1038/nature09639

Sequence Information:

  • Length: 736
  • Mass: 78948
  • Checksum: 4BAD95B6C3FE531B
  • Sequence:
    • MAGSSTGGGG VGETKVIYHL DEEETPYLVK IPVPAERITL GDFKSVLQRP AGAKYFFKSM 
DQDFGVVKEE ISDDNARLPC FNGRVVSWLV SSDNPQPEMA PPVHEPRAEL APPAPPLPPL 
PPERTSGIGD SRPPSFHPNV SSSHENLEPE TETESVVSLR RERPRRRDSS EHGAGGHRTG 
GPSRLERHLA GYESSSTLMT SELESTSLGD SDEEDTMSRF SSSTEQSSAS RLLKRHRRRR 
KQRPPRLERT SSFSSVTDST MSLNIITVTL NMEKYNFLGI SIVGQSNERG DGGIYIGSIM 
KGGAVAADGR IEPGDMLLQV NDMNFENMSN DDAVRVLRDI VHKPGPIVLT VAKCWDPSPQ 
AYFTLPRNEP IQPIDPAAWV SHSAALTGTF PAYPGSSSMS TITSGSSLPD GCEGRGLSVH 
TDMASVTKAM AAPESGLEVR DRMWLKITIP NAFLGSDVVD WLYHHVEGFP ERREARKYAS 
GLLKAGLIRH TVNKITFSEQ CYYVFGDLSG GCESYLVNLS LNDNDGSSGA SDQDTLAPLP 
GATPWPLLPT FSYQYPAPHP YSPQPPPYHE LSSYTYGGGS ASSQHSEGSR SSGSTRSDGG 
AGRTGRPEER APESKSGSGS ESEPSSRGGS LRRGGEASGT SDGGPPPSRG STGGAPNLRA 
HPGLHPYGPP PGMALPYNPM MVVMMPPPPP PVPPAVQPPG APPVRDLGSV PPELTASRQS 
FHMAMGNPSE FFVDVM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.