Details for: DVL3

Gene ID: 1857

Symbol: DVL3

Ensembl ID: ENSG00000161202

Description: dishevelled segment polarity protein 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.52
    Marker Score: 6342.5
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.37
    Marker Score: 5731
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.2
    Marker Score: 5899.5
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.18
    Marker Score: 2893
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.16
    Marker Score: 1555.5
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.04
    Marker Score: 2440
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.02
    Marker Score: 15911
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.01
    Marker Score: 1132
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71727
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47950
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.99
    Marker Score: 672.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30394
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.97
    Marker Score: 1431
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.97
    Marker Score: 1838
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.96
    Marker Score: 1020
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.95
    Marker Score: 460
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2397
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 479
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.93
    Marker Score: 1120
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 435
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2705
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.86
    Marker Score: 1333.5
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.86
    Marker Score: 29322
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.85
    Marker Score: 269
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.85
    Marker Score: 3342
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.85
    Marker Score: 3143
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.85
    Marker Score: 4837
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.85
    Marker Score: 7264
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.84
    Marker Score: 1922
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.84
    Marker Score: 868
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.8
    Marker Score: 866
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.79
    Marker Score: 846
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.79
    Marker Score: 48501
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.79
    Marker Score: 181
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.78
    Marker Score: 719
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.77
    Marker Score: 2068
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.77
    Marker Score: 451
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 580
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.76
    Marker Score: 4548
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.76
    Marker Score: 766
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.75
    Marker Score: 514
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.75
    Marker Score: 789
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 299
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.74
    Marker Score: 408
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.73
    Marker Score: 6975
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 373
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.72
    Marker Score: 479
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.71
    Marker Score: 288
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.71
    Marker Score: 1934
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.71
    Marker Score: 1556.5
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.7
    Marker Score: 7259
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7
    Marker Score: 24322
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7
    Marker Score: 7899
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.7
    Marker Score: 244
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.7
    Marker Score: 875
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.7
    Marker Score: 25673
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.69
    Marker Score: 893
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.69
    Marker Score: 5102
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2855.5
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.68
    Marker Score: 4422
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.68
    Marker Score: 721
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.67
    Marker Score: 447
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.67
    Marker Score: 3984.5
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.67
    Marker Score: 389
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.67
    Marker Score: 329
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 608
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.66
    Marker Score: 372
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.66
    Marker Score: 377
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.65
    Marker Score: 6152
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.65
    Marker Score: 1364
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.65
    Marker Score: 743
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.64
    Marker Score: 686
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.64
    Marker Score: 1136
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.64
    Marker Score: 24201
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.63
    Marker Score: 2454
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.63
    Marker Score: 296
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.63
    Marker Score: 603.5
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.63
    Marker Score: 13492
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.63
    Marker Score: 2572
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.63
    Marker Score: 397.5
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.63
    Marker Score: 6317.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.63
    Marker Score: 377
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.63
    Marker Score: 1580
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.62
    Marker Score: 673
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.62
    Marker Score: 154
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.62
    Marker Score: 209
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.61
    Marker Score: 716
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.61
    Marker Score: 288
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.61
    Marker Score: 175
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.61
    Marker Score: 3865
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.6
    Marker Score: 171
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.6
    Marker Score: 1226.5
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.6
    Marker Score: 398
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.59
    Marker Score: 221
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.59
    Marker Score: 1851
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.59
    Marker Score: 709

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Other Information

**Key characteristics:** - DVL3 is a transmembrane protein with a predicted molecular weight of approximately 450 kDa. - It is localized to the cytoplasm and nucleus of cells. - It is a key component of the beta-catenin independent wnt signaling pathway, where it acts as a negative regulator of the pathway. - It is also involved in the degradation of dvl and the disassembly of the destruction complex. - It is expressed in a variety of cell types, including pigmented epithelial cells, GABAergic neurons, myoepithelial cells of the mammary gland, and various cell types of the central nervous system. **Pathways and functions:** - DVL3 is involved in the regulation of cell polarity through the beta-catenin independent wnt signaling pathway. - In this pathway, DVL3 acts as a negative regulator by interacting with the beta-catenin/TCF complex and inhibiting its activity. - This leads to the degradation of dvl and the disassembly of the destruction complex, which is required for the full activation of the wnt signaling pathway. - DVL3 is also involved in the regulation of other signaling pathways, such as the TCF-dependent signaling pathway. **Clinical significance:** - Mutations in DVL3 have been linked to a number of human diseases, including leishmaniasis, cancer, and developmental disorders. - In leishmaniasis, mutations in DVL3 have been shown to impair the regulation of the wnt signaling pathway, leading to the uncontrolled proliferation of leishmanial parasites. - In cancer, mutations in DVL3 have been shown to promote the survival and proliferation of cancer cells. - Therefore, DVL3 is a promising target for the treatment of human diseases that are caused by parasites or cancer cells.

Genular Protein ID: 273684780

Symbol: DVL3_HUMAN

Name: Segment polarity protein dishevelled homolog DVL-3

UniProtKB Accession Codes:

Q92997 B4E3E5 D3DNT0 O14642 Q13531 Q8N5E9 Q92607

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 22 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 13 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 8 PIR 1 PRINTS 2 PRO 1 PROSITE 3 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 8 RefSeq 1 SAM 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8817329

Title: cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene.

PubMed ID: 8817329

DOI: 10.1093/hmg/5.7.953

PubMed ID: 9344861

Title: cDNA cloning of a human dishevelled DVL-3 gene, mapping to 3q27, and expression in human breast and colon carcinomas.

PubMed ID: 9344861

DOI: 10.1006/bbrc.1997.7500

PubMed ID: 9192851

Title: Human dishevelled genes constitute a DHR-containing multigene family.

PubMed ID: 9192851

DOI: 10.1006/geno.1997.4713

PubMed ID: 9039502

Title: Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.

PubMed ID: 9039502

DOI: 10.1093/dnares/3.5.321

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12805222

Title: Regulation of the Wnt signaling pathway by disabled-2 (Dab2).

PubMed ID: 12805222

DOI: 10.1093/emboj/cdg286

PubMed ID: 15677333

Title: Identification of the Wnt signaling activator leucine-rich repeat in Flightless interaction protein 2 by a genome-wide functional analysis.

PubMed ID: 15677333

DOI: 10.1073/pnas.0409472102

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20227366

Title: Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl.

PubMed ID: 20227366

DOI: 10.1016/j.molcel.2010.01.035

PubMed ID: 21422228

Title: Casein kinase 1 delta functions at the centrosome to mediate Wnt-3a-dependent neurite outgrowth.

PubMed ID: 21422228

DOI: 10.1083/jcb.201011111

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22863007

Title: Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling.

PubMed ID: 22863007

DOI: 10.1016/j.cell.2012.06.028

PubMed ID: 22612246

Title: Delicate analysis of post-translational modifications on Dishevelled 3.

PubMed ID: 22612246

DOI: 10.1021/pr300314d

PubMed ID: 23150776

Title: Dishevelled3 is a novel arginine methyl transferase substrate.

PubMed ID: 23150776

DOI: 10.1038/srep00805

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25557784

Title: DCDC2 mutations cause a renal-hepatic ciliopathy by disrupting Wnt signaling.

PubMed ID: 25557784

DOI: 10.1016/j.ajhg.2014.12.002

PubMed ID: 25805136

Title: FOXKs promote Wnt/beta-catenin signaling by translocating DVL into the nucleus.

PubMed ID: 25805136

DOI: 10.1016/j.devcel.2015.01.031

PubMed ID: 26924530

Title: DVL3 alleles resulting in a -1 frameshift of the last exon mediate autosomal-dominant Robinow syndrome.

PubMed ID: 26924530

DOI: 10.1016/j.ajhg.2016.01.005

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 716
  • Mass: 78055
  • Checksum: B1A55EBF9507D06E
  • Sequence:
    • MGETKIIYHL DGQETPYLVK LPLPAERVTL ADFKGVLQRP SYKFFFKSMD DDFGVVKEEI 
SDDNAKLPCF NGRVVSWLVS AEGSHPDPAP FCADNPSELP PPMERTGGIG DSRPPSFHPH 
AGGGSQENLD NDTETDSLVS AQRERPRRRD GPEHATRLNG TAKGERRREP GGYDSSSTLM 
SSELETTSFF DSDEDDSTSR FSSSTEQSSA SRLMRRHKRR RRKQKVSRIE RSSSFSSITD 
STMSLNIITV TLNMEKYNFL GISIVGQSNE RGDGGIYIGS IMKGGAVAAD GRIEPGDMLL 
QVNEINFENM SNDDAVRVLR EIVHKPGPIT LTVAKCWDPS PRGCFTLPRS EPIRPIDPAA 
WVSHTAAMTG TFPAYGMSPS LSTITSTSSS ITSSIPDTER LDDFHLSIHS DMAAIVKAMA 
SPESGLEVRD RMWLKITIPN AFIGSDVVDW LYHNVEGFTD RREARKYASN LLKAGFIRHT 
VNKITFSEQC YYIFGDLCGN MANLSLHDHD GSSGASDQDT LAPLPHPGAA PWPMAFPYQY 
PPPPHPYNPH PGFPELGYSY GGGSASSQHS EGSRSSGSNR SGSDRRKEKD PKAGDSKSGG 
SGSESDHTTR SSLRGPRERA PSERSGPAAS EHSHRSHHSL ASSLRSHHTH PSYGPPGVPP 
LYGPPMLMMP PPPAAMGPPG APPGRDLASV PPELTASRQS FRMAMGNPSE FFVDVM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.