Details for: DVL3
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 181.8121
Cell Significance Index: -28.2800 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 112.5990
Cell Significance Index: -28.5600 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 62.7591
Cell Significance Index: -29.6300 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 57.5498
Cell Significance Index: -23.3800 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 54.1423
Cell Significance Index: -27.8500 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 24.6140
Cell Significance Index: -23.5000 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 23.7073
Cell Significance Index: -29.2300 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 10.4410
Cell Significance Index: -27.9700 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 7.5062
Cell Significance Index: -29.6200 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 2.0244
Cell Significance Index: 54.0600 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.4223
Cell Significance Index: 19.4100 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9310
Cell Significance Index: 151.4200 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.9233
Cell Significance Index: 55.4300 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.7833
Cell Significance Index: 149.0600 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.7221
Cell Significance Index: 143.3100 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.6512
Cell Significance Index: 33.8300 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.6020
Cell Significance Index: 108.5300 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.5894
Cell Significance Index: 26.7200 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.5797
Cell Significance Index: 12.5600 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.5763
Cell Significance Index: 70.8700 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5634
Cell Significance Index: 55.7300 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.5392
Cell Significance Index: 108.1700 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.5362
Cell Significance Index: 37.0800 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.4611
Cell Significance Index: 21.5000 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.4277
Cell Significance Index: 58.7300 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.3651
Cell Significance Index: 199.3700 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.3511
Cell Significance Index: 26.9500 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3281
Cell Significance Index: 296.2900 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.2847
Cell Significance Index: 7.7500 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.2754
Cell Significance Index: 13.9200 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.2556
Cell Significance Index: 7.3700 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.2530
Cell Significance Index: 90.7300 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.2355
Cell Significance Index: 104.1200 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.2127
Cell Significance Index: 36.3200 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.1845
Cell Significance Index: 11.3400 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1791
Cell Significance Index: 123.8500 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.1671
Cell Significance Index: 19.1400 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1525
Cell Significance Index: 287.1500 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.1524
Cell Significance Index: 4.3700 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.1233
Cell Significance Index: 7.7700 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0907
Cell Significance Index: 11.6300 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.0859
Cell Significance Index: 5.5500 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0840
Cell Significance Index: 1.7900 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0618
Cell Significance Index: 113.9000 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0509
Cell Significance Index: 1.7900 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0455
Cell Significance Index: 70.0500 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.0249
Cell Significance Index: 1.1700 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.0197
Cell Significance Index: 1.4000 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0060
Cell Significance Index: 8.1400 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0051
Cell Significance Index: 3.2700 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0051
Cell Significance Index: -2.3000 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0072
Cell Significance Index: -4.4800 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0073
Cell Significance Index: -5.3300 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0082
Cell Significance Index: -6.0600 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0177
Cell Significance Index: -2.5700 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0213
Cell Significance Index: -16.1200 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0237
Cell Significance Index: -1.7700 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0318
Cell Significance Index: -17.9100 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.0356
Cell Significance Index: -0.9500 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.0368
Cell Significance Index: -0.3000 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0370
Cell Significance Index: -4.2200 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0433
Cell Significance Index: -5.6000 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0479
Cell Significance Index: -5.6500 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0621
Cell Significance Index: -6.3400 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0681
Cell Significance Index: -14.3500 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0731
Cell Significance Index: -4.1000 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0768
Cell Significance Index: -4.0000 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0794
Cell Significance Index: -22.8500 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0822
Cell Significance Index: -1.3800 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.1016
Cell Significance Index: -1.5000 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1292
Cell Significance Index: -15.0600 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1619
Cell Significance Index: -8.5000 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1697
Cell Significance Index: -11.4100 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.1746
Cell Significance Index: -4.5900 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1922
Cell Significance Index: -4.9400 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2021
Cell Significance Index: -21.0400 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2801
Cell Significance Index: -22.1800 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.3233
Cell Significance Index: -11.2400 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.3242
Cell Significance Index: -2.9900 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.3313
Cell Significance Index: -3.4300 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.3616
Cell Significance Index: -11.5800 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.3688
Cell Significance Index: -7.7200 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3826
Cell Significance Index: -23.4600 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.4013
Cell Significance Index: -17.7500 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.4150
Cell Significance Index: -8.1000 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.4382
Cell Significance Index: -7.5100 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.4694
Cell Significance Index: -12.5600 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.4772
Cell Significance Index: -7.1500 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.4830
Cell Significance Index: -18.2900 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.5351
Cell Significance Index: -15.7600 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.5366
Cell Significance Index: -12.8700 - Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.5440
Cell Significance Index: -7.6300 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.5867
Cell Significance Index: -8.9100 - Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: -0.5944
Cell Significance Index: -3.8800 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.6124
Cell Significance Index: -13.4100 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.6125
Cell Significance Index: -11.3200 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.6194
Cell Significance Index: -20.2800 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.6223
Cell Significance Index: -21.8000 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.6435
Cell Significance Index: -20.5000 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.6449
Cell Significance Index: -23.6800
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 273684780
Symbol: DVL3_HUMAN
Name: Segment polarity protein dishevelled homolog DVL-3
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8817329
Title: cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene.
PubMed ID: 8817329
DOI: 10.1093/hmg/5.7.953
PubMed ID: 9344861
Title: cDNA cloning of a human dishevelled DVL-3 gene, mapping to 3q27, and expression in human breast and colon carcinomas.
PubMed ID: 9344861
PubMed ID: 9192851
Title: Human dishevelled genes constitute a DHR-containing multigene family.
PubMed ID: 9192851
PubMed ID: 9039502
Title: Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.
PubMed ID: 9039502
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12805222
Title: Regulation of the Wnt signaling pathway by disabled-2 (Dab2).
PubMed ID: 12805222
DOI: 10.1093/emboj/cdg286
PubMed ID: 15677333
Title: Identification of the Wnt signaling activator leucine-rich repeat in Flightless interaction protein 2 by a genome-wide functional analysis.
PubMed ID: 15677333
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 20227366
Title: Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl.
PubMed ID: 20227366
PubMed ID: 21422228
Title: Casein kinase 1 delta functions at the centrosome to mediate Wnt-3a-dependent neurite outgrowth.
PubMed ID: 21422228
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22863007
Title: Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling.
PubMed ID: 22863007
PubMed ID: 22612246
Title: Delicate analysis of post-translational modifications on Dishevelled 3.
PubMed ID: 22612246
DOI: 10.1021/pr300314d
PubMed ID: 23150776
Title: Dishevelled3 is a novel arginine methyl transferase substrate.
PubMed ID: 23150776
DOI: 10.1038/srep00805
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25557784
Title: DCDC2 mutations cause a renal-hepatic ciliopathy by disrupting Wnt signaling.
PubMed ID: 25557784
PubMed ID: 25805136
Title: FOXKs promote Wnt/beta-catenin signaling by translocating DVL into the nucleus.
PubMed ID: 25805136
PubMed ID: 26924530
Title: DVL3 alleles resulting in a -1 frameshift of the last exon mediate autosomal-dominant Robinow syndrome.
PubMed ID: 26924530
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
Sequence Information:
- Length: 716
- Mass: 78055
- Checksum: B1A55EBF9507D06E
- Sequence:
MGETKIIYHL DGQETPYLVK LPLPAERVTL ADFKGVLQRP SYKFFFKSMD DDFGVVKEEI SDDNAKLPCF NGRVVSWLVS AEGSHPDPAP FCADNPSELP PPMERTGGIG DSRPPSFHPH AGGGSQENLD NDTETDSLVS AQRERPRRRD GPEHATRLNG TAKGERRREP GGYDSSSTLM SSELETTSFF DSDEDDSTSR FSSSTEQSSA SRLMRRHKRR RRKQKVSRIE RSSSFSSITD STMSLNIITV TLNMEKYNFL GISIVGQSNE RGDGGIYIGS IMKGGAVAAD GRIEPGDMLL QVNEINFENM SNDDAVRVLR EIVHKPGPIT LTVAKCWDPS PRGCFTLPRS EPIRPIDPAA WVSHTAAMTG TFPAYGMSPS LSTITSTSSS ITSSIPDTER LDDFHLSIHS DMAAIVKAMA SPESGLEVRD RMWLKITIPN AFIGSDVVDW LYHNVEGFTD RREARKYASN LLKAGFIRHT VNKITFSEQC YYIFGDLCGN MANLSLHDHD GSSGASDQDT LAPLPHPGAA PWPMAFPYQY PPPPHPYNPH PGFPELGYSY GGGSASSQHS EGSRSSGSNR SGSDRRKEKD PKAGDSKSGG SGSESDHTTR SSLRGPRERA PSERSGPAAS EHSHRSHHSL ASSLRSHHTH PSYGPPGVPP LYGPPMLMMP PPPAAMGPPG APPGRDLASV PPELTASRQS FRMAMGNPSE FFVDVM
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.