Details for: DVL3

Gene ID: 1857

Symbol: DVL3

Ensembl ID: ENSG00000161202

Description: dishevelled segment polarity protein 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 181.8121
    Cell Significance Index: -28.2800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 112.5990
    Cell Significance Index: -28.5600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 62.7591
    Cell Significance Index: -29.6300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 57.5498
    Cell Significance Index: -23.3800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 54.1423
    Cell Significance Index: -27.8500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 24.6140
    Cell Significance Index: -23.5000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 23.7073
    Cell Significance Index: -29.2300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.4410
    Cell Significance Index: -27.9700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.5062
    Cell Significance Index: -29.6200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.0244
    Cell Significance Index: 54.0600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.4223
    Cell Significance Index: 19.4100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9310
    Cell Significance Index: 151.4200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9233
    Cell Significance Index: 55.4300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7833
    Cell Significance Index: 149.0600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7221
    Cell Significance Index: 143.3100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6512
    Cell Significance Index: 33.8300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6020
    Cell Significance Index: 108.5300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5894
    Cell Significance Index: 26.7200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5797
    Cell Significance Index: 12.5600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5763
    Cell Significance Index: 70.8700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5634
    Cell Significance Index: 55.7300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5392
    Cell Significance Index: 108.1700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5362
    Cell Significance Index: 37.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4611
    Cell Significance Index: 21.5000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4277
    Cell Significance Index: 58.7300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3651
    Cell Significance Index: 199.3700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3511
    Cell Significance Index: 26.9500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3281
    Cell Significance Index: 296.2900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2847
    Cell Significance Index: 7.7500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2754
    Cell Significance Index: 13.9200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2556
    Cell Significance Index: 7.3700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2530
    Cell Significance Index: 90.7300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2355
    Cell Significance Index: 104.1200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2127
    Cell Significance Index: 36.3200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1845
    Cell Significance Index: 11.3400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1791
    Cell Significance Index: 123.8500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1671
    Cell Significance Index: 19.1400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1525
    Cell Significance Index: 287.1500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1524
    Cell Significance Index: 4.3700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1233
    Cell Significance Index: 7.7700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0907
    Cell Significance Index: 11.6300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0859
    Cell Significance Index: 5.5500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0840
    Cell Significance Index: 1.7900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0618
    Cell Significance Index: 113.9000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0509
    Cell Significance Index: 1.7900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0455
    Cell Significance Index: 70.0500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0249
    Cell Significance Index: 1.1700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0197
    Cell Significance Index: 1.4000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0060
    Cell Significance Index: 8.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0051
    Cell Significance Index: 3.2700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0051
    Cell Significance Index: -2.3000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0072
    Cell Significance Index: -4.4800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0073
    Cell Significance Index: -5.3300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0082
    Cell Significance Index: -6.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0177
    Cell Significance Index: -2.5700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0213
    Cell Significance Index: -16.1200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0237
    Cell Significance Index: -1.7700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0318
    Cell Significance Index: -17.9100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0356
    Cell Significance Index: -0.9500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0368
    Cell Significance Index: -0.3000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0370
    Cell Significance Index: -4.2200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0433
    Cell Significance Index: -5.6000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0479
    Cell Significance Index: -5.6500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0621
    Cell Significance Index: -6.3400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0681
    Cell Significance Index: -14.3500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0731
    Cell Significance Index: -4.1000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0768
    Cell Significance Index: -4.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0794
    Cell Significance Index: -22.8500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0822
    Cell Significance Index: -1.3800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1016
    Cell Significance Index: -1.5000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1292
    Cell Significance Index: -15.0600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1619
    Cell Significance Index: -8.5000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1697
    Cell Significance Index: -11.4100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1746
    Cell Significance Index: -4.5900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1922
    Cell Significance Index: -4.9400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2021
    Cell Significance Index: -21.0400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2801
    Cell Significance Index: -22.1800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3233
    Cell Significance Index: -11.2400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3242
    Cell Significance Index: -2.9900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3313
    Cell Significance Index: -3.4300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3616
    Cell Significance Index: -11.5800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3688
    Cell Significance Index: -7.7200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3826
    Cell Significance Index: -23.4600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4013
    Cell Significance Index: -17.7500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4150
    Cell Significance Index: -8.1000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4382
    Cell Significance Index: -7.5100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4694
    Cell Significance Index: -12.5600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4772
    Cell Significance Index: -7.1500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4830
    Cell Significance Index: -18.2900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5351
    Cell Significance Index: -15.7600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5366
    Cell Significance Index: -12.8700
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.5440
    Cell Significance Index: -7.6300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.5867
    Cell Significance Index: -8.9100
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.5944
    Cell Significance Index: -3.8800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.6124
    Cell Significance Index: -13.4100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6125
    Cell Significance Index: -11.3200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6194
    Cell Significance Index: -20.2800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6223
    Cell Significance Index: -21.8000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6435
    Cell Significance Index: -20.5000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6449
    Cell Significance Index: -23.6800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DVL3 is a member of the Dishevelled family of proteins, which are known for their involvement in Wnt signaling. The protein consists of three main domains: the N-terminal PDZ domain, the central guanylate kinase domain, and the C-terminal proline-rich domain. DVL3 is highly conserved across species, suggesting its essential role in evolution. Its expression is widespread, with significant levels detected in various tissues, including the nervous system, epithelial cells, and muscle cells. **Pathways and Functions:** DVL3 is a key mediator of Wnt signaling, which is a highly conserved pathway involved in numerous cellular processes. The Wnt pathway consists of three main branches: canonical, non-canonical, and planar cell polarity. DVL3 plays a central role in the non-canonical Wnt pathway, which regulates cell migration, polarity, and differentiation. This pathway involves the recruitment of axin to the membrane, leading to the degradation of β-catenin and the activation of downstream signaling cascades. In addition to its role in Wnt signaling, DVL3 is involved in other cellular processes, including: 1. **Cell polarity**: DVL3 regulates the establishment of cell polarity, which is essential for tissue organization and function. 2. **Neuronal development**: DVL3 is required for the proper development and function of neurons, including the regulation of neuron projection arborization and the establishment of neural tube closure. 3. **Muscle cell differentiation**: DVL3 is involved in the regulation of muscle cell differentiation and the maintenance of muscle cell polarity. 4. **Epithelial-mesenchymal transition**: DVL3 regulates the epithelial-mesenchymal transition, a process involved in tissue remodeling and cancer progression. **Clinical Significance:** DVL3 has been implicated in various human diseases, including: 1. **Neurological disorders**: Mutations in DVL3 have been associated with neurological disorders, such as neural tube defects and schizophrenia. 2. **Cancer**: DVL3 is involved in the regulation of cancer cell invasion and metastasis, making it a potential therapeutic target. 3. **Infectious diseases**: DVL3 has been shown to play a role in the regulation of immune responses to Leishmania infection. 4. **Musculoskeletal disorders**: DVL3 is involved in the regulation of muscle cell differentiation and the maintenance of muscle cell polarity, making it a potential therapeutic target for muscle-related disorders. In conclusion, DVL3 is a multifaceted protein with a wide range of functions in human health and disease. Its involvement in Wnt signaling, cell polarity, and other cellular processes underscores its importance in tissue homeostasis. Further research is needed to fully elucidate the role of DVL3 in human disease and to develop therapeutic strategies targeting this protein.

Genular Protein ID: 273684780

Symbol: DVL3_HUMAN

Name: Segment polarity protein dishevelled homolog DVL-3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8817329

Title: cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene.

PubMed ID: 8817329

DOI: 10.1093/hmg/5.7.953

PubMed ID: 9344861

Title: cDNA cloning of a human dishevelled DVL-3 gene, mapping to 3q27, and expression in human breast and colon carcinomas.

PubMed ID: 9344861

DOI: 10.1006/bbrc.1997.7500

PubMed ID: 9192851

Title: Human dishevelled genes constitute a DHR-containing multigene family.

PubMed ID: 9192851

DOI: 10.1006/geno.1997.4713

PubMed ID: 9039502

Title: Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.

PubMed ID: 9039502

DOI: 10.1093/dnares/3.5.321

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12805222

Title: Regulation of the Wnt signaling pathway by disabled-2 (Dab2).

PubMed ID: 12805222

DOI: 10.1093/emboj/cdg286

PubMed ID: 15677333

Title: Identification of the Wnt signaling activator leucine-rich repeat in Flightless interaction protein 2 by a genome-wide functional analysis.

PubMed ID: 15677333

DOI: 10.1073/pnas.0409472102

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20227366

Title: Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl.

PubMed ID: 20227366

DOI: 10.1016/j.molcel.2010.01.035

PubMed ID: 21422228

Title: Casein kinase 1 delta functions at the centrosome to mediate Wnt-3a-dependent neurite outgrowth.

PubMed ID: 21422228

DOI: 10.1083/jcb.201011111

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22863007

Title: Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling.

PubMed ID: 22863007

DOI: 10.1016/j.cell.2012.06.028

PubMed ID: 22612246

Title: Delicate analysis of post-translational modifications on Dishevelled 3.

PubMed ID: 22612246

DOI: 10.1021/pr300314d

PubMed ID: 23150776

Title: Dishevelled3 is a novel arginine methyl transferase substrate.

PubMed ID: 23150776

DOI: 10.1038/srep00805

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25557784

Title: DCDC2 mutations cause a renal-hepatic ciliopathy by disrupting Wnt signaling.

PubMed ID: 25557784

DOI: 10.1016/j.ajhg.2014.12.002

PubMed ID: 25805136

Title: FOXKs promote Wnt/beta-catenin signaling by translocating DVL into the nucleus.

PubMed ID: 25805136

DOI: 10.1016/j.devcel.2015.01.031

PubMed ID: 26924530

Title: DVL3 alleles resulting in a -1 frameshift of the last exon mediate autosomal-dominant Robinow syndrome.

PubMed ID: 26924530

DOI: 10.1016/j.ajhg.2016.01.005

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 716
  • Mass: 78055
  • Checksum: B1A55EBF9507D06E
  • Sequence:
  • MGETKIIYHL DGQETPYLVK LPLPAERVTL ADFKGVLQRP SYKFFFKSMD DDFGVVKEEI 
    SDDNAKLPCF NGRVVSWLVS AEGSHPDPAP FCADNPSELP PPMERTGGIG DSRPPSFHPH 
    AGGGSQENLD NDTETDSLVS AQRERPRRRD GPEHATRLNG TAKGERRREP GGYDSSSTLM 
    SSELETTSFF DSDEDDSTSR FSSSTEQSSA SRLMRRHKRR RRKQKVSRIE RSSSFSSITD 
    STMSLNIITV TLNMEKYNFL GISIVGQSNE RGDGGIYIGS IMKGGAVAAD GRIEPGDMLL 
    QVNEINFENM SNDDAVRVLR EIVHKPGPIT LTVAKCWDPS PRGCFTLPRS EPIRPIDPAA 
    WVSHTAAMTG TFPAYGMSPS LSTITSTSSS ITSSIPDTER LDDFHLSIHS DMAAIVKAMA 
    SPESGLEVRD RMWLKITIPN AFIGSDVVDW LYHNVEGFTD RREARKYASN LLKAGFIRHT 
    VNKITFSEQC YYIFGDLCGN MANLSLHDHD GSSGASDQDT LAPLPHPGAA PWPMAFPYQY 
    PPPPHPYNPH PGFPELGYSY GGGSASSQHS EGSRSSGSNR SGSDRRKEKD PKAGDSKSGG 
    SGSESDHTTR SSLRGPRERA PSERSGPAAS EHSHRSHHSL ASSLRSHHTH PSYGPPGVPP 
    LYGPPMLMMP PPPAAMGPPG APPGRDLASV PPELTASRQS FRMAMGNPSE FFVDVM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.