Details for: E2F6

Gene ID: 1876

Symbol: E2F6

Ensembl ID: ENSG00000169016

Description: E2F transcription factor 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 110.4823
    Cell Significance Index: -17.1900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 65.4462
    Cell Significance Index: -16.6000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 37.0947
    Cell Significance Index: -15.0700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 15.7844
    Cell Significance Index: -15.0700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.3882
    Cell Significance Index: -17.7400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.2564
    Cell Significance Index: -16.7600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.5134
    Cell Significance Index: -17.8100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.7442
    Cell Significance Index: -11.5000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9848
    Cell Significance Index: 68.1100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9149
    Cell Significance Index: 90.5100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8942
    Cell Significance Index: 12.2000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8545
    Cell Significance Index: 23.2600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6838
    Cell Significance Index: 617.3800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.6569
    Cell Significance Index: 76.5500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6452
    Cell Significance Index: 128.0400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5480
    Cell Significance Index: 14.6900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5412
    Cell Significance Index: 108.5700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5384
    Cell Significance Index: 58.5700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5295
    Cell Significance Index: 31.7900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4968
    Cell Significance Index: 80.8000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.3552
    Cell Significance Index: 9.1300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3440
    Cell Significance Index: 9.9100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3363
    Cell Significance Index: 9.6400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3111
    Cell Significance Index: 19.6100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3084
    Cell Significance Index: 13.9800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2633
    Cell Significance Index: 7.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2280
    Cell Significance Index: 81.7900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2232
    Cell Significance Index: 4.8400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.2033
    Cell Significance Index: 4.9600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1997
    Cell Significance Index: 88.3100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1917
    Cell Significance Index: 6.6600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1848
    Cell Significance Index: 35.1700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1792
    Cell Significance Index: 22.0400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1704
    Cell Significance Index: 8.8500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1590
    Cell Significance Index: 21.8300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1590
    Cell Significance Index: 12.2100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1550
    Cell Significance Index: 27.9500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1547
    Cell Significance Index: 11.5300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1421
    Cell Significance Index: 18.3600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1401
    Cell Significance Index: 96.9100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1385
    Cell Significance Index: 75.6600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1096
    Cell Significance Index: 5.1500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1023
    Cell Significance Index: 5.7400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0643
    Cell Significance Index: 3.0000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0580
    Cell Significance Index: 0.9700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0542
    Cell Significance Index: 1.5200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0502
    Cell Significance Index: 3.5500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0424
    Cell Significance Index: 5.4400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0392
    Cell Significance Index: 1.0300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0373
    Cell Significance Index: 1.3100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0358
    Cell Significance Index: 0.7500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0247
    Cell Significance Index: 1.6600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0231
    Cell Significance Index: 0.6800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0122
    Cell Significance Index: 0.2600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0046
    Cell Significance Index: 0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0001
    Cell Significance Index: -0.2500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0004
    Cell Significance Index: -0.2600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0069
    Cell Significance Index: -12.7500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0080
    Cell Significance Index: -12.2500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0099
    Cell Significance Index: -4.5000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0103
    Cell Significance Index: -14.0500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0128
    Cell Significance Index: -9.4000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0143
    Cell Significance Index: -10.8100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0148
    Cell Significance Index: -10.9900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0231
    Cell Significance Index: -13.0400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0316
    Cell Significance Index: -19.7200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0394
    Cell Significance Index: -4.6500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0416
    Cell Significance Index: -7.1000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0436
    Cell Significance Index: -1.9300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0477
    Cell Significance Index: -4.8700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0494
    Cell Significance Index: -14.2200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0513
    Cell Significance Index: -5.8800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0572
    Cell Significance Index: -2.1700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0625
    Cell Significance Index: -9.0900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0784
    Cell Significance Index: -1.1900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0863
    Cell Significance Index: -18.1800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1114
    Cell Significance Index: -7.1900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1154
    Cell Significance Index: -7.0900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1258
    Cell Significance Index: -0.7600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1272
    Cell Significance Index: -7.8000
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.1376
    Cell Significance Index: -2.2200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1398
    Cell Significance Index: -2.4700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1503
    Cell Significance Index: -3.8400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1505
    Cell Significance Index: -7.9000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1636
    Cell Significance Index: -17.0400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1778
    Cell Significance Index: -9.2600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1828
    Cell Significance Index: -4.5700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1949
    Cell Significance Index: -15.4400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2107
    Cell Significance Index: -10.6500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2292
    Cell Significance Index: -6.5400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2383
    Cell Significance Index: -4.6500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2551
    Cell Significance Index: -2.0800
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.2883
    Cell Significance Index: -3.0100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2901
    Cell Significance Index: -9.2900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3010
    Cell Significance Index: -6.5900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3058
    Cell Significance Index: -8.1800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3468
    Cell Significance Index: -2.3500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3506
    Cell Significance Index: -11.4800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3532
    Cell Significance Index: -11.2500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3599
    Cell Significance Index: -4.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional regulation:** E2F6 acts as a transcriptional repressor, inhibiting the activity of the E2F transcription factor family and thereby regulating cell cycle progression, differentiation, and apoptosis. 2. **Cell cycle regulation:** E2F6 is involved in the G1/S transition, a critical checkpoint in the cell cycle, where it inhibits the expression of genes required for DNA replication and cell division. 3. **DNA binding:** E2F6 possesses a DNA-binding domain, allowing it to interact with specific DNA sequences and regulate transcriptional activity. 4. **Protein-protein interactions:** E2F6 interacts with other proteins, including MLL1, to modulate its transcriptional activity and influence chromatin structure. **Pathways and Functions:** 1. **Cell cycle regulation:** E2F6 is involved in the G1/S transition, where it inhibits the expression of genes required for DNA replication and cell division, ensuring proper cell cycle progression. 2. **Transcriptional regulation:** E2F6 acts as a transcriptional repressor, inhibiting the activity of the E2F transcription factor family and regulating the expression of target genes involved in cell cycle progression, differentiation, and apoptosis. 3. **Chromatin regulation:** E2F6 interacts with chromatin-modifying enzymes, such as MLL1, to regulate chromatin structure and transcriptional activity. 4. **Apoptosis regulation:** E2F6 has been implicated in regulating apoptosis, particularly in the context of cancer, where its dysregulation can contribute to tumorigenesis. **Clinical Significance:** 1. **Cancer:** Dysregulation of E2F6 has been linked to various types of cancer, including breast, ovarian, and lung cancer, where its loss or inactivation can contribute to tumorigenesis. 2. **Neurological disorders:** E2F6 has been implicated in the regulation of neuronal differentiation and apoptosis, and its dysregulation has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Developmental disorders:** E2F6 plays a critical role in the development of various tissues, including the heart, brain, and intestine, and its dysregulation can contribute to developmental disorders, such as congenital heart defects and intestinal abnormalities. 4. **Regenerative medicine:** E2F6 has been identified as a potential therapeutic target for regenerative medicine, particularly in the context of tissue repair and regeneration. In conclusion, the E2F6 gene is a critical regulator of transcription and cell cycle progression, and its dysregulation has been implicated in various diseases, including cancer, neurological disorders, and developmental disorders. Further research is needed to fully elucidate the functions of E2F6 and its role in human disease.

Genular Protein ID: 1157676999

Symbol: E2F6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9689056

Title: Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6.

PubMed ID: 9689056

DOI: 10.1073/pnas.95.16.9190

PubMed ID: 9704927

Title: E2F-6: a novel member of the E2F family is an inhibitor of E2F-dependent transcription.

PubMed ID: 9704927

DOI: 10.1038/sj.onc.1201975

PubMed ID: 15081404

Title: Human E2F6 is alternatively spliced to generate multiple protein isoforms.

PubMed ID: 15081404

DOI: 10.1016/j.bbrc.2004.03.099

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9501179

Title: E2F-6, a member of the E2F family that can behave as a transcriptional repressor.

PubMed ID: 9501179

DOI: 10.1073/pnas.95.6.2850

PubMed ID: 12004135

Title: A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells.

PubMed ID: 12004135

DOI: 10.1126/science.1069861

PubMed ID: 15960975

Title: Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.

PubMed ID: 15960975

DOI: 10.1016/j.cell.2005.04.031

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 281
  • Mass: 31844
  • Checksum: 539E049C15AD3508
  • Sequence:
  • MSQQRPARKL PSLLLDPTEE TVRRRCRDPI NVEGLLPSKI RINLEDNVQY VSMRKALKVK 
    RPRFDVSLVY LTRKFMDLVR SAPGGILDLN KVATKLGVRK RRVYDITNVL DGIDLVEKKS 
    KNHIRWIGSD LSNFGAVPQQ KKLQEELSDL SAMEDALDEL IKDCAQQLFE LTDDKENERL 
    AYVTYQDIHS IQAFHEQIVI AVKAPAETRL DVPAPREDSI TVHIRSTNGP IDVYLCEVEQ 
    GQTSNKRSEG VGTSSSESTH PEGPEEEENP QQSEELLEVS N

Genular Protein ID: 3981682292

Symbol: Q6Q9Z5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15081404

Title: Human E2F6 is alternatively spliced to generate multiple protein isoforms.

PubMed ID: 15081404

DOI: 10.1016/j.bbrc.2004.03.099

Sequence Information:

  • Length: 129
  • Mass: 14440
  • Checksum: 97F8FC3A3E748510
  • Sequence:
  • MEDALDELIK DCAQQLFELT DDKENERLAY VTYQDIHSIQ AFHEQIVIAV KAPAETRLDV 
    PAPREDSITV HIRSTNGPID VYLCEVEQGQ TSNKRSEGVG TSSSESTHPE GPEEEENPQQ 
    SEELLEVSN

Genular Protein ID: 813063836

Symbol: Q53YM3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15081404

Title: Human E2F6 is alternatively spliced to generate multiple protein isoforms.

PubMed ID: 15081404

DOI: 10.1016/j.bbrc.2004.03.099

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 206
  • Mass: 22982
  • Checksum: 6C79669AFD6F42EC
  • Sequence:
  • MDLVRSAPGG ILDLNKVATK LGVRKRRVYD ITNVLDGIDL VEKKSKNHIR WIGSDLSNFG 
    AVPQQKKLQE ELSDLSAMED ALDELIKDCA QQLFELTDDK ENERLAYVTY QDIHSIQAFH 
    EQIVIAVKAP AETRLDVPAP REDSITVHIR STNGPIDVYL CEVEQGQTSN KRSEGVGTSS 
    SESTHPEGPE EEENPQQSEE LLEVSN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.