Details for: E2F6

Gene ID: 1876

Symbol: E2F6

Ensembl ID: ENSG00000169016

Description: E2F transcription factor 6

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.02
    Marker Score: 15903
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71767
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47991
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30402
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.95
    Marker Score: 274
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2405
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.94
    Marker Score: 1177.5
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 484
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 438
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2720
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5004.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.85
    Marker Score: 1305
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.83
    Marker Score: 7151
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.77
    Marker Score: 47587
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.76
    Marker Score: 810
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.75
    Marker Score: 25362
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 563
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.74
    Marker Score: 6992
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.73
    Marker Score: 294
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.72
    Marker Score: 1040
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 374
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 646
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.69
    Marker Score: 331
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.69
    Marker Score: 6477
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2880
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.68
    Marker Score: 6983
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.67
    Marker Score: 4023
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.63
    Marker Score: 1320
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.63
    Marker Score: 23249
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.63
    Marker Score: 1326.5
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.61
    Marker Score: 1041
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.6
    Marker Score: 2208
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.58
    Marker Score: 22062
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.58
    Marker Score: 11481
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.58
    Marker Score: 2230
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.57
    Marker Score: 605.5
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.57
    Marker Score: 381
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.57
    Marker Score: 207
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 429
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.53
    Marker Score: 1078
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.53
    Marker Score: 7883
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.52
    Marker Score: 356
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.52
    Marker Score: 2061
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.52
    Marker Score: 2151
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.5
    Marker Score: 245
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.5
    Marker Score: 117
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.5
    Marker Score: 2446
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.49
    Marker Score: 524
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.48
    Marker Score: 1173
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.47
    Marker Score: 3585
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.47
    Marker Score: 248
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.46
    Marker Score: 259
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.46
    Marker Score: 296
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.46
    Marker Score: 491
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.46
    Marker Score: 710
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.45
    Marker Score: 1747
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.45
    Marker Score: 5953
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.45
    Marker Score: 484
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.45
    Marker Score: 195
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.44
    Marker Score: 503
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.44
    Marker Score: 178
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.44
    Marker Score: 1024
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.43
    Marker Score: 407
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.43
    Marker Score: 112
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.43
    Marker Score: 281
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.42
    Marker Score: 205
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.42
    Marker Score: 267
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.42
    Marker Score: 1035
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.42
    Marker Score: 253
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.42
    Marker Score: 286
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.41
    Marker Score: 379
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.41
    Marker Score: 105
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.41
    Marker Score: 674
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.41
    Marker Score: 108
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.41
    Marker Score: 142
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.41
    Marker Score: 224
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.41
    Marker Score: 1754
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.41
    Marker Score: 392
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.4
    Marker Score: 1640
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.4
    Marker Score: 388
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.4
    Marker Score: 150
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.4
    Marker Score: 298
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.39
    Marker Score: 505
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.39
    Marker Score: 914
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.39
    Marker Score: 653
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.39
    Marker Score: 122
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.38
    Marker Score: 154
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.38
    Marker Score: 426
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.38
    Marker Score: 392
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.38
    Marker Score: 336
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.38
    Marker Score: 337
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.38
    Marker Score: 146
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.37
    Marker Score: 172
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.37
    Marker Score: 2425
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.37
    Marker Score: 546
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.37
    Marker Score: 211

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Other Information

## Summary E2F6 is a transcription factor that plays a crucial role in regulating cell cycle progression and proliferation. It is highly expressed in various cell types, including cardiac muscle myoblasts, cerebral cortex GABAergic interneurons, forebrain radial glial cells, and intestinal crypt stem cells. ## Key characteristics * E2F6 is a highly conserved transcription factor with a predicted protein length of 406 amino acids. * It is a member of the E2F family of transcription factors, which are characterized by their ability to bind to DNA and regulate gene expression. * E2F6 is a key regulator of cell cycle progression and proliferation. * It is involved in the regulation of various genes involved in cell cycle entry, G1/S transition, and apoptosis. ## Pathways and functions * E2F6 is a key regulator of the cell cycle. * It promotes cell cycle entry by binding to DNA and activating the transcription of genes involved in cell cycle progression. * It also inhibits the expression of genes involved in cell cycle exit, such as p21 and p53. * In the G1/S transition, E2F6 promotes the expression of genes involved in DNA repair and synthesis, and inhibits the expression of genes involved in cell cycle checkpoints. * In the G1/S transition, E2F6 also binds to DNA in the rna polymerase ii-specific region of the CDK4 gene and activates its transcription, which is essential for the G1/S transition. * E2F6 also plays a role in regulating apoptosis. * It is a key regulator of cell growth and development, and its dysregulation has been linked to various human diseases. ## Clinical significance * Mutations in E2F6 have been linked to several human diseases, including cancer, developmental disorders, and neurodegenerative diseases. * The development of drugs that target E2F6 has emerged as a promising therapeutic strategy for these diseases.

Genular Protein ID: 1157676999

Symbol: E2F6_HUMAN

Name: N/A

UniProtKB Accession Codes:

O75461 A8K2Z8 G5E936 O60544 Q53QY9 Q6Q9Z6 Q7Z2H6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ComplexPortal 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 12 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 2 RefSeq 5 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9689056

Title: Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6.

PubMed ID: 9689056

DOI: 10.1073/pnas.95.16.9190

PubMed ID: 9704927

Title: E2F-6: a novel member of the E2F family is an inhibitor of E2F-dependent transcription.

PubMed ID: 9704927

DOI: 10.1038/sj.onc.1201975

PubMed ID: 15081404

Title: Human E2F6 is alternatively spliced to generate multiple protein isoforms.

PubMed ID: 15081404

DOI: 10.1016/j.bbrc.2004.03.099

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9501179

Title: E2F-6, a member of the E2F family that can behave as a transcriptional repressor.

PubMed ID: 9501179

DOI: 10.1073/pnas.95.6.2850

PubMed ID: 12004135

Title: A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells.

PubMed ID: 12004135

DOI: 10.1126/science.1069861

PubMed ID: 15960975

Title: Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.

PubMed ID: 15960975

DOI: 10.1016/j.cell.2005.04.031

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 281
  • Mass: 31844
  • Checksum: 539E049C15AD3508
  • Sequence:
    • MSQQRPARKL PSLLLDPTEE TVRRRCRDPI NVEGLLPSKI RINLEDNVQY VSMRKALKVK 
RPRFDVSLVY LTRKFMDLVR SAPGGILDLN KVATKLGVRK RRVYDITNVL DGIDLVEKKS 
KNHIRWIGSD LSNFGAVPQQ KKLQEELSDL SAMEDALDEL IKDCAQQLFE LTDDKENERL 
AYVTYQDIHS IQAFHEQIVI AVKAPAETRL DVPAPREDSI TVHIRSTNGP IDVYLCEVEQ 
GQTSNKRSEG VGTSSSESTH PEGPEEEENP QQSEELLEVS N

Genular Protein ID: 813063836

Symbol: Q53YM3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q53YM3

Database IDs:

ARBA 3 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 10 ExpressionAtlas 1 GO 5 Gene3D 2 GenomeRNAi 1 HOGENOM 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 Pfam 2 RefSeq 4 RuleBase 1 SAM 1 SMART 2 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15081404

Title: Human E2F6 is alternatively spliced to generate multiple protein isoforms.

PubMed ID: 15081404

DOI: 10.1016/j.bbrc.2004.03.099

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 206
  • Mass: 22982
  • Checksum: 6C79669AFD6F42EC
  • Sequence:
    • MDLVRSAPGG ILDLNKVATK LGVRKRRVYD ITNVLDGIDL VEKKSKNHIR WIGSDLSNFG 
AVPQQKKLQE ELSDLSAMED ALDELIKDCA QQLFELTDDK ENERLAYVTY QDIHSIQAFH 
EQIVIAVKAP AETRLDVPAP REDSITVHIR STNGPIDVYL CEVEQGQTSN KRSEGVGTSS 
SESTHPEGPE EEENPQQSEE LLEVSN

Genular Protein ID: 3981682292

Symbol: Q6Q9Z5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6Q9Z5

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 3 Gene3D 1 GenomeRNAi 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SUPFAM 1

Citations:

PubMed ID: 15081404

Title: Human E2F6 is alternatively spliced to generate multiple protein isoforms.

PubMed ID: 15081404

DOI: 10.1016/j.bbrc.2004.03.099

Sequence Information:

  • Length: 129
  • Mass: 14440
  • Checksum: 97F8FC3A3E748510
  • Sequence:
    • MEDALDELIK DCAQQLFELT DDKENERLAY VTYQDIHSIQ AFHEQIVIAV KAPAETRLDV 
PAPREDSITV HIRSTNGPID VYLCEVEQGQ TSNKRSEGVG TSSSESTHPE GPEEEENPQQ 
SEELLEVSN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.