Details for: E4F1

Gene ID: 1877

Symbol: E4F1

Ensembl ID: ENSG00000167967

Description: E4F transcription factor 1

Associated with

  • Camp response element binding
    (GO:0035497)
  • Cell division
    (GO:0051301)
  • Cytoplasm
    (GO:0005737)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna replication
    (GO:0006260)
  • Metal ion binding
    (GO:0046872)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nuclear body
    (GO:0016604)
  • Nucleoplasm
    (GO:0005654)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Protein ubiquitination
    (GO:0016567)
  • Regulation of cell cycle
    (GO:0051726)
  • Regulation of cell cycle process
    (GO:0010564)
  • Regulation of mitotic cell cycle, embryonic
    (GO:0009794)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii-specific dna-binding transcription factor binding
    (GO:0061629)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Spindle
    (GO:0005819)
  • Transferase activity
    (GO:0016740)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 88.2059
    Cell Significance Index: -13.7200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 56.2207
    Cell Significance Index: -14.2600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 33.2329
    Cell Significance Index: -15.6900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 32.4425
    Cell Significance Index: -13.1800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 13.9828
    Cell Significance Index: -13.3500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.2389
    Cell Significance Index: -15.0900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.8864
    Cell Significance Index: -13.0900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.9001
    Cell Significance Index: -15.3900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.7572
    Cell Significance Index: -11.5400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.1262
    Cell Significance Index: 210.3300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.3446
    Cell Significance Index: 92.9900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1920
    Cell Significance Index: 193.8700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7383
    Cell Significance Index: 80.3100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6817
    Cell Significance Index: 30.9000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.6763
    Cell Significance Index: 78.8100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6477
    Cell Significance Index: 33.7400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6358
    Cell Significance Index: 38.1700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5724
    Cell Significance Index: 12.4000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5296
    Cell Significance Index: 15.2600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4959
    Cell Significance Index: 447.7500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4407
    Cell Significance Index: 83.8700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3764
    Cell Significance Index: 74.7100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3339
    Cell Significance Index: 3.0800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3235
    Cell Significance Index: 9.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3076
    Cell Significance Index: 61.7100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2727
    Cell Significance Index: 3.7200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2157
    Cell Significance Index: 149.2200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1995
    Cell Significance Index: 5.4300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1954
    Cell Significance Index: 9.1100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1924
    Cell Significance Index: 14.7700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1851
    Cell Significance Index: 25.4200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1817
    Cell Significance Index: 9.4400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1750
    Cell Significance Index: 4.6900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1699
    Cell Significance Index: 30.6300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1635
    Cell Significance Index: 20.1000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1603
    Cell Significance Index: 87.5300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1415
    Cell Significance Index: 62.5700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1325
    Cell Significance Index: 47.5300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1306
    Cell Significance Index: 4.5900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1284
    Cell Significance Index: 3.2100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0922
    Cell Significance Index: 11.8200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0910
    Cell Significance Index: 5.8700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0876
    Cell Significance Index: 10.3300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0826
    Cell Significance Index: 5.2100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0721
    Cell Significance Index: 5.1000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0705
    Cell Significance Index: 1.0100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0526
    Cell Significance Index: 2.4700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0362
    Cell Significance Index: 2.7000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0334
    Cell Significance Index: 1.1600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0324
    Cell Significance Index: 5.5300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0135
    Cell Significance Index: 1.7500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0101
    Cell Significance Index: 0.5300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0043
    Cell Significance Index: 8.0300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0023
    Cell Significance Index: 0.0500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0010
    Cell Significance Index: 0.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0001
    Cell Significance Index: 0.1600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0023
    Cell Significance Index: -3.0800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0031
    Cell Significance Index: -4.8000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0075
    Cell Significance Index: -0.2000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0086
    Cell Significance Index: -0.2200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0113
    Cell Significance Index: -8.5400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0122
    Cell Significance Index: -7.7800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0125
    Cell Significance Index: -9.1500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0165
    Cell Significance Index: -12.2000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0166
    Cell Significance Index: -7.5500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0199
    Cell Significance Index: -2.0300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0233
    Cell Significance Index: -13.1200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0269
    Cell Significance Index: -16.8200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0300
    Cell Significance Index: -4.3600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0419
    Cell Significance Index: -2.3500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0442
    Cell Significance Index: -12.7300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0451
    Cell Significance Index: -0.7600
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0460
    Cell Significance Index: -0.3000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0537
    Cell Significance Index: -1.7200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0683
    Cell Significance Index: -1.8000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0800
    Cell Significance Index: -9.1700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0800
    Cell Significance Index: -16.8500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0884
    Cell Significance Index: -0.9200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0890
    Cell Significance Index: -5.4700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0961
    Cell Significance Index: -6.4600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1216
    Cell Significance Index: -1.4500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1355
    Cell Significance Index: -3.9800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1396
    Cell Significance Index: -14.5400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1593
    Cell Significance Index: -2.7300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1762
    Cell Significance Index: -4.5300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1806
    Cell Significance Index: -7.9900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1809
    Cell Significance Index: -14.3300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1995
    Cell Significance Index: -2.8000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2041
    Cell Significance Index: -5.8500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2176
    Cell Significance Index: -8.2400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2210
    Cell Significance Index: -13.5500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2414
    Cell Significance Index: -6.8900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2557
    Cell Significance Index: -2.0900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2617
    Cell Significance Index: -5.7300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2659
    Cell Significance Index: -3.9300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2748
    Cell Significance Index: -3.9400
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: -0.2821
    Cell Significance Index: -0.3700
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.2928
    Cell Significance Index: -0.6600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3159
    Cell Significance Index: -10.0600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3239
    Cell Significance Index: -8.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Regulation:** E4F1 is a transcription factor that binds to specific DNA sequences, thereby modulating the expression of target genes involved in cell cycle progression, DNA replication, and transcriptional regulation. 2. **Cell Cycle Regulation:** E4F1 has been shown to regulate the cell cycle, particularly during the G1/S phase transition, by modulating the expression of key cell cycle regulators. 3. **DNA Replication:** E4F1 is involved in the regulation of DNA replication, ensuring the accurate replication of genetic material during cell division. 4. **Cellular Differentiation:** E4F1 plays a role in promoting cellular differentiation, particularly in the development of the central nervous system and the gut epithelium. 5. **Neuroprotection:** E4F1 has been implicated in neuroprotection, with potential therapeutic implications for neurodegenerative diseases. **Pathways and Functions:** 1. **Camp Response Element Binding (CREB):** E4F1 interacts with CREB, a transcription factor that regulates gene expression in response to various stimuli, including calcium signaling. 2. **Cell Cycle Regulation:** E4F1 modulates the expression of key cell cycle regulators, including cyclin-dependent kinases (CDKs) and cyclin-dependent kinase inhibitors (CKIs). 3. **DNA Replication:** E4F1 regulates DNA replication by modulating the expression of DNA polymerases and other replication-related proteins. 4. **Transcriptional Regulation:** E4F1 interacts with other transcriptional regulators, including RNA polymerase II and histone-modifying enzymes, to regulate gene expression. 5. **Neurotransmission:** E4F1 has been implicated in the regulation of neurotransmission, particularly in the development and maintenance of GABAergic interneurons in the cerebral cortex. **Clinical Significance:** 1. **Cancer:** E4F1 has been implicated in the development and progression of various cancers, including colon cancer, where it may serve as a therapeutic target. 2. **Neurodegenerative Diseases:** E4F1's role in neuroprotection suggests its potential as a therapeutic agent for neurodegenerative diseases, such as Alzheimer's and Parkinson's. 3. **Developmental Disorders:** E4F1's involvement in cellular differentiation and development highlights its potential as a therapeutic target for developmental disorders, such as autism spectrum disorder. 4. **Regenerative Medicine:** E4F1's role in regulating cellular proliferation and differentiation makes it an attractive candidate for regenerative medicine applications, including tissue engineering and stem cell therapy. In conclusion, E4F1 is a multifunctional transcription factor that plays a crucial role in regulating various cellular processes, including cell cycle, DNA replication, and transcription. Its involvement in cancer, neurodegenerative diseases, developmental disorders, and regenerative medicine underscores its significance as a therapeutic target and potential therapeutic agent.

Genular Protein ID: 3085525268

Symbol: E4F1_HUMAN

Name: Transcription factor E4F1

UniProtKB Accession Codes:

Q66K89 A8K2R4 O00146

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9121437

Title: The adenovirus E1A-regulated transcription factor E4F is generated from the human homolog of nuclear factor phiAP3.

PubMed ID: 9121437

DOI: 10.1128/mcb.17.4.1890

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9530632

Title: Chromosomal location and tissue expression of the gene encoding the adenovirus E1A-regulated transcription factor E4F in humans and mice.

PubMed ID: 9530632

DOI: 10.1007/s003359900758

PubMed ID: 9418893

Title: Adenovirus E1A-regulated transcription factor p120E4F inhibits cell growth and induces the stabilization of the cdk inhibitor p21WAF1.

PubMed ID: 9418893

DOI: 10.1128/mcb.18.1.459

PubMed ID: 9512539

Title: Mutational analysis of p50E4F suggests that DNA binding activity is mediated through an alternative structure in a zinc finger domain that is regulated by phosphorylation.

PubMed ID: 9512539

DOI: 10.1093/nar/26.7.1681

PubMed ID: 10373523

Title: Suppression of E1A-mediated transformation by the p50E4F transcription factor.

PubMed ID: 10373523

DOI: 10.1128/mcb.19.7.4739

PubMed ID: 10644996

Title: p53 is involved in the p120E4F-mediated growth arrest.

PubMed ID: 10644996

DOI: 10.1038/sj.onc.1203250

PubMed ID: 10869426

Title: pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F.

PubMed ID: 10869426

DOI: 10.1073/pnas.130198397

PubMed ID: 11283272

Title: Cyclin A is a mediator of p120E4F-dependent cell cycle arrest in G1.

PubMed ID: 11283272

DOI: 10.1128/mcb.21.8.2956-2966.2001

PubMed ID: 12446718

Title: Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition.

PubMed ID: 12446718

DOI: 10.1074/jbc.m210978200

PubMed ID: 14645522

Title: Transcriptional activation of the cyclin A gene by the architectural transcription factor HMGA2.

PubMed ID: 14645522

DOI: 10.1128/mcb.23.24.9104-9116.2003

PubMed ID: 12730668

Title: Modulation of p120E4F transcriptional activity by the Gam1 adenoviral early protein.

PubMed ID: 12730668

DOI: 10.1038/sj.onc.1206379

PubMed ID: 15579445

Title: E4F1, a novel estrogen-responsive gene in possible atheroprotection, revealed by microarray analysis.

PubMed ID: 15579445

DOI: 10.1016/s0002-9440(10)63253-1

PubMed ID: 14729613

Title: Identification of the E1A-regulated transcription factor p120 E4F as an interacting partner of the RASSF1A candidate tumor suppressor gene.

PubMed ID: 14729613

DOI: 10.1158/0008-5472.can-03-2622

PubMed ID: 15805267

Title: Transcriptional regulation of cyclin A2 by RASSF1A through the enhanced binding of p120E4F to the cyclin A2 promoter.

PubMed ID: 15805267

DOI: 10.1158/0008-5472.can-04-3593

PubMed ID: 15876874

Title: p14ARF interacts with the SUMO-conjugating enzyme Ubc9 and promotes the sumoylation of its binding partners.

PubMed ID: 15876874

DOI: 10.4161/cc.4.4.1597

PubMed ID: 17110336

Title: E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation.

PubMed ID: 17110336

DOI: 10.1016/j.cell.2006.09.031

PubMed ID: 16882984

Title: E4F1: a novel candidate factor for mediating BMI1 function in primitive hematopoietic cells.

PubMed ID: 16882984

DOI: 10.1101/gad.1453406

PubMed ID: 16652157

Title: The LIM-only protein FHL2 is a negative regulator of E4F1.

PubMed ID: 16652157

DOI: 10.1038/sj.onc.1209567

PubMed ID: 16112766

Title: Interaction of the hepatitis B virus protein HBx with the human transcription regulatory protein p120E4F in vitro.

PubMed ID: 16112766

DOI: 10.1016/j.virusres.2005.07.003

PubMed ID: 17557114

Title: The role of LANP and ataxin 1 in E4F-mediated transcriptional repression.

PubMed ID: 17557114

DOI: 10.1038/sj.embor.7400983

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

Sequence Information:

  • Length: 784
  • Mass: 83496
  • Checksum: 60F6E711F2748FD8
  • Sequence:
    • MEGAMAVRVT AAHTAEAQAE AGREAGEGAV AAVAAALAPS GFLGLPAPFS EEDEDDVHRC 
GRCQAEFTAL EDFVQHKIQK ACQRAPPEAL PATPATTALL GQEVVPAAPG PEEPITVAHI 
VVEAASLAAD ISHASDLVGG GHIKEVIVAA EAELGDGEMA EAPGSPRQQG LGLAGEGEQA 
QVKLLVNKDG RYVCALCHKT FKTGSILKAH MVTHSSRKDH ECKLCGASFR TKGSLIRHHR 
RHTDERPYKC SKCGKSFRES GALTRHLKSL TPCTEKIRFS VSKDVVVSKE DARAGSGAGA 
AGLGTATSSV TGEPIETSPV IHLVTDAKGT VIHEVHVQMQ ELSLGMKALA PEPPVSQELP 
CSSEGSRENL LHQAMQNSGI VLERAAGEEG ALEPAPAAGS SPQPLAVAAP QLPVLEVQPL 
ETQVASEASA VPRTHPCPQC SETFPTAATL EAHKRGHTGP RPFACAQCGK AFPKAYLLKK 
HQEVHVRERR FRCGDCGKLY KTIAHVRGHR RVHSDERPYP CPKCGKRYKT KNAQQVHFRT 
HLEEKPHVCQ FCSRGFREKG SLVRHVRHHT GEKPFKCYKC GRGFAEHGTL NRHLRTKGGC 
LLEVEELLVS EDSPAAATTV LTEDPHTVLV EFSSVVADTQ EYIIEATADD AETSEATEII 
EGTQTEVDSH IMKVVQQIVH QASAGHQIIV QNVTMDEETA LGPEAAAADT ITIATPESLT 
EQVAMTLASA ISEGTVLAAR AGTSGTEQAT VTMVSSEDIE ILEHAGELVI ASPEGQLEVQ 
TVIV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.