Details for: E4F1

Gene ID: 1877

Symbol: E4F1

Ensembl ID: ENSG00000167967

Description: E4F transcription factor 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168779
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71749
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47973
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30401
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2404
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 481
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 435
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2712
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5288
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4949
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.86
    Marker Score: 13407
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 304
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.82
    Marker Score: 803
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.82
    Marker Score: 1549
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.78
    Marker Score: 8073
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.72
    Marker Score: 550.5
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 372
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.71
    Marker Score: 286
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.69
    Marker Score: 631
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.68
    Marker Score: 975
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.68
    Marker Score: 284
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.66
    Marker Score: 605
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.66
    Marker Score: 2764
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.65
    Marker Score: 5696
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.65
    Marker Score: 209
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.63
    Marker Score: 418
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.62
    Marker Score: 1460
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.62
    Marker Score: 776.5
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.61
    Marker Score: 177
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.61
    Marker Score: 941
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6
    Marker Score: 2369
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.58
    Marker Score: 1233.5
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.58
    Marker Score: 254
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.58
    Marker Score: 158
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.57
    Marker Score: 377
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.56
    Marker Score: 309
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.56
    Marker Score: 672
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.55
    Marker Score: 2053
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.55
    Marker Score: 592
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.55
    Marker Score: 33525
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.53
    Marker Score: 425
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.53
    Marker Score: 3198
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.52
    Marker Score: 392
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.52
    Marker Score: 4935
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.51
    Marker Score: 306
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.5
    Marker Score: 1579
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.49
    Marker Score: 1692
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.49
    Marker Score: 518
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.49
    Marker Score: 4177
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.49
    Marker Score: 234
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.48
    Marker Score: 168
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.48
    Marker Score: 231
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.48
    Marker Score: 993
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.47
    Marker Score: 110
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.47
    Marker Score: 196
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.46
    Marker Score: 779
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.45
    Marker Score: 216
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.45
    Marker Score: 9976
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.45
    Marker Score: 4191
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.44
    Marker Score: 16158
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.42
    Marker Score: 209
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.42
    Marker Score: 3665
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.42
    Marker Score: 199
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.42
    Marker Score: 1807
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.42
    Marker Score: 111
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.42
    Marker Score: 404
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.42
    Marker Score: 170
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.42
    Marker Score: 372
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.42
    Marker Score: 91
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.42
    Marker Score: 4179
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.41
    Marker Score: 435
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.41
    Marker Score: 1119
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.41
    Marker Score: 260
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.4
    Marker Score: 377
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.4
    Marker Score: 1087.5
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.4
    Marker Score: 271
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.4
    Marker Score: 648
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.39
    Marker Score: 960
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.39
    Marker Score: 117
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.39
    Marker Score: 178
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.39
    Marker Score: 264
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.38
    Marker Score: 383
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.38
    Marker Score: 186
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.38
    Marker Score: 81
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.38
    Marker Score: 5114
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.38
    Marker Score: 382
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.38
    Marker Score: 251
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.38
    Marker Score: 390
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.38
    Marker Score: 325
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.37
    Marker Score: 234
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.37
    Marker Score: 92
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.37
    Marker Score: 249
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.37
    Marker Score: 165
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.37
    Marker Score: 140
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.37
    Marker Score: 91
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.37
    Marker Score: 101
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.37
    Marker Score: 88

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Other Information

**Key characteristics:** - E4F1 is a highly conserved transcription factor that is expressed in various cell types. - It is a member of the E4F family of transcription factors, which are characterized by their ability to bind to DNA and regulate gene expression. - E4F1 is a key regulator of the cell cycle, particularly in the G1 and S phases. - It is involved in the regulation of cell proliferation, differentiation, and apoptosis. - It also plays a role in embryonic development and tissue homeostasis. **Pathways and functions:** - E4F1 binds to DNA sequences known as the Rna polymerase ii-specific DNA binding region (RnaPB) on the promoter regions of target genes. - It forms a complex with other transcription factors, such as c-Myc and p53, to regulate gene expression. - In the G1 phase, E4F1 is phosphorylated by the protein kinase Ras, leading to its dissociation from the DNA and the release of its transcriptional activity. - After phosphorylation, E4F1 forms a complex with p53 and recruits it to the DNA, resulting in transcriptional repression. - In the S phase, E4F1 is phosphorylated and degraded by the proteasome, leading to its loss of transcriptional activity. **Clinical significance:** - Mutations in the E4F1 gene have been linked to several human cancers, including breast cancer, lung cancer, and leukemia. - Targeting E4F1 has emerged as a promising strategy for cancer therapy. - E4F1 inhibitors are being investigated as potential treatments for cancer and other diseases where E4F1 is overexpressed. **Additional notes:** - E4F1 is a highly controversial gene and has been the subject of much controversy due to conflicting results and contradictory roles in different cell types. - Recent studies have suggested that E4F1 may have both tumor suppressor and oncogenic functions depending on the cellular context and the specific microenvironment.

Genular Protein ID: 3085525268

Symbol: E4F1_HUMAN

Name: Transcription factor E4F1

UniProtKB Accession Codes:

Q66K89 A8K2R4 O00146

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 5 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9121437

Title: The adenovirus E1A-regulated transcription factor E4F is generated from the human homolog of nuclear factor phiAP3.

PubMed ID: 9121437

DOI: 10.1128/mcb.17.4.1890

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9530632

Title: Chromosomal location and tissue expression of the gene encoding the adenovirus E1A-regulated transcription factor E4F in humans and mice.

PubMed ID: 9530632

DOI: 10.1007/s003359900758

PubMed ID: 9418893

Title: Adenovirus E1A-regulated transcription factor p120E4F inhibits cell growth and induces the stabilization of the cdk inhibitor p21WAF1.

PubMed ID: 9418893

DOI: 10.1128/mcb.18.1.459

PubMed ID: 9512539

Title: Mutational analysis of p50E4F suggests that DNA binding activity is mediated through an alternative structure in a zinc finger domain that is regulated by phosphorylation.

PubMed ID: 9512539

DOI: 10.1093/nar/26.7.1681

PubMed ID: 10373523

Title: Suppression of E1A-mediated transformation by the p50E4F transcription factor.

PubMed ID: 10373523

DOI: 10.1128/mcb.19.7.4739

PubMed ID: 10644996

Title: p53 is involved in the p120E4F-mediated growth arrest.

PubMed ID: 10644996

DOI: 10.1038/sj.onc.1203250

PubMed ID: 10869426

Title: pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F.

PubMed ID: 10869426

DOI: 10.1073/pnas.130198397

PubMed ID: 11283272

Title: Cyclin A is a mediator of p120E4F-dependent cell cycle arrest in G1.

PubMed ID: 11283272

DOI: 10.1128/mcb.21.8.2956-2966.2001

PubMed ID: 12446718

Title: Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition.

PubMed ID: 12446718

DOI: 10.1074/jbc.m210978200

PubMed ID: 14645522

Title: Transcriptional activation of the cyclin A gene by the architectural transcription factor HMGA2.

PubMed ID: 14645522

DOI: 10.1128/mcb.23.24.9104-9116.2003

PubMed ID: 12730668

Title: Modulation of p120E4F transcriptional activity by the Gam1 adenoviral early protein.

PubMed ID: 12730668

DOI: 10.1038/sj.onc.1206379

PubMed ID: 15579445

Title: E4F1, a novel estrogen-responsive gene in possible atheroprotection, revealed by microarray analysis.

PubMed ID: 15579445

DOI: 10.1016/s0002-9440(10)63253-1

PubMed ID: 14729613

Title: Identification of the E1A-regulated transcription factor p120 E4F as an interacting partner of the RASSF1A candidate tumor suppressor gene.

PubMed ID: 14729613

DOI: 10.1158/0008-5472.can-03-2622

PubMed ID: 15805267

Title: Transcriptional regulation of cyclin A2 by RASSF1A through the enhanced binding of p120E4F to the cyclin A2 promoter.

PubMed ID: 15805267

DOI: 10.1158/0008-5472.can-04-3593

PubMed ID: 15876874

Title: p14ARF interacts with the SUMO-conjugating enzyme Ubc9 and promotes the sumoylation of its binding partners.

PubMed ID: 15876874

DOI: 10.4161/cc.4.4.1597

PubMed ID: 17110336

Title: E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation.

PubMed ID: 17110336

DOI: 10.1016/j.cell.2006.09.031

PubMed ID: 16882984

Title: E4F1: a novel candidate factor for mediating BMI1 function in primitive hematopoietic cells.

PubMed ID: 16882984

DOI: 10.1101/gad.1453406

PubMed ID: 16652157

Title: The LIM-only protein FHL2 is a negative regulator of E4F1.

PubMed ID: 16652157

DOI: 10.1038/sj.onc.1209567

PubMed ID: 16112766

Title: Interaction of the hepatitis B virus protein HBx with the human transcription regulatory protein p120E4F in vitro.

PubMed ID: 16112766

DOI: 10.1016/j.virusres.2005.07.003

PubMed ID: 17557114

Title: The role of LANP and ataxin 1 in E4F-mediated transcriptional repression.

PubMed ID: 17557114

DOI: 10.1038/sj.embor.7400983

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

Sequence Information:

  • Length: 784
  • Mass: 83496
  • Checksum: 60F6E711F2748FD8
  • Sequence:
    • MEGAMAVRVT AAHTAEAQAE AGREAGEGAV AAVAAALAPS GFLGLPAPFS EEDEDDVHRC 
GRCQAEFTAL EDFVQHKIQK ACQRAPPEAL PATPATTALL GQEVVPAAPG PEEPITVAHI 
VVEAASLAAD ISHASDLVGG GHIKEVIVAA EAELGDGEMA EAPGSPRQQG LGLAGEGEQA 
QVKLLVNKDG RYVCALCHKT FKTGSILKAH MVTHSSRKDH ECKLCGASFR TKGSLIRHHR 
RHTDERPYKC SKCGKSFRES GALTRHLKSL TPCTEKIRFS VSKDVVVSKE DARAGSGAGA 
AGLGTATSSV TGEPIETSPV IHLVTDAKGT VIHEVHVQMQ ELSLGMKALA PEPPVSQELP 
CSSEGSRENL LHQAMQNSGI VLERAAGEEG ALEPAPAAGS SPQPLAVAAP QLPVLEVQPL 
ETQVASEASA VPRTHPCPQC SETFPTAATL EAHKRGHTGP RPFACAQCGK AFPKAYLLKK 
HQEVHVRERR FRCGDCGKLY KTIAHVRGHR RVHSDERPYP CPKCGKRYKT KNAQQVHFRT 
HLEEKPHVCQ FCSRGFREKG SLVRHVRHHT GEKPFKCYKC GRGFAEHGTL NRHLRTKGGC 
LLEVEELLVS EDSPAAATTV LTEDPHTVLV EFSSVVADTQ EYIIEATADD AETSEATEII 
EGTQTEVDSH IMKVVQQIVH QASAGHQIIV QNVTMDEETA LGPEAAAADT ITIATPESLT 
EQVAMTLASA ISEGTVLAAR AGTSGTEQAT VTMVSSEDIE ILEHAGELVI ASPEGQLEVQ 
TVIV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.