Details for: ELAVL1

Gene ID: 1994

Symbol: ELAVL1

Ensembl ID: ENSG00000066044

Description: ELAV like RNA binding protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 257.8671
    Cell Significance Index: -40.1100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 178.7155
    Cell Significance Index: -45.3300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 110.6810
    Cell Significance Index: -52.2600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 108.1581
    Cell Significance Index: -43.9400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 97.8255
    Cell Significance Index: -50.3200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 78.2910
    Cell Significance Index: -52.5400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 46.5675
    Cell Significance Index: -44.4600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 40.8206
    Cell Significance Index: -50.3300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.6298
    Cell Significance Index: -41.8700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.6483
    Cell Significance Index: -41.9200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.1955
    Cell Significance Index: -52.0700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.9895
    Cell Significance Index: -26.2400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 7.2815
    Cell Significance Index: 116.8200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.8944
    Cell Significance Index: 65.8300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.7017
    Cell Significance Index: 35.6200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.6990
    Cell Significance Index: 18.4700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.5082
    Cell Significance Index: 42.1500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.5021
    Cell Significance Index: 163.3800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.4974
    Cell Significance Index: 89.9000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.3862
    Cell Significance Index: 36.4500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.3123
    Cell Significance Index: 213.4400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2286
    Cell Significance Index: 243.8200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.2036
    Cell Significance Index: 32.7600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1607
    Cell Significance Index: 232.8300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.0626
    Cell Significance Index: 125.3100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9573
    Cell Significance Index: 522.8000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8898
    Cell Significance Index: 57.4100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7798
    Cell Significance Index: 140.5700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7796
    Cell Significance Index: 95.8600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7774
    Cell Significance Index: 106.7600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7706
    Cell Significance Index: 40.0300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7562
    Cell Significance Index: 35.5400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.7253
    Cell Significance Index: 37.7800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7077
    Cell Significance Index: 48.9400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6167
    Cell Significance Index: 221.2000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6123
    Cell Significance Index: 28.5500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5928
    Cell Significance Index: 262.0900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5770
    Cell Significance Index: 43.0100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5474
    Cell Significance Index: 70.7200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3417
    Cell Significance Index: 9.1200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3334
    Cell Significance Index: 18.7100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3076
    Cell Significance Index: 39.4300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2749
    Cell Significance Index: 248.1700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2593
    Cell Significance Index: 179.3800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2547
    Cell Significance Index: 18.0100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2194
    Cell Significance Index: 16.8400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1849
    Cell Significance Index: 35.1900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0677
    Cell Significance Index: 1.9500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0650
    Cell Significance Index: 122.4100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.0445
    Cell Significance Index: 0.7500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0148
    Cell Significance Index: 22.8300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0122
    Cell Significance Index: 2.0800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0116
    Cell Significance Index: 21.3300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0005
    Cell Significance Index: 0.3000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0029
    Cell Significance Index: -0.1300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0065
    Cell Significance Index: -8.8200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0079
    Cell Significance Index: -5.9500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0305
    Cell Significance Index: -22.3900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0338
    Cell Significance Index: -2.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0342
    Cell Significance Index: -15.5200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0461
    Cell Significance Index: -0.5900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0481
    Cell Significance Index: -0.8100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0586
    Cell Significance Index: -43.3900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0662
    Cell Significance Index: -4.0700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0888
    Cell Significance Index: -50.1000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0944
    Cell Significance Index: -58.9700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0998
    Cell Significance Index: -10.1900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1156
    Cell Significance Index: -7.7700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1452
    Cell Significance Index: -41.7900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1736
    Cell Significance Index: -20.2300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2032
    Cell Significance Index: -29.5400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2531
    Cell Significance Index: -7.2600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2671
    Cell Significance Index: -30.6000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2769
    Cell Significance Index: -58.3200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2776
    Cell Significance Index: -12.2800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.3176
    Cell Significance Index: -31.4200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3605
    Cell Significance Index: -9.2100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3749
    Cell Significance Index: -2.5400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3901
    Cell Significance Index: -12.5000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4015
    Cell Significance Index: -21.0800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4270
    Cell Significance Index: -16.1700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4469
    Cell Significance Index: -46.5300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4715
    Cell Significance Index: -8.0800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4893
    Cell Significance Index: -13.1100
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.4985
    Cell Significance Index: -2.1700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5269
    Cell Significance Index: -41.7300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5657
    Cell Significance Index: -12.2600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.5955
    Cell Significance Index: -8.7900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.6803
    Cell Significance Index: -6.2700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.6875
    Cell Significance Index: -9.3800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7005
    Cell Significance Index: -17.5100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7415
    Cell Significance Index: -45.4600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.8049
    Cell Significance Index: -9.6000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.8187
    Cell Significance Index: -17.4400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.9020
    Cell Significance Index: -5.4500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.9131
    Cell Significance Index: -23.4700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.0265
    Cell Significance Index: -18.1400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.0338
    Cell Significance Index: -23.8900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.0356
    Cell Significance Index: -22.6800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.0560
    Cell Significance Index: -31.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ELAVL1 is a member of the ELAV family of RNA-binding proteins, which are known for their ability to bind to AU-rich elements (ARE) in the 3'-UTR of target mRNAs. This binding event stabilizes the mRNA, leading to increased translation and protein production. ELAVL1 is uniquely characterized by its ability to bind to a wide range of mRNAs, including those involved in immune responses, cell proliferation, and differentiation. **Pathways and Functions:** ELAVL1 is involved in several key pathways, including: 1. **3'-UTR-mediated mRNA stabilization:** ELAVL1 binds to AREs in target mRNAs, leading to increased stability and translation. 2. **Cytoplasmic stress granule formation:** ELAVL1 is a key component of stress granules, which are cytoplasmic structures that regulate mRNA translation in response to cellular stress. 3. **Regulation of microRNA-mediated gene silencing:** ELAVL1 binds to microRNAs, preventing their ability to silence target gene expression. 4. **Regulation of translation:** ELAVL1 influences the translation of mRNAs involved in immune responses, cell proliferation, and differentiation. 5. **Post-transcriptional gene silencing:** ELAVL1 plays a role in regulating the expression of genes involved in immune responses and cellular homeostasis. **Clinical Significance:** ELAVL1's involvement in various diseases highlights its potential as a therapeutic target. For example: 1. **Neuroinflammation:** ELAVL1's role in regulating immune responses in the brain makes it a potential target for treating neuroinflammatory disorders, such as multiple sclerosis and Alzheimer's disease. 2. **Cancer:** ELAVL1's ability to regulate mRNA stability and translation makes it a potential target for cancer therapy, particularly in the context of immune checkpoint inhibitors. 3. **Autoimmune diseases:** ELAVL1's involvement in regulating immune responses makes it a potential target for treating autoimmune diseases, such as rheumatoid arthritis and lupus. In conclusion, ELAVL1 is a complex gene that plays a critical role in regulating mRNA stability, translation, and stability in various cellular contexts. Its involvement in immune responses, cancer, and autoimmune diseases highlights its potential as a therapeutic target. Further research is necessary to fully elucidate the mechanisms by which ELAVL1 influences cellular homeostasis and to explore its potential as a therapeutic agent.

Genular Protein ID: 4139371170

Symbol: ELAV1_HUMAN

Name: ELAV-like protein 1

UniProtKB Accession Codes:

Q15717 B4DVB8 Q53XN6 Q9BTT1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CPTAC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugCentral 1 EMBL 7 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 32 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 10 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8626503

Title: Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein.

PubMed ID: 8626503

DOI: 10.1074/jbc.271.14.8144

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11729309

Title: Delineation of mRNA export pathways by the use of cell-permeable peptides.

PubMed ID: 11729309

DOI: 10.1126/science.1064693

PubMed ID: 12237300

Title: Lipopolysaccharide-induced methylation of HuR, an mRNA-stabilizing protein, by CARM1. Coactivator-associated arginine methyltransferase.

PubMed ID: 12237300

DOI: 10.1074/jbc.m206187200

PubMed ID: 14517288

Title: Stabilization of urokinase and urokinase receptor mRNAs by HuR is linked to its cytoplasmic accumulation induced by activated mitogen-activated protein kinase-activated protein kinase 2.

PubMed ID: 14517288

DOI: 10.1128/mcb.23.20.7177-7188.2003

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 14731398

Title: Facilitation of mRNA deadenylation and decay by the exosome-bound, DExH protein RHAU.

PubMed ID: 14731398

DOI: 10.1016/s1097-2765(03)00481-7

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17932509

Title: Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells.

PubMed ID: 17932509

DOI: 10.1038/sj.embor.7401088

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 17632515

Title: Identification and mechanistic characterization of low-molecular-weight inhibitors for HuR.

PubMed ID: 17632515

DOI: 10.1038/nchembio.2007.14

PubMed ID: 18191643

Title: Novel tyrosine phosphorylated and cardiolipin-binding protein CLPABP functions as mitochondrial RNA granule.

PubMed ID: 18191643

DOI: 10.1016/j.bbamcr.2007.12.009

PubMed ID: 18161049

Title: Natural antisense transcript stabilizes inducible nitric oxide synthase messenger RNA in rat hepatocytes.

PubMed ID: 18161049

DOI: 10.1002/hep.22036

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18285462

Title: Posttranslational modification of the AU-rich element binding protein HuR by protein kinase Cdelta elicits angiotensin II-induced stabilization and nuclear export of cyclooxygenase 2 mRNA.

PubMed ID: 18285462

DOI: 10.1128/mcb.01530-07

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19561594

Title: Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins.

PubMed ID: 19561594

DOI: 10.1038/nbt.1550

PubMed ID: 19029303

Title: Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs.

PubMed ID: 19029303

DOI: 10.1261/rna.1175909

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23640942

Title: Subcellular localization and RNP formation of IGF2BPs (IGF2 mRNA-binding proteins) is modulated by distinct RNA-binding domains.

PubMed ID: 23640942

DOI: 10.1515/hsz-2013-0111

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27616329

Title: Antagonizing effect of CLPABP on the function of HuR as a regulator of ARE-containing leptin mRNA stability and the effect of its depletion on obesity in old male mouse.

PubMed ID: 27616329

DOI: 10.1016/j.bbalip.2016.09.006

PubMed ID: 27974568

Title: IRAV (FLJ11286), an Interferon-Stimulated Gene with Antiviral Activity against Dengue Virus, Interacts with MOV10.

PubMed ID: 27974568

DOI: 10.1128/jvi.01606-16

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 29180010

Title: Role of N-myristoylation in stability and subcellular localization of the CLPABP protein.

PubMed ID: 29180010

DOI: 10.1016/j.bbrc.2017.11.112

PubMed ID: 30067974

Title: FXR1 is an IL-19-responsive RNA-binding protein that destabilizes pro-inflammatory transcripts in vascular smooth muscle cells.

PubMed ID: 30067974

DOI: 10.1016/j.celrep.2018.07.002

PubMed ID: 29476152

Title: Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation.

PubMed ID: 29476152

DOI: 10.1038/s41556-018-0045-z

PubMed ID: 31358969

Title: 5-methylcytosine promotes pathogenesis of bladder cancer through stabilizing mRNAs.

PubMed ID: 31358969

DOI: 10.1038/s41556-019-0361-y

PubMed ID: 32245947

Title: An oncopeptide regulates m6A recognition by the m6A reader IGF2BP1 and tumorigenesis.

PubMed ID: 32245947

DOI: 10.1038/s41467-020-15403-9

PubMed ID: 20219472

Title: The X-ray crystal structure of the first RNA recognition motif and site-directed mutagenesis suggest a possible HuR redox sensing mechanism.

PubMed ID: 20219472

DOI: 10.1016/j.jmb.2010.02.043

PubMed ID: 23519412

Title: The structure of the ARE-binding domains of Hu antigen R (HuR) undergoes conformational changes during RNA binding.

PubMed ID: 23519412

DOI: 10.1107/s0907444912047828

Sequence Information:

  • Length: 326
  • Mass: 36092
  • Checksum: 0B86143805264DEF
  • Sequence:
    • MSNGYEDHMA EDCRGDIGRT NLIVNYLPQN MTQDELRSLF SSIGEVESAK LIRDKVAGHS 
LGYGFVNYVT AKDAERAINT LNGLRLQSKT IKVSYARPSS EVIKDANLYI SGLPRTMTQK 
DVEDMFSRFG RIINSRVLVD QTTGLSRGVA FIRFDKRSEA EEAITSFNGH KPPGSSEPIT 
VKFAANPNQN KNVALLSQLY HSPARRFGGP VHHQAQRFRF SPMGVDHMSG LSGVNVPGNA 
SSGWCIFIYN LGQDADEGIL WQMFGPFGAV TNVKVIRDFN TNKCKGFGFV TMTNYEEAAM 
AIASLNGYRL GDKILQVSFK TNKSHK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.