Details for: ELAVL3

Gene ID: 1995

Symbol: ELAVL3

Ensembl ID: ENSG00000196361

Description: ELAV like RNA binding protein 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 4.39
    Marker Score: 23016
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 4.33
    Marker Score: 146394
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 2.97
    Marker Score: 9957
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.94
    Marker Score: 2776
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 2.92
    Marker Score: 4110
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.88
    Marker Score: 15452
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.87
    Marker Score: 3471
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.83
    Marker Score: 13073
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 2.8
    Marker Score: 11668
  • Cell Name: granule cell (CL0000120)
    Fold Change: 2.76
    Marker Score: 20845
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.68
    Marker Score: 5439
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.66
    Marker Score: 39832
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 2.62
    Marker Score: 6026
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.57
    Marker Score: 19708
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.54
    Marker Score: 50617.5
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.52
    Marker Score: 95581
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.47
    Marker Score: 10239.5
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.35
    Marker Score: 86846
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.35
    Marker Score: 2636
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.29
    Marker Score: 960
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.28
    Marker Score: 8800
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.2
    Marker Score: 5258
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.13
    Marker Score: 20056
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 2.04
    Marker Score: 685
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.01
    Marker Score: 123856
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.97
    Marker Score: 8035
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.94
    Marker Score: 1150
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.9
    Marker Score: 19620
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.86
    Marker Score: 17644
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.84
    Marker Score: 15782
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.83
    Marker Score: 864.5
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.75
    Marker Score: 477
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.7
    Marker Score: 2126
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.69
    Marker Score: 537
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.64
    Marker Score: 2528
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1175
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.6
    Marker Score: 6204.5
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.49
    Marker Score: 31876
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168868
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 874
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.34
    Marker Score: 2251
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 1.32
    Marker Score: 402
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.18
    Marker Score: 3365
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.12
    Marker Score: 2313
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.11
    Marker Score: 622
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.09
    Marker Score: 419
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.07
    Marker Score: 725
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.03
    Marker Score: 1185
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.03
    Marker Score: 644
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.02
    Marker Score: 424
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71830
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48055
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 513
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 466
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.95
    Marker Score: 315
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 377
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5354
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 329
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.9
    Marker Score: 685
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.89
    Marker Score: 3750.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.85
    Marker Score: 491
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.84
    Marker Score: 1598.5
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.83
    Marker Score: 8461
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.83
    Marker Score: 547
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 400
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.75
    Marker Score: 363
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.74
    Marker Score: 4950
  • Cell Name: visceromotor neuron (CL0005025)
    Fold Change: 0.71
    Marker Score: 206
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.7
    Marker Score: 871
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.64
    Marker Score: 1310
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.62
    Marker Score: 399
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.61
    Marker Score: 295
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.61
    Marker Score: 485
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.61
    Marker Score: 525
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.56
    Marker Score: 597
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 175
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.52
    Marker Score: 164
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.52
    Marker Score: 488
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.48
    Marker Score: 202
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.46
    Marker Score: 240
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.44
    Marker Score: 6936
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.44
    Marker Score: 140
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.42
    Marker Score: 251
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.41
    Marker Score: 195
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.4
    Marker Score: 396
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.39
    Marker Score: 687
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.39
    Marker Score: 424
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.38
    Marker Score: 123
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.34
    Marker Score: 158.5
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.32
    Marker Score: 326.5
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.29
    Marker Score: 299

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Other Information

**Key characteristics:** - ELAVL3 is a large protein (150 kDa) with a complex structure consisting of multiple domains. - It contains a central RNA recognition domain (RRD) that is responsible for binding to specific DNA sequences. - ELAVL3 is also involved in the regulation of gene expression through interactions with other proteins. **Pathways and functions:** - ELAVL3 is primarily expressed in neurons and retinal cells. - It is involved in the regulation of neurogenesis, the process by which new neurons are generated. - ELAVL3 is also important for the maintenance of retinal function and the survival of retinal neurons. - It is involved in the development of the nervous system by promoting the migration of neural stem cells to their final destinations. **Clinical significance:** Mutations in the ELAVL3 gene have been linked to a number of neurological disorders, including autism, schizophrenia, and retinal degenerative diseases. These diseases are characterized by a variety of symptoms, including cognitive impairment, social withdrawal, and vision problems. **Conclusion:** ELAVL3 is a key regulator of neuronal development and function. Its mutations can have a significant impact on brain development and can lead to neurological disorders. Further research on ELAVL3 may lead to the development of new treatments for these diseases.

Genular Protein ID: 1782368921

Symbol: ELAV3_HUMAN

Name: ELAV-like protein 3

UniProtKB Accession Codes:

Q14576 Q16135 Q96CL8 Q96QS9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7511893

Title: A hippocampal protein associated with paraneoplastic neurologic syndrome and small cell lung carcinoma.

PubMed ID: 7511893

DOI: 10.1006/bbrc.1994.1358

PubMed ID: 10710437

Title: RNA-binding analyses of HuC and HuD with the VEGF and c-myc 3'-untranslated regions using a novel ELISA-based assay.

PubMed ID: 10710437

DOI: 10.1093/nar/28.7.e20

Sequence Information:

  • Length: 367
  • Mass: 39547
  • Checksum: 03FB3BD4D112B326
  • Sequence:
    • MVTQILGAME SQVGGGPAGP ALPNGPLLGT NGATDDSKTN LIVNYLPQNM TQDEFKSLFG 
SIGDIESCKL VRDKITGQSL GYGFVNYSDP NDADKAINTL NGLKLQTKTI KVSYARPSSA 
SIRDANLYVS GLPKTMSQKE MEQLFSQYGR IITSRILVDQ VTGVSRGVGF IRFDKRIEAE 
EAIKGLNGQK PLGAAEPITV KFANNPSQKT GQALLTHLYQ SSARRYAGPL HHQTQRFRLD 
NLLNMAYGVK SPLSLIARFS PIAIDGMSGL AGVGLSGGAA GAGWCIFVYN LSPEADESVL 
WQLFGPFGAV TNVKVIRDFT TNKCKGFGFV TMTNYDEAAM AIASLNGYRL GERVLQVSFK 
TSKQHKA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.