Details for: ELAVL3

Gene ID: 1995

Symbol: ELAVL3

Ensembl ID: ENSG00000196361

Description: ELAV like RNA binding protein 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 519.9774
    Cell Significance Index: -80.8800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 321.3173
    Cell Significance Index: -81.5000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 200.8265
    Cell Significance Index: -82.7300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.1575
    Cell Significance Index: 165.7800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.7744
    Cell Significance Index: 995.1400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.4954
    Cell Significance Index: 500.5700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.2606
    Cell Significance Index: 49.5000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.9463
    Cell Significance Index: 24.1400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.5436
    Cell Significance Index: 94.8800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.5138
    Cell Significance Index: 92.8100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.2572
    Cell Significance Index: 30.1500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.8282
    Cell Significance Index: 572.8200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.8133
    Cell Significance Index: 20.3300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.7018
    Cell Significance Index: 47.1900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.5263
    Cell Significance Index: 15.0200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.4511
    Cell Significance Index: 7.7300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4075
    Cell Significance Index: 77.5600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2416
    Cell Significance Index: 218.1700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0231
    Cell Significance Index: 1.0200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0073
    Cell Significance Index: 4.5500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0444
    Cell Significance Index: -83.6800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0454
    Cell Significance Index: -33.6500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0577
    Cell Significance Index: -106.4200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0695
    Cell Significance Index: -106.9300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0781
    Cell Significance Index: -106.1400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0873
    Cell Significance Index: -49.2500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1167
    Cell Significance Index: -4.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1202
    Cell Significance Index: -76.3300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.1202
    Cell Significance Index: -90.9500
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1414
    Cell Significance Index: -1.6500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.1487
    Cell Significance Index: -81.2300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.1529
    Cell Significance Index: -15.1300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1651
    Cell Significance Index: -34.7700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1851
    Cell Significance Index: -84.0100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2002
    Cell Significance Index: -7.5800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.2227
    Cell Significance Index: -36.2300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2281
    Cell Significance Index: -65.6200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.2557
    Cell Significance Index: -46.1000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2809
    Cell Significance Index: -47.9600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3272
    Cell Significance Index: -10.4800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3467
    Cell Significance Index: -9.6900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3495
    Cell Significance Index: -15.8400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.4257
    Cell Significance Index: -84.4900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.4418
    Cell Significance Index: -48.0600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4626
    Cell Significance Index: -11.8900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.4652
    Cell Significance Index: -59.6300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.4890
    Cell Significance Index: -60.1300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5458
    Cell Significance Index: -62.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.5588
    Cell Significance Index: -81.2300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.5930
    Cell Significance Index: -76.6100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.5954
    Cell Significance Index: -81.7700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.6650
    Cell Significance Index: -19.1600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.7034
    Cell Significance Index: -81.9700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.7458
    Cell Significance Index: -7.0700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.7614
    Cell Significance Index: -86.9100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.7618
    Cell Significance Index: -9.5000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.7662
    Cell Significance Index: -78.2700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.7839
    Cell Significance Index: -8.5400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.7962
    Cell Significance Index: -44.6800
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.8085
    Cell Significance Index: -5.2600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.8182
    Cell Significance Index: -85.1900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.8970
    Cell Significance Index: -105.7800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.9474
    Cell Significance Index: -65.5200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.0222
    Cell Significance Index: -21.7000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -1.0306
    Cell Significance Index: -76.8100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -1.0324
    Cell Significance Index: -61.9800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.0782
    Cell Significance Index: -34.3400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.0929
    Cell Significance Index: -21.6100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.0993
    Cell Significance Index: -35.9900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.1397
    Cell Significance Index: -22.8800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -1.1750
    Cell Significance Index: -14.8300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.1971
    Cell Significance Index: -91.8600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.2756
    Cell Significance Index: -66.4500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -1.3281
    Cell Significance Index: -85.6800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.3756
    Cell Significance Index: -48.1900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -1.4006
    Cell Significance Index: -30.2600
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -1.4352
    Cell Significance Index: -14.9500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.4443
    Cell Significance Index: -91.0300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.5053
    Cell Significance Index: -37.5500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -1.5715
    Cell Significance Index: -73.8600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -1.6039
    Cell Significance Index: -33.4800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.7147
    Cell Significance Index: -79.9500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -1.7446
    Cell Significance Index: -36.1900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -1.7888
    Cell Significance Index: -12.1200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -2.1040
    Cell Significance Index: -26.5500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -2.2431
    Cell Significance Index: -116.5200
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -2.2627
    Cell Significance Index: -24.2600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -2.2772
    Cell Significance Index: -49.3400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -2.2999
    Cell Significance Index: -79.9200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -2.3308
    Cell Significance Index: -40.3000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -2.3407
    Cell Significance Index: -46.0700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -2.3722
    Cell Significance Index: -87.0800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -2.3758
    Cell Significance Index: -26.9900
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -2.4993
    Cell Significance Index: -20.6300
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -2.6236
    Cell Significance Index: -23.8500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -2.6561
    Cell Significance Index: -76.1400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -2.6723
    Cell Significance Index: -38.2700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -2.7289
    Cell Significance Index: -57.1200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -2.7754
    Cell Significance Index: -69.2100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.8566
    Cell Significance Index: -84.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ELAVL3 is a member of the ELAV (Embryonic Lethal, Abnormal Vision) family of RNA binding proteins, which are characterized by their ability to bind to AU-rich elements (AREs) in the 3'-untranslated regions (UTRs) of target mRNAs. These proteins are predominantly expressed in neurons and other cells of the nervous system, highlighting their critical role in neuronal development and function. ELAVL3 is specifically localized to the cytoplasm and nucleus, where it interacts with various RNA molecules, influencing their stability, localization, and translation. **Pathways and Functions:** ELAVL3 is involved in several critical pathways, including: 1. **Cell differentiation:** ELAVL3 regulates the expression of genes involved in neuronal differentiation, promoting the development of specific neuronal subtypes, such as Purkinje cells and inhibitory interneurons. 2. **mRNA 3'-UTR AU-rich region binding:** ELAVL3 binds to AREs in the 3'-UTRs of target mRNAs, influencing their stability and translation. This interaction is essential for regulating the expression of genes involved in neuronal development and function. 3. **Nervous system development:** ELAVL3 is involved in the regulation of genes involved in nervous system development, including the expression of neurotransmitters and ion channels. 4. **Ribonucleoprotein complex:** ELAVL3 interacts with various ribonucleoproteins, influencing the assembly and disassembly of ribonucleoprotein complexes, which are essential for RNA processing and translation. **Clinical Significance:** Dysregulation of ELAVL3 has been implicated in various neurological disorders, including: 1. **Neurodegenerative diseases:** ELAVL3 has been linked to neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS), where its dysregulation contributes to neuronal dysfunction and death. 2. **Neurodevelopmental disorders:** ELAVL3 has been implicated in neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia, where its dysregulation contributes to neuronal development and function. 3. **Cancer:** ELAVL3 has been shown to be overexpressed in certain types of cancer, including glioblastoma and breast cancer, where its dysregulation contributes to tumorigenesis and progression. In conclusion, ELAVL3 is a critical RNA binding protein involved in various cellular processes, particularly in neuronal development and function. Its dysregulation has been implicated in various neurological and cancerous disorders, highlighting the need for further research into the mechanisms underlying ELAVL3 function and its potential therapeutic applications.

Genular Protein ID: 1782368921

Symbol: ELAV3_HUMAN

Name: ELAV-like protein 3

UniProtKB Accession Codes:

Q14576 Q16135 Q96CL8 Q96QS9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7511893

Title: A hippocampal protein associated with paraneoplastic neurologic syndrome and small cell lung carcinoma.

PubMed ID: 7511893

DOI: 10.1006/bbrc.1994.1358

PubMed ID: 10710437

Title: RNA-binding analyses of HuC and HuD with the VEGF and c-myc 3'-untranslated regions using a novel ELISA-based assay.

PubMed ID: 10710437

DOI: 10.1093/nar/28.7.e20

Sequence Information:

  • Length: 367
  • Mass: 39547
  • Checksum: 03FB3BD4D112B326
  • Sequence:
    • MVTQILGAME SQVGGGPAGP ALPNGPLLGT NGATDDSKTN LIVNYLPQNM TQDEFKSLFG 
SIGDIESCKL VRDKITGQSL GYGFVNYSDP NDADKAINTL NGLKLQTKTI KVSYARPSSA 
SIRDANLYVS GLPKTMSQKE MEQLFSQYGR IITSRILVDQ VTGVSRGVGF IRFDKRIEAE 
EAIKGLNGQK PLGAAEPITV KFANNPSQKT GQALLTHLYQ SSARRYAGPL HHQTQRFRLD 
NLLNMAYGVK SPLSLIARFS PIAIDGMSGL AGVGLSGGAA GAGWCIFVYN LSPEADESVL 
WQLFGPFGAV TNVKVIRDFT TNKCKGFGFV TMTNYDEAAM AIASLNGYRL GERVLQVSFK 
TSKQHKA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.