Details for: ELF4

Gene ID: 2000

Symbol: ELF4

Ensembl ID: ENSG00000102034

Description: E74 like ETS transcription factor 4

Associated with

  • Cell differentiation
    (GO:0030154)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Natural killer cell proliferation
    (GO:0001787)
  • Negative regulation of inflammatory response
    (GO:0050728)
  • Negative regulation of interleukin-1 beta production
    (GO:0032691)
  • Negative regulation of interleukin-6 production
    (GO:0032715)
  • Negative regulation of tumor necrosis factor production
    (GO:0032720)
  • Nk t cell proliferation
    (GO:0001866)
  • Nuclear body
    (GO:0016604)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Pml body
    (GO:0016605)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 48.2175
    Cell Significance Index: -7.5000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 27.5584
    Cell Significance Index: -6.9900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 17.2059
    Cell Significance Index: -6.9900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 15.9219
    Cell Significance Index: -8.1900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 7.5518
    Cell Significance Index: -7.2100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.1154
    Cell Significance Index: -7.5400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.8520
    Cell Significance Index: -7.6400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.9418
    Cell Significance Index: -7.6600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.5185
    Cell Significance Index: 78.8800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.3985
    Cell Significance Index: 19.0800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.1161
    Cell Significance Index: 29.9100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.8386
    Cell Significance Index: 15.5000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.7982
    Cell Significance Index: 11.9600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.7661
    Cell Significance Index: 89.2800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7540
    Cell Significance Index: 680.8000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6928
    Cell Significance Index: 18.5000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.6316
    Cell Significance Index: 8.8700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5962
    Cell Significance Index: 35.7900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5732
    Cell Significance Index: 62.3500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5147
    Cell Significance Index: 26.8100
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.5095
    Cell Significance Index: 3.3800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4835
    Cell Significance Index: 78.6400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4571
    Cell Significance Index: 20.7200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4177
    Cell Significance Index: 9.0500
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.3943
    Cell Significance Index: 2.4500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3330
    Cell Significance Index: 9.0700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3214
    Cell Significance Index: 9.2600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3197
    Cell Significance Index: 22.1100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2388
    Cell Significance Index: 12.0700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.2346
    Cell Significance Index: 3.3400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2135
    Cell Significance Index: 26.2500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1924
    Cell Significance Index: 19.0300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1874
    Cell Significance Index: 35.6600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1683
    Cell Significance Index: 10.8600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.1652
    Cell Significance Index: 2.6500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1563
    Cell Significance Index: 4.1800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1287
    Cell Significance Index: 23.2100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1142
    Cell Significance Index: 13.4700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1065
    Cell Significance Index: 21.1300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.1015
    Cell Significance Index: 1.4600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0986
    Cell Significance Index: 2.7600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0933
    Cell Significance Index: 3.2800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0927
    Cell Significance Index: 0.5600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0772
    Cell Significance Index: 1.9300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0681
    Cell Significance Index: 1.3300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0620
    Cell Significance Index: 1.3200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0494
    Cell Significance Index: 0.4600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0475
    Cell Significance Index: 21.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0424
    Cell Significance Index: 6.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0362
    Cell Significance Index: 4.9700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0341
    Cell Significance Index: 18.6400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0184
    Cell Significance Index: 0.1900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0181
    Cell Significance Index: 0.5200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0069
    Cell Significance Index: 0.1600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0036
    Cell Significance Index: 6.6600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0011
    Cell Significance Index: 1.7200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0000
    Cell Significance Index: -0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0004
    Cell Significance Index: -0.7900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0010
    Cell Significance Index: -0.0300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0034
    Cell Significance Index: -0.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0056
    Cell Significance Index: -4.1600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0080
    Cell Significance Index: -5.8500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0082
    Cell Significance Index: -6.1900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0094
    Cell Significance Index: -6.0000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0113
    Cell Significance Index: -5.1300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0128
    Cell Significance Index: -7.2300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0137
    Cell Significance Index: -8.5300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0141
    Cell Significance Index: -1.4400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0160
    Cell Significance Index: -5.7600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0165
    Cell Significance Index: -3.3000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0212
    Cell Significance Index: -2.7400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0224
    Cell Significance Index: -6.4500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0258
    Cell Significance Index: -2.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0262
    Cell Significance Index: -4.4700
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0266
    Cell Significance Index: -0.1700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0266
    Cell Significance Index: -1.8800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0321
    Cell Significance Index: -4.1200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0395
    Cell Significance Index: -8.3300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0427
    Cell Significance Index: -1.0900
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0505
    Cell Significance Index: -0.5900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0556
    Cell Significance Index: -1.7800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0557
    Cell Significance Index: -4.1500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0599
    Cell Significance Index: -2.8200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0694
    Cell Significance Index: -7.2300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0714
    Cell Significance Index: -3.3300
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0777
    Cell Significance Index: -0.6600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0893
    Cell Significance Index: -6.8500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0939
    Cell Significance Index: -7.4400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0973
    Cell Significance Index: -1.7200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1002
    Cell Significance Index: -1.5100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1072
    Cell Significance Index: -6.5700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1114
    Cell Significance Index: -2.9300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1154
    Cell Significance Index: -7.7600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1265
    Cell Significance Index: -7.1000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1336
    Cell Significance Index: -8.2100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1634
    Cell Significance Index: -2.8000
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.1700
    Cell Significance Index: -2.3900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1708
    Cell Significance Index: -6.2700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1747
    Cell Significance Index: -6.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1784
    Cell Significance Index: -7.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ELF4 is a transcription factor that belongs to the ETS family of proteins, which are characterized by the presence of an ETS domain. This domain is responsible for recognizing and binding to specific DNA sequences, thereby regulating gene expression. ELF4 is specifically involved in the regulation of transcription by RNA polymerase II, which is a key enzyme responsible for the transcription of protein-coding genes. ELF4 has been shown to interact with other transcription factors and co-regulators to modulate gene expression. **Pathways and Functions:** ELF4 is involved in several key pathways and processes, including: 1. **Cell differentiation:** ELF4 plays a crucial role in regulating the differentiation of various cell types, including natural killer cells, GABAergic interneurons, and intestinal crypt stem cells. 2. **Inflammatory response:** ELF4 has been shown to negatively regulate the production of pro-inflammatory cytokines, such as IL-1β, IL-6, and TNF-α, thereby modulating the inflammatory response. 3. **Transcriptional regulation:** ELF4 interacts with RNA polymerase II to regulate the transcription of protein-coding genes, including those involved in the immune response. 4. **Nuclear body formation:** ELF4 has been implicated in the formation of nuclear bodies, which are structures involved in the regulation of gene expression and cellular differentiation. **Clinical Significance:** The dysregulation of ELF4 has been implicated in various diseases, including: 1. **Immunological disorders:** ELF4 has been shown to play a role in the regulation of immune responses, and its dysregulation may contribute to the development of immunological disorders, such as autoimmune diseases. 2. **Cancer:** ELF4 has been implicated in the regulation of cell proliferation and differentiation, and its dysregulation may contribute to the development of cancer. 3. **Neurological disorders:** ELF4 has been shown to play a role in the regulation of neuronal differentiation and survival, and its dysregulation may contribute to the development of neurological disorders, such as Alzheimer's disease. In conclusion, ELF4 is a critical transcription factor that plays a significant role in regulating gene expression, particularly in the context of immune responses and cellular differentiation. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of ELF4 and its potential therapeutic applications.

Genular Protein ID: 661935353

Symbol: ELF4_HUMAN

Name: ETS-related transcription factor Elf-4

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8895518

Title: MEF, a novel transcription factor with an Elf-1 like DNA binding domain but distinct transcriptional activating properties.

PubMed ID: 8895518

PubMed ID: 9524226

Title: Cloning of a novel human ELF-1-related ETS transcription factor, ELFR, its characterization and chromosomal assignment relative to ELF-1.

PubMed ID: 9524226

DOI: 10.1016/s0378-1119(98)00022-5

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10207087

Title: Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias.

PubMed ID: 10207087

DOI: 10.1128/mcb.19.5.3635

PubMed ID: 14625302

Title: Myeloid ELF1-like factor is a potent activator of interleukin-8 expression in hematopoietic cells.

PubMed ID: 14625302

DOI: 10.1074/jbc.m307524200

PubMed ID: 14976184

Title: Myeloid Elf-1-like factor, an ETS transcription factor, up-regulates lysozyme transcription in epithelial cells through interaction with promyelocytic leukemia protein.

PubMed ID: 14976184

DOI: 10.1074/jbc.m312439200

PubMed ID: 16303180

Title: ELF4 is fused to ERG in a case of acute myeloid leukemia with a t(X;21)(q25-26;q22).

PubMed ID: 16303180

DOI: 10.1016/j.leukres.2005.10.014

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19380490

Title: ELF4/MEF activates MDM2 expression and blocks oncogene-induced p16 activation to promote transformation.

PubMed ID: 19380490

DOI: 10.1128/mcb.01551-08

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 34326534

Title: Human autoinflammatory disease reveals ELF4 as a transcriptional regulator of inflammation.

PubMed ID: 34326534

DOI: 10.1038/s41590-021-00984-4

PubMed ID: 35266071

Title: Loss of Function Mutation in ELF4 Causes Autoinflammatory and Immunodeficiency Disease in Human.

PubMed ID: 35266071

DOI: 10.1007/s10875-022-01243-3

Sequence Information:

  • Length: 663
  • Mass: 70730
  • Checksum: 1696085D31B09BC5
  • Sequence:
  • MAITLQPSDL IFEFASNGMD DDIHQLEDPS VFPAVIVEQV PYPDLLHLYS GLELDDVHNG 
    IITDGTLCMT QDQILEGSFL LTDDNEATSH TMSTAEVLLN MESPSDILDE KQIFSTSEML 
    PDSDPAPAVT LPNYLFPASE PDALNRAGDT SDQEGHSLEE KASREESAKK TGKSKKRIRK 
    TKGNRSTSPV TDPSIPIRKK SKDGKGSTIY LWEFLLALLQ DRNTCPKYIK WTQREKGIFK 
    LVDSKAVSKL WGKQKNKPDM NYETMGRALR YYYQRGILAK VEGQRLVYQF KEMPKDLVVI 
    EDEDESSEAT AAPPQASTAS VASASTTRRT SSRVSSRSAP QGKGSSSWEK PKIQHVGLQP 
    SASLELGPSL DEEIPTTSTM LVSPAEGQVK LTKAVSASSV PSNIHLGVAP VGSGSALTLQ 
    TIPLTTVLTN GPPASTTAPT QLVLQSVPAA STFKDTFTLQ ASFPLNASFQ DSQVAAPGAP 
    LILSGLPQLL AGANRPTNPA PPTVTGAGPA GPSSQPPGTV IAAFIRTSGT TAAPRVKEGP 
    LRSSSYVQGM VTGAPMEGLL VPEETLRELL RDQAHLQPLP TQVVSRGSHN PSLLGNQTLS 
    PPSRPTVGLT PVAELELSSG SGSLLMAEPS VTTSGSLLTR SPTPAPFSPF NPTSLIKMEP 
    HDI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.