Details for: ELF4
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 48.2175
Cell Significance Index: -7.5000 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 27.5584
Cell Significance Index: -6.9900 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 17.2059
Cell Significance Index: -6.9900 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 15.9219
Cell Significance Index: -8.1900 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 7.5518
Cell Significance Index: -7.2100 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 6.1154
Cell Significance Index: -7.5400 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 2.8520
Cell Significance Index: -7.6400 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 1.9418
Cell Significance Index: -7.6600 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.5185
Cell Significance Index: 78.8800 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.3985
Cell Significance Index: 19.0800 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 1.1161
Cell Significance Index: 29.9100 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.8386
Cell Significance Index: 15.5000 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.7982
Cell Significance Index: 11.9600 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.7661
Cell Significance Index: 89.2800 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.7540
Cell Significance Index: 680.8000 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.6928
Cell Significance Index: 18.5000 - Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.6316
Cell Significance Index: 8.8700 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.5962
Cell Significance Index: 35.7900 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.5732
Cell Significance Index: 62.3500 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.5147
Cell Significance Index: 26.8100 - Cell Name: late promyelocyte (CL0002151)
Fold Change: 0.5095
Cell Significance Index: 3.3800 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.4835
Cell Significance Index: 78.6400 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.4571
Cell Significance Index: 20.7200 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.4177
Cell Significance Index: 9.0500 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.3943
Cell Significance Index: 2.4500 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.3330
Cell Significance Index: 9.0700 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3214
Cell Significance Index: 9.2600 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3197
Cell Significance Index: 22.1100 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.2388
Cell Significance Index: 12.0700 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.2346
Cell Significance Index: 3.3400 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.2135
Cell Significance Index: 26.2500 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1924
Cell Significance Index: 19.0300 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1874
Cell Significance Index: 35.6600 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.1683
Cell Significance Index: 10.8600 - Cell Name: decidual cell (CL2000002)
Fold Change: 0.1652
Cell Significance Index: 2.6500 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.1563
Cell Significance Index: 4.1800 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.1287
Cell Significance Index: 23.2100 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.1142
Cell Significance Index: 13.4700 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.1065
Cell Significance Index: 21.1300 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.1015
Cell Significance Index: 1.4600 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.0986
Cell Significance Index: 2.7600 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0933
Cell Significance Index: 3.2800 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.0927
Cell Significance Index: 0.5600 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0772
Cell Significance Index: 1.9300 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.0681
Cell Significance Index: 1.3300 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0620
Cell Significance Index: 1.3200 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.0494
Cell Significance Index: 0.4600 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0475
Cell Significance Index: 21.0200 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.0424
Cell Significance Index: 6.1600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0362
Cell Significance Index: 4.9700 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0341
Cell Significance Index: 18.6400 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.0184
Cell Significance Index: 0.1900 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.0181
Cell Significance Index: 0.5200 - Cell Name: peg cell (CL4033014)
Fold Change: 0.0069
Cell Significance Index: 0.1600 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0036
Cell Significance Index: 6.6600 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0011
Cell Significance Index: 1.7200 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0000
Cell Significance Index: -0.0100 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0004
Cell Significance Index: -0.7900 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.0010
Cell Significance Index: -0.0300 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0034
Cell Significance Index: -0.0700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0056
Cell Significance Index: -4.1600 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0080
Cell Significance Index: -5.8500 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0082
Cell Significance Index: -6.1900 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0094
Cell Significance Index: -6.0000 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0113
Cell Significance Index: -5.1300 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0128
Cell Significance Index: -7.2300 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0137
Cell Significance Index: -8.5300 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0141
Cell Significance Index: -1.4400 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0160
Cell Significance Index: -5.7600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0165
Cell Significance Index: -3.3000 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0212
Cell Significance Index: -2.7400 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0224
Cell Significance Index: -6.4500 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0258
Cell Significance Index: -2.9600 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0262
Cell Significance Index: -4.4700 - Cell Name: early promyelocyte (CL0002154)
Fold Change: -0.0266
Cell Significance Index: -0.1700 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0266
Cell Significance Index: -1.8800 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0321
Cell Significance Index: -4.1200 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0395
Cell Significance Index: -8.3300 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0427
Cell Significance Index: -1.0900 - Cell Name: taste receptor cell (CL0000209)
Fold Change: -0.0505
Cell Significance Index: -0.5900 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0556
Cell Significance Index: -1.7800 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0557
Cell Significance Index: -4.1500 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0599
Cell Significance Index: -2.8200 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0694
Cell Significance Index: -7.2300 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0714
Cell Significance Index: -3.3300 - Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: -0.0777
Cell Significance Index: -0.6600 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0893
Cell Significance Index: -6.8500 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0939
Cell Significance Index: -7.4400 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.0973
Cell Significance Index: -1.7200 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.1002
Cell Significance Index: -1.5100 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1072
Cell Significance Index: -6.5700 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.1114
Cell Significance Index: -2.9300 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1154
Cell Significance Index: -7.7600 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1265
Cell Significance Index: -7.1000 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1336
Cell Significance Index: -8.2100 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.1634
Cell Significance Index: -2.8000 - Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.1700
Cell Significance Index: -2.3900 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.1708
Cell Significance Index: -6.2700 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1747
Cell Significance Index: -6.1200 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1784
Cell Significance Index: -7.8900
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 661935353
Symbol: ELF4_HUMAN
Name: ETS-related transcription factor Elf-4
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8895518
Title: MEF, a novel transcription factor with an Elf-1 like DNA binding domain but distinct transcriptional activating properties.
PubMed ID: 8895518
PubMed ID: 9524226
Title: Cloning of a novel human ELF-1-related ETS transcription factor, ELFR, its characterization and chromosomal assignment relative to ELF-1.
PubMed ID: 9524226
PubMed ID: 15772651
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10207087
Title: Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias.
PubMed ID: 10207087
PubMed ID: 14625302
Title: Myeloid ELF1-like factor is a potent activator of interleukin-8 expression in hematopoietic cells.
PubMed ID: 14625302
PubMed ID: 14976184
Title: Myeloid Elf-1-like factor, an ETS transcription factor, up-regulates lysozyme transcription in epithelial cells through interaction with promyelocytic leukemia protein.
PubMed ID: 14976184
PubMed ID: 16303180
Title: ELF4 is fused to ERG in a case of acute myeloid leukemia with a t(X;21)(q25-26;q22).
PubMed ID: 16303180
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19380490
Title: ELF4/MEF activates MDM2 expression and blocks oncogene-induced p16 activation to promote transformation.
PubMed ID: 19380490
DOI: 10.1128/mcb.01551-08
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 34326534
Title: Human autoinflammatory disease reveals ELF4 as a transcriptional regulator of inflammation.
PubMed ID: 34326534
PubMed ID: 35266071
Title: Loss of Function Mutation in ELF4 Causes Autoinflammatory and Immunodeficiency Disease in Human.
PubMed ID: 35266071
Sequence Information:
- Length: 663
- Mass: 70730
- Checksum: 1696085D31B09BC5
- Sequence:
MAITLQPSDL IFEFASNGMD DDIHQLEDPS VFPAVIVEQV PYPDLLHLYS GLELDDVHNG IITDGTLCMT QDQILEGSFL LTDDNEATSH TMSTAEVLLN MESPSDILDE KQIFSTSEML PDSDPAPAVT LPNYLFPASE PDALNRAGDT SDQEGHSLEE KASREESAKK TGKSKKRIRK TKGNRSTSPV TDPSIPIRKK SKDGKGSTIY LWEFLLALLQ DRNTCPKYIK WTQREKGIFK LVDSKAVSKL WGKQKNKPDM NYETMGRALR YYYQRGILAK VEGQRLVYQF KEMPKDLVVI EDEDESSEAT AAPPQASTAS VASASTTRRT SSRVSSRSAP QGKGSSSWEK PKIQHVGLQP SASLELGPSL DEEIPTTSTM LVSPAEGQVK LTKAVSASSV PSNIHLGVAP VGSGSALTLQ TIPLTTVLTN GPPASTTAPT QLVLQSVPAA STFKDTFTLQ ASFPLNASFQ DSQVAAPGAP LILSGLPQLL AGANRPTNPA PPTVTGAGPA GPSSQPPGTV IAAFIRTSGT TAAPRVKEGP LRSSSYVQGM VTGAPMEGLL VPEETLRELL RDQAHLQPLP TQVVSRGSHN PSLLGNQTLS PPSRPTVGLT PVAELELSSG SGSLLMAEPS VTTSGSLLTR SPTPAPFSPF NPTSLIKMEP HDI
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.