Details for: ELF4

Gene ID: 2000

Symbol: ELF4

Ensembl ID: ENSG00000102034

Description: E74 like ETS transcription factor 4

Associated with

  • Cell differentiation
    (GO:0030154)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Natural killer cell proliferation
    (GO:0001787)
  • Negative regulation of inflammatory response
    (GO:0050728)
  • Negative regulation of interleukin-1 beta production
    (GO:0032691)
  • Negative regulation of interleukin-6 production
    (GO:0032715)
  • Negative regulation of tumor necrosis factor production
    (GO:0032720)
  • Nk t cell proliferation
    (GO:0001866)
  • Nuclear body
    (GO:0016604)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Pml body
    (GO:0016605)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.52
    Marker Score: 3152
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71783
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48008
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30404
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.97
    Marker Score: 1436
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 488
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 442
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2723
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5058
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.89
    Marker Score: 532
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5266
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 310
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.83
    Marker Score: 13065
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.75
    Marker Score: 1457
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 570
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 377
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.71
    Marker Score: 39813
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.7
    Marker Score: 1433
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.7
    Marker Score: 280
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 624
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.67
    Marker Score: 211
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 168
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.65
    Marker Score: 2746
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.63
    Marker Score: 697
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.63
    Marker Score: 203
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.62
    Marker Score: 3926
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.57
    Marker Score: 553.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 429
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.53
    Marker Score: 3162
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.51
    Marker Score: 4501
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.51
    Marker Score: 1270
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.5
    Marker Score: 506.5
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5
    Marker Score: 521
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.49
    Marker Score: 1194
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.48
    Marker Score: 882
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.48
    Marker Score: 120
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.47
    Marker Score: 224
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.41
    Marker Score: 1017.5
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.4
    Marker Score: 436
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.4
    Marker Score: 97
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.4
    Marker Score: 1258
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4
    Marker Score: 256
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.4
    Marker Score: 197
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.39
    Marker Score: 2387
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.39
    Marker Score: 567
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.38
    Marker Score: 238
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.37
    Marker Score: 872
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.36
    Marker Score: 241
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.36
    Marker Score: 96
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.35
    Marker Score: 275
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.34
    Marker Score: 928
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.34
    Marker Score: 546
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.34
    Marker Score: 1326
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.34
    Marker Score: 216
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.33
    Marker Score: 114
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.33
    Marker Score: 133
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.33
    Marker Score: 332
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.33
    Marker Score: 295
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.33
    Marker Score: 317
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.32
    Marker Score: 171
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.32
    Marker Score: 418
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.32
    Marker Score: 138
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.32
    Marker Score: 110
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.32
    Marker Score: 142
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.32
    Marker Score: 996
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.31
    Marker Score: 81
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.31
    Marker Score: 125
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.31
    Marker Score: 7944
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.31
    Marker Score: 1479
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.31
    Marker Score: 266
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.31
    Marker Score: 204
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.31
    Marker Score: 3561.5
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.31
    Marker Score: 211
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.3
    Marker Score: 61
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.3
    Marker Score: 184
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.3
    Marker Score: 284
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3
    Marker Score: 626
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.3
    Marker Score: 66
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.29
    Marker Score: 109
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.29
    Marker Score: 555
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.29
    Marker Score: 145
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.29
    Marker Score: 211
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.29
    Marker Score: 121
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.28
    Marker Score: 64
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.28
    Marker Score: 161
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.28
    Marker Score: 130
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.28
    Marker Score: 138
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.28
    Marker Score: 2863
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.28
    Marker Score: 255
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.28
    Marker Score: 640
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.28
    Marker Score: 176
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.28
    Marker Score: 88
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.28
    Marker Score: 278
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.28
    Marker Score: 277
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.27
    Marker Score: 79
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.27
    Marker Score: 121
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.27
    Marker Score: 118
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.27
    Marker Score: 61

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Other Information

**Key characteristics:** - ELF4 is a highly conserved protein with a conserved N-terminal DNA-binding domain and a C-terminal ETS domain. - It is a member of the ETS family of transcription factors, which are involved in a wide range of cellular processes, including cell differentiation, proliferation, and apoptosis. - ELF4 is a key regulator of the expression of many genes involved in cell differentiation, proliferation, and survival. **Pathways and functions:** - ELF4 is a key regulator of cell differentiation in the developing embryo. - It is expressed in proliferating and differentiating cells in many tissues, including the kidney, brain, and gut. - It promotes the expression of genes involved in cell cycle regulation, proliferation, and differentiation. - It also inhibits the expression of genes involved in apoptosis. - In the adult, ELF4 is expressed in a variety of cell types, including epithelial cells, immune cells, and cancer cells. - It plays a critical role in maintaining tissue homeostasis, preventing cancer, and suppressing inflammation. **Clinical significance:** - Mutations in ELF4 have been linked to several human diseases, including cancer, autoimmune disorders, and developmental abnormalities. - Inhibition of ELF4 has been shown to suppress cancer growth and metastasis. - Therefore, ELF4 is a promising target for cancer therapy. **Additional notes:** - ELF4 is a highly conserved protein that is expressed in all vertebrates. - It is a key regulator of the immune response, and its expression is regulated by a variety of cytokines and growth factors. - It is also involved in the regulation of inflammation, cell cycle regulation, and apoptosis.

Genular Protein ID: 661935353

Symbol: ELF4_HUMAN

Name: ETS-related transcription factor Elf-4

UniProtKB Accession Codes:

Q99607 D3DTG1 O60435

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 3 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8895518

Title: MEF, a novel transcription factor with an Elf-1 like DNA binding domain but distinct transcriptional activating properties.

PubMed ID: 8895518

PubMed ID: 9524226

Title: Cloning of a novel human ELF-1-related ETS transcription factor, ELFR, its characterization and chromosomal assignment relative to ELF-1.

PubMed ID: 9524226

DOI: 10.1016/s0378-1119(98)00022-5

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10207087

Title: Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias.

PubMed ID: 10207087

DOI: 10.1128/mcb.19.5.3635

PubMed ID: 14625302

Title: Myeloid ELF1-like factor is a potent activator of interleukin-8 expression in hematopoietic cells.

PubMed ID: 14625302

DOI: 10.1074/jbc.m307524200

PubMed ID: 14976184

Title: Myeloid Elf-1-like factor, an ETS transcription factor, up-regulates lysozyme transcription in epithelial cells through interaction with promyelocytic leukemia protein.

PubMed ID: 14976184

DOI: 10.1074/jbc.m312439200

PubMed ID: 16303180

Title: ELF4 is fused to ERG in a case of acute myeloid leukemia with a t(X;21)(q25-26;q22).

PubMed ID: 16303180

DOI: 10.1016/j.leukres.2005.10.014

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19380490

Title: ELF4/MEF activates MDM2 expression and blocks oncogene-induced p16 activation to promote transformation.

PubMed ID: 19380490

DOI: 10.1128/mcb.01551-08

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 34326534

Title: Human autoinflammatory disease reveals ELF4 as a transcriptional regulator of inflammation.

PubMed ID: 34326534

DOI: 10.1038/s41590-021-00984-4

PubMed ID: 35266071

Title: Loss of Function Mutation in ELF4 Causes Autoinflammatory and Immunodeficiency Disease in Human.

PubMed ID: 35266071

DOI: 10.1007/s10875-022-01243-3

Sequence Information:

  • Length: 663
  • Mass: 70730
  • Checksum: 1696085D31B09BC5
  • Sequence:
    • MAITLQPSDL IFEFASNGMD DDIHQLEDPS VFPAVIVEQV PYPDLLHLYS GLELDDVHNG 
IITDGTLCMT QDQILEGSFL LTDDNEATSH TMSTAEVLLN MESPSDILDE KQIFSTSEML 
PDSDPAPAVT LPNYLFPASE PDALNRAGDT SDQEGHSLEE KASREESAKK TGKSKKRIRK 
TKGNRSTSPV TDPSIPIRKK SKDGKGSTIY LWEFLLALLQ DRNTCPKYIK WTQREKGIFK 
LVDSKAVSKL WGKQKNKPDM NYETMGRALR YYYQRGILAK VEGQRLVYQF KEMPKDLVVI 
EDEDESSEAT AAPPQASTAS VASASTTRRT SSRVSSRSAP QGKGSSSWEK PKIQHVGLQP 
SASLELGPSL DEEIPTTSTM LVSPAEGQVK LTKAVSASSV PSNIHLGVAP VGSGSALTLQ 
TIPLTTVLTN GPPASTTAPT QLVLQSVPAA STFKDTFTLQ ASFPLNASFQ DSQVAAPGAP 
LILSGLPQLL AGANRPTNPA PPTVTGAGPA GPSSQPPGTV IAAFIRTSGT TAAPRVKEGP 
LRSSSYVQGM VTGAPMEGLL VPEETLRELL RDQAHLQPLP TQVVSRGSHN PSLLGNQTLS 
PPSRPTVGLT PVAELELSSG SGSLLMAEPS VTTSGSLLTR SPTPAPFSPF NPTSLIKMEP 
HDI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.