Details for: EPS8

Gene ID: 2059

Symbol: EPS8

Ensembl ID: ENSG00000151491

Description: EGFR pathway substrate 8, signaling adaptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 422.2566
    Cell Significance Index: -65.6800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 260.3261
    Cell Significance Index: -66.0300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 144.1151
    Cell Significance Index: -68.0400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 143.3329
    Cell Significance Index: -58.2300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 127.4142
    Cell Significance Index: -65.5400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 61.2416
    Cell Significance Index: -58.4700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 53.2866
    Cell Significance Index: -65.7000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 25.1114
    Cell Significance Index: -67.2700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 18.4731
    Cell Significance Index: -40.4300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 16.7281
    Cell Significance Index: -66.0100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 7.2580
    Cell Significance Index: 86.5200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.9364
    Cell Significance Index: 57.3100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.1717
    Cell Significance Index: 47.0500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.1432
    Cell Significance Index: 97.1500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.9489
    Cell Significance Index: 386.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.9338
    Cell Significance Index: 877.7100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.9298
    Cell Significance Index: 237.2900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.7152
    Cell Significance Index: 186.5600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.5408
    Cell Significance Index: 277.7600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.3878
    Cell Significance Index: 39.9900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.3750
    Cell Significance Index: 18.7600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.3404
    Cell Significance Index: 480.7700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1310
    Cell Significance Index: 58.7500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.0524
    Cell Significance Index: 66.3300
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.9299
    Cell Significance Index: 11.7100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.9268
    Cell Significance Index: 118.8100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.7845
    Cell Significance Index: 11.2700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7355
    Cell Significance Index: 101.0000
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.6627
    Cell Significance Index: 3.0600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6207
    Cell Significance Index: 61.4000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6024
    Cell Significance Index: 28.3100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4180
    Cell Significance Index: 228.3000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2626
    Cell Significance Index: 181.6200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2282
    Cell Significance Index: 8.0200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1855
    Cell Significance Index: 167.5300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1308
    Cell Significance Index: 57.8100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1080
    Cell Significance Index: 20.5600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0621
    Cell Significance Index: 1.7800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0547
    Cell Significance Index: 0.8200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0420
    Cell Significance Index: 0.7200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0194
    Cell Significance Index: 14.6500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0012
    Cell Significance Index: -0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0020
    Cell Significance Index: -3.6800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0214
    Cell Significance Index: -1.2000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0297
    Cell Significance Index: -54.8400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0322
    Cell Significance Index: -49.5900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0326
    Cell Significance Index: -44.3300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0415
    Cell Significance Index: -30.7400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0493
    Cell Significance Index: -8.4100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0587
    Cell Significance Index: -37.2600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0678
    Cell Significance Index: -4.1700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0719
    Cell Significance Index: -52.7200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0839
    Cell Significance Index: -52.4200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0850
    Cell Significance Index: -47.9100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0999
    Cell Significance Index: -10.2000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1196
    Cell Significance Index: -3.8300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1285
    Cell Significance Index: -3.4300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1476
    Cell Significance Index: -1.2400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1803
    Cell Significance Index: -51.8800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1937
    Cell Significance Index: -25.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1951
    Cell Significance Index: -39.1400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2373
    Cell Significance Index: -2.1900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2396
    Cell Significance Index: -5.9900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.2501
    Cell Significance Index: -3.8700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2802
    Cell Significance Index: -59.0200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2826
    Cell Significance Index: -6.5300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2936
    Cell Significance Index: -34.2200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3457
    Cell Significance Index: -9.6600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3470
    Cell Significance Index: -7.3900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3656
    Cell Significance Index: -9.9500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3821
    Cell Significance Index: -55.5400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4062
    Cell Significance Index: -18.9400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4093
    Cell Significance Index: -46.9000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4134
    Cell Significance Index: -31.7300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4141
    Cell Significance Index: -48.8300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.4170
    Cell Significance Index: -7.0300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4375
    Cell Significance Index: -45.5500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.5191
    Cell Significance Index: -36.7200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5248
    Cell Significance Index: -33.8600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5512
    Cell Significance Index: -9.2300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5735
    Cell Significance Index: -65.4600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.6153
    Cell Significance Index: -45.8600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7398
    Cell Significance Index: -58.5900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.7589
    Cell Significance Index: -39.5300
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.7603
    Cell Significance Index: -7.6700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.7896
    Cell Significance Index: -5.3500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.8330
    Cell Significance Index: -56.0100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.8609
    Cell Significance Index: -22.1300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.8610
    Cell Significance Index: -22.6400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0764
    Cell Significance Index: -66.0000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -1.0969
    Cell Significance Index: -16.1900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.1808
    Cell Significance Index: -59.6800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.2528
    Cell Significance Index: -65.7800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.4235
    Cell Significance Index: -25.1600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.4297
    Cell Significance Index: -14.8000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.4537
    Cell Significance Index: -64.3000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.4676
    Cell Significance Index: -30.7200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.5470
    Cell Significance Index: -37.1000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.5792
    Cell Significance Index: -57.9700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.5977
    Cell Significance Index: -52.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Substrate of EGFR pathway**: EPS8 is a downstream effector of the EGFR signaling pathway, which is involved in cell growth, differentiation, and survival. 2. **Actin cytoskeleton regulator**: EPS8 interacts with actin-binding proteins to regulate actin filament assembly, polymerization, and capping, which is essential for cell motility, shape, and morphology. 3. **Neuronal expression**: EPS8 is highly expressed in neuronal cells, including neurons, photoreceptor cells, and inner/outer hair cells, suggesting its involvement in neural development and function. 4. **Multi-functional protein**: EPS8 interacts with various signaling proteins, including Rac and rho GTPases, to regulate actin cytoskeleton dynamics and cell motility. **Pathways and Functions** EPS8 is involved in several signaling pathways, including: 1. **Actin polymerization-dependent cell motility**: EPS8 regulates actin filament assembly and polymerization, which is essential for cell motility and migration. 2. **Rho protein signal transduction**: EPS8 interacts with rho GTPases to regulate actin cytoskeleton dynamics and cell motility. 3. **EGFR pathway**: EPS8 is a downstream effector of the EGFR signaling pathway, which is involved in cell growth, differentiation, and survival. 4. **Neurotransmission**: EPS8 interacts with actin-binding proteins to regulate actin filament assembly and polymerization, which is essential for neurotransmitter release and synaptic plasticity. **Clinical Significance** Dysregulation of EPS8 has been implicated in various neurological disorders, including: 1. **Neurodegenerative diseases**: EPS8 has been shown to be involved in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 2. **Neurodevelopmental disorders**: EPS8 has been implicated in neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 3. **Cancer**: EPS8 has been shown to be overexpressed in certain types of cancer, including breast and lung cancer. In conclusion, EPS8 is a multifunctional protein that plays a crucial role in regulating actin cytoskeleton dynamics, cell motility, and neurotransmission. Its dysregulation has been implicated in various neurological disorders, making it a potential therapeutic target for the treatment of these diseases.

Genular Protein ID: 2950986876

Symbol: EPS8_HUMAN

Name: Epidermal growth factor receptor kinase substrate 8

UniProtKB Accession Codes:

Q12929 A6NMC3 A8K6W2 A8KA66 B4DX66 Q8N6J0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 12 EvolutionaryTrace 1 ExpressionAtlas 1 GO 30 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8084614

Title: Evolutionary conservation of the EPS8 gene and its mapping to human chromosome 12q23-q24.

PubMed ID: 8084614

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7537362

Title: Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins.

PubMed ID: 7537362

PubMed ID: 11244499

Title: Overexpression of p97Eps8 leads to cellular transformation: implication of pleckstrin homology domain in p97Eps8-mediated ERK activation.

PubMed ID: 11244499

DOI: 10.1038/sj.onc.1204069

PubMed ID: 15289329

Title: IRSp53/Eps8 complex is important for positive regulation of Rac and cancer cell motility/invasiveness.

PubMed ID: 15289329

DOI: 10.1158/0008-5472.can-04-0327

PubMed ID: 15558031

Title: Eps8 controls actin-based motility by capping the barbed ends of actin filaments.

PubMed ID: 15558031

DOI: 10.1038/ncb1199

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17115031

Title: Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8-IRSp53 complex.

PubMed ID: 17115031

DOI: 10.1038/ncb1502

PubMed ID: 17537571

Title: Eps8 is increased in pancreatic cancer and required for dynamic actin-based cell protrusions and intercellular cytoskeletal organization.

PubMed ID: 17537571

DOI: 10.1016/j.canlet.2007.04.008

PubMed ID: 18566210

Title: Eps8 decreases chemosensitivity and affects survival of cervical cancer patients.

PubMed ID: 18566210

DOI: 10.1158/1535-7163.mct-07-2388

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19008210

Title: Role for EPS8 in squamous carcinogenesis.

PubMed ID: 19008210

DOI: 10.1093/carcin/bgn252

PubMed ID: 19116338

Title: Epidermal growth factor receptor pathway substrate 8 is overexpressed in human pituitary tumors: role in proliferation and survival.

PubMed ID: 19116338

DOI: 10.1210/en.2008-1265

PubMed ID: 19448673

Title: Upregulation of Eps8 in oral squamous cell carcinoma promotes cell migration and invasion through integrin-dependent Rac1 activation.

PubMed ID: 19448673

DOI: 10.1038/onc.2009.105

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24741995

Title: EPS8, encoding an actin-binding protein of cochlear hair cell stereocilia, is a new causal gene for autosomal recessive profound deafness.

PubMed ID: 24741995

DOI: 10.1186/1750-1172-9-55

PubMed ID: 26721930

Title: Homozygous mutation of PLCZ1 leads to defective human oocyte activation and infertility that is not rescued by the WW-binding protein PAWP.

PubMed ID: 26721930

DOI: 10.1093/hmg/ddv617

Sequence Information:

  • Length: 822
  • Mass: 91882
  • Checksum: AC5EB1D28B784B3B
  • Sequence:
    • MNGHISNHPS SFGMYPSQMN GYGSSPTFSQ TDREHGSKTS AKALYEQRKN YARDSVSSVS 
DISQYRVEHL TTFVLDRKDA MITVDDGIRK LKLLDAKGKV WTQDMILQVD DRAVSLIDLE 
SKNELENFPL NTIQHCQAVM HSCSYDSVLA LVCKEPTQNK PDLHLFQCDE VKANLISEDI 
ESAISDSKGG KQKRRPDALR MISNADPSIP PPPRAPAPAP PGTVTQVDVR SRVAAWSAWA 
ADQGDFEKPR QYHEQEETPE MMAARIDRDV QILNHILDDI EFFITKLQKA AEAFSELSKR 
KKNKKGKRKG PGEGVLTLRA KPPPPDEFLD CFQKFKHGFN LLAKLKSHIQ NPSAADLVHF 
LFTPLNMVVQ ATGGPELASS VLSPLLNKDT IDFLNYTVNG DERQLWMSLG GTWMKARAEW 
PKEQFIPPYV PRFRNGWEPP MLNFMGATME QDLYQLAESV ANVAEHQRKQ EIKRLSTEHS 
SVSEYHPADG YAFSSNIYTR GSHLDQGEAA VAFKPTSNRH IDRNYEPLKT QPKKYAKSKY 
DFVARNNSEL SVLKDDILEI LDDRKQWWKV RNASGDSGFV PNNILDIVRP PESGLGRADP 
PYTHTIQKQR MEYGPRPADT PPAPSPPPTP APVPVPLPPS TPAPVPVSKV PANITRQNSS 
SSDSGGSIVR DSQRHKQLPV DRRKSQMEEV QDELIHRLTI GRSAAQKKFH VPRQNVPVIN 
ITYDSTPEDV KTWLQSKGFN PVTVNSLGVL NGAQLFSLNK DELRTVCPEG ARVYSQITVQ 
KAALEDSSGS SELQEIMRRR QEKISAAASD SGVESFDEGS SH

Genular Protein ID: 3741814358

Symbol: B4E3T6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4E3T6

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 1 Gene3D 2 InterPro 8 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 1 SAM 1 SMART 2 SUPFAM 2

Sequence Information:

  • Length: 691
  • Mass: 77088
  • Checksum: 6070E058A6F64672
  • Sequence:
    • MNGHISNHPS SFGMYPSQMN GYGSSPTFSQ TDREHGSKTS AKALYEQRKN YARDSVSSVS 
DISQYRVEHL TTFVLDRKDA MITVDDGIRK LKLLDAKGKV WTQDMILQVD DRAVSLIDLE 
SKNELENFPL NTIQHCQAVM HSCSYDSVLA LVCKEPTQNK PDLHLFQCDE VKANLISEDI 
ESAISDSKGG KQKRRPDALR MISNADPSIP PPPRAPAPAP PGTVTQVDVR SRVAAWSAWA 
ADQGDFEKPR QYHEQEETPE MMAARIDRDV QILNHILDDI EFFITKLQKA AEAFSELSKR 
KKNKKGKRKG PGEGVLTLRA KPPPPDEFLD CFQKFKHGFN LLAKLKSHIQ NPSAADLVHF 
LFTPLNMVVQ ATGGPELASS VLSPLLNKDT IDFLNYTVNG DERQLWMSLG GTWMKARAEW 
PKEQFIPPYV PRFRNGWEPP MLNFMGATME QDLYQLAESV ANVAEHQRKQ EIKRLSTEHS 
SVSEYHPADG YAFSSNIYTR GSHLDQGEAA VAFKPTSNRH IDRNYEPLKT QPKKYAKSKY 
DFVARNNSEL SVLKDDILEI LDDRKQWWKV RNASGDSGFV PNNILDIVRP PESGLGRADP 
PYTHTIQKQR MEYGPRPADT PPAPSPPPTP APVPVPLPPS TPAPVPVSKV PANITRQNSS 
SSDSGGSIVR DSQRHRTSGG PKEISDGGSA R

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.