Details for: EYA4

Gene ID: 2070

Symbol: EYA4

Ensembl ID: ENSG00000112319

Description: EYA transcriptional coactivator and phosphatase 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 15.8996
    Cell Significance Index: -15.1800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 12.1740
    Cell Significance Index: 1769.6400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 9.3392
    Cell Significance Index: 227.8700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 8.6292
    Cell Significance Index: 221.8100
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 7.4130
    Cell Significance Index: 119.6100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 4.3279
    Cell Significance Index: 332.1200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.7188
    Cell Significance Index: 2646.0700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.9744
    Cell Significance Index: 65.5200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.8485
    Cell Significance Index: 1564.8000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7884
    Cell Significance Index: 282.7900
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.6935
    Cell Significance Index: 7.2400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.6161
    Cell Significance Index: 1160.0700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.5866
    Cell Significance Index: 797.6600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5727
    Cell Significance Index: 15.3500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.5536
    Cell Significance Index: 11.9600
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.4781
    Cell Significance Index: 6.2000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.4385
    Cell Significance Index: 278.4800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2770
    Cell Significance Index: 14.3900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2712
    Cell Significance Index: 12.0000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2569
    Cell Significance Index: 9.7300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1511
    Cell Significance Index: 7.6300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.1262
    Cell Significance Index: 78.8000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1039
    Cell Significance Index: 20.8500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.0779
    Cell Significance Index: 8.1100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0636
    Cell Significance Index: 1.4700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0387
    Cell Significance Index: 6.9700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0226
    Cell Significance Index: 2.7800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.0165
    Cell Significance Index: 0.2400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0056
    Cell Significance Index: 0.0800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0026
    Cell Significance Index: -1.1900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0039
    Cell Significance Index: -2.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0058
    Cell Significance Index: -4.3200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0071
    Cell Significance Index: -4.9300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0230
    Cell Significance Index: -16.9000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0248
    Cell Significance Index: -18.7500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0262
    Cell Significance Index: -0.3300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0275
    Cell Significance Index: -0.4700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0282
    Cell Significance Index: -5.9300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0312
    Cell Significance Index: -17.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0425
    Cell Significance Index: -7.2600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0473
    Cell Significance Index: -9.3900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0487
    Cell Significance Index: -0.9500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0489
    Cell Significance Index: -14.0600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0643
    Cell Significance Index: -0.9500
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.0730
    Cell Significance Index: -0.6700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1058
    Cell Significance Index: -10.8100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1201
    Cell Significance Index: -1.7200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1206
    Cell Significance Index: -16.5600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1289
    Cell Significance Index: -16.6500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1339
    Cell Significance Index: -15.2800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1433
    Cell Significance Index: -8.8100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1459
    Cell Significance Index: -8.1900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1475
    Cell Significance Index: -17.3900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1532
    Cell Significance Index: -17.5500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1573
    Cell Significance Index: -18.3300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1643
    Cell Significance Index: -3.9400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1662
    Cell Significance Index: -21.3100
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1677
    Cell Significance Index: -2.1500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2022
    Cell Significance Index: -13.0500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2213
    Cell Significance Index: -16.4900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2477
    Cell Significance Index: -3.9300
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.2642
    Cell Significance Index: -2.7300
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.2788
    Cell Significance Index: -3.7600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2912
    Cell Significance Index: -15.1700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2950
    Cell Significance Index: -8.0300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2982
    Cell Significance Index: -10.4500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3093
    Cell Significance Index: -16.2400
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.3173
    Cell Significance Index: -3.9300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3305
    Cell Significance Index: -10.5300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3487
    Cell Significance Index: -16.3900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3565
    Cell Significance Index: -6.1100
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.3566
    Cell Significance Index: -4.1500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3694
    Cell Significance Index: -16.7500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3804
    Cell Significance Index: -12.0300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3925
    Cell Significance Index: -7.7600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4142
    Cell Significance Index: -8.6700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4169
    Cell Significance Index: -13.6500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4378
    Cell Significance Index: -8.7900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4438
    Cell Significance Index: -16.2900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4501
    Cell Significance Index: -15.6400
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: -0.4904
    Cell Significance Index: -5.1900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4957
    Cell Significance Index: -12.3700
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.5148
    Cell Significance Index: -5.5200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5249
    Cell Significance Index: -15.4600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.5290
    Cell Significance Index: -18.5900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5334
    Cell Significance Index: -11.3200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5379
    Cell Significance Index: -15.3500
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.5403
    Cell Significance Index: -6.2800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.5451
    Cell Significance Index: -7.8400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.5497
    Cell Significance Index: -11.4700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5749
    Cell Significance Index: -16.4800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.5856
    Cell Significance Index: -14.9200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.5948
    Cell Significance Index: -11.8600
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.6103
    Cell Significance Index: -9.1300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.6144
    Cell Significance Index: -17.1700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.6176
    Cell Significance Index: -26.8500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6327
    Cell Significance Index: -16.9300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.6330
    Cell Significance Index: -15.7900
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.6348
    Cell Significance Index: -6.0400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.6459
    Cell Significance Index: -18.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Coactivator and Phosphatase:** EYA4 possesses both coactivator and phosphatase activities, allowing it to regulate transcriptional responses to DNA damage and other signals. 2. **Tissue-Specific Expression:** EYA4 is expressed in a variety of tissues, including the inner ear, lens, and visual system, highlighting its role in developmental and morphogenic processes. 3. **DNA Repair and Response:** EYA4 is involved in the recruitment and phosphorylation of repair and signaling proteins at DNA double-strand breaks, underscoring its critical role in maintaining genome stability. 4. **Visual Perception:** EYA4 has been implicated in the development and function of the visual system, suggesting a potential role in visual perception and disease. **Pathways and Functions:** 1. **Anatomical Structure Development:** EYA4 is involved in the development and morphogenesis of various tissues, including the inner ear, lens, and visual system. 2. **DNA Double-Strand Break Response:** EYA4 regulates the recruitment and phosphorylation of repair and signaling proteins at DNA double-strand breaks, ensuring genome stability. 3. **Cell Differentiation:** EYA4 is involved in the regulation of cell differentiation, particularly in tissues such as the lens and visual system. 4. **Chromatin Organization:** EYA4 has been shown to interact with chromatin-modifying enzymes, influencing chromatin organization and gene expression. 5. **Metal Ion Binding:** EYA4 possesses metal ion-binding capabilities, which may be important for its regulatory functions. **Clinical Significance:** 1. **Inner Ear Development:** Mutations in EYA4 have been linked to inner ear development disorders, such as cochlear dysplasia and hearing loss. 2. **Visual System Disorders:** EYA4 has been implicated in the development and function of the visual system, and mutations have been associated with visual perception disorders. 3. **Cancer:** EYA4 has been identified as a potential oncogene, with its overexpression linked to the development of certain cancers, including renal cell carcinoma. 4. **Neurological Disorders:** EYA4 has been implicated in the development and function of the nervous system, and mutations have been associated with neurological disorders, such as autism spectrum disorder. In conclusion, the EYA4 gene is a critical regulator of developmental and morphogenic processes, with implications for tissue homeostasis, DNA repair, and visual perception. Its dysregulation has been linked to various clinical disorders, highlighting the importance of further research into the molecular mechanisms underlying EYA4 function.

Genular Protein ID: 266853678

Symbol: EYA4_HUMAN

Name: Eyes absent homolog 4

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9887327

Title: EYA4, a novel vertebrate gene related to Drosophila eyes absent.

PubMed ID: 9887327

DOI: 10.1093/hmg/8.1.11

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11159937

Title: Mutations in the transcriptional activator EYA4 cause late-onset deafness at the DFNA10 locus.

PubMed ID: 11159937

DOI: 10.1093/hmg/10.3.195

PubMed ID: 15735644

Title: Mutation in the transcriptional coactivator EYA4 causes dilated cardiomyopathy and sensorineural hearing loss.

PubMed ID: 15735644

DOI: 10.1038/ng1527

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19606496

Title: EYA4, deleted in a case with middle interhemispheric variant of holoprosencephaly, interacts with SIX3 both physically and functionally.

PubMed ID: 19606496

DOI: 10.1002/humu.21094

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 22938506

Title: Targeted massive parallel sequencing: the effective detection of novel causative mutations associated with hearing loss in small families.

PubMed ID: 22938506

DOI: 10.1186/1750-1172-7-60

PubMed ID: 25809937

Title: A novel mutation of EYA4 in a large Chinese family with autosomal dominant middle-frequency sensorineural hearing loss by targeted exome sequencing.

PubMed ID: 25809937

DOI: 10.1038/jhg.2015.19

PubMed ID: 25961296

Title: Exome sequencing identifies a mutation in EYA4 as a novel cause of autosomal dominant non-syndromic hearing loss.

PubMed ID: 25961296

DOI: 10.1371/journal.pone.0126602

Sequence Information:

  • Length: 639
  • Mass: 69505
  • Checksum: CC59A8FB1527A0EC
  • Sequence:
  • MEDSQDLNEQ SVKKTCTESD VSQSQNSRSM EMQDLASPHT LVGGGDTPGS SKLEKSNLSS 
    TSVTTNGTGG ENMTVLNTAD WLLSCNTPSS ATMSLLAVKT EPLNSSETTA TTGDGALDTF 
    TGSVITSSGY SPRSAHQYSP QLYPSKPYPH ILSTPAAQTM SAYAGQTQYS GMQQPAVYTA 
    YSQTGQPYSL PTYDLGVMLP AIKTESGLSQ TQSPLQSGCL SYSPGFSTPQ PGQTPYSYQM 
    PGSSFAPSST IYANNSVSNS TNFSGSQQDY PSYTAFGQNQ YAQYYSASTY GAYMTSNNTA 
    DGTPSSTSTY QLQESLPGLT NQPGEFDTMQ SPSTPIKDLD ERTCRSSGSK SRGRGRKNNP 
    SPPPDSDLER VFVWDLDETI IVFHSLLTGS YAQKYGKDPP MAVTLGLRME EMIFNLADTH 
    LFFNDLEECD QVHIDDVSSD DNGQDLSTYS FATDGFHAAA SSANLCLPTG VRGGVDWMRK 
    LAFRYRRVKE LYNTYKNNVG GLLGPAKRDA WLQLRAEIEG LTDSWLTNAL KSLSIISTRS 
    NCINVLVTTT QLIPALAKVL LYSLGGAFPI ENIYSATKIG KESCFERIMQ RFGRKVVYVV 
    IGDGVEEEQA AKKHNMPFWR ISSHSDLLAL HQALELEYL

Genular Protein ID: 100935041

Symbol: A0A0S2Z3V9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 616
  • Mass: 67065
  • Checksum: 61BC97D2981AC16E
  • Sequence:
  • MEDSQDLNEQ SVKKTCTESD VSQSQNSRSM EMQDLASPHT LVGGGDTPGS SKLEKSNLSS 
    TSVTTNGTGV SLLAVKTEPL NSSETTATTG DGALDTFTGS VITSSGYSPR SAHQYSPQLY 
    PSKPYPHILS TPAAQTMSAY AGQTQYSGMQ QPAVYTAYSQ TGQPYSLPTY DLGVMLPAIK 
    TESGLSQTQS PLQSGCLSYS PGFSTPQPGQ TPYSYQMPGS SFAPSSTIYA NNSVSNSTNF 
    SGSQQDYPSY TAFGQNQYAQ YYSASTYGAY MTSNNTADGT PSSTSTYQLQ ESLPGLTNQP 
    GEFDTMQSPS TPIKDLDERT CRSSGSKSRG RGRKNNPSPP PDSDLERVFV WDLDETIIVF 
    HSLLTGSYAQ KYGKDPPMAV TLGLRMEEMI FNLADTHLFF NDLEECDQVH IDDVSSDDNG 
    QDLSTYSFAT DGFHAAASSA NLCLPTGVRG GVDWMRKLAF RYRRVKELYN TYKNNVGGLL 
    GPAKRDAWLQ LRAEIEGLTD SWLTNALKSL SIISTRSNCI NVLVTTTQLI PALAKVLLYS 
    LGGAFPIENI YSATKIGKES CFERIMQRFG RKVVYVVIGD GVEEEQAAKK HNMPFWRISS 
    HSDLLALHQA LELEYL

Genular Protein ID: 4284130207

Symbol: F2Z2Y1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 645
  • Mass: 70126
  • Checksum: EB9E0B04BC726886
  • Sequence:
  • MEDSQDLNEQ SVKKTCTESD VSQSQNSRSM EMQDLASPHT LVGGGDTPGS SKLEKSNLSS 
    TSVTTNGTGG ENMTVLNTAD WLLSCNTPSS ATMSLLAVKT EPLNSSETTA TTGDGALDTF 
    TGSVITSSGY SPRSAHQYSP QLYPSKPYPH ILSTPAAQTM SAYAGQTQYS GMQQPAVYTA 
    YSQTGQPYSL PTYDLGVMLP AIKTESGLSQ TQSPLQSGCL SYSPGFSTPQ PGQTPYSYQM 
    PGSSFAPSST IYANNSVSNS TNFSGSQQDY PSYTAFGQNQ YAQYYSASTY GAYMTSNNTA 
    DGTPSSTSTY QLQESLPGLT NQPGTDLHPG EFDTMQSPST PIKDLDERTC RSSGSKSRGR 
    GRKNNPSPPP DSDLERVFVW DLDETIIVFH SLLTGSYAQK YGKDPPMAVT LGLRMEEMIF 
    NLADTHLFFN DLEECDQVHI DDVSSDDNGQ DLSTYSFATD GFHAAASSAN LCLPTGVRGG 
    VDWMRKLAFR YRRVKELYNT YKNNVGGLLG PAKRDAWLQL RAEIEGLTDS WLTNALKSLS 
    IISTRSNCIN VLVTTTQLIP ALAKVLLYSL GGAFPIENIY SATKIGKESC FERIMQRFGR 
    KVVYVVIGDG VEEEQAAKKH NMPFWRISSH SDLLALHQAL ELEYL

Genular Protein ID: 1368819022

Symbol: B4DIV6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 570
  • Mass: 61894
  • Checksum: 92C3B1E96BA31021
  • Sequence:
  • MEDSQDLNEQ SVKKTCTESD VSQSQNSRSM EMQDLASPHT LVGGGDTPGS SKLEKSNLSS 
    TSVTTNGTGV ITSSGYSPRS AHQYSPQLYP SKPYPHILST PAAQTMSAYA GQTQYSGMQQ 
    PAVYTAYSQT GQPYSLPTYD LGVMLPAIKT ESGLSQTQSP LQSGCLSYSP GFSTPQPGQT 
    PYSYQMPGSS FAPSSTIYAN NSVSNSTNFS GSQQDYPSYT AFGQNQYAQY YSASTYGAYM 
    TSNNTADGTP SSTSTYQLQE SLPGLTNQPG TDLHPGEFDT MQSPSTPIKD LDERTCRSSG 
    SKSRGRGRKN NPSPPPDSDL ERVFVWDLDE TIIVFHSLLT GSYAQKYGKD PPMAVTLGLR 
    MEEMIFNLAD THLFFNDLEE CDQVHIDDVS SDDNGQDLST YSFATDGFHA AASSANLCLP 
    TGVRGGVDWM RKLAFRYGRV KELYNTYKNN VGGLLGPAKR DAWLQLRAEI EGLTDSWLTN 
    ALKSLSIIST RSNCINVLVT TTQLIPALAK VLLYSLGGAF PIENIYSATK IGKESCFERI 
    VSRFGTNITY VVIGDGRDEE HAANQKRLPA

Genular Protein ID: 2007007315

Symbol: A0A0S2Z3Q2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 585
  • Mass: 63911
  • Checksum: F11418BAC8175189
  • Sequence:
  • MEDSQDLNEQ SVKKTCTESD VSQSQNSRSM EMQDLASPHT LVGGGDTPGS SKLEKSNLSS 
    TSVTTNGTGV ITSSGYSPRS AHQYSPQLYP SKPYPHILST PAAQTMSAYA GQTQYSGMQQ 
    PAVYTAYSQT GQPYSLPTYD LGVMLPAIKT ESGLSQTQSP LQSGCLSYSP GFSTPQPGQT 
    PYSYQMPGSS FAPSSTIYAN NSVSNSTNFS GSQQDYPSYT AFGQNQYAQY YSASTYGAYM 
    TSNNTADGTP SSTSTYQLQE SLPGLTNQPG EFDTMQSPST PIKDLDERTC RSSGSKSRGR 
    GRKNNPSPPP DSDLERVFVW DLDETIIVFH SLLTGSYAQK YGKDPPMAVT LGLRMEEMIF 
    NLADTHLFFN DLEECDQVHI DDVSSDDNGQ DLSTYSFATD GFHAAASSAN LCLPTGVRGG 
    VDWMRKLAFR YRRVKELYNT YKNNVGGLLG PAKRDAWLQL RAEIEGLTDS WLTNALKSLS 
    IISTRSNCIN VLVTTTQLIP ALAKVLLYSL GGAFPIENIY SATKIGKESC FERIVSRFGT 
    NITYVVIGDG RDEEHAANQH NMPFWRISSH SDLLALHQAL ELEYL

Genular Protein ID: 3965059271

Symbol: Q96CJ7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 410
  • Mass: 45477
  • Checksum: CE1D6661EA60E0AF
  • Sequence:
  • YSYQMPGSSF APSSTIYANN SVSNSTNFSG SQQDYPSYTA FGQNQYAQYY SASTYGAYMT 
    SNNTADGTPS STSTYQLQES LPGLTNQPGT DLHPGEFDTM QSPSTPIKDL DERTCRSSGS 
    KSRGRGRKNN PSPPPDSDLE RVFVWDLDET IIVFHSLLTG SYAQKYGKDP PMAVTLGLRM 
    EEMIFNLADT HLFFNDLEEC DQVHIDDVSS DDNGQDLSTY SFATDGFHAA ASSANLCLPT 
    GVRGGVDWMR KLAFRYRRVK ELYNTYKNNV GGLLGPAKRD AWLQLRAEIE GLTDSWLTNA 
    LKSLSIISTR SNCINVLVTT TQLIPALAKV LLYSLGGAFP IENIYSATKI GKESCFERIM 
    QRFGRKVVYV VIGDGVEEEQ AAKKHNMPFW RISSHSDLLA LHQALELEYL

Genular Protein ID: 3771541530

Symbol: B4DRQ6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 645
  • Mass: 70067
  • Checksum: 3B80EE3D2F4D3386
  • Sequence:
  • MEDSQDLNEQ SVKKTCTESD VSQSQNSRSM EMQDLASPHT LVGGGDTPGS SKLEKSNLSS 
    TSVTTNGTGG ENMTVLNTAD WLLSCSTPSS ATMSLLAVKT EPLNSSETTA TTGDGALDTF 
    TGSVITSSGY SPRSAHQYSP QLYPSKPYPH ILSTPAAQTM SAYAGQTQYS GMQQPAVYTA 
    YSQTGQPYSL PTYDLGVMLP AIKTESGLSQ TQSPLQSGCL SYSPGFSTPQ PGQTPYSYQM 
    PGSSFAPSST IYANNSVSNS TNFSGSQQDY PSYTAFGQNQ YAQYYSASTY GAYMTSNNTA 
    DGTPSSTSTY QLQESLPGLT NQPGTDLHPG EFDTVQSPST PIKDLDERTC RSSGSKSRGR 
    GRKNNPSPPP DSDLERVFVW DLDETIIVFH SLLTGSYAQK YGKDPPMAVT LGLRMEEMIF 
    NLADTHLFFN DLEECDQVHI DDVSSDDNGQ DLSTYSFATD GFHAAASSAN LCLPTGVRGG 
    VDWMRKLAFR YRRVKELYNT YKNNVGGLLG PAKRDAWLQL RAEIEGLTDS WLTNALKSLS 
    IISTRSNCIN VLVTTTQLIP ALAKVLLYSL GGAFPIENIY SATKIGKESC FERIMQRFGR 
    KVVYVVIGDG VEEEQAAKKH NMPFWRISSH SDLLALHQAL ELEYL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.