Details for: EYA4

Gene ID: 2070

Symbol: EYA4

Ensembl ID: ENSG00000112319

Description: EYA transcriptional coactivator and phosphatase 4

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 6.85
    Marker Score: 3,793
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 6.56
    Marker Score: 16,439
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 4.04
    Marker Score: 4,887
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 3.7
    Marker Score: 4,980
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 3.62
    Marker Score: 5,095
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.58
    Marker Score: 30,302
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 3.36
    Marker Score: 11,958
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 3.26
    Marker Score: 72,827
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 3.16
    Marker Score: 9,373
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.67
    Marker Score: 1,563
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.55
    Marker Score: 7,284
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 2.4
    Marker Score: 816
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.37
    Marker Score: 4,562
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.36
    Marker Score: 35,238
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.2
    Marker Score: 1,695
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.08
    Marker Score: 8,718
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 2.06
    Marker Score: 5,905
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.01
    Marker Score: 586
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.82
    Marker Score: 3,457
  • Cell Name: interneuron (CL0000099)
    Fold Change: 1.74
    Marker Score: 797
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 1.65
    Marker Score: 1,256
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.59
    Marker Score: 665
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.5
    Marker Score: 389
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,304
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.41
    Marker Score: 1,349
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.41
    Marker Score: 2,180
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 865
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.28
    Marker Score: 19,974
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.26
    Marker Score: 2,558
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.26
    Marker Score: 841
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.25
    Marker Score: 319
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.2
    Marker Score: 670
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.13
    Marker Score: 356
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.1
    Marker Score: 660
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.09
    Marker Score: 1,783
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,796
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,020
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.94
    Marker Score: 3,248
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,341
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.93
    Marker Score: 9,623
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.93
    Marker Score: 804
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,736
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,280
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.85
    Marker Score: 316
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.85
    Marker Score: 3,163
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.84
    Marker Score: 408
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.83
    Marker Score: 436
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.83
    Marker Score: 1,982
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.82
    Marker Score: 990
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 626
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.8
    Marker Score: 850
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.79
    Marker Score: 4,750
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.78
    Marker Score: 7,414
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,255
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.77
    Marker Score: 5,734
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 698
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.75
    Marker Score: 1,885
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.73
    Marker Score: 406
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.73
    Marker Score: 480
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.71
    Marker Score: 2,748
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.66
    Marker Score: 191
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.64
    Marker Score: 1,813
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.63
    Marker Score: 200
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.63
    Marker Score: 301
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.62
    Marker Score: 880
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.61
    Marker Score: 184
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.61
    Marker Score: 192
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.61
    Marker Score: 157
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.6
    Marker Score: 294
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 451
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.56
    Marker Score: 179
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.52
    Marker Score: 173
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.51
    Marker Score: 134
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.5
    Marker Score: 882
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.5
    Marker Score: 461
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.5
    Marker Score: 432
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.49
    Marker Score: 791
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.49
    Marker Score: 256
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.48
    Marker Score: 138
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.47
    Marker Score: 238
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.47
    Marker Score: 94
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.46
    Marker Score: 491
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.45
    Marker Score: 3,875
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.44
    Marker Score: 272
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.44
    Marker Score: 1,033
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.43
    Marker Score: 192
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.43
    Marker Score: 242
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.42
    Marker Score: 7,523
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.42
    Marker Score: 764
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.42
    Marker Score: 131
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.41
    Marker Score: 367
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.41
    Marker Score: 271
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.4
    Marker Score: 2,641
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.39
    Marker Score: 112
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.38
    Marker Score: 179

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Coactivator and Phosphatase:** EYA4 possesses both coactivator and phosphatase activities, allowing it to regulate transcriptional responses to DNA damage and other signals. 2. **Tissue-Specific Expression:** EYA4 is expressed in a variety of tissues, including the inner ear, lens, and visual system, highlighting its role in developmental and morphogenic processes. 3. **DNA Repair and Response:** EYA4 is involved in the recruitment and phosphorylation of repair and signaling proteins at DNA double-strand breaks, underscoring its critical role in maintaining genome stability. 4. **Visual Perception:** EYA4 has been implicated in the development and function of the visual system, suggesting a potential role in visual perception and disease. **Pathways and Functions:** 1. **Anatomical Structure Development:** EYA4 is involved in the development and morphogenesis of various tissues, including the inner ear, lens, and visual system. 2. **DNA Double-Strand Break Response:** EYA4 regulates the recruitment and phosphorylation of repair and signaling proteins at DNA double-strand breaks, ensuring genome stability. 3. **Cell Differentiation:** EYA4 is involved in the regulation of cell differentiation, particularly in tissues such as the lens and visual system. 4. **Chromatin Organization:** EYA4 has been shown to interact with chromatin-modifying enzymes, influencing chromatin organization and gene expression. 5. **Metal Ion Binding:** EYA4 possesses metal ion-binding capabilities, which may be important for its regulatory functions. **Clinical Significance:** 1. **Inner Ear Development:** Mutations in EYA4 have been linked to inner ear development disorders, such as cochlear dysplasia and hearing loss. 2. **Visual System Disorders:** EYA4 has been implicated in the development and function of the visual system, and mutations have been associated with visual perception disorders. 3. **Cancer:** EYA4 has been identified as a potential oncogene, with its overexpression linked to the development of certain cancers, including renal cell carcinoma. 4. **Neurological Disorders:** EYA4 has been implicated in the development and function of the nervous system, and mutations have been associated with neurological disorders, such as autism spectrum disorder. In conclusion, the EYA4 gene is a critical regulator of developmental and morphogenic processes, with implications for tissue homeostasis, DNA repair, and visual perception. Its dysregulation has been linked to various clinical disorders, highlighting the importance of further research into the molecular mechanisms underlying EYA4 function.

Genular Protein ID: 266853678

Symbol: EYA4_HUMAN

Name: Eyes absent homolog 4

UniProtKB Accession Codes:

O95677 B7Z7F7 O95464 O95679 Q8IW39 Q9NTR7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 8 ChiTaRS 1 DEPOD 1 DNASU 1 DisGeNET 1 EC 1 EMBL 9 Ensembl 4 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 1 RefSeq 5 Rhea 3 SAM 1 SFLD 2 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9887327

Title: EYA4, a novel vertebrate gene related to Drosophila eyes absent.

PubMed ID: 9887327

DOI: 10.1093/hmg/8.1.11

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11159937

Title: Mutations in the transcriptional activator EYA4 cause late-onset deafness at the DFNA10 locus.

PubMed ID: 11159937

DOI: 10.1093/hmg/10.3.195

PubMed ID: 15735644

Title: Mutation in the transcriptional coactivator EYA4 causes dilated cardiomyopathy and sensorineural hearing loss.

PubMed ID: 15735644

DOI: 10.1038/ng1527

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19606496

Title: EYA4, deleted in a case with middle interhemispheric variant of holoprosencephaly, interacts with SIX3 both physically and functionally.

PubMed ID: 19606496

DOI: 10.1002/humu.21094

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 22938506

Title: Targeted massive parallel sequencing: the effective detection of novel causative mutations associated with hearing loss in small families.

PubMed ID: 22938506

DOI: 10.1186/1750-1172-7-60

PubMed ID: 25809937

Title: A novel mutation of EYA4 in a large Chinese family with autosomal dominant middle-frequency sensorineural hearing loss by targeted exome sequencing.

PubMed ID: 25809937

DOI: 10.1038/jhg.2015.19

PubMed ID: 25961296

Title: Exome sequencing identifies a mutation in EYA4 as a novel cause of autosomal dominant non-syndromic hearing loss.

PubMed ID: 25961296

DOI: 10.1371/journal.pone.0126602

Sequence Information:

  • Length: 639
  • Mass: 69505
  • Checksum: CC59A8FB1527A0EC
  • Sequence:
    • MEDSQDLNEQ SVKKTCTESD VSQSQNSRSM EMQDLASPHT LVGGGDTPGS SKLEKSNLSS 
TSVTTNGTGG ENMTVLNTAD WLLSCNTPSS ATMSLLAVKT EPLNSSETTA TTGDGALDTF 
TGSVITSSGY SPRSAHQYSP QLYPSKPYPH ILSTPAAQTM SAYAGQTQYS GMQQPAVYTA 
YSQTGQPYSL PTYDLGVMLP AIKTESGLSQ TQSPLQSGCL SYSPGFSTPQ PGQTPYSYQM 
PGSSFAPSST IYANNSVSNS TNFSGSQQDY PSYTAFGQNQ YAQYYSASTY GAYMTSNNTA 
DGTPSSTSTY QLQESLPGLT NQPGEFDTMQ SPSTPIKDLD ERTCRSSGSK SRGRGRKNNP 
SPPPDSDLER VFVWDLDETI IVFHSLLTGS YAQKYGKDPP MAVTLGLRME EMIFNLADTH 
LFFNDLEECD QVHIDDVSSD DNGQDLSTYS FATDGFHAAA SSANLCLPTG VRGGVDWMRK 
LAFRYRRVKE LYNTYKNNVG GLLGPAKRDA WLQLRAEIEG LTDSWLTNAL KSLSIISTRS 
NCINVLVTTT QLIPALAKVL LYSLGGAFPI ENIYSATKIG KESCFERIMQ RFGRKVVYVV 
IGDGVEEEQA AKKHNMPFWR ISSHSDLLAL HQALELEYL

Genular Protein ID: 1368819022

Symbol: B4DIV6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DIV6

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 8 DNASU 1 EC 1 EMBL 2 GO 3 Gene3D 1 GenomeRNAi 1 InterPro 4 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PIRSR 2 Pfam 1 RefSeq 1 Rhea 3 RuleBase 1 SAM 1 SFLD 2

Sequence Information:

  • Length: 570
  • Mass: 61894
  • Checksum: 92C3B1E96BA31021
  • Sequence:
    • MEDSQDLNEQ SVKKTCTESD VSQSQNSRSM EMQDLASPHT LVGGGDTPGS SKLEKSNLSS 
TSVTTNGTGV ITSSGYSPRS AHQYSPQLYP SKPYPHILST PAAQTMSAYA GQTQYSGMQQ 
PAVYTAYSQT GQPYSLPTYD LGVMLPAIKT ESGLSQTQSP LQSGCLSYSP GFSTPQPGQT 
PYSYQMPGSS FAPSSTIYAN NSVSNSTNFS GSQQDYPSYT AFGQNQYAQY YSASTYGAYM 
TSNNTADGTP SSTSTYQLQE SLPGLTNQPG TDLHPGEFDT MQSPSTPIKD LDERTCRSSG 
SKSRGRGRKN NPSPPPDSDL ERVFVWDLDE TIIVFHSLLT GSYAQKYGKD PPMAVTLGLR 
MEEMIFNLAD THLFFNDLEE CDQVHIDDVS SDDNGQDLST YSFATDGFHA AASSANLCLP 
TGVRGGVDWM RKLAFRYGRV KELYNTYKNN VGGLLGPAKR DAWLQLRAEI EGLTDSWLTN 
ALKSLSIIST RSNCINVLVT TTQLIPALAK VLLYSLGGAF PIENIYSATK IGKESCFERI 
VSRFGTNITY VVIGDGRDEE HAANQKRLPA

Genular Protein ID: 3965059271

Symbol: Q96CJ7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q96CJ7

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 8 ChiTaRS 1 DNASU 1 EC 1 EMBL 2 GO 3 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PIRSR 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 3 Rhea 3 RuleBase 1 SAM 1 SFLD 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 410
  • Mass: 45477
  • Checksum: CE1D6661EA60E0AF
  • Sequence:
    • YSYQMPGSSF APSSTIYANN SVSNSTNFSG SQQDYPSYTA FGQNQYAQYY SASTYGAYMT 
SNNTADGTPS STSTYQLQES LPGLTNQPGT DLHPGEFDTM QSPSTPIKDL DERTCRSSGS 
KSRGRGRKNN PSPPPDSDLE RVFVWDLDET IIVFHSLLTG SYAQKYGKDP PMAVTLGLRM 
EEMIFNLADT HLFFNDLEEC DQVHIDDVSS DDNGQDLSTY SFATDGFHAA ASSANLCLPT 
GVRGGVDWMR KLAFRYRRVK ELYNTYKNNV GGLLGPAKRD AWLQLRAEIE GLTDSWLTNA 
LKSLSIISTR SNCINVLVTT TQLIPALAKV LLYSLGGAFP IENIYSATKI GKESCFERIM 
QRFGRKVVYV VIGDGVEEEQ AAKKHNMPFW RISSHSDLLA LHQALELEYL

Genular Protein ID: 3771541530

Symbol: B4DRQ6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DRQ6

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 8 DNASU 1 EC 1 EMBL 2 GO 3 Gene3D 1 GenomeRNAi 1 InterPro 4 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PIRSR 2 PeptideAtlas 1 Pfam 1 RefSeq 1 Rhea 3 RuleBase 1 SAM 1 SFLD 2

Sequence Information:

  • Length: 645
  • Mass: 70067
  • Checksum: 3B80EE3D2F4D3386
  • Sequence:
    • MEDSQDLNEQ SVKKTCTESD VSQSQNSRSM EMQDLASPHT LVGGGDTPGS SKLEKSNLSS 
TSVTTNGTGG ENMTVLNTAD WLLSCSTPSS ATMSLLAVKT EPLNSSETTA TTGDGALDTF 
TGSVITSSGY SPRSAHQYSP QLYPSKPYPH ILSTPAAQTM SAYAGQTQYS GMQQPAVYTA 
YSQTGQPYSL PTYDLGVMLP AIKTESGLSQ TQSPLQSGCL SYSPGFSTPQ PGQTPYSYQM 
PGSSFAPSST IYANNSVSNS TNFSGSQQDY PSYTAFGQNQ YAQYYSASTY GAYMTSNNTA 
DGTPSSTSTY QLQESLPGLT NQPGTDLHPG EFDTVQSPST PIKDLDERTC RSSGSKSRGR 
GRKNNPSPPP DSDLERVFVW DLDETIIVFH SLLTGSYAQK YGKDPPMAVT LGLRMEEMIF 
NLADTHLFFN DLEECDQVHI DDVSSDDNGQ DLSTYSFATD GFHAAASSAN LCLPTGVRGG 
VDWMRKLAFR YRRVKELYNT YKNNVGGLLG PAKRDAWLQL RAEIEGLTDS WLTNALKSLS 
IISTRSNCIN VLVTTTQLIP ALAKVLLYSL GGAFPIENIY SATKIGKESC FERIMQRFGR 
KVVYVVIGDG VEEEQAAKKH NMPFWRISSH SDLLALHQAL ELEYL

Genular Protein ID: 100935041

Symbol: A0A0S2Z3V9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z3V9

Database IDs:

ARBA 11 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 8 ChiTaRS 1 DNASU 1 EC 1 EMBL 2 ExpressionAtlas 1 GO 3 Gene3D 1 GenomeRNAi 1 InterPro 4 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PIRSR 2 Pfam 1 RefSeq 1 Rhea 3 RuleBase 1 SAM 1 SFLD 2 SMR 1 VEuPathDB 1

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 616
  • Mass: 67065
  • Checksum: 61BC97D2981AC16E
  • Sequence:
    • MEDSQDLNEQ SVKKTCTESD VSQSQNSRSM EMQDLASPHT LVGGGDTPGS SKLEKSNLSS 
TSVTTNGTGV SLLAVKTEPL NSSETTATTG DGALDTFTGS VITSSGYSPR SAHQYSPQLY 
PSKPYPHILS TPAAQTMSAY AGQTQYSGMQ QPAVYTAYSQ TGQPYSLPTY DLGVMLPAIK 
TESGLSQTQS PLQSGCLSYS PGFSTPQPGQ TPYSYQMPGS SFAPSSTIYA NNSVSNSTNF 
SGSQQDYPSY TAFGQNQYAQ YYSASTYGAY MTSNNTADGT PSSTSTYQLQ ESLPGLTNQP 
GEFDTMQSPS TPIKDLDERT CRSSGSKSRG RGRKNNPSPP PDSDLERVFV WDLDETIIVF 
HSLLTGSYAQ KYGKDPPMAV TLGLRMEEMI FNLADTHLFF NDLEECDQVH IDDVSSDDNG 
QDLSTYSFAT DGFHAAASSA NLCLPTGVRG GVDWMRKLAF RYRRVKELYN TYKNNVGGLL 
GPAKRDAWLQ LRAEIEGLTD SWLTNALKSL SIISTRSNCI NVLVTTTQLI PALAKVLLYS 
LGGAFPIENI YSATKIGKES CFERIMQRFG RKVVYVVIGD GVEEEQAAKK HNMPFWRISS 
HSDLLALHQA LELEYL

Genular Protein ID: 4284130207

Symbol: F2Z2Y1_HUMAN

Name: N/A

UniProtKB Accession Codes:

F2Z2Y1

Database IDs:

ARBA 11 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 8 ChiTaRS 1 DNASU 1 EC 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 4 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PIRSR 2 PeptideAtlas 2 Pfam 1 PhylomeDB 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 3 RuleBase 1 SAM 1 SFLD 2 SMR 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 645
  • Mass: 70126
  • Checksum: EB9E0B04BC726886
  • Sequence:
    • MEDSQDLNEQ SVKKTCTESD VSQSQNSRSM EMQDLASPHT LVGGGDTPGS SKLEKSNLSS 
TSVTTNGTGG ENMTVLNTAD WLLSCNTPSS ATMSLLAVKT EPLNSSETTA TTGDGALDTF 
TGSVITSSGY SPRSAHQYSP QLYPSKPYPH ILSTPAAQTM SAYAGQTQYS GMQQPAVYTA 
YSQTGQPYSL PTYDLGVMLP AIKTESGLSQ TQSPLQSGCL SYSPGFSTPQ PGQTPYSYQM 
PGSSFAPSST IYANNSVSNS TNFSGSQQDY PSYTAFGQNQ YAQYYSASTY GAYMTSNNTA 
DGTPSSTSTY QLQESLPGLT NQPGTDLHPG EFDTMQSPST PIKDLDERTC RSSGSKSRGR 
GRKNNPSPPP DSDLERVFVW DLDETIIVFH SLLTGSYAQK YGKDPPMAVT LGLRMEEMIF 
NLADTHLFFN DLEECDQVHI DDVSSDDNGQ DLSTYSFATD GFHAAASSAN LCLPTGVRGG 
VDWMRKLAFR YRRVKELYNT YKNNVGGLLG PAKRDAWLQL RAEIEGLTDS WLTNALKSLS 
IISTRSNCIN VLVTTTQLIP ALAKVLLYSL GGAFPIENIY SATKIGKESC FERIMQRFGR 
KVVYVVIGDG VEEEQAAKKH NMPFWRISSH SDLLALHQAL ELEYL

Genular Protein ID: 2007007315

Symbol: A0A0S2Z3Q2_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z3Q2

Database IDs:

ARBA 11 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 8 ChiTaRS 1 DNASU 1 EC 1 EMBL 2 ExpressionAtlas 1 GO 3 Gene3D 1 GenomeRNAi 1 InterPro 4 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PIRSR 2 Pfam 1 RefSeq 1 Rhea 3 RuleBase 1 SAM 1 SFLD 2 SMR 1 VEuPathDB 1

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 585
  • Mass: 63911
  • Checksum: F11418BAC8175189
  • Sequence:
    • MEDSQDLNEQ SVKKTCTESD VSQSQNSRSM EMQDLASPHT LVGGGDTPGS SKLEKSNLSS 
TSVTTNGTGV ITSSGYSPRS AHQYSPQLYP SKPYPHILST PAAQTMSAYA GQTQYSGMQQ 
PAVYTAYSQT GQPYSLPTYD LGVMLPAIKT ESGLSQTQSP LQSGCLSYSP GFSTPQPGQT 
PYSYQMPGSS FAPSSTIYAN NSVSNSTNFS GSQQDYPSYT AFGQNQYAQY YSASTYGAYM 
TSNNTADGTP SSTSTYQLQE SLPGLTNQPG EFDTMQSPST PIKDLDERTC RSSGSKSRGR 
GRKNNPSPPP DSDLERVFVW DLDETIIVFH SLLTGSYAQK YGKDPPMAVT LGLRMEEMIF 
NLADTHLFFN DLEECDQVHI DDVSSDDNGQ DLSTYSFATD GFHAAASSAN LCLPTGVRGG 
VDWMRKLAFR YRRVKELYNT YKNNVGGLLG PAKRDAWLQL RAEIEGLTDS WLTNALKSLS 
IISTRSNCIN VLVTTTQLIP ALAKVLLYSL GGAFPIENIY SATKIGKESC FERIVSRFGT 
NITYVVIGDG RDEEHAANQH NMPFWRISSH SDLLALHQAL ELEYL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.