ERCC3 | ENSG00000163161 | NCBI 2071

Details for: ERCC3

Gene ID: 2071

Symbol: ERCC3

Ensembl ID: ENSG00000163161

Description: ERCC excision repair 3, TFIIH core complex helicase subunit

Associated with

Disease
(R-HSA-1643685)
Dual incision in gg-ner
(R-HSA-5696400)
Dual incision in tc-ner
(R-HSA-6782135)
Epigenetic regulation of gene expression
(R-HSA-212165)
Formation of hiv-1 elongation complex containing hiv-1 tat
(R-HSA-167200)
Formation of hiv elongation complex in the absence of hiv tat
(R-HSA-167152)
Formation of incision complex in gg-ner
(R-HSA-5696395)
Formation of rna pol ii elongation complex
(R-HSA-112382)
Formation of tc-ner pre-incision complex
(R-HSA-6781823)
Formation of the early elongation complex
(R-HSA-113418)
Formation of the hiv-1 early elongation complex
(R-HSA-167158)
Gap-filling dna repair synthesis and ligation in tc-ner
(R-HSA-6782210)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Global genome nucleotide excision repair (gg-ner)
(R-HSA-5696399)
Hiv infection
(R-HSA-162906)
Hiv life cycle
(R-HSA-162587)
Hiv transcription elongation
(R-HSA-167169)
Hiv transcription initiation
(R-HSA-167161)
Infectious disease
(R-HSA-5663205)
Late phase of hiv life cycle
(R-HSA-162599)
Metabolism of rna
(R-HSA-8953854)
Mrna capping
(R-HSA-72086)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Norc negatively regulates rrna expression
(R-HSA-427413)
Nucleotide excision repair
(R-HSA-5696398)
Rna pol ii ctd phosphorylation and interaction with ce
(R-HSA-77075)
Rna pol ii ctd phosphorylation and interaction with ce during hiv infection
(R-HSA-167160)
Rna polymerase ii hiv promoter escape
(R-HSA-167162)
Rna polymerase ii pre-transcription events
(R-HSA-674695)
Rna polymerase ii promoter escape
(R-HSA-73776)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase ii transcription elongation
(R-HSA-75955)
Rna polymerase ii transcription initiation
(R-HSA-75953)
Rna polymerase ii transcription initiation and promoter clearance
(R-HSA-76042)
Rna polymerase ii transcription pre-initiation and promoter opening
(R-HSA-73779)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i transcription
(R-HSA-73864)
Rna polymerase i transcription initiation
(R-HSA-73762)
Rna polymerase i transcription termination
(R-HSA-73863)
Tat-mediated elongation of the hiv-1 transcript
(R-HSA-167246)
Tp53 regulates transcription of dna repair genes
(R-HSA-6796648)
Transcription-coupled nucleotide excision repair (tc-ner)
(R-HSA-6781827)
Transcriptional regulation by tp53
(R-HSA-3700989)
Transcription of the hiv genome
(R-HSA-167172)
Viral infection pathways
(R-HSA-9824446)
3'-5' dna helicase activity
(GO:0043138)
Apoptotic process
(GO:0006915)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Damaged dna binding
(GO:0003684)
Dna binding
(GO:0003677)
Dna repair
(GO:0006281)
Dna topological change
(GO:0006265)
Embryonic organ development
(GO:0048568)
Hair cell differentiation
(GO:0035315)
Isomerase activity
(GO:0016853)
Nucleoplasm
(GO:0005654)
Nucleotide-excision repair
(GO:0006289)
Nucleotide-excision repair, dna duplex unwinding
(GO:0000717)
Nucleotide-excision repair factor 3 complex
(GO:0000112)
Nucleus
(GO:0005634)
Positive regulation of apoptotic process
(GO:0043065)
Promoter-specific chromatin binding
(GO:1990841)
Protein binding
(GO:0005515)
Protein localization
(GO:0008104)
Regulation of mitotic cell cycle phase transition
(GO:1901990)
Response to hypoxia
(GO:0001666)
Response to oxidative stress
(GO:0006979)
Response to uv
(GO:0009411)
Transcription-coupled nucleotide-excision repair
(GO:0006283)
Transcription by rna polymerase ii
(GO:0006366)
Transcription elongation by rna polymerase ii
(GO:0006368)
Transcription factor tfiid complex
(GO:0005669)
Transcription factor tfiih core complex
(GO:0000439)
Transcription factor tfiih holo complex
(GO:0005675)
Transcription initiation at rna polymerase ii promoter
(GO:0006367)
Transcription preinitiation complex
(GO:0097550)
Uv protection
(GO:0009650)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 142.3380
Cell Significance Index: -22.1400
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 86.5782
Cell Significance Index: -21.9600
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 19.2059
Cell Significance Index: -23.6800
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 7.8914
Cell Significance Index: -21.1400
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 6.5669
Cell Significance Index: -20.1700
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 6.0744
Cell Significance Index: -23.9700
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 5.5013
Cell Significance Index: -12.0400
Cell Name: colon goblet cell (CL0009039)
Fold Change: 2.5320
Cell Significance Index: 250.4800
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.0070
Cell Significance Index: 199.8500
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.8505
Cell Significance Index: 170.6000
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.7209
Cell Significance Index: 117.2500
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.6468
Cell Significance Index: 75.3800
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.5404
Cell Significance Index: 32.4400
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.5035
Cell Significance Index: 14.0700
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.4492
Cell Significance Index: 161.1100
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.3334
Cell Significance Index: 18.7100
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3329
Cell Significance Index: 23.0200
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.3086
Cell Significance Index: 36.3900
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.3056
Cell Significance Index: 6.6200
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2871
Cell Significance Index: 259.2400
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.2525
Cell Significance Index: 45.5200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.2477
Cell Significance Index: 30.4600
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2350
Cell Significance Index: 128.3400
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2182
Cell Significance Index: 9.8900
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.2076
Cell Significance Index: 5.9800
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.1899
Cell Significance Index: 12.7700
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.1750
Cell Significance Index: 13.4300
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1741
Cell Significance Index: 33.1400
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1719
Cell Significance Index: 8.9300
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1680
Cell Significance Index: 116.1800
Cell Name: odontoblast (CL0000060)
Fold Change: 0.1612
Cell Significance Index: 20.6600
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.1492
Cell Significance Index: 9.1700
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1436
Cell Significance Index: 63.4900
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1391
Cell Significance Index: 19.1100
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.1296
Cell Significance Index: 3.2400
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.1047
Cell Significance Index: 4.6300
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.1012
Cell Significance Index: 4.7200
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.1008
Cell Significance Index: 6.3500
Cell Name: preadipocyte (CL0002334)
Fold Change: 0.0974
Cell Significance Index: 1.9000
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.0481
Cell Significance Index: 1.8200
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.0468
Cell Significance Index: 1.2600
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0162
Cell Significance Index: 29.8000
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0150
Cell Significance Index: 28.2000
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0119
Cell Significance Index: 2.0300
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0060
Cell Significance Index: 9.3000
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0005
Cell Significance Index: -0.2300
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0014
Cell Significance Index: -0.9200
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0067
Cell Significance Index: -0.1800
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0069
Cell Significance Index: -9.4100
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0073
Cell Significance Index: -0.4700
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0111
Cell Significance Index: -0.1900
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0195
Cell Significance Index: -14.2700
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0206
Cell Significance Index: -15.5600
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0245
Cell Significance Index: -18.1300
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0364
Cell Significance Index: -5.2900
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0369
Cell Significance Index: -4.7700
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0406
Cell Significance Index: -22.8700
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0417
Cell Significance Index: -1.9600
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0428
Cell Significance Index: -26.7300
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0511
Cell Significance Index: -5.2200
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0704
Cell Significance Index: -20.2700
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.0725
Cell Significance Index: -2.1300
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0737
Cell Significance Index: -1.5700
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0749
Cell Significance Index: -5.3000
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.1070
Cell Significance Index: -3.7600
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.1080
Cell Significance Index: -2.3700
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1206
Cell Significance Index: -8.9900
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1240
Cell Significance Index: -26.1200
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.1282
Cell Significance Index: -3.4900
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1295
Cell Significance Index: -14.8400
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.1377
Cell Significance Index: -3.6200
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1400
Cell Significance Index: -4.8700
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1530
Cell Significance Index: -2.5600
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.1552
Cell Significance Index: -4.4300
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.1680
Cell Significance Index: -4.0300
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1695
Cell Significance Index: -8.9000
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1727
Cell Significance Index: -5.5300
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.1919
Cell Significance Index: -3.9800
Cell Name: germ cell (CL0000586)
Fold Change: -0.2046
Cell Significance Index: -1.5500
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2086
Cell Significance Index: -21.7200
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.2297
Cell Significance Index: -6.1500
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.2331
Cell Significance Index: -3.1800
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2522
Cell Significance Index: -15.4600
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2582
Cell Significance Index: -20.4500
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.2622
Cell Significance Index: -6.7400
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.2652
Cell Significance Index: -7.8100
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.2766
Cell Significance Index: -7.0700
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.2931
Cell Significance Index: -6.2700
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.3325
Cell Significance Index: -6.9600
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.3647
Cell Significance Index: -7.7400
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.4137
Cell Significance Index: -13.1800
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.4267
Cell Significance Index: -13.9700
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.4718
Cell Significance Index: -7.0700
Cell Name: peg cell (CL4033014)
Fold Change: -0.4965
Cell Significance Index: -11.4700
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.5030
Cell Significance Index: -17.6200
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.5031
Cell Significance Index: -10.1000
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.5108
Cell Significance Index: -6.3400
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.5236
Cell Significance Index: -15.0100
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.5274
Cell Significance Index: -19.3600
Cell Name: proerythroblast (CL0000547)
Fold Change: -0.5387
Cell Significance Index: -7.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** * **Function**: ERCC3 is a helicase subunit of the TFIIH core complex, which is involved in the unwinding of DNA and the removal of damaged bases from the DNA strand. * **Expression**: The ERCC3 gene is significantly expressed in cells involved in DNA repair, transcription, and cell cycle regulation, including germ cells, oogonial cells, mural cells, and neurons. * **Protein Structure**: The ERCC3 protein is a helicase subunit of the TFIIH core complex, which consists of eight subunits, including ERCC3, ERCC2, ERCC4, ERCC5, ERCC6, ERCC7, and XPA. * **Post-translational Modification**: The ERCC3 protein is phosphorylated at serine 76, which is essential for its activity. **Pathways and Functions** * **DNA Repair**: ERCC3 is involved in the nucleotide excision repair (NER) pathway, which is responsible for repairing DNA damage caused by UV light and other mutagens. * **Transcription**: ERCC3 is also involved in transcription, specifically in the initiation of transcription at RNA polymerase II promoters. * **Cell Cycle Regulation**: ERCC3 is involved in the regulation of the cell cycle, specifically in the transition from the G1 to the S phase. * **Apoptosis**: ERCC3 has been implicated in the regulation of apoptosis, specifically in the response to DNA damage. * **HIV Life Cycle**: ERCC3 has been shown to play a role in the life cycle of HIV, specifically in the transcription elongation process. **Clinical Significance** * **Cancer**: Dysregulation of the ERCC3 gene has been implicated in various cancers, including breast, lung, and colon cancer. * **Neurodegenerative Disorders**: ERCC3 has been implicated in the pathogenesis of neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. * **DNA Damage Response**: ERCC3 plays a critical role in the response to DNA damage, and its dysregulation can lead to increased susceptibility to cancer and other diseases. * **HIV Infection**: ERCC3 has been shown to play a role in the life cycle of HIV, and its dysregulation may contribute to the development of HIV-related diseases. In conclusion, the ERCC3 gene plays a critical role in the regulation of DNA repair, transcription, and cell cycle regulation, and its dysregulation has been implicated in various diseases, including cancer and neurodegenerative disorders. Further research is needed to fully understand the function of ERCC3 and its role in human disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Genular Protein ID: 1993828114

Symbol: ERCC3_HUMAN

Name: Basic transcription factor 2 89 kDa subunit

UniProtKB Accession Codes:

P19447 Q53QM0

Database IDs:

Citations:

PubMed ID: 2111438

Title: Molecular cloning and biological characterization of the human excision repair gene ERCC-3.

PubMed ID: 2111438

DOI: 10.1128/mcb.10.6.2570-2581.1990

PubMed ID: 2167179

Title: A presumed DNA helicase encoded by ERCC-3 is involved in the human repair disorders Xeroderma pigmentosum and Cockayne's syndrome.

PubMed ID: 2167179

DOI: 10.1016/0092-8674(90)90122-u

PubMed ID: 1956789

Title: Structure and expression of the human XPBC/ERCC-3 gene involved in DNA repair disorders xeroderma pigmentosum and Cockayne's syndrome.

PubMed ID: 1956789

DOI: 10.1093/nar/19.22.6301

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8465201

Title: DNA repair helicase: a component of BTF2 (TFIIH) basic transcription factor.

PubMed ID: 8465201

DOI: 10.1126/science.8465201

PubMed ID: 8157004

Title: Correction of xeroderma pigmentosum repair defect by basal transcription factor BTF2 (TFIIH).

PubMed ID: 8157004

DOI: 10.1002/j.1460-2075.1994.tb06428.x

PubMed ID: 7724549

Title: The 62- and 80-kDa subunits of transcription factor IIH mediate the interaction with Epstein-Barr virus nuclear protein 2.

PubMed ID: 7724549

DOI: 10.1073/pnas.92.8.3259

PubMed ID: 8663148

Title: A 3' --> 5' XPB helicase defect in repair/transcription factor TFIIH of xeroderma pigmentosum group B affects both DNA repair and transcription.

PubMed ID: 8663148

DOI: 10.1074/jbc.271.27.15898

PubMed ID: 9852112

Title: Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes.

PubMed ID: 9852112

DOI: 10.1074/jbc.273.51.34444

PubMed ID: 10024882

Title: Reconstitution of the transcription factor TFIIH: assignment of functions for the three enzymatic subunits, XPB, XPD, and cdk7.

PubMed ID: 10024882

DOI: 10.1016/s1097-2765(00)80177-x

PubMed ID: 10882074

Title: The FBP interacting repressor targets TFIIH to inhibit activated transcription.

PubMed ID: 10882074

DOI: 10.1016/s1097-2765(00)80428-1

PubMed ID: 11239393

Title: Defective interplay of activators and repressors with TFIH in xeroderma pigmentosum.

PubMed ID: 11239393

DOI: 10.1016/s0092-8674(01)00223-9

PubMed ID: 15549133

Title: Phosphorylation of XPB helicase regulates TFIIH nucleotide excision repair activity.

PubMed ID: 15549133

DOI: 10.1038/sj.emboj.7600480

PubMed ID: 17466626

Title: Distinct roles for the XPB/p52 and XPD/p44 subcomplexes of TFIIH in damaged DNA opening during nucleotide excision repair.

PubMed ID: 17466626

DOI: 10.1016/j.molcel.2007.03.009

PubMed ID: 10447254

Title: A summary of mutations in the UV-sensitive disorders: xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy.

PubMed ID: 10447254

DOI: 10.1002/(sici)1098-1004(1999)14:1<9::aid-humu2>3.0.co;2-6

PubMed ID: 19106100

Title: MCAF1/AM is involved in Sp1-mediated maintenance of cancer-associated telomerase activity.

PubMed ID: 19106100

DOI: 10.1074/jbc.m807098200

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 30894545

Title: Functional interplay between TFIIH and KAT2A regulates higher-order chromatin structure and class II gene expression.

PubMed ID: 30894545

DOI: 10.1038/s41467-019-09270-2

PubMed ID: 23385459

Title: Structure of the C-terminal half of human XPB helicase and the impact of the disease-causing mutation XP11BE.

PubMed ID: 23385459

DOI: 10.1107/s0907444912045040

PubMed ID: 27193682

Title: Near-atomic resolution visualization of human transcription promoter opening.

PubMed ID: 27193682

DOI: 10.1038/nature17970

PubMed ID: 31253769

Title: Structural basis of TFIIH activation for nucleotide excision repair.

PubMed ID: 31253769

DOI: 10.1038/s41467-019-10745-5

PubMed ID: 33902107

Title: Structures of mammalian RNA polymerase II pre-initiation complexes.

PubMed ID: 33902107

DOI: 10.1038/s41586-021-03554-8

PubMed ID: 8304337

Title: Clinical heterogeneity within xeroderma pigmentosum associated with mutations in the DNA repair and transcription gene ERCC3.

PubMed ID: 8304337

PubMed ID: 9012405

Title: A mutation in the XPB/ERCC3 DNA repair transcription gene, associated with trichothiodystrophy.

PubMed ID: 9012405

PubMed ID: 10862089

Title: Identification of four single nucleotide polymorphisms in DNA repair genes: XPA and XPB (ERCC3) in Polish population.

PubMed ID: 10862089

DOI: 10.1002/1098-1004(200006)15:6<577::aid-humu11>3.0.co;2-w

PubMed ID: 16947863

Title: Phenotypic heterogeneity in the XPB DNA helicase gene (ERCC3): xeroderma pigmentosum without and with Cockayne syndrome.

PubMed ID: 16947863

DOI: 10.1002/humu.20392

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

Length: 782
Mass: 89278
Checksum: F5F4D3A89A7DF826
Sequence:

MGKRDRADRD KKKSRKRHYE DEEDDEEDAP GNDPQEAVPS AAGKQVDESG TKVDEYGAKD 
YRLQMPLKDD HTSRPLWVAP DGHIFLEAFS PVYKYAQDFL VAIAEPVCRP THVHEYKLTA 
YSLYAAVSVG LQTSDITEYL RKLSKTGVPD GIMQFIKLCT VSYGKVKLVL KHNRYFVESC 
HPDVIQHLLQ DPVIRECRLR NSEGEATELI TETFTSKSAI SKTAESSGGP STSRVTDPQG 
KSDIPMDLFD FYEQMDKDEE EEEETQTVSF EVKQEMIEEL QKRCIHLEYP LLAEYDFRND 
SVNPDINIDL KPTAVLRPYQ EKSLRKMFGN GRARSGVIVL PCGAGKSLVG VTAACTVRKR 
CLVLGNSAVS VEQWKAQFKM WSTIDDSQIC RFTSDAKDKP IGCSVAISTY SMLGHTTKRS 
WEAERVMEWL KTQEWGLMIL DEVHTIPAKM FRRVLTIVQA HCKLGLTATL VREDDKIVDL 
NFLIGPKLYE ANWMELQNNG YIAKVQCAEV WCPMSPEFYR EYVAIKTKKR ILLYTMNPNK 
FRACQFLIKF HERRNDKIIV FADNVFALKE YAIRLNKPYI YGPTSQGERM QILQNFKHNP 
KINTIFISKV GDTSFDLPEA NVLIQISSHG GSRRQEAQRL GRVLRAKKGM VAEEYNAFFY 
SLVSQDTQEM AYSTKRQRFL VDQGYSFKVI TKLAGMEEED LAFSTKEEQQ QLLQKVLAAT 
DLDAEEEVVA GEFGSRSSQA SRRFGTMSSM SGADDTVYME YHSSRSKAPS KHVHPLFKRF 
RK

Genular Protein ID: 325580115

Symbol: B3KRG2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KRG2

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

Length: 718
Mass: 82012
Checksum: 37BB0F843DAB4BD9
Sequence:

MPLKDDHTSR PLWVAPDGHI FLEAFSPVYK YAQDFLVAIA EPVCRPTHVH EYKLTAYSLY 
AAVSVGLQTS DITEYLRKLS KTGVPDGIMQ FIKLCTVSYG KVKLVLKHNR YFVESCHPDV 
IQHLLQDPVI RECRLRNSEG EATELITETF TSKSAISKTA ESSGGPSTSR VTDPQGKSDI 
PMDLFDFYEQ MDKDEEEEEE TQTVSFEVKQ EMIEELQKRC IHLEYPLLAE YDFRNDSVNP 
DINIDLKPTA VLRPYQEKSL RKMFGNGRAR SGVIVLPCGA GKSLVGVTAV CTVRKRCLVL 
GNSAVSVEQW KAQFKMWSTI DDSQICRFTS DAKDKPIGCS VAISTYSMLG HTTKRSWEAE 
RVMEWLKTQE WGLMILDEVH TIPAKMFRRV LTIVQAHCKL GLTATLVRED DKIVDLNFLI 
GPKLYEANWM ELQNNGYIAK VQCAEVWCPM SPEFYREYVA IKTKKRILLY TMNPNKFRAC 
QFLIKFHERR NDKIIVFADN VFALKEYAIR LNKPYIYGPT SQGERMQILQ NFKHNPKINT 
IFISKVGDTS FDLPEANVLI QISSHGGSRR QEAQRLGRVL RAKKGMVAEE YNAFFYSLVS 
QDTQEMAYST KRQRFLVDQG YSFKVITKLA GMEEEDLAFS TKEEQQQLLQ KVLAATDLDA 
EEEVVAGEFG SRSSQASRRF GTMSSMSGAD DTVYMEYHSS RSKAPSKHVH PLFKRFRK

Genular Protein ID: 1633057564

Symbol: B3KTH1_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KTH1

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

Length: 718
Mass: 81886
Checksum: 33369E27C1EB5D16
Sequence:

MPLKDDHTSR PLWVAPDGHI FLEAFSPVYK YAQDFLVAIA EPVCRPTHVH EYKLTAHSLY 
AAVSVGLQTS DITEYLRKLS KTGVPDGIMQ FIKLCTVSYG KVKLVLKHNR YFVESCHPDV 
IQHLLQDPVI RECRLRNSEG EATELITETF TSKSAISKTA ESSGGPSTSR VTDPQGKSDI 
PMDLFDFYEQ MDKDEEEEEE TQTVSFEVKQ EMIGELQKRC IHLEYPLLAE YDFRNDSVNP 
DINIDLKPTA VLRPYQEKSL RKMFGNGRAR SGVIVLPCGA GKSLVGVTAA CTVRKRCLVL 
GNSAVSVEQW KAQFKMWSTI DDSQICRFTS DAKDKPIGCS VAISTYSMLG HTTKRSWEAE 
RVMEWLKTQE WGLMILDEVH TIPAKMFRRV LTIVQAHCKL GLTATLVRED DKIVDLNFLI 
GPKLYEANWM ELQNNGYIAK VQCAEVWCPM SPEFYREYVA IKTKKRILLY TMNPNKFRAC 
QFLIKFHERR NDKIIVFADN VFALKEYAIR LNKPYIYGPT SQGERMQILQ NFKHNPKINT 
IFISKVGDTS FDLPEANVLI QISSHGGSRR QEAQRLGRVL RAKKGMVAEE YNAFFYSLVS 
QDTQEMAYST KRQRFLVDQG YSFKVITKLA GMEEEDLAFS TKEEQQQLLQ KVLAATDLDA 
EEEVVAGEFG SRSSQASRRF GTMSSMSGAD DTVYMEYHSS RSKAPSKHVH PLFKRFRK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ERCC3

Associated with

Cells (max top 100)

Other Information

Molecular cloning and biological characterization of the human excision repair gene ERCC-3. PubMed ID: 2111438

A presumed DNA helicase encoded by ERCC-3 is involved in the human repair disorders Xeroderma pigmentosum and Cockayne's syndrome. PubMed ID: 2167179

Structure and expression of the human XPBC/ERCC-3 gene involved in DNA repair disorders xeroderma pigmentosum and Cockayne's syndrome. PubMed ID: 1956789

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

DNA repair helicase: a component of BTF2 (TFIIH) basic transcription factor. PubMed ID: 8465201

Correction of xeroderma pigmentosum repair defect by basal transcription factor BTF2 (TFIIH). PubMed ID: 8157004

The 62- and 80-kDa subunits of transcription factor IIH mediate the interaction with Epstein-Barr virus nuclear protein 2. PubMed ID: 7724549

A 3' --&gt; 5' XPB helicase defect in repair/transcription factor TFIIH of xeroderma pigmentosum group B affects both DNA repair and transcription. PubMed ID: 8663148

Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. PubMed ID: 9852112

Reconstitution of the transcription factor TFIIH: assignment of functions for the three enzymatic subunits, XPB, XPD, and cdk7. PubMed ID: 10024882

The FBP interacting repressor targets TFIIH to inhibit activated transcription. PubMed ID: 10882074

Defective interplay of activators and repressors with TFIH in xeroderma pigmentosum. PubMed ID: 11239393

Phosphorylation of XPB helicase regulates TFIIH nucleotide excision repair activity. PubMed ID: 15549133

Distinct roles for the XPB/p52 and XPD/p44 subcomplexes of TFIIH in damaged DNA opening during nucleotide excision repair. PubMed ID: 17466626

A summary of mutations in the UV-sensitive disorders: xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy. PubMed ID: 10447254

MCAF1/AM is involved in Sp1-mediated maintenance of cancer-associated telomerase activity. PubMed ID: 19106100

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Functional interplay between TFIIH and KAT2A regulates higher-order chromatin structure and class II gene expression. PubMed ID: 30894545

Structure of the C-terminal half of human XPB helicase and the impact of the disease-causing mutation XP11BE. PubMed ID: 23385459

Near-atomic resolution visualization of human transcription promoter opening. PubMed ID: 27193682

Structural basis of TFIIH activation for nucleotide excision repair. PubMed ID: 31253769

Structures of mammalian RNA polymerase II pre-initiation complexes. PubMed ID: 33902107

Clinical heterogeneity within xeroderma pigmentosum associated with mutations in the DNA repair and transcription gene ERCC3. PubMed ID: 8304337

A mutation in the XPB/ERCC3 DNA repair transcription gene, associated with trichothiodystrophy. PubMed ID: 9012405

Identification of four single nucleotide polymorphisms in DNA repair genes: XPA and XPB (ERCC3) in Polish population. PubMed ID: 10862089

Phenotypic heterogeneity in the XPB DNA helicase gene (ERCC3): xeroderma pigmentosum without and with Cockayne syndrome. PubMed ID: 16947863

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Database document:

PubMed ID: 2111438

PubMed ID: 2167179

PubMed ID: 1956789

PubMed ID: 15815621

PubMed ID: 15489334

PubMed ID: 8465201

PubMed ID: 8157004

PubMed ID: 7724549

PubMed ID: 8663148

PubMed ID: 9852112

PubMed ID: 10024882

PubMed ID: 10882074

PubMed ID: 11239393

PubMed ID: 15549133

PubMed ID: 17466626

PubMed ID: 10447254

PubMed ID: 19106100

PubMed ID: 23186163

PubMed ID: 24275569

PubMed ID: 30894545

PubMed ID: 23385459

PubMed ID: 27193682

PubMed ID: 31253769

PubMed ID: 33902107

PubMed ID: 8304337

PubMed ID: 9012405

PubMed ID: 10862089

PubMed ID: 16947863

PubMed ID: 16959974

PubMed ID: 14702039

PubMed ID: 14702039