Details for: ERV3 1

Gene ID: 2086

Symbol: ERV3 1

Ensembl ID: ENSG00000213462

Description: endogenous retrovirus group 3 member 1, envelope

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 1.91
    Marker Score: 686
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.84
    Marker Score: 32603
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.2
    Marker Score: 2432
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.19
    Marker Score: 813
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.15
    Marker Score: 2172
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 1.13
    Marker Score: 1105.5
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.09
    Marker Score: 288
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.09
    Marker Score: 17044
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.03
    Marker Score: 1878
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71741
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47965
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2403
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.94
    Marker Score: 1668
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 478
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 434
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.91
    Marker Score: 1094
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2714
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.89
    Marker Score: 312
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.88
    Marker Score: 384
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5251
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4931
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 306
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.83
    Marker Score: 1689
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.81
    Marker Score: 8199
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.79
    Marker Score: 1669
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.79
    Marker Score: 1341
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.79
    Marker Score: 474
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.79
    Marker Score: 16756
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.78
    Marker Score: 871
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.77
    Marker Score: 1601
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.75
    Marker Score: 10014
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.73
    Marker Score: 293
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.72
    Marker Score: 439
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.72
    Marker Score: 7444
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 373
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.71
    Marker Score: 542.5
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.71
    Marker Score: 836.5
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.7
    Marker Score: 1646
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.68
    Marker Score: 160
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.68
    Marker Score: 667
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.67
    Marker Score: 318
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.67
    Marker Score: 809
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.67
    Marker Score: 447
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.67
    Marker Score: 2807.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.66
    Marker Score: 705
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.66
    Marker Score: 601
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.65
    Marker Score: 550
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.65
    Marker Score: 1475
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.64
    Marker Score: 647
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.64
    Marker Score: 5534
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.63
    Marker Score: 373
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.61
    Marker Score: 418
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.61
    Marker Score: 578.5
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.61
    Marker Score: 490
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.61
    Marker Score: 337
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.6
    Marker Score: 383
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.6
    Marker Score: 260
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.6
    Marker Score: 288
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.59
    Marker Score: 7825
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.59
    Marker Score: 281
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.58
    Marker Score: 35869
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.58
    Marker Score: 322
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.57
    Marker Score: 4917
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.57
    Marker Score: 2199
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.57
    Marker Score: 279
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.57
    Marker Score: 190
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.57
    Marker Score: 182
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.56
    Marker Score: 531
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.56
    Marker Score: 255
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.56
    Marker Score: 981
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.56
    Marker Score: 827
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.56
    Marker Score: 335
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.55
    Marker Score: 2256
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.55
    Marker Score: 292
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.55
    Marker Score: 458
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.55
    Marker Score: 489
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.55
    Marker Score: 1484.5
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.54
    Marker Score: 648.5
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.54
    Marker Score: 327
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.53
    Marker Score: 426
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.53
    Marker Score: 184
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.53
    Marker Score: 107
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.53
    Marker Score: 187
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.52
    Marker Score: 347
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.52
    Marker Score: 2160
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.51
    Marker Score: 131
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.51
    Marker Score: 1487
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.51
    Marker Score: 344
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.51
    Marker Score: 248
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 485
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.5
    Marker Score: 277
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5
    Marker Score: 321
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5
    Marker Score: 1971
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.5
    Marker Score: 280
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.5
    Marker Score: 199
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.49
    Marker Score: 310
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.49
    Marker Score: 172

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * ERV3 is a large glycoprotein with a molecular weight of approximately 150 kDa. * It is a member of the ERV3 family of retroviruses, which are characterized by their ability to infect and replicate in human cells. * ERV3 is expressed in a variety of cell types, including gut endothelial cells, cortical cells of the adrenal gland, immature innate lymphoid cells, squamous epithelial cells, cardiac endothelial cells, pancreatic A cells, adipocytes of epicardial fat of the left ventricle, cardiac muscle myoblasts, microglial cells, and cerebral cortex GABAergic interneurons. * ERV3 is a key regulator of inflammation and tissue remodeling. It is involved in the regulation of the inflammatory response to injury and infection and in the development and maintenance of tissue homeostasis. **Pathways and functions:** * ERV3 is a key player in the regulation of inflammation. It is expressed in cells that are involved in the inflammatory response, such as epithelial cells and macrophages. ERV3 binds to the CD155 receptor on immune cells, which is expressed on activated macrophages and dendritic cells. This binding triggers a signaling cascade that leads to the activation of nuclear factor kappa B (NF-κB), a key transcription factor that is responsible for the expression of inflammatory genes. * ERV3 also plays a role in the development and maintenance of tissue homeostasis. It is expressed in cells that are responsible for maintaining tissue integrity and preventing the development of cancer. ERV3 binds to the p53 tumor suppressor protein and inhibits its activity. This leads to the activation of the p53 tumor suppressor pathway, which is a key mechanism for preventing cancer. **Clinical significance:** ERV3 is a potential therapeutic target for a variety of diseases. It is expressed in cells that are involved in inflammation and tissue remodeling, and it is therefore a potential target for the development of new drugs that are used to treat inflammatory diseases, such as Crohn's disease and rheumatoid arthritis.

Genular Protein ID: 1215551285

Symbol: ENR1_HUMAN

Name: Endogenous retrovirus group 3 member 1 Env polyprotein

UniProtKB Accession Codes:

Q14264

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 3840930

Title: The nucleotide sequence of the env gene from the human provirus ERV3 and isolation and characterization of an ERV3-specific cDNA.

PubMed ID: 3840930

DOI: 10.1016/0042-6822(85)90147-3

PubMed ID: 7645262

Title: Abundance of an endogenous retroviral envelope protein in placental trophoblasts suggests a biological function.

PubMed ID: 7645262

DOI: 10.1006/viro.1995.1442

PubMed ID: 10692254

Title: The cellular mechanism by which the human endogenous retrovirus ERV-3 env gene affects proliferation and differentiation in a human placental trophoblast model, BeWo.

PubMed ID: 10692254

DOI: 10.1053/plac.1999.0443

PubMed ID: 14557543

Title: Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.

PubMed ID: 14557543

DOI: 10.1073/pnas.2132646100

PubMed ID: 12970426

Title: Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.

PubMed ID: 12970426

DOI: 10.1128/jvi.77.19.10414-10422.2003

PubMed ID: 12083821

Title: Developmental expression of HERV-R (ERV3) and HERV-K in human tissue.

PubMed ID: 12083821

DOI: 10.1006/viro.2002.1428

PubMed ID: 9525678

Title: Physiological knockout of the envelope gene of the single-copy ERV-3 human endogenous retrovirus in a fraction of the Caucasian population.

PubMed ID: 9525678

DOI: 10.1128/jvi.72.4.3442-3445.1998

PubMed ID: 10427470

Title: Large number of polymorphic nucleotides and a termination codon in the env gene of the endogenous human retrovirus ERV3.

PubMed ID: 10427470

DOI: 10.1155/1998/958379

Sequence Information:

  • Length: 604
  • Mass: 67942
  • Checksum: C426D9193857D4BD
  • Sequence:
    • MLGMNMLLIT LFLLLPLSML KGEPWEGCLH CTHTTWSGNI MTKTLLYHTY YECAGTCLGT 
CTHNQTTYSV CDPGRGQPYV CYDPKSSPGT WFEIHVGSKE GDLLNQTKVF PSGKDVVSLY 
FDVCQIVSMG SLFPVIFSSM EYYSSCHKNR YAHPACSTDS PVTTCWDCTT WSTNQQSLGP 
IMLTKIPLEP DCKTSTCNSV NLTILEPDQP IWTTGLKAPL GARVSGEEIG PGAYVYLYII 
KKTRTRSTQQ FRVFESFYEH VNQKLPEPPP LASNLFAQLA ENIASSLHVA SCYVCGGMNM 
GDQWPWEARE LMPQDNFTLT ASSLEPAPSS QSIWFLKTSI IGKFCIARWG KAFTDPVGEL 
TCLGQQYYNE TLGKTLWRGK SNNSESPHPS PFSRFPSLNH SWYQLEAPNT WQAPSGLYWI 
CGPQAYRQLP AKWSGACVLG TIRPSFFLMP LKQGEALGYP IYDETKRKSK RGITIGDWKD 
NEWPPERIIQ YYGPATWAED GMWGYRTPVY MLNRIIRLQA VLEIITNETA GALNLLAQQA 
TKMRNVIYQN RLALDYLLAQ EEGVCGKFNL TNCCLELDDE GKVIKEITAK IQKLAHIPVQ 
TWKG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.