Details for: ERV3 1

Gene ID: 2086

Symbol: ERV3 1

Ensembl ID: ENSG00000213462

Description: endogenous retrovirus group 3 member 1, envelope

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 87.0486
    Cell Significance Index: -13.5400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 43.3877
    Cell Significance Index: -11.0100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 36.3153
    Cell Significance Index: -14.9600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 28.9958
    Cell Significance Index: -14.9200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.9550
    Cell Significance Index: -14.7400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.1100
    Cell Significance Index: -11.0100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.8558
    Cell Significance Index: -15.2200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.7208
    Cell Significance Index: 99.7000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7516
    Cell Significance Index: 678.6400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7501
    Cell Significance Index: 48.4000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6531
    Cell Significance Index: 36.6500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5670
    Cell Significance Index: 34.8500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5670
    Cell Significance Index: 61.6700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5610
    Cell Significance Index: 33.6800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.5573
    Cell Significance Index: 29.2600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5117
    Cell Significance Index: 83.2300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5107
    Cell Significance Index: 13.9000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4872
    Cell Significance Index: 25.3100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4860
    Cell Significance Index: 16.8900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.3753
    Cell Significance Index: 9.0000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3228
    Cell Significance Index: 24.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3004
    Cell Significance Index: 41.2600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2965
    Cell Significance Index: 59.4800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2964
    Cell Significance Index: 20.5000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2816
    Cell Significance Index: 53.5900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.2762
    Cell Significance Index: 2.2100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2759
    Cell Significance Index: 7.9500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2641
    Cell Significance Index: 26.1300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.2479
    Cell Significance Index: 3.0800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2365
    Cell Significance Index: 42.6400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2143
    Cell Significance Index: 10.0700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1892
    Cell Significance Index: 3.9600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1746
    Cell Significance Index: 8.1400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1718
    Cell Significance Index: 61.6400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1710
    Cell Significance Index: 1.5800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1666
    Cell Significance Index: 3.6100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1209
    Cell Significance Index: 5.4800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1184
    Cell Significance Index: 14.5600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1184
    Cell Significance Index: 2.9600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1130
    Cell Significance Index: 49.9700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1033
    Cell Significance Index: 13.3400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1026
    Cell Significance Index: 56.0100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0948
    Cell Significance Index: 11.1900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0763
    Cell Significance Index: 1.6700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.0658
    Cell Significance Index: 0.4000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0601
    Cell Significance Index: 3.7900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0479
    Cell Significance Index: 3.6800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0434
    Cell Significance Index: 5.5600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0273
    Cell Significance Index: 0.9600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0259
    Cell Significance Index: 0.6800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0009
    Cell Significance Index: 0.6900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0006
    Cell Significance Index: 0.0100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0016
    Cell Significance Index: -0.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0064
    Cell Significance Index: -12.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0065
    Cell Significance Index: -11.9300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0066
    Cell Significance Index: -4.8100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0084
    Cell Significance Index: -12.9700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0113
    Cell Significance Index: -15.4100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0115
    Cell Significance Index: -8.5400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0134
    Cell Significance Index: -7.5300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0179
    Cell Significance Index: -5.1500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0188
    Cell Significance Index: -0.4000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0214
    Cell Significance Index: -13.5900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0231
    Cell Significance Index: -0.5900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0254
    Cell Significance Index: -15.8400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0263
    Cell Significance Index: -2.6900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0321
    Cell Significance Index: -14.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0406
    Cell Significance Index: -4.6500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0419
    Cell Significance Index: -0.8700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0439
    Cell Significance Index: -7.4900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0535
    Cell Significance Index: -6.2300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0551
    Cell Significance Index: -0.5700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0583
    Cell Significance Index: -1.5600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0595
    Cell Significance Index: -1.5900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0634
    Cell Significance Index: -12.5800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0649
    Cell Significance Index: -1.5000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0718
    Cell Significance Index: -15.1200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0943
    Cell Significance Index: -1.8400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0953
    Cell Significance Index: -1.3000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0986
    Cell Significance Index: -1.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0997
    Cell Significance Index: -14.4900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1450
    Cell Significance Index: -15.1000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1472
    Cell Significance Index: -1.6000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1678
    Cell Significance Index: -10.2900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1775
    Cell Significance Index: -14.0600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1836
    Cell Significance Index: -5.1300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1873
    Cell Significance Index: -5.3700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1948
    Cell Significance Index: -5.7200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2004
    Cell Significance Index: -5.1500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2128
    Cell Significance Index: -10.7500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2265
    Cell Significance Index: -15.2300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2287
    Cell Significance Index: -6.7400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2370
    Cell Significance Index: -7.7600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2397
    Cell Significance Index: -7.6400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2573
    Cell Significance Index: -5.4600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2611
    Cell Significance Index: -3.9400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2648
    Cell Significance Index: -8.4800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2684
    Cell Significance Index: -9.4000
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.2848
    Cell Significance Index: -4.2600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3031
    Cell Significance Index: -5.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ERV3 1, also known as ENR1_HUMAN, is a polyprotein encoded by an endogenous retrovirus group 3. This gene exhibits a high degree of expression in various cell types, including gut endothelial cells, cortical cells of the adrenal gland, immature innate lymphoid cells, squamous epithelial cells, cardiac endothelial cells, pancreatic A cells, adipocytes of epicardial fat, cardiac muscle myoblasts, microglial cells, and cerebral cortex GABAergic interneurons. The widespread expression of ERV3 1 suggests its involvement in multiple physiological and pathological processes. **Pathways and Functions:** The ERV3 1 gene is associated with several biological processes, including the regulation of immune responses and the modulation of cellular signaling pathways. Research suggests that ERV3 1 plays a crucial role in the development and function of innate lymphoid cells, which are essential for the initiation of immune responses. Additionally, ERV3 1 may influence the regulation of cell growth, differentiation, and survival in various cell types. One of the most intriguing aspects of ERV3 1 is its potential involvement in the regulation of the immune system's cross-talk with other cell types. Studies have shown that ERV3 1 can interact with other gene products to modulate the expression of cytokines, chemokines, and other immune-related genes. This interaction may contribute to the development of immune-related disorders, such as autoimmune diseases and inflammatory conditions. **Clinical Significance:** The clinical significance of ERV3 1 is multifaceted and far-reaching. Its expression in various tissues and cell types suggests that ERV3 1 may play a role in the development and progression of multiple diseases, including: 1. **Autoimmune diseases**: ERV3 1 may contribute to the dysregulation of immune responses in autoimmune diseases, such as rheumatoid arthritis, lupus, and multiple sclerosis. 2. **Inflammatory conditions**: ERV3 1's involvement in the regulation of immune responses and its interaction with other gene products may contribute to the development of inflammatory conditions, such as asthma, allergies, and inflammatory bowel disease. 3. **Cancer**: ERV3 1's expression in various cell types, including cancer cells, suggests its potential involvement in the development and progression of cancer. 4. **Neurological disorders**: ERV3 1's expression in cerebral cortex GABAergic interneurons and its potential involvement in the regulation of immune responses in the central nervous system may contribute to the development of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, ERV3 1 is a complex gene with far-reaching implications for our understanding of immunological processes and disease. Further research is necessary to fully elucidate the mechanisms by which ERV3 1 regulates immune responses and its potential contribution to multiple diseases. As an expert immunologist, it is essential to continue exploring the intricacies of ERV3 1, with the ultimate goal of developing novel therapeutic strategies for the treatment of immune-related disorders.

Genular Protein ID: 1215551285

Symbol: ENR1_HUMAN

Name: Endogenous retrovirus group 3 member 1 Env polyprotein

UniProtKB Accession Codes:

Q14264

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 3840930

Title: The nucleotide sequence of the env gene from the human provirus ERV3 and isolation and characterization of an ERV3-specific cDNA.

PubMed ID: 3840930

DOI: 10.1016/0042-6822(85)90147-3

PubMed ID: 7645262

Title: Abundance of an endogenous retroviral envelope protein in placental trophoblasts suggests a biological function.

PubMed ID: 7645262

DOI: 10.1006/viro.1995.1442

PubMed ID: 10692254

Title: The cellular mechanism by which the human endogenous retrovirus ERV-3 env gene affects proliferation and differentiation in a human placental trophoblast model, BeWo.

PubMed ID: 10692254

DOI: 10.1053/plac.1999.0443

PubMed ID: 14557543

Title: Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.

PubMed ID: 14557543

DOI: 10.1073/pnas.2132646100

PubMed ID: 12970426

Title: Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.

PubMed ID: 12970426

DOI: 10.1128/jvi.77.19.10414-10422.2003

PubMed ID: 12083821

Title: Developmental expression of HERV-R (ERV3) and HERV-K in human tissue.

PubMed ID: 12083821

DOI: 10.1006/viro.2002.1428

PubMed ID: 9525678

Title: Physiological knockout of the envelope gene of the single-copy ERV-3 human endogenous retrovirus in a fraction of the Caucasian population.

PubMed ID: 9525678

DOI: 10.1128/jvi.72.4.3442-3445.1998

PubMed ID: 10427470

Title: Large number of polymorphic nucleotides and a termination codon in the env gene of the endogenous human retrovirus ERV3.

PubMed ID: 10427470

DOI: 10.1155/1998/958379

Sequence Information:

  • Length: 604
  • Mass: 67942
  • Checksum: C426D9193857D4BD
  • Sequence:
    • MLGMNMLLIT LFLLLPLSML KGEPWEGCLH CTHTTWSGNI MTKTLLYHTY YECAGTCLGT 
CTHNQTTYSV CDPGRGQPYV CYDPKSSPGT WFEIHVGSKE GDLLNQTKVF PSGKDVVSLY 
FDVCQIVSMG SLFPVIFSSM EYYSSCHKNR YAHPACSTDS PVTTCWDCTT WSTNQQSLGP 
IMLTKIPLEP DCKTSTCNSV NLTILEPDQP IWTTGLKAPL GARVSGEEIG PGAYVYLYII 
KKTRTRSTQQ FRVFESFYEH VNQKLPEPPP LASNLFAQLA ENIASSLHVA SCYVCGGMNM 
GDQWPWEARE LMPQDNFTLT ASSLEPAPSS QSIWFLKTSI IGKFCIARWG KAFTDPVGEL 
TCLGQQYYNE TLGKTLWRGK SNNSESPHPS PFSRFPSLNH SWYQLEAPNT WQAPSGLYWI 
CGPQAYRQLP AKWSGACVLG TIRPSFFLMP LKQGEALGYP IYDETKRKSK RGITIGDWKD 
NEWPPERIIQ YYGPATWAED GMWGYRTPVY MLNRIIRLQA VLEIITNETA GALNLLAQQA 
TKMRNVIYQN RLALDYLLAQ EEGVCGKFNL TNCCLELDDE GKVIKEITAK IQKLAHIPVQ 
TWKG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.