Details for: FABP1

Gene ID: 2168

Symbol: FABP1

Ensembl ID: ENSG00000163586

Description: fatty acid binding protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: precursor cell (CL0011115)
    Fold Change: 56.1182
    Cell Significance Index: 425.5500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 26.9210
    Cell Significance Index: -12.7100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 10.5174
    Cell Significance Index: 476.7200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 8.9041
    Cell Significance Index: 256.5500
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 7.4198
    Cell Significance Index: 74.8500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 6.5430
    Cell Significance Index: 98.0400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 4.2554
    Cell Significance Index: 844.5000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.0350
    Cell Significance Index: 34.2800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.0216
    Cell Significance Index: 1825.3700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.7048
    Cell Significance Index: 185.4400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6208
    Cell Significance Index: 160.3400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.3821
    Cell Significance Index: 20.4000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.2892
    Cell Significance Index: 41.2900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.2245
    Cell Significance Index: 84.6800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7953
    Cell Significance Index: 129.3400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6916
    Cell Significance Index: 14.7300
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.6653
    Cell Significance Index: 7.2100
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.4489
    Cell Significance Index: 2.5900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3749
    Cell Significance Index: 71.3500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2846
    Cell Significance Index: 10.0000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.2376
    Cell Significance Index: 2.4600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.2240
    Cell Significance Index: 3.2100
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.1194
    Cell Significance Index: 0.8400
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.0715
    Cell Significance Index: 0.5200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.0596
    Cell Significance Index: 4.7200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0491
    Cell Significance Index: 1.2600
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.0017
    Cell Significance Index: 0.0100
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.0016
    Cell Significance Index: 0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0051
    Cell Significance Index: -9.6200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0056
    Cell Significance Index: -0.2300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0092
    Cell Significance Index: -0.2000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0141
    Cell Significance Index: -10.4700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0143
    Cell Significance Index: -8.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0177
    Cell Significance Index: -9.6600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0180
    Cell Significance Index: -0.4500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0194
    Cell Significance Index: -14.2200
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: -0.0210
    Cell Significance Index: -0.1600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0260
    Cell Significance Index: -1.2100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0293
    Cell Significance Index: -10.5200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0333
    Cell Significance Index: -21.1500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0446
    Cell Significance Index: -0.5100
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0534
    Cell Significance Index: -0.5900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0559
    Cell Significance Index: -16.0700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0562
    Cell Significance Index: -11.2800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0602
    Cell Significance Index: -1.2600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0623
    Cell Significance Index: -7.2600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0655
    Cell Significance Index: -8.0500
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.0688
    Cell Significance Index: -0.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0698
    Cell Significance Index: -9.5900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0724
    Cell Significance Index: -12.3600
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.0745
    Cell Significance Index: -0.8100
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0895
    Cell Significance Index: -0.8100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0952
    Cell Significance Index: -12.3000
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.1028
    Cell Significance Index: -0.9300
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.1044
    Cell Significance Index: -1.4200
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.1075
    Cell Significance Index: -1.2200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1083
    Cell Significance Index: -12.4100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1177
    Cell Significance Index: -1.2800
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.1214
    Cell Significance Index: -0.6400
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.1251
    Cell Significance Index: -1.2600
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.1262
    Cell Significance Index: -1.2400
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.1278
    Cell Significance Index: -1.2400
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.1315
    Cell Significance Index: -1.2500
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.1396
    Cell Significance Index: -1.5800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1415
    Cell Significance Index: -2.3800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1450
    Cell Significance Index: -1.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1461
    Cell Significance Index: -21.2400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1642
    Cell Significance Index: -16.7800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1673
    Cell Significance Index: -12.4700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1762
    Cell Significance Index: -13.5200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1806
    Cell Significance Index: -11.0800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1822
    Cell Significance Index: -12.2500
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: -0.1977
    Cell Significance Index: -1.5700
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.1985
    Cell Significance Index: -1.9100
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.2269
    Cell Significance Index: -1.3900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2321
    Cell Significance Index: -6.2200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.2436
    Cell Significance Index: -4.0200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2461
    Cell Significance Index: -13.8100
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.2487
    Cell Significance Index: -1.4600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.2729
    Cell Significance Index: -3.7900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2871
    Cell Significance Index: -17.6500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3076
    Cell Significance Index: -16.1500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3182
    Cell Significance Index: -16.5300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3286
    Cell Significance Index: -7.9600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3362
    Cell Significance Index: -14.8700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3369
    Cell Significance Index: -10.6600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3471
    Cell Significance Index: -12.1600
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.3610
    Cell Significance Index: -3.8400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3797
    Cell Significance Index: -12.4300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3802
    Cell Significance Index: -5.7300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3881
    Cell Significance Index: -12.3600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3932
    Cell Significance Index: -14.8900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3976
    Cell Significance Index: -20.7100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4047
    Cell Significance Index: -8.4000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.4061
    Cell Significance Index: -7.9400
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.4170
    Cell Significance Index: -3.8700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4248
    Cell Significance Index: -7.1100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4275
    Cell Significance Index: -12.2000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4340
    Cell Significance Index: -12.4400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4353
    Cell Significance Index: -20.4600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** FABP1 is a 14-kDa protein that consists of a single chain of 123 amino acids. It is highly conserved across species, with a high degree of sequence identity among different species. FABP1 is characterized by its ability to bind to fatty acids, which are essential for energy production, cell growth, and differentiation. The protein has four distinct domains: the N-terminal domain, the fatty acid-binding domain, the C-terminal domain, and a hydrophobic core that facilitates fatty acid binding. FABP1 is also known for its ability to regulate the activity of various transcription factors, including PPARα, which plays a critical role in lipid metabolism. **Pathways and Functions** FABP1 is involved in several key biological pathways, including: 1. **Fatty acid uptake and oxidation**: FABP1 facilitates the uptake and oxidation of fatty acids, which are essential for energy production and cell growth. 2. **Cellular protection against oxidative stress**: FABP1 has antioxidant properties, which help protect cells against oxidative damage caused by reactive oxygen species (ROS). 3. **Apoptosis regulation**: FABP1 regulates apoptosis by inhibiting the activity of cysteine-type endopeptidases involved in the apoptotic process. 4. **Lipid metabolism regulation**: FABP1 regulates lipid metabolism by modulating the activity of PPARα, which plays a critical role in lipid metabolism. **Clinical Significance** FABP1 has been implicated in various diseases, including: 1. **Metabolic disorders**: FABP1 has been linked to metabolic disorders, such as obesity, insulin resistance, and type 2 diabetes. 2. **Liver disease**: FABP1 has been implicated in liver disease, including fatty liver disease and liver cancer. 3. **Cardiovascular disease**: FABP1 has been linked to cardiovascular disease, including atherosclerosis and myocardial infarction. 4. **Cancer**: FABP1 has been implicated in cancer, including colorectal cancer and breast cancer. In conclusion, FABP1 is a critical protein that plays a central role in regulating lipid metabolism and cellular response to oxidative stress. Its dysregulation has been implicated in various diseases, highlighting the importance of FABP1 in maintaining cellular homeostasis and preventing disease. Further research is needed to fully understand the mechanisms by which FABP1 regulates lipid metabolism and to explore its potential as a therapeutic target for metabolic and cardiovascular diseases.

Genular Protein ID: 1087010587

Symbol: FABPL_HUMAN

Name: Fatty acid-binding protein, liver

UniProtKB Accession Codes:

P07148

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EMBL 3 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PCDDB 1 PDB 37 PDBsum 37 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 5 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3838309

Title: Human liver fatty acid binding protein cDNA and amino acid sequence. Functional and evolutionary implications.

PubMed ID: 3838309

DOI: 10.1016/s0021-9258(18)89406-6

PubMed ID: 3838313

Title: Human liver fatty acid binding protein. Isolation of a full length cDNA and comparative sequence analyses of orthologous and paralogous proteins.

PubMed ID: 3838313

DOI: 10.1016/s0021-9258(19)83637-2

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25732850

Title: Human FABP1 T94A variant enhances cholesterol uptake.

PubMed ID: 25732850

DOI: 10.1016/j.bbalip.2015.02.015

PubMed ID: 17536800

Title: Rapid data collection for protein structure determination by NMR spectroscopy.

PubMed ID: 17536800

DOI: 10.1021/ja071442e

Sequence Information:

  • Length: 127
  • Mass: 14208
  • Checksum: 065DCEFB08DAB6B6
  • Sequence:
    • MSFSGKYQLQ SQENFEAFMK AIGLPEELIQ KGKDIKGVSE IVQNGKHFKF TITAGSKVIQ 
NEFTVGEECE LETMTGEKVK TVVQLEGDNK LVTTFKNIKS VTELNGDIIT NTMTLGDIVF 
KRISKRI

Genular Protein ID: 1219877391

Symbol: Q05CP7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q05CP7

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 1 RuleBase 1 SMR 1 SUPFAM 1 TCDB 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 134
  • Mass: 15093
  • Checksum: 5B42856E122363F5
  • Sequence:
    • MSFSGKYQLQ SQENFEAFMK AIGLPEELIQ KGKDIKGVSE IVQNGKHFKF TITAGSKVIQ 
NEFTVGEECE LETMTGEKVK TVVQLEGDNK LVTTFKNIKS VTELNGDIIT NTMTLGDIVF 
KRISKKKKKK KKKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.