Details for: FABP1

Gene ID: 2168

Symbol: FABP1

Ensembl ID: ENSG00000163586

Description: fatty acid binding protein 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 6.88
    Marker Score: 22547
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 4.23
    Marker Score: 13291
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 3.62
    Marker Score: 17388
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 3.01
    Marker Score: 16171
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 3
    Marker Score: 2879
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.73
    Marker Score: 4207
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 2.65
    Marker Score: 765
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.25
    Marker Score: 2269
  • Cell Name: stem cell (CL0000034)
    Fold Change: 2.17
    Marker Score: 5151
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 2.11
    Marker Score: 9100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1994
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.87
    Marker Score: 12037
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.76
    Marker Score: 541
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.67
    Marker Score: 5933
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.63
    Marker Score: 613
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.62
    Marker Score: 1009
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.57
    Marker Score: 1677
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.54
    Marker Score: 1538
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.44
    Marker Score: 350
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.26
    Marker Score: 313
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.18
    Marker Score: 802.5
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.15
    Marker Score: 434
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.14
    Marker Score: 7599
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.13
    Marker Score: 325
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.12
    Marker Score: 6769
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.03
    Marker Score: 655
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.02
    Marker Score: 781
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71787
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48012
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 497
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 451
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.94
    Marker Score: 1530
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5350
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.91
    Marker Score: 14288
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.91
    Marker Score: 771
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.89
    Marker Score: 648
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.89
    Marker Score: 193
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.87
    Marker Score: 225
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.79
    Marker Score: 172
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 387
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.74
    Marker Score: 3112
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 467
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.73
    Marker Score: 225
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.71
    Marker Score: 283
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.71
    Marker Score: 164
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.7
    Marker Score: 192
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.69
    Marker Score: 626
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.68
    Marker Score: 827
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.65
    Marker Score: 339
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.65
    Marker Score: 1033
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.65
    Marker Score: 171
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.63
    Marker Score: 171
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.61
    Marker Score: 282
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.6
    Marker Score: 418
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.6
    Marker Score: 1130
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.57
    Marker Score: 235
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.56
    Marker Score: 298
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 435
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.51
    Marker Score: 192
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.49
    Marker Score: 131
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.48
    Marker Score: 202
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.46
    Marker Score: 458
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.45
    Marker Score: 271
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.45
    Marker Score: 501
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.45
    Marker Score: 911
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.45
    Marker Score: 501
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.44
    Marker Score: 200
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.43
    Marker Score: 1022
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.43
    Marker Score: 222
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.43
    Marker Score: 94
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.42
    Marker Score: 447
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.41
    Marker Score: 296
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.41
    Marker Score: 309
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.4
    Marker Score: 128
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.4
    Marker Score: 379
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.38
    Marker Score: 95
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.37
    Marker Score: 2374
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.37
    Marker Score: 155
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.34
    Marker Score: 357
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.32
    Marker Score: 305
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.32
    Marker Score: 285
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.32
    Marker Score: 62
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.31
    Marker Score: 94
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.31
    Marker Score: 184
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.3
    Marker Score: 159
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.3
    Marker Score: 137
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.29
    Marker Score: 73
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.28
    Marker Score: 63
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.28
    Marker Score: 283
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.27
    Marker Score: 159
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.27
    Marker Score: 94
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.27
    Marker Score: 612
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.27
    Marker Score: 153
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.27
    Marker Score: 130
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.26
    Marker Score: 205

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Other Information

**Key characteristics:** * FABP1 is a transmembrane protein that is expressed in a variety of cell types. * It is a key regulator of lipid metabolism, and its expression is highly regulated by hormones and signaling pathways. * FABP1 is involved in the regulation of lipid uptake, storage, and metabolism. * It is also involved in the regulation of inflammation and cell survival. **Pathways and functions:** * FABP1 is a key regulator of lipid metabolism. * It is involved in the uptake and storage of fatty acids from the blood. * It is also involved in the metabolism of cholesterol and other lipids. * FABP1 is involved in the regulation of inflammation and cell survival. **Clinical significance:** * Mutations in the FABP1 gene have been linked to a number of human diseases, including liver disease, obesity, and cancer. * FABP1 inhibitors are being investigated as a treatment for these diseases. **Additional information:** * The FABP1 gene is located on chromosome 15q21.1. * It is a large gene that encodes for a protein that is approximately 1000 amino acids long. * FABP1 is a highly conserved protein that is found in organisms from yeast to humans.

Genular Protein ID: 1087010587

Symbol: FABPL_HUMAN

Name: Fatty acid-binding protein, liver

UniProtKB Accession Codes:

P07148

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EMBL 3 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PCDDB 1 PDB 39 PDBsum 37 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 5 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 SwissLipids 1 TreeFam 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3838309

Title: Human liver fatty acid binding protein cDNA and amino acid sequence. Functional and evolutionary implications.

PubMed ID: 3838309

DOI: 10.1016/s0021-9258(18)89406-6

PubMed ID: 3838313

Title: Human liver fatty acid binding protein. Isolation of a full length cDNA and comparative sequence analyses of orthologous and paralogous proteins.

PubMed ID: 3838313

DOI: 10.1016/s0021-9258(19)83637-2

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25732850

Title: Human FABP1 T94A variant enhances cholesterol uptake.

PubMed ID: 25732850

DOI: 10.1016/j.bbalip.2015.02.015

PubMed ID: 17536800

Title: Rapid data collection for protein structure determination by NMR spectroscopy.

PubMed ID: 17536800

DOI: 10.1021/ja071442e

Sequence Information:

  • Length: 127
  • Mass: 14208
  • Checksum: 065DCEFB08DAB6B6
  • Sequence:
    • MSFSGKYQLQ SQENFEAFMK AIGLPEELIQ KGKDIKGVSE IVQNGKHFKF TITAGSKVIQ 
NEFTVGEECE LETMTGEKVK TVVQLEGDNK LVTTFKNIKS VTELNGDIIT NTMTLGDIVF 
KRISKRI

Genular Protein ID: 1219877391

Symbol: Q05CP7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q05CP7

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 3 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 3 KEGG 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 1 RuleBase 1 SMR 1 SUPFAM 1 TCDB 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 134
  • Mass: 15093
  • Checksum: 5B42856E122363F5
  • Sequence:
    • MSFSGKYQLQ SQENFEAFMK AIGLPEELIQ KGKDIKGVSE IVQNGKHFKF TITAGSKVIQ 
NEFTVGEECE LETMTGEKVK TVVQLEGDNK LVTTFKNIKS VTELNGDIIT NTMTLGDIVF 
KRISKKKKKK KKKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.