Details for: FABP1

Gene ID: 2168

Symbol: FABP1

Ensembl ID: ENSG00000163586

Description: fatty acid binding protein 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 6.88
    Marker Score: 22,547
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 4.23
    Marker Score: 13,291
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 3.62
    Marker Score: 17,388
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 3.01
    Marker Score: 16,171
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 3
    Marker Score: 2,879
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.73
    Marker Score: 4,207
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 2.65
    Marker Score: 765
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.25
    Marker Score: 2,269
  • Cell Name: stem cell (CL0000034)
    Fold Change: 2.17
    Marker Score: 5,151
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 2.11
    Marker Score: 9,100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1,994
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.87
    Marker Score: 12,037
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.76
    Marker Score: 541
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.67
    Marker Score: 5,933
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.63
    Marker Score: 613
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.62
    Marker Score: 1,009
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.57
    Marker Score: 1,677
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.54
    Marker Score: 1,538
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.44
    Marker Score: 350
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.26
    Marker Score: 313
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.18
    Marker Score: 803
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.15
    Marker Score: 434
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.14
    Marker Score: 7,599
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.13
    Marker Score: 325
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.12
    Marker Score: 6,769
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.03
    Marker Score: 655
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.02
    Marker Score: 781
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,787
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,012
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 497
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 451
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,411
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.94
    Marker Score: 1,530
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,350
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,738
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.91
    Marker Score: 14,288
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.91
    Marker Score: 771
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.89
    Marker Score: 648
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.89
    Marker Score: 193
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.87
    Marker Score: 225
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.79
    Marker Score: 172
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 387
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.74
    Marker Score: 3,112
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 467
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.73
    Marker Score: 225
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.71
    Marker Score: 283
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.71
    Marker Score: 164
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.7
    Marker Score: 192
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.69
    Marker Score: 626
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.68
    Marker Score: 827
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.65
    Marker Score: 339
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.65
    Marker Score: 1,033
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.65
    Marker Score: 171
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.63
    Marker Score: 171
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.61
    Marker Score: 282
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.6
    Marker Score: 418
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.6
    Marker Score: 1,130
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.57
    Marker Score: 235
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.56
    Marker Score: 298
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 435
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.51
    Marker Score: 192
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.49
    Marker Score: 131
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.48
    Marker Score: 202
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.46
    Marker Score: 458
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.45
    Marker Score: 271
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.45
    Marker Score: 501
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.45
    Marker Score: 911
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.45
    Marker Score: 501
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.44
    Marker Score: 200
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.43
    Marker Score: 1,022
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.43
    Marker Score: 222
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.43
    Marker Score: 94
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.42
    Marker Score: 447
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.41
    Marker Score: 296
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.41
    Marker Score: 309
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.4
    Marker Score: 128
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.4
    Marker Score: 379
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.38
    Marker Score: 95
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.37
    Marker Score: 2,374
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.37
    Marker Score: 155
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.34
    Marker Score: 357
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.32
    Marker Score: 305
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.32
    Marker Score: 285
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.32
    Marker Score: 62
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.31
    Marker Score: 94
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.31
    Marker Score: 184
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.3
    Marker Score: 159
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.3
    Marker Score: 137
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.29
    Marker Score: 73
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.28
    Marker Score: 63
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.28
    Marker Score: 283
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.27
    Marker Score: 159
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.27
    Marker Score: 94
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.27
    Marker Score: 612
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.27
    Marker Score: 153
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.27
    Marker Score: 130
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.26
    Marker Score: 205

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** FABP1 is a 14-kDa protein that consists of a single chain of 123 amino acids. It is highly conserved across species, with a high degree of sequence identity among different species. FABP1 is characterized by its ability to bind to fatty acids, which are essential for energy production, cell growth, and differentiation. The protein has four distinct domains: the N-terminal domain, the fatty acid-binding domain, the C-terminal domain, and a hydrophobic core that facilitates fatty acid binding. FABP1 is also known for its ability to regulate the activity of various transcription factors, including PPARα, which plays a critical role in lipid metabolism. **Pathways and Functions** FABP1 is involved in several key biological pathways, including: 1. **Fatty acid uptake and oxidation**: FABP1 facilitates the uptake and oxidation of fatty acids, which are essential for energy production and cell growth. 2. **Cellular protection against oxidative stress**: FABP1 has antioxidant properties, which help protect cells against oxidative damage caused by reactive oxygen species (ROS). 3. **Apoptosis regulation**: FABP1 regulates apoptosis by inhibiting the activity of cysteine-type endopeptidases involved in the apoptotic process. 4. **Lipid metabolism regulation**: FABP1 regulates lipid metabolism by modulating the activity of PPARα, which plays a critical role in lipid metabolism. **Clinical Significance** FABP1 has been implicated in various diseases, including: 1. **Metabolic disorders**: FABP1 has been linked to metabolic disorders, such as obesity, insulin resistance, and type 2 diabetes. 2. **Liver disease**: FABP1 has been implicated in liver disease, including fatty liver disease and liver cancer. 3. **Cardiovascular disease**: FABP1 has been linked to cardiovascular disease, including atherosclerosis and myocardial infarction. 4. **Cancer**: FABP1 has been implicated in cancer, including colorectal cancer and breast cancer. In conclusion, FABP1 is a critical protein that plays a central role in regulating lipid metabolism and cellular response to oxidative stress. Its dysregulation has been implicated in various diseases, highlighting the importance of FABP1 in maintaining cellular homeostasis and preventing disease. Further research is needed to fully understand the mechanisms by which FABP1 regulates lipid metabolism and to explore its potential as a therapeutic target for metabolic and cardiovascular diseases.

Genular Protein ID: 1087010587

Symbol: FABPL_HUMAN

Name: Fatty acid-binding protein, liver

UniProtKB Accession Codes:

P07148

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EMBL 3 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PCDDB 1 PDB 39 PDBsum 37 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 5 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 SwissLipids 1 TreeFam 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3838309

Title: Human liver fatty acid binding protein cDNA and amino acid sequence. Functional and evolutionary implications.

PubMed ID: 3838309

DOI: 10.1016/s0021-9258(18)89406-6

PubMed ID: 3838313

Title: Human liver fatty acid binding protein. Isolation of a full length cDNA and comparative sequence analyses of orthologous and paralogous proteins.

PubMed ID: 3838313

DOI: 10.1016/s0021-9258(19)83637-2

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25732850

Title: Human FABP1 T94A variant enhances cholesterol uptake.

PubMed ID: 25732850

DOI: 10.1016/j.bbalip.2015.02.015

PubMed ID: 17536800

Title: Rapid data collection for protein structure determination by NMR spectroscopy.

PubMed ID: 17536800

DOI: 10.1021/ja071442e

Sequence Information:

  • Length: 127
  • Mass: 14208
  • Checksum: 065DCEFB08DAB6B6
  • Sequence:
    • MSFSGKYQLQ SQENFEAFMK AIGLPEELIQ KGKDIKGVSE IVQNGKHFKF TITAGSKVIQ 
NEFTVGEECE LETMTGEKVK TVVQLEGDNK LVTTFKNIKS VTELNGDIIT NTMTLGDIVF 
KRISKRI

Genular Protein ID: 1219877391

Symbol: Q05CP7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q05CP7

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 3 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 3 KEGG 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 1 RuleBase 1 SMR 1 SUPFAM 1 TCDB 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 134
  • Mass: 15093
  • Checksum: 5B42856E122363F5
  • Sequence:
    • MSFSGKYQLQ SQENFEAFMK AIGLPEELIQ KGKDIKGVSE IVQNGKHFKF TITAGSKVIQ 
NEFTVGEECE LETMTGEKVK TVVQLEGDNK LVTTFKNIKS VTELNGDIIT NTMTLGDIVF 
KRISKKKKKK KKKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.