Details for: FABP7

Gene ID: 2173

Symbol: FABP7

Ensembl ID: ENSG00000164434

Description: fatty acid binding protein 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.2689
    Cell Significance Index: -13.7200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 4.4590
    Cell Significance Index: 455.4900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.7539
    Cell Significance Index: 56.1800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.2956
    Cell Significance Index: 81.6600
  • Cell Name: glioblast (CL0000030)
    Fold Change: 1.1514
    Cell Significance Index: 7.2300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.9835
    Cell Significance Index: 69.5600
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.7516
    Cell Significance Index: 4.6500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.7272
    Cell Significance Index: 44.7000
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 0.7213
    Cell Significance Index: 4.1000
  • Cell Name: granular cell of epidermis (CL0002189)
    Fold Change: 0.6168
    Cell Significance Index: 0.7100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6017
    Cell Significance Index: 77.7400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5891
    Cell Significance Index: 12.3300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.5395
    Cell Significance Index: 9.2500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4958
    Cell Significance Index: 219.2100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1781
    Cell Significance Index: 28.9600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1007
    Cell Significance Index: 1.2000
  • Cell Name: brush cell of tracheobronchial tree (CL0002075)
    Fold Change: 0.0694
    Cell Significance Index: 0.6300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0661
    Cell Significance Index: 3.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0605
    Cell Significance Index: 2.8500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0599
    Cell Significance Index: 21.5000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0540
    Cell Significance Index: 1.1700
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0394
    Cell Significance Index: 0.3900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0111
    Cell Significance Index: -2.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0113
    Cell Significance Index: -2.2600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0144
    Cell Significance Index: -27.1300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0165
    Cell Significance Index: -0.9900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0200
    Cell Significance Index: -2.5600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0239
    Cell Significance Index: -6.8900
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0260
    Cell Significance Index: -0.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0383
    Cell Significance Index: -28.9800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0395
    Cell Significance Index: -29.2600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0405
    Cell Significance Index: -25.7400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0519
    Cell Significance Index: -29.2700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0726
    Cell Significance Index: -5.0200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1310
    Cell Significance Index: -6.8800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1419
    Cell Significance Index: -29.8800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1433
    Cell Significance Index: -25.8300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1567
    Cell Significance Index: -18.2600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1602
    Cell Significance Index: -4.3600
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.1678
    Cell Significance Index: -1.2200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1773
    Cell Significance Index: -25.7700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1800
    Cell Significance Index: -12.1000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1834
    Cell Significance Index: -3.9200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1852
    Cell Significance Index: -31.6300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.2157
    Cell Significance Index: -1.2800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2312
    Cell Significance Index: -31.7500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.2361
    Cell Significance Index: -25.6900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2494
    Cell Significance Index: -2.9100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2608
    Cell Significance Index: -29.8800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2616
    Cell Significance Index: -27.2400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2632
    Cell Significance Index: -19.6200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2651
    Cell Significance Index: -4.5700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2683
    Cell Significance Index: -31.6400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2690
    Cell Significance Index: -5.5800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2867
    Cell Significance Index: -6.8800
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.3996
    Cell Significance Index: -2.6000
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.4013
    Cell Significance Index: -4.3800
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.4074
    Cell Significance Index: -4.5000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.4300
    Cell Significance Index: -12.3900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4426
    Cell Significance Index: -14.4900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4468
    Cell Significance Index: -9.5200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4744
    Cell Significance Index: -22.1200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4781
    Cell Significance Index: -12.2900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.4882
    Cell Significance Index: -22.1300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.5392
    Cell Significance Index: -13.4500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5435
    Cell Significance Index: -17.3100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.5617
    Cell Significance Index: -14.0300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5932
    Cell Significance Index: -20.7800
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.6118
    Cell Significance Index: -6.2900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6265
    Cell Significance Index: -27.7100
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.6277
    Cell Significance Index: -6.0900
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.6294
    Cell Significance Index: -4.5200
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.6463
    Cell Significance Index: -4.0000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.6561
    Cell Significance Index: -17.5200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.6623
    Cell Significance Index: -18.9000
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.6655
    Cell Significance Index: -6.0500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6998
    Cell Significance Index: -25.6900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7344
    Cell Significance Index: -27.8100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7432
    Cell Significance Index: -25.8300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.7638
    Cell Significance Index: -7.2400
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.8464
    Cell Significance Index: -11.5100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.8561
    Cell Significance Index: -21.3500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8581
    Cell Significance Index: -25.2800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.9027
    Cell Significance Index: -26.5100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.9054
    Cell Significance Index: -25.9600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.9189
    Cell Significance Index: -22.4200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.9417
    Cell Significance Index: -20.6200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.9537
    Cell Significance Index: -16.4900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.9631
    Cell Significance Index: -10.4700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.9974
    Cell Significance Index: -17.0500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -1.0085
    Cell Significance Index: -25.7000
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -1.0266
    Cell Significance Index: -11.7500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -1.0279
    Cell Significance Index: -15.4900
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -1.0512
    Cell Significance Index: -11.9000
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -1.0656
    Cell Significance Index: -5.5800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.0659
    Cell Significance Index: -28.5600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.0761
    Cell Significance Index: -22.8400
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -1.0784
    Cell Significance Index: -11.8200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.0827
    Cell Significance Index: -28.4700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.0883
    Cell Significance Index: -21.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FABP7 is a small, cytoplasmic protein that belongs to the FABP family, which consists of six members. FABP7 is characterized by its ability to bind to long-chain fatty acids, particularly palmitate and oleate, with high affinity. This binding property is essential for the transport of fatty acids across cell membranes and their subsequent metabolism. FABP7 is also known to regulate the activity of other proteins involved in fatty acid metabolism, such as carnitine palmitoyltransferase 1 (CPT1). **Pathways and Functions:** FABP7 is involved in various biological pathways, including: 1. **Fatty Acid Binding and Transport:** FABP7 binds to fatty acids, facilitating their transport across cell membranes and their subsequent uptake by cells. 2. **Fatty Acid Metabolism:** FABP7 regulates the activity of enzymes involved in fatty acid metabolism, such as CPT1, which is essential for the transport of fatty acids into mitochondria for beta-oxidation. 3. **Negative Regulation of Cell Population Proliferation:** FABP7 has been shown to inhibit the proliferation of cells, including neural progenitor cells and immune cells such as T cells. 4. **Nervous System Development:** FABP7 is expressed in neural progenitor cells and plays a role in the development of the nervous system. 5. **Triglyceride Catabolism and Metabolism:** FABP7 is involved in the regulation of triglyceride metabolism, which is essential for energy homeostasis. **Clinical Significance:** The dysregulation of FABP7 has been implicated in various diseases, including: 1. **Neurodegenerative Disorders:** Altered expression of FABP7 has been observed in neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. 2. **Immune-Mediated Disorders:** FABP7 has been implicated in immune-mediated disorders such as multiple sclerosis and rheumatoid arthritis. 3. **Metabolic Disorders:** Dysregulation of FABP7 has been linked to metabolic disorders such as obesity and type 2 diabetes. 4. **Cancer:** FABP7 has been shown to regulate the proliferation of cancer cells, making it a potential target for cancer therapy. In conclusion, FABP7 is a multifunctional protein that plays a critical role in fatty acid metabolism and regulation of cell population proliferation. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the molecular mechanisms underlying FABP7 function and its clinical significance.

Genular Protein ID: 1141577476

Symbol: FABP7_HUMAN

Name: Fatty acid-binding protein, brain

UniProtKB Accession Codes:

O15540 B2R4L1 O14951 Q6IAU7 Q9H047

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 1 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 4 EMBL 13 Ensembl 2 EvolutionaryTrace 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9375786

Title: Isolation and expression of a cDNA for human brain fatty acid-binding protein (B-FABP).

PubMed ID: 9375786

DOI: 10.1016/s0167-4781(97)00115-2

PubMed ID: 9591779

Title: Correlation of B-FABP and GFAP expression in malignant glioma.

PubMed ID: 9591779

DOI: 10.1038/sj.onc.1201740

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10854433

Title: Crystal structure and thermodynamic analysis of human brain fatty acid-binding protein.

PubMed ID: 10854433

DOI: 10.1074/jbc.m003001200

PubMed ID: 12479569

Title: Solution structure of fatty acid-binding protein from human brain.

PubMed ID: 12479569

DOI: 10.1023/a:1020566909213

Sequence Information:

  • Length: 132
  • Mass: 14889
  • Checksum: F1E8EE12B9474B97
  • Sequence:
    • MVEAFCATWK LTNSQNFDEY MKALGVGFAT RQVGNVTKPT VIISQEGDKV VIRTLSTFKN 
TEISFQLGEE FDETTADDRN CKSVVSLDGD KLVHIQKWDG KETNFVREIK DGKMVMTLTF 
GDVVAVRHYE KA

Genular Protein ID: 1454191309

Symbol: A0A077H155_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A077H155

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 2 RefSeq 1 SUPFAM 1

Citations:

PubMed ID: 25114248

Title: Distinct isoform of FABP7 revealed by screening for retroelement-activated genes in diffuse large B-cell lymphoma.

PubMed ID: 25114248

Sequence Information:

  • Length: 128
  • Mass: 14464
  • Checksum: 2D60120610450D87
  • Sequence:
    • MQLKEKDWRS ALIKTANQQK GVGFATRQVG NVTKPTVIIS QEGDKVVIRT LSTFKNTEIS 
FQLGEEFDET TADDRNCKSV VSLDGDKLVH IQKWDGKETN FVREIKDGKM VMTLTFGDVV 
AVRHYEKA

Genular Protein ID: 1152292474

Symbol: Q59HE4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59HE4

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 1 RuleBase 1 SUPFAM 1

Sequence Information:

  • Length: 103
  • Mass: 11698
  • Checksum: 047EE3498E9A0FCD
  • Sequence:
    • RGERARMVEA FCATWKLTNS QNFDEYMKAL GVGFATRQVG NVTKPTVIIS QEGDKVVIRT 
LSTFKNTEIS FQLGEEFDET TADDRNCKVR NCFFFRVGMG RGE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.