Details for: FABP7

Gene ID: 2173

Symbol: FABP7

Ensembl ID: ENSG00000164434

Description: fatty acid binding protein 7

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 5.98
    Marker Score: 2204
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 5.49
    Marker Score: 21242
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.59
    Marker Score: 3586
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.29
    Marker Score: 2307.5
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1989
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1168
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.5
    Marker Score: 1197
  • Cell Name: T cell (CL0000084)
    Fold Change: 1.28
    Marker Score: 2204
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 855
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 488
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4807
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 503
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71814
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48038
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5344
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 375
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2744
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 328
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 463
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.72
    Marker Score: 6740
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.72
    Marker Score: 322
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.68
    Marker Score: 278
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.65
    Marker Score: 195
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.63
    Marker Score: 368
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 474
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.59
    Marker Score: 726.5
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.58
    Marker Score: 1334
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.56
    Marker Score: 176
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.55
    Marker Score: 478
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.52
    Marker Score: 2185
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.51
    Marker Score: 383
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.5
    Marker Score: 480.5
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.5
    Marker Score: 278
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.48
    Marker Score: 430.5
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.48
    Marker Score: 981
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.45
    Marker Score: 1841
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.44
    Marker Score: 832
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.42
    Marker Score: 3595
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.39
    Marker Score: 255
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.37
    Marker Score: 747
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.36
    Marker Score: 591
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.36
    Marker Score: 405.5
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.36
    Marker Score: 335
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.33
    Marker Score: 589
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.33
    Marker Score: 198
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.33
    Marker Score: 938
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.33
    Marker Score: 161
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.32
    Marker Score: 5064
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.32
    Marker Score: 348
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.31
    Marker Score: 3175
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.3
    Marker Score: 2884.5
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.3
    Marker Score: 117
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.3
    Marker Score: 2246
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.3
    Marker Score: 103
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.28
    Marker Score: 351.5
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.28
    Marker Score: 335
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.28
    Marker Score: 400
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.27
    Marker Score: 474
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.27
    Marker Score: 5789
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.27
    Marker Score: 1625.5
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.27
    Marker Score: 1425
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.26
    Marker Score: 156
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.25
    Marker Score: 133
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.24
    Marker Score: 86
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.24
    Marker Score: 919
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 76
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.22
    Marker Score: 78
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.21
    Marker Score: 617
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.21
    Marker Score: 605
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.21
    Marker Score: 109
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.2
    Marker Score: 97
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.2
    Marker Score: 480
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.19
    Marker Score: 299
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.19
    Marker Score: 1006.5
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.19
    Marker Score: 95
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.19
    Marker Score: 158
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.18
    Marker Score: 684
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.18
    Marker Score: 607
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.18
    Marker Score: 44
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.18
    Marker Score: 284
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.17
    Marker Score: 76
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.16
    Marker Score: 327.5
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.16
    Marker Score: 41
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.15
    Marker Score: 64
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.15
    Marker Score: 589.5
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.15
    Marker Score: 156
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.14
    Marker Score: 670
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 0.14
    Marker Score: 36
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.14
    Marker Score: 80
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.14
    Marker Score: 135

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Other Information

**Key characteristics** * FABP7 is a transmembrane protein that is found in the cytoplasm of cells. * It is a member of the FABP family of proteins, which are involved in the metabolism of fatty acids. * FABP7 is a key regulator of cell proliferation in various tissues. * It is involved in the regulation of epithelial cell proliferation, migration, and differentiation. * It is also involved in the development of the nervous system. **Pathways and functions** FABP7 is involved in a variety of cellular pathways, including: * Cytosol: FABP7 is involved in the regulation of cell proliferation, survival, and migration in the cytosol. * Epithelial cell proliferation: FABP7 is expressed in high levels in epithelial cells, where it plays a role in cell proliferation. * Fatty acid binding: FABP7 is a key regulator of fatty acid metabolism. It binds to fatty acids and facilitates their uptake into cells. * Fatty acid transport: FABP7 is involved in the transport of fatty acids into cells. * Lipid binding: FABP7 is involved in the binding of lipids to cell surfaces. * Metabolism: FABP7 is involved in the metabolism of lipids, including the regulation of triglyceride catabolism and the metabolism of very-low-density lipoprotein (VLDL). * Negative regulation of cell population proliferation: FABP7 is a key regulator of cell proliferation in various tissues. It inhibits cell proliferation in epithelial cells and promotes cell death in cancer cells. * Nervous system development: FABP7 is expressed in neural progenitor cells, which are responsible for the development of the nervous system. * Notch3 intracellular domain regulates transcription: The Notch3 intracellular domain of FABP7 is a key regulator of Notch3-mediated transcription. **Clinical significance** Mutations in the FABP7 gene have been linked to several human diseases, including cancer and cardiovascular disease. FABP7 is a potential therapeutic target for these diseases.

Genular Protein ID: 1141577476

Symbol: FABP7_HUMAN

Name: Fatty acid-binding protein, brain

UniProtKB Accession Codes:

O15540 B2R4L1 O14951 Q6IAU7 Q9H047

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 1 ChEMBL 1 ChiTaRS 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 DrugBank 4 EMBL 13 EPD 1 Ensembl 2 EvolutionaryTrace 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 6 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9375786

Title: Isolation and expression of a cDNA for human brain fatty acid-binding protein (B-FABP).

PubMed ID: 9375786

DOI: 10.1016/s0167-4781(97)00115-2

PubMed ID: 9591779

Title: Correlation of B-FABP and GFAP expression in malignant glioma.

PubMed ID: 9591779

DOI: 10.1038/sj.onc.1201740

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10854433

Title: Crystal structure and thermodynamic analysis of human brain fatty acid-binding protein.

PubMed ID: 10854433

DOI: 10.1074/jbc.m003001200

PubMed ID: 12479569

Title: Solution structure of fatty acid-binding protein from human brain.

PubMed ID: 12479569

DOI: 10.1023/a:1020566909213

Sequence Information:

  • Length: 132
  • Mass: 14889
  • Checksum: F1E8EE12B9474B97
  • Sequence:
    • MVEAFCATWK LTNSQNFDEY MKALGVGFAT RQVGNVTKPT VIISQEGDKV VIRTLSTFKN 
TEISFQLGEE FDETTADDRN CKSVVSLDGD KLVHIQKWDG KETNFVREIK DGKMVMTLTF 
GDVVAVRHYE KA

Genular Protein ID: 1454191309

Symbol: A0A077H155_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A077H155

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 1 Gene3D 1 GenomeRNAi 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 2 RefSeq 1 SUPFAM 1

Citations:

PubMed ID: 25114248

Title: Distinct isoform of FABP7 revealed by screening for retroelement-activated genes in diffuse large B-cell lymphoma.

PubMed ID: 25114248

Sequence Information:

  • Length: 128
  • Mass: 14464
  • Checksum: 2D60120610450D87
  • Sequence:
    • MQLKEKDWRS ALIKTANQQK GVGFATRQVG NVTKPTVIIS QEGDKVVIRT LSTFKNTEIS 
FQLGEEFDET TADDRNCKSV VSLDGDKLVH IQKWDGKETN FVREIKDGKM VMTLTFGDVV 
AVRHYEKA

Genular Protein ID: 1152292474

Symbol: Q59HE4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59HE4

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 1 Gene3D 1 GenomeRNAi 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 1 RuleBase 1 SUPFAM 1

Sequence Information:

  • Length: 103
  • Mass: 11698
  • Checksum: 047EE3498E9A0FCD
  • Sequence:
    • RGERARMVEA FCATWKLTNS QNFDEYMKAL GVGFATRQVG NVTKPTVIIS QEGDKVVIRT 
LSTFKNTEIS FQLGEEFDET TADDRNCKVR NCFFFRVGMG RGE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.