Details for: PTK2B

Gene ID: 2185

Symbol: PTK2B

Ensembl ID: ENSG00000120899

Description: protein tyrosine kinase 2 beta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 178.2118
    Cell Significance Index: -27.7200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 98.3862
    Cell Significance Index: -24.9600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 64.8604
    Cell Significance Index: -26.3500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 57.6805
    Cell Significance Index: -29.6700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.5637
    Cell Significance Index: -27.8200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.3404
    Cell Significance Index: -31.7600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.7425
    Cell Significance Index: -23.4200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.5939
    Cell Significance Index: -16.6200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.2782
    Cell Significance Index: -28.7200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 4.0945
    Cell Significance Index: 116.8500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 3.6447
    Cell Significance Index: 245.0700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.2557
    Cell Significance Index: 452.5000
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.5265
    Cell Significance Index: 13.5500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.4416
    Cell Significance Index: 39.2400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.4138
    Cell Significance Index: 26.1300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.1939
    Cell Significance Index: 45.2100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.1904
    Cell Significance Index: 52.6600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.1705
    Cell Significance Index: 75.5200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.0976
    Cell Significance Index: 129.4400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9068
    Cell Significance Index: 147.4800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6928
    Cell Significance Index: 41.5900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6301
    Cell Significance Index: 68.5400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6274
    Cell Significance Index: 8.5600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5861
    Cell Significance Index: 116.3200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.5436
    Cell Significance Index: 63.3500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4847
    Cell Significance Index: 47.9500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3578
    Cell Significance Index: 128.3400
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.3290
    Cell Significance Index: 3.1300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3123
    Cell Significance Index: 21.6000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2932
    Cell Significance Index: 7.3300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2926
    Cell Significance Index: 6.3400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2891
    Cell Significance Index: 8.0800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.2645
    Cell Significance Index: 165.2000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2364
    Cell Significance Index: 213.4300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2341
    Cell Significance Index: 6.7500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1796
    Cell Significance Index: 22.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1767
    Cell Significance Index: 31.8600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.1368
    Cell Significance Index: 1.8300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1352
    Cell Significance Index: 93.5200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1027
    Cell Significance Index: 1.7600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0910
    Cell Significance Index: 17.3200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0868
    Cell Significance Index: 38.3900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0446
    Cell Significance Index: 2.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0342
    Cell Significance Index: 64.4500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0312
    Cell Significance Index: 42.3800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0061
    Cell Significance Index: 11.2300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0054
    Cell Significance Index: 2.4300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0044
    Cell Significance Index: 2.3900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0029
    Cell Significance Index: -4.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0031
    Cell Significance Index: -2.3400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0046
    Cell Significance Index: -0.3600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0077
    Cell Significance Index: -4.8700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0174
    Cell Significance Index: -12.9000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0264
    Cell Significance Index: -14.8700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0337
    Cell Significance Index: -5.7600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0363
    Cell Significance Index: -26.6000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0579
    Cell Significance Index: -5.9200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0867
    Cell Significance Index: -18.2700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0919
    Cell Significance Index: -26.4400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0923
    Cell Significance Index: -2.4700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1164
    Cell Significance Index: -4.0900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1199
    Cell Significance Index: -17.4300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1582
    Cell Significance Index: -2.3700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1613
    Cell Significance Index: -18.4100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1782
    Cell Significance Index: -24.4700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1785
    Cell Significance Index: -9.2700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1798
    Cell Significance Index: -23.2300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1864
    Cell Significance Index: -1.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2063
    Cell Significance Index: -23.6300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2164
    Cell Significance Index: -3.6500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2184
    Cell Significance Index: -10.2700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2194
    Cell Significance Index: -28.1200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2235
    Cell Significance Index: -4.7600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2370
    Cell Significance Index: -6.9600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2419
    Cell Significance Index: -25.1900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2665
    Cell Significance Index: -18.8500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2949
    Cell Significance Index: -16.5500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3002
    Cell Significance Index: -22.3700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3273
    Cell Significance Index: -20.0700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3394
    Cell Significance Index: -20.8600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3521
    Cell Significance Index: -27.8900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3595
    Cell Significance Index: -16.7600
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: -0.3774
    Cell Significance Index: -2.9000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3823
    Cell Significance Index: -5.4800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4101
    Cell Significance Index: -13.0600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4265
    Cell Significance Index: -4.4200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4343
    Cell Significance Index: -27.3700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4459
    Cell Significance Index: -6.7200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4482
    Cell Significance Index: -11.4500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.4536
    Cell Significance Index: -6.7000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4580
    Cell Significance Index: -14.6700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4738
    Cell Significance Index: -24.6800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4777
    Cell Significance Index: -15.6400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5061
    Cell Significance Index: -13.5600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5302
    Cell Significance Index: -27.8400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5324
    Cell Significance Index: -18.6500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.5764
    Cell Significance Index: -15.3900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.5838
    Cell Significance Index: -6.3600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.5954
    Cell Significance Index: -8.4600
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.6172
    Cell Significance Index: -8.6300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular Localization:** PTK2B is primarily expressed in the nervous system, particularly in neurons, glial cells, and neural progenitor cells. 2. **Tyrosine Kinase Activity:** PTK2B is a non-receptor tyrosine kinase that phosphorylates tyrosine residues on target proteins, leading to various signaling cascades. 3. **Cell Surface Receptor Signaling:** PTK2B is involved in signaling pathways mediated by cell surface receptors, including integrins, growth factor receptors, and cytokine receptors. 4. **Regulation of Cell Adhesion:** PTK2B modulates cell adhesion through its interaction with cytoskeletal proteins and cell surface receptors. **Pathways and Functions:** 1. **Cell Migration and Adhesion:** PTK2B regulates cell migration, adhesion, and invasion through its interaction with cytoskeletal proteins and cell surface receptors. 2. **Neuroplasticity and Synaptic Transmission:** PTK2B plays a crucial role in neuroplasticity, synaptic transmission, and learning and memory processes. 3. **Immune Response:** PTK2B is involved in the regulation of immune responses, including the activation of immune cells and the modulation of cytokine production. 4. **Angiogenesis and Vascular Endothelial Growth Factor (VEGF) Signaling:** PTK2B regulates angiogenesis and VEGF signaling, which is essential for tissue repair and growth. **Clinical Significance:** 1. **Neurological Disorders:** Alterations in PTK2B expression and activity have been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and stroke. 2. **Cancer:** PTK2B is overexpressed in several types of cancer, including breast, lung, and colon cancer, and is associated with tumor progression and metastasis. 3. **Inflammatory Diseases:** PTK2B is involved in the regulation of immune responses and inflammation, making it a potential target for the treatment of inflammatory diseases, such as rheumatoid arthritis and multiple sclerosis. 4. **Cardiovascular Diseases:** PTK2B plays a role in the regulation of cardiovascular function and is involved in the development of cardiovascular diseases, including hypertension and atherosclerosis. In conclusion, PTK2B is a multifunctional protein that plays a crucial role in various cellular processes, including cell adhesion, migration, proliferation, and survival. Its dysregulation has been implicated in various diseases, making it a potential target for the development of novel therapeutic strategies. Further research is needed to fully understand the mechanisms of PTK2B and its clinical significance.

Genular Protein ID: 2834155170

Symbol: FAK2_HUMAN

Name: Protein-tyrosine kinase 2-beta

UniProtKB Accession Codes:

Q14289 D3DST0 Q13475 Q14290 Q16709 Q6PID4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CORUM 1 CPTAC 3 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EC 2 ELM 1 EMBL 11 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 100 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 18 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NIAGADS 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 26 PDBsum 26 PIR 1 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 4 RefSeq 7 Rhea 3 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 5 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7544443

Title: Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions.

PubMed ID: 7544443

DOI: 10.1038/376737a0

PubMed ID: 8838818

Title: Molecular cloning and assignment of FAK2, a novel human focal adhesion kinase, to 8p11.2-p22 by nonisotopic in situ hybridization.

PubMed ID: 8838818

DOI: 10.1006/geno.1996.0149

PubMed ID: 7673154

Title: Cloning and characterization of cell adhesion kinase beta, a novel protein-tyrosine kinase of the focal adhesion kinase subfamily.

PubMed ID: 7673154

DOI: 10.1074/jbc.270.36.21206

PubMed ID: 7499242

Title: Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brain.

PubMed ID: 7499242

DOI: 10.1074/jbc.270.46.27742

PubMed ID: 9545257

Title: A calcium-dependent tyrosine kinase splice variant in human monocytes. Activation by a two-stage process involving adherence and a subsequent intracellular signal.

PubMed ID: 9545257

DOI: 10.1074/jbc.273.16.9361

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8849729

Title: A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation.

PubMed ID: 8849729

DOI: 10.1038/383547a0

PubMed ID: 8670418

Title: Activation of Pyk2 by stress signals and coupling with JNK signaling pathway.

PubMed ID: 8670418

DOI: 10.1126/science.273.5276.792

PubMed ID: 9422762

Title: Cell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesions.

PubMed ID: 9422762

DOI: 10.1074/jbc.273.2.1003

PubMed ID: 10022920

Title: Identification of a new Pyk2 target protein with Arf-GAP activity.

PubMed ID: 10022920

DOI: 10.1128/mcb.19.3.2338

PubMed ID: 10769033

Title: Suppression of Pyk2 kinase and cellular activities by FIP200.

PubMed ID: 10769033

DOI: 10.1083/jcb.149.2.423

PubMed ID: 11493697

Title: Nephrocystin interacts with Pyk2, p130(Cas), and tensin and triggers phosphorylation of Pyk2.

PubMed ID: 11493697

DOI: 10.1073/pnas.171269898

PubMed ID: 12771146

Title: The tyrosine kinase Pyk2 regulates Arf1 activity by phosphorylation and inhibition of the Arf-GTPase-activating protein ASAP1.

PubMed ID: 12771146

DOI: 10.1074/jbc.m302278200

PubMed ID: 12893833

Title: Identification and characterization of a novel Pyk2/related adhesion focal tyrosine kinase-associated protein that inhibits alpha-synuclein phosphorylation.

PubMed ID: 12893833

DOI: 10.1074/jbc.m213217200

PubMed ID: 14585963

Title: Pyk2- and Src-dependent tyrosine phosphorylation of PDK1 regulates focal adhesions.

PubMed ID: 14585963

DOI: 10.1128/mcb.23.22.8019-8029.2003

PubMed ID: 12522270

Title: Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.

PubMed ID: 12522270

DOI: 10.1073/pnas.2436191100

PubMed ID: 15050747

Title: Integrin engagement-induced inhibition of human myelopoiesis is mediated by proline-rich tyrosine kinase 2 gene products.

PubMed ID: 15050747

DOI: 10.1016/j.exphem.2004.01.001

PubMed ID: 15166227

Title: RAFTK/Pyk2 activation is mediated by trans-acting autophosphorylation in a Src-independent manner.

PubMed ID: 15166227

DOI: 10.1074/jbc.m313527200

PubMed ID: 17329398

Title: Interaction of Pyk2 and PTP-PEST with leupaxin in prostate cancer cells.

PubMed ID: 17329398

DOI: 10.1152/ajpcell.00503.2006

PubMed ID: 17634955

Title: Ephrin-A1 stimulates migration of CD8+CCR7+ T lymphocytes.

PubMed ID: 17634955

DOI: 10.1002/eji.200737111

PubMed ID: 18339875

Title: Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271.

PubMed ID: 18339875

DOI: 10.1158/0008-5472.can-07-5155

PubMed ID: 18765415

Title: Proline-rich tyrosine kinase 2 (Pyk2) promotes proliferation and invasiveness of hepatocellular carcinoma cells through c-Src/ERK activation.

PubMed ID: 18765415

DOI: 10.1093/carcin/bgn203

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18086875

Title: The atypical Rho GTPase Wrch1 collaborates with the nonreceptor tyrosine kinases Pyk2 and Src in regulating cytoskeletal dynamics.

PubMed ID: 18086875

DOI: 10.1128/mcb.00201-07

PubMed ID: 18587400

Title: Nonmuscle myosin light-chain kinase mediates neutrophil transmigration in sepsis-induced lung inflammation by activating beta2 integrins.

PubMed ID: 18587400

DOI: 10.1038/ni.1628

PubMed ID: 19207108

Title: A Pyk2-Vav1 complex is recruited to beta3-adhesion sites to initiate Rho activation.

PubMed ID: 19207108

DOI: 10.1042/bj20090037

PubMed ID: 19648005

Title: Identification of small molecule inhibitors of proline-rich tyrosine kinase 2 (Pyk2) with osteogenic activity in osteoblast cells.

PubMed ID: 19648005

DOI: 10.1016/j.bmcl.2009.07.084

PubMed ID: 19086031

Title: Pyk2 mediates endothelin-1 signaling via p130Cas/BCAR3 cascade and regulates human glomerular mesangial cell adhesion and spreading.

PubMed ID: 19086031

DOI: 10.1002/jcp.21649

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20521079

Title: Recruitment of Pyk2 to SHPS-1 signaling complex is required for IGF-I-dependent mitogenic signaling in vascular smooth muscle cells.

PubMed ID: 20521079

DOI: 10.1007/s00018-010-0411-x

PubMed ID: 19880522

Title: Pyk2 inhibition of p53 as an adaptive and intrinsic mechanism facilitating cell proliferation and survival.

PubMed ID: 19880522

DOI: 10.1074/jbc.m109.064212

PubMed ID: 20028775

Title: The T cell receptor-mediated phosphorylation of Pyk2 tyrosines 402 and 580 occurs via a distinct mechanism than other receptor systems.

PubMed ID: 20028775

DOI: 10.1189/jlb.0409227

PubMed ID: 20381867

Title: T cell receptor activation leads to two distinct phases of Pyk2 activation and actin cytoskeletal rearrangement in human T cells.

PubMed ID: 20381867

DOI: 10.1016/j.molimm.2010.03.009

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21357692

Title: Nephrocystin-4 regulates Pyk2-induced tyrosine phosphorylation of nephrocystin-1 to control targeting to monocilia.

PubMed ID: 21357692

DOI: 10.1074/jbc.m110.165464

PubMed ID: 21533080

Title: Proline-rich tyrosine kinase 2 (Pyk2) promotes cell motility of hepatocellular carcinoma through induction of epithelial to mesenchymal transition.

PubMed ID: 21533080

DOI: 10.1371/journal.pone.0018878

PubMed ID: 15888917

Title: Focal adhesion kinase-related protein tyrosine kinase Pyk2 in T-cell activation and function.

PubMed ID: 15888917

DOI: 10.1385/ir:31:3:267

PubMed ID: 20001213

Title: Targeting Pyk2 for therapeutic intervention.

PubMed ID: 20001213

DOI: 10.1517/14728220903473194

PubMed ID: 20332118

Title: Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions.

PubMed ID: 20332118

DOI: 10.1242/jcs.045112

PubMed ID: 21196189

Title: Redox sensitive Pyk2 as a target for therapeutics in breast cancer.

PubMed ID: 21196189

DOI: 10.2741/3706

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 18951788

Title: Trifluoromethylpyrimidine-based inhibitors of proline-rich tyrosine kinase 2 (PYK2): structure-activity relationships and strategies for the elimination of reactive metabolite formation.

PubMed ID: 18951788

DOI: 10.1016/j.bmcl.2008.10.030

PubMed ID: 19358827

Title: Crystal structures of free and ligand-bound focal adhesion targeting domain of Pyk2.

PubMed ID: 19358827

DOI: 10.1016/j.bbrc.2009.04.011

PubMed ID: 19428251

Title: Sulfoximine-substituted trifluoromethylpyrimidine analogs as inhibitors of proline-rich tyrosine kinase 2 (PYK2) show reduced hERG activity.

PubMed ID: 19428251

DOI: 10.1016/j.bmcl.2009.04.093

PubMed ID: 19244237

Title: Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a unique (DFG-out) conformation and enables inhibitor design.

PubMed ID: 19244237

DOI: 10.1074/jbc.m809038200

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 1009
  • Mass: 115875
  • Checksum: 420B21046274E7C2
  • Sequence:
    • MSGVSEPLSR VKLGTLRRPE GPAEPMVVVP VDVEKEDVRI LKVCFYSNSF NPGKNFKLVK 
CTVQTEIREI ITSILLSGRI GPNIRLAECY GLRLKHMKSD EIHWLHPQMT VGEVQDKYEC 
LHVEAEWRYD LQIRYLPEDF MESLKEDRTT LLYFYQQLRN DYMQRYASKV SEGMALQLGC 
LELRRFFKDM PHNALDKKSN FELLEKEVGL DLFFPKQMQE NLKPKQFRKM IQQTFQQYAS 
LREEECVMKF FNTLAGFANI DQETYRCELI QGWNITVDLV IGPKGIRQLT SQDAKPTCLA 
EFKQIRSIRC LPLEEGQAVL QLGIEGAPQA LSIKTSSLAE AENMADLIDG YCRLQGEHQG 
SLIIHPRKDG EKRNSLPQIP MLNLEARRSH LSESCSIESD IYAEIPDETL RRPGGPQYGI 
AREDVVLNRI LGEGFFGEVY EGVYTNHKGE KINVAVKTCK KDCTLDNKEK FMSEAVIMKN 
LDHPHIVKLI GIIEEEPTWI IMELYPYGEL GHYLERNKNS LKVLTLVLYS LQICKAMAYL 
ESINCVHRDI AVRNILVASP ECVKLGDFGL SRYIEDEDYY KASVTRLPIK WMSPESINFR 
RFTTASDVWM FAVCMWEILS FGKQPFFWLE NKDVIGVLEK GDRLPKPDLC PPVLYTLMTR 
CWDYDPSDRP RFTELVCSLS DVYQMEKDIA MEQERNARYR TPKILEPTAF QEPPPKPSRP 
KYRPPPQTNL LAPKLQFQVP EGLCASSPTL TSPMEYPSPV NSLHTPPLHR HNVFKRHSMR 
EEDFIQPSSR EEAQQLWEAE KVKMRQILDK QQKQMVEDYQ WLRQEEKSLD PMVYMNDKSP 
LTPEKEVGYL EFTGPPQKPP RLGAQSIQPT ANLDRTDDLV YLNVMELVRA VLELKNELCQ 
LPPEGYVVVV KNVGLTLRKL IGSVDDLLPS LPSSSRTEIE GTQKLLNKDL AELINKMRLA 
QQNAVTSLSE ECKRQMLTAS HTLAVDAKNL LDAVDQAKVL ANLAHPPAE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.