Details for: PTK2B

Gene ID: 2185

Symbol: PTK2B

Ensembl ID: ENSG00000120899

Description: protein tyrosine kinase 2 beta

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 3.05
    Marker Score: 11790.5
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.32
    Marker Score: 6627
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.8
    Marker Score: 17082
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.77
    Marker Score: 2972.5
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.68
    Marker Score: 14396
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.61
    Marker Score: 1777
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.58
    Marker Score: 2441
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.58
    Marker Score: 96881
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.56
    Marker Score: 503
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.55
    Marker Score: 86706
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.54
    Marker Score: 3830
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.52
    Marker Score: 3669
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167041
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.44
    Marker Score: 1274
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.4
    Marker Score: 3291
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.38
    Marker Score: 4099.5
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.34
    Marker Score: 15615
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.31
    Marker Score: 13284
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.31
    Marker Score: 786
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.29
    Marker Score: 634
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.28
    Marker Score: 2500.5
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.27
    Marker Score: 397
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.19
    Marker Score: 18572
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.15
    Marker Score: 1030
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.13
    Marker Score: 660
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.12
    Marker Score: 3094
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.1
    Marker Score: 832
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.06
    Marker Score: 1070
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.05
    Marker Score: 22473.5
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.05
    Marker Score: 454
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.04
    Marker Score: 2186
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.02
    Marker Score: 1351
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.01
    Marker Score: 1764
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71676
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1
    Marker Score: 936
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47901
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.98
    Marker Score: 591
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.98
    Marker Score: 25121
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30386
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.98
    Marker Score: 3083
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.97
    Marker Score: 9628.5
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.97
    Marker Score: 956
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.97
    Marker Score: 36672
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.95
    Marker Score: 408.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2398
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.94
    Marker Score: 598
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.94
    Marker Score: 328
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 479
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 435
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.92
    Marker Score: 329
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.91
    Marker Score: 1479
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.91
    Marker Score: 18033
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2704
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.9
    Marker Score: 393.5
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.88
    Marker Score: 1939
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.88
    Marker Score: 303
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.87
    Marker Score: 739
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.86
    Marker Score: 3517
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.86
    Marker Score: 652
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.86
    Marker Score: 523
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.86
    Marker Score: 959
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.86
    Marker Score: 924
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.86
    Marker Score: 2690
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.85
    Marker Score: 3551
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.85
    Marker Score: 851
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.85
    Marker Score: 195
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.85
    Marker Score: 4833
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.85
    Marker Score: 493
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.84
    Marker Score: 772.5
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.84
    Marker Score: 876
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.84
    Marker Score: 6403
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.83
    Marker Score: 703
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.83
    Marker Score: 2321
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.82
    Marker Score: 298
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.82
    Marker Score: 291
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.82
    Marker Score: 1163
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.82
    Marker Score: 5278
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.82
    Marker Score: 283
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.81
    Marker Score: 930
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8
    Marker Score: 322
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.8
    Marker Score: 249
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.8
    Marker Score: 400
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.8
    Marker Score: 398
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.8
    Marker Score: 583
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.8
    Marker Score: 485
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 608
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.78
    Marker Score: 3384
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.78
    Marker Score: 196
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.78
    Marker Score: 174
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.78
    Marker Score: 12470
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.78
    Marker Score: 3257
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.77
    Marker Score: 202
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.76
    Marker Score: 1856
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.76
    Marker Score: 499
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.76
    Marker Score: 2211
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.76
    Marker Score: 823
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.75
    Marker Score: 737
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.75
    Marker Score: 4571

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Other Information

**Key characteristics:** - PTK2B is a transmembrane protein with a cytoplasmic domain and a single transmembrane helix. - It is a member of the protein tyrosine kinase family, which is known for its involvement in cell signaling. - PTK2B is a serine/threonine kinase that is activated by the binding of various growth factors and cytokines. - It is a key regulator of neuronal survival, differentiation, and plasticity. **Pathways and functions:** - PTK2B is involved in cell-cell communication and signaling by various pathways, including the calmodulin-dependent protein kinase (CaMK) pathway, the cell-cell adhesion molecule (CAM) pathway, the cytokine signaling pathway, and the immune system pathway. - It is critical for the survival, proliferation, and differentiation of neural progenitor cells, as well as for the development and function of neurons. - It is also involved in the regulation of inflammation and immune responses. **Clinical significance:** - Mutations in PTK2B have been linked to several neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. - Targeting PTK2B signaling has emerged as a promising therapeutic approach for these diseases. - Small molecule inhibitors of PTK2B have shown efficacy in preclinical models of neurodegenerative diseases, suggesting that they may be potential treatments for these conditions.

Genular Protein ID: 2834155170

Symbol: FAK2_HUMAN

Name: Protein-tyrosine kinase 2-beta

UniProtKB Accession Codes:

Q14289 D3DST0 Q13475 Q14290 Q16709 Q6PID4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CORUM 1 CPTAC 3 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EC 2 ELM 1 EMBL 11 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 100 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 18 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NIAGADS 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 32 PDBsum 24 PIR 1 PRINTS 1 PRO 1 PROSITE 4 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 4 RefSeq 7 Rhea 3 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 5 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7544443

Title: Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions.

PubMed ID: 7544443

DOI: 10.1038/376737a0

PubMed ID: 8838818

Title: Molecular cloning and assignment of FAK2, a novel human focal adhesion kinase, to 8p11.2-p22 by nonisotopic in situ hybridization.

PubMed ID: 8838818

DOI: 10.1006/geno.1996.0149

PubMed ID: 7673154

Title: Cloning and characterization of cell adhesion kinase beta, a novel protein-tyrosine kinase of the focal adhesion kinase subfamily.

PubMed ID: 7673154

DOI: 10.1074/jbc.270.36.21206

PubMed ID: 7499242

Title: Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brain.

PubMed ID: 7499242

DOI: 10.1074/jbc.270.46.27742

PubMed ID: 9545257

Title: A calcium-dependent tyrosine kinase splice variant in human monocytes. Activation by a two-stage process involving adherence and a subsequent intracellular signal.

PubMed ID: 9545257

DOI: 10.1074/jbc.273.16.9361

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8849729

Title: A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation.

PubMed ID: 8849729

DOI: 10.1038/383547a0

PubMed ID: 8670418

Title: Activation of Pyk2 by stress signals and coupling with JNK signaling pathway.

PubMed ID: 8670418

DOI: 10.1126/science.273.5276.792

PubMed ID: 9422762

Title: Cell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesions.

PubMed ID: 9422762

DOI: 10.1074/jbc.273.2.1003

PubMed ID: 10022920

Title: Identification of a new Pyk2 target protein with Arf-GAP activity.

PubMed ID: 10022920

DOI: 10.1128/mcb.19.3.2338

PubMed ID: 10769033

Title: Suppression of Pyk2 kinase and cellular activities by FIP200.

PubMed ID: 10769033

DOI: 10.1083/jcb.149.2.423

PubMed ID: 11493697

Title: Nephrocystin interacts with Pyk2, p130(Cas), and tensin and triggers phosphorylation of Pyk2.

PubMed ID: 11493697

DOI: 10.1073/pnas.171269898

PubMed ID: 12771146

Title: The tyrosine kinase Pyk2 regulates Arf1 activity by phosphorylation and inhibition of the Arf-GTPase-activating protein ASAP1.

PubMed ID: 12771146

DOI: 10.1074/jbc.m302278200

PubMed ID: 12893833

Title: Identification and characterization of a novel Pyk2/related adhesion focal tyrosine kinase-associated protein that inhibits alpha-synuclein phosphorylation.

PubMed ID: 12893833

DOI: 10.1074/jbc.m213217200

PubMed ID: 14585963

Title: Pyk2- and Src-dependent tyrosine phosphorylation of PDK1 regulates focal adhesions.

PubMed ID: 14585963

DOI: 10.1128/mcb.23.22.8019-8029.2003

PubMed ID: 12522270

Title: Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.

PubMed ID: 12522270

DOI: 10.1073/pnas.2436191100

PubMed ID: 15050747

Title: Integrin engagement-induced inhibition of human myelopoiesis is mediated by proline-rich tyrosine kinase 2 gene products.

PubMed ID: 15050747

DOI: 10.1016/j.exphem.2004.01.001

PubMed ID: 15166227

Title: RAFTK/Pyk2 activation is mediated by trans-acting autophosphorylation in a Src-independent manner.

PubMed ID: 15166227

DOI: 10.1074/jbc.m313527200

PubMed ID: 17329398

Title: Interaction of Pyk2 and PTP-PEST with leupaxin in prostate cancer cells.

PubMed ID: 17329398

DOI: 10.1152/ajpcell.00503.2006

PubMed ID: 17634955

Title: Ephrin-A1 stimulates migration of CD8+CCR7+ T lymphocytes.

PubMed ID: 17634955

DOI: 10.1002/eji.200737111

PubMed ID: 18339875

Title: Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271.

PubMed ID: 18339875

DOI: 10.1158/0008-5472.can-07-5155

PubMed ID: 18765415

Title: Proline-rich tyrosine kinase 2 (Pyk2) promotes proliferation and invasiveness of hepatocellular carcinoma cells through c-Src/ERK activation.

PubMed ID: 18765415

DOI: 10.1093/carcin/bgn203

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18086875

Title: The atypical Rho GTPase Wrch1 collaborates with the nonreceptor tyrosine kinases Pyk2 and Src in regulating cytoskeletal dynamics.

PubMed ID: 18086875

DOI: 10.1128/mcb.00201-07

PubMed ID: 18587400

Title: Nonmuscle myosin light-chain kinase mediates neutrophil transmigration in sepsis-induced lung inflammation by activating beta2 integrins.

PubMed ID: 18587400

DOI: 10.1038/ni.1628

PubMed ID: 19207108

Title: A Pyk2-Vav1 complex is recruited to beta3-adhesion sites to initiate Rho activation.

PubMed ID: 19207108

DOI: 10.1042/bj20090037

PubMed ID: 19648005

Title: Identification of small molecule inhibitors of proline-rich tyrosine kinase 2 (Pyk2) with osteogenic activity in osteoblast cells.

PubMed ID: 19648005

DOI: 10.1016/j.bmcl.2009.07.084

PubMed ID: 19086031

Title: Pyk2 mediates endothelin-1 signaling via p130Cas/BCAR3 cascade and regulates human glomerular mesangial cell adhesion and spreading.

PubMed ID: 19086031

DOI: 10.1002/jcp.21649

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20521079

Title: Recruitment of Pyk2 to SHPS-1 signaling complex is required for IGF-I-dependent mitogenic signaling in vascular smooth muscle cells.

PubMed ID: 20521079

DOI: 10.1007/s00018-010-0411-x

PubMed ID: 19880522

Title: Pyk2 inhibition of p53 as an adaptive and intrinsic mechanism facilitating cell proliferation and survival.

PubMed ID: 19880522

DOI: 10.1074/jbc.m109.064212

PubMed ID: 20028775

Title: The T cell receptor-mediated phosphorylation of Pyk2 tyrosines 402 and 580 occurs via a distinct mechanism than other receptor systems.

PubMed ID: 20028775

DOI: 10.1189/jlb.0409227

PubMed ID: 20381867

Title: T cell receptor activation leads to two distinct phases of Pyk2 activation and actin cytoskeletal rearrangement in human T cells.

PubMed ID: 20381867

DOI: 10.1016/j.molimm.2010.03.009

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21357692

Title: Nephrocystin-4 regulates Pyk2-induced tyrosine phosphorylation of nephrocystin-1 to control targeting to monocilia.

PubMed ID: 21357692

DOI: 10.1074/jbc.m110.165464

PubMed ID: 21533080

Title: Proline-rich tyrosine kinase 2 (Pyk2) promotes cell motility of hepatocellular carcinoma through induction of epithelial to mesenchymal transition.

PubMed ID: 21533080

DOI: 10.1371/journal.pone.0018878

PubMed ID: 15888917

Title: Focal adhesion kinase-related protein tyrosine kinase Pyk2 in T-cell activation and function.

PubMed ID: 15888917

DOI: 10.1385/ir:31:3:267

PubMed ID: 20001213

Title: Targeting Pyk2 for therapeutic intervention.

PubMed ID: 20001213

DOI: 10.1517/14728220903473194

PubMed ID: 20332118

Title: Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions.

PubMed ID: 20332118

DOI: 10.1242/jcs.045112

PubMed ID: 21196189

Title: Redox sensitive Pyk2 as a target for therapeutics in breast cancer.

PubMed ID: 21196189

DOI: 10.2741/3706

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 18951788

Title: Trifluoromethylpyrimidine-based inhibitors of proline-rich tyrosine kinase 2 (PYK2): structure-activity relationships and strategies for the elimination of reactive metabolite formation.

PubMed ID: 18951788

DOI: 10.1016/j.bmcl.2008.10.030

PubMed ID: 19358827

Title: Crystal structures of free and ligand-bound focal adhesion targeting domain of Pyk2.

PubMed ID: 19358827

DOI: 10.1016/j.bbrc.2009.04.011

PubMed ID: 19428251

Title: Sulfoximine-substituted trifluoromethylpyrimidine analogs as inhibitors of proline-rich tyrosine kinase 2 (PYK2) show reduced hERG activity.

PubMed ID: 19428251

DOI: 10.1016/j.bmcl.2009.04.093

PubMed ID: 19244237

Title: Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a unique (DFG-out) conformation and enables inhibitor design.

PubMed ID: 19244237

DOI: 10.1074/jbc.m809038200

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 1009
  • Mass: 115875
  • Checksum: 420B21046274E7C2
  • Sequence:
    • MSGVSEPLSR VKLGTLRRPE GPAEPMVVVP VDVEKEDVRI LKVCFYSNSF NPGKNFKLVK 
CTVQTEIREI ITSILLSGRI GPNIRLAECY GLRLKHMKSD EIHWLHPQMT VGEVQDKYEC 
LHVEAEWRYD LQIRYLPEDF MESLKEDRTT LLYFYQQLRN DYMQRYASKV SEGMALQLGC 
LELRRFFKDM PHNALDKKSN FELLEKEVGL DLFFPKQMQE NLKPKQFRKM IQQTFQQYAS 
LREEECVMKF FNTLAGFANI DQETYRCELI QGWNITVDLV IGPKGIRQLT SQDAKPTCLA 
EFKQIRSIRC LPLEEGQAVL QLGIEGAPQA LSIKTSSLAE AENMADLIDG YCRLQGEHQG 
SLIIHPRKDG EKRNSLPQIP MLNLEARRSH LSESCSIESD IYAEIPDETL RRPGGPQYGI 
AREDVVLNRI LGEGFFGEVY EGVYTNHKGE KINVAVKTCK KDCTLDNKEK FMSEAVIMKN 
LDHPHIVKLI GIIEEEPTWI IMELYPYGEL GHYLERNKNS LKVLTLVLYS LQICKAMAYL 
ESINCVHRDI AVRNILVASP ECVKLGDFGL SRYIEDEDYY KASVTRLPIK WMSPESINFR 
RFTTASDVWM FAVCMWEILS FGKQPFFWLE NKDVIGVLEK GDRLPKPDLC PPVLYTLMTR 
CWDYDPSDRP RFTELVCSLS DVYQMEKDIA MEQERNARYR TPKILEPTAF QEPPPKPSRP 
KYRPPPQTNL LAPKLQFQVP EGLCASSPTL TSPMEYPSPV NSLHTPPLHR HNVFKRHSMR 
EEDFIQPSSR EEAQQLWEAE KVKMRQILDK QQKQMVEDYQ WLRQEEKSLD PMVYMNDKSP 
LTPEKEVGYL EFTGPPQKPP RLGAQSIQPT ANLDRTDDLV YLNVMELVRA VLELKNELCQ 
LPPEGYVVVV KNVGLTLRKL IGSVDDLLPS LPSSSRTEIE GTQKLLNKDL AELINKMRLA 
QQNAVTSLSE ECKRQMLTAS HTLAVDAKNL LDAVDQAKVL ANLAHPPAE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.