Details for: FGF13

Gene ID: 2258

Symbol: FGF13

Ensembl ID: ENSG00000129682

Description: fibroblast growth factor 13

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 6.1
    Marker Score: 20452
  • Cell Name: granule cell (CL0000120)
    Fold Change: 5.44
    Marker Score: 41037
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 5.11
    Marker Score: 27475
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 4.65
    Marker Score: 10682
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 4.54
    Marker Score: 6395
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 4.31
    Marker Score: 22622
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 3.65
    Marker Score: 1754
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 3.45
    Marker Score: 2003
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 3.39
    Marker Score: 7444
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 3.34
    Marker Score: 112853
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 3.1
    Marker Score: 1390
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 3.08
    Marker Score: 2345
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.82
    Marker Score: 42223
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.74
    Marker Score: 6852
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.5
    Marker Score: 10353
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.48
    Marker Score: 11481
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.29
    Marker Score: 881
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.14
    Marker Score: 8256
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.12
    Marker Score: 1187
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.04
    Marker Score: 75147
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.91
    Marker Score: 1439
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.82
    Marker Score: 7637
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.8
    Marker Score: 1067
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.76
    Marker Score: 18131
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.65
    Marker Score: 868
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.52
    Marker Score: 30314
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.48
    Marker Score: 4021
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.48
    Marker Score: 496
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168123
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.45
    Marker Score: 377
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.42
    Marker Score: 2892
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.4
    Marker Score: 408
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.35
    Marker Score: 425
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.34
    Marker Score: 11471
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.32
    Marker Score: 624
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.32
    Marker Score: 12505
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.31
    Marker Score: 2658
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.3
    Marker Score: 331
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.29
    Marker Score: 1556
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 1.29
    Marker Score: 390
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.26
    Marker Score: 1945
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.24
    Marker Score: 2354
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.22
    Marker Score: 679
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.19
    Marker Score: 1657
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.18
    Marker Score: 9013
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.17
    Marker Score: 72139
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.17
    Marker Score: 11774.5
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.16
    Marker Score: 479
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.13
    Marker Score: 1403
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.1
    Marker Score: 2594
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.08
    Marker Score: 1245
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.06
    Marker Score: 672
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.03
    Marker Score: 620
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.02
    Marker Score: 15965
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71777
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48002
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.98
    Marker Score: 539
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.98
    Marker Score: 679
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 501
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.97
    Marker Score: 3937
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 454
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5288
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2733
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.91
    Marker Score: 333
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.9
    Marker Score: 589
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.87
    Marker Score: 323
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.86
    Marker Score: 3038.5
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.85
    Marker Score: 2007
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.85
    Marker Score: 244.5
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.83
    Marker Score: 1178
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.82
    Marker Score: 1025.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 624.5
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.81
    Marker Score: 392
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 316.5
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.78
    Marker Score: 744
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1258
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.77
    Marker Score: 1484
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 701
  • Cell Name: visceromotor neuron (CL0005025)
    Fold Change: 0.76
    Marker Score: 221
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 390
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.74
    Marker Score: 184
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.74
    Marker Score: 300
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.74
    Marker Score: 1807.5
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.74
    Marker Score: 27928
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.73
    Marker Score: 3067.5
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.73
    Marker Score: 171
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.73
    Marker Score: 561
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.72
    Marker Score: 227
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.72
    Marker Score: 3010
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.72
    Marker Score: 662
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.72
    Marker Score: 2024.5
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.7
    Marker Score: 6618
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.7
    Marker Score: 942
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.69
    Marker Score: 251
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.68
    Marker Score: 191

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Other Information

**Key characteristics:** * FGF13 is a transmembrane protein with a molecular weight of approximately 130 kDa. * It is a member of the fibroblast growth factor family of proteins. * FGF13 is expressed in a variety of cell types, including neurons, glial cells, and endothelial cells. * It is known to interact with beta-tubulin, which is a major component of microtubules. * FGF13 is involved in the regulation of neuronal survival, migration, and differentiation. * It is also involved in synaptic plasticity and learning and memory. **Pathways and functions:** * FGF13 binds to beta-tubulin and promotes the polymerization of microtubules, leading to the formation of stable microtubule structures. * It is involved in the regulation of neuronal migration by promoting the migration of neurons along the developing neural tube. * FGF13 also plays a role in the differentiation of neural stem cells into neurons. * It is involved in the regulation of synaptic plasticity by promoting the formation and strengthening of synapses. * It is also involved in learning and memory by regulating the expression of genes involved in memory formation. **Clinical significance:** * Mutations in FGF13 have been linked to several neurological disorders, including autism, schizophrenia, and Alzheimer's disease. * FGF13 is a potential therapeutic target for these disorders, as it can be used to promote neuronal survival, migration, and differentiation. * Studies have shown that FGF13 inhibitors can improve neuronal function in animal models of neurodegenerative diseases.

Genular Protein ID: 291956521

Symbol: FGF13_HUMAN

Name: Fibroblast growth factor homologous factor 2

UniProtKB Accession Codes:

Q92913 B1AK18 B7Z4M7 B7Z8N0 D3DWH4 O95830 Q9NZH9 Q9NZI0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 25 EPD 1 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 37 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 3 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 1 RefSeq 7 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8790420

Title: Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development.

PubMed ID: 8790420

DOI: 10.1073/pnas.93.18.9850

PubMed ID: 10071193

Title: Fibroblast growth factor homologous factor 2 (FHF2): gene structure, expression and mapping to the Borjeson-Forssman-Lehmann syndrome region in Xq26 delineated by a duplication breakpoint in a BFLS-like patient.

PubMed ID: 10071193

DOI: 10.1007/s004390050910

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10644718

Title: Isoform diversity among fibroblast growth factor homologous factors is generated by alternative promoter usage and differential splicing.

PubMed ID: 10644718

DOI: 10.1074/jbc.275.4.2589

PubMed ID: 9232594

Title: Murine FGF-12 and FGF-13: expression in embryonic nervous system, connective tissue and heart.

PubMed ID: 9232594

DOI: 10.1016/s0925-4773(97)00042-7

PubMed ID: 11378392

Title: Fibroblast growth factor homologous factors are intracellular signaling proteins.

PubMed ID: 11378392

DOI: 10.1016/s0960-9822(01)00232-9

PubMed ID: 15282281

Title: Fibroblast growth factor homologous factor 2B: association with Nav1.6 and selective colocalization at nodes of Ranvier of dorsal root axons.

PubMed ID: 15282281

DOI: 10.1523/jneurosci.1628-04.2004

PubMed ID: 21817159

Title: Fibroblast growth factor homologous factor 13 regulates Na+ channels and conduction velocity in murine hearts.

PubMed ID: 21817159

DOI: 10.1161/circresaha.111.247957

PubMed ID: 21566136

Title: Identification of novel interaction sites that determine specificity between fibroblast growth factor homologous factors and voltage-gated sodium channels.

PubMed ID: 21566136

DOI: 10.1074/jbc.m111.245803

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 36696443

Title: Cryo-EM structure of human voltage-gated sodium channel Nav1.6.

PubMed ID: 36696443

DOI: 10.1073/pnas.2220578120

PubMed ID: 34184986

Title: 5'-UTR SNP of FGF13 causes translational defect and intellectual disability.

PubMed ID: 34184986

DOI: 10.7554/elife.63021

PubMed ID: 19406745

Title: Crystal structure of a fibroblast growth factor homologous factor (FHF) defines a conserved surface on FHFs for binding and modulation of voltage-gated sodium channels.

PubMed ID: 19406745

DOI: 10.1074/jbc.m109.001842

PubMed ID: 33245860

Title: Missense variants in the N-terminal domain of the A isoform of FHF2/FGF13 cause an X-linked developmental and epileptic encephalopathy.

PubMed ID: 33245860

DOI: 10.1016/j.ajhg.2020.10.017

PubMed ID: 34871784

Title: Further evidence of affected females with a heterozygous variant in FGF13 causing X-linked developmental and epileptic encephalopathy 90.

PubMed ID: 34871784

DOI: 10.1016/j.ejmg.2021.104403

Sequence Information:

  • Length: 245
  • Mass: 27564
  • Checksum: 30FB62C6B2669F29
  • Sequence:
    • MAAAIASSLI RQKRQARERE KSNACKCVSS PSKGKTSCDK NKLNVFSRVK LFGSKKRRRR 
RPEPQLKGIV TKLYSRQGYH LQLQADGTID GTKDEDSTYT LFNLIPVGLR VVAIQGVQTK 
LYLAMNSEGY LYTSELFTPE CKFKESVFEN YYVTYSSMIY RQQQSGRGWY LGLNKEGEIM 
KGNHVKKNKP AAHFLPKPLK VAMYKEPSLH DLTEFSRSGS GTPTKSRSVS GVLNGGKSMS 
HNEST

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.