Details for: FGFR1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 328.3932
Cell Significance Index: -51.0800 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 200.4783
Cell Significance Index: -50.8500 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 112.3687
Cell Significance Index: -46.2900 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 109.2513
Cell Significance Index: -51.5800 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 100.2075
Cell Significance Index: -40.7100 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 41.5100
Cell Significance Index: -51.1800 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 15.9829
Cell Significance Index: -34.9800 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 12.9801
Cell Significance Index: -51.2200 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 10.8418
Cell Significance Index: -33.3000 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 5.8774
Cell Significance Index: 168.4800 - Cell Name: preadipocyte (CL0002334)
Fold Change: 3.9217
Cell Significance Index: 76.5400 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 2.7972
Cell Significance Index: 58.5500 - Cell Name: odontoblast (CL0000060)
Fold Change: 2.2966
Cell Significance Index: 294.4100 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.6200
Cell Significance Index: 51.8900 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.3835
Cell Significance Index: 2604.9100 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.3497
Cell Significance Index: 857.2100 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.2979
Cell Significance Index: 45.1000 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.2933
Cell Significance Index: 99.2500 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 1.1114
Cell Significance Index: 7.5300 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.9305
Cell Significance Index: 69.3500 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.9165
Cell Significance Index: 19.5900 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.8323
Cell Significance Index: 165.1700 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.8014
Cell Significance Index: 136.8500 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.7968
Cell Significance Index: 40.2700 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.6362
Cell Significance Index: 281.2700 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.5417
Cell Significance Index: 30.4000 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.5399
Cell Significance Index: 7.7700 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.5187
Cell Significance Index: 71.2300 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.4264
Cell Significance Index: 294.9400 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.3971
Cell Significance Index: 142.4400 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.3940
Cell Significance Index: 215.1500 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.3575
Cell Significance Index: 16.8000 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.3029
Cell Significance Index: 4.3500 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.2993
Cell Significance Index: 38.6700 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.2143
Cell Significance Index: 2.7500 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.1922
Cell Significance Index: 173.5500 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1503
Cell Significance Index: 14.8700 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1155
Cell Significance Index: 21.9800 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.1024
Cell Significance Index: 46.4600 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.0812
Cell Significance Index: 9.2700 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0659
Cell Significance Index: 101.4800 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0567
Cell Significance Index: 11.3800 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.0381
Cell Significance Index: 0.2300 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0284
Cell Significance Index: 0.4800 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.0280
Cell Significance Index: 3.2600 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0238
Cell Significance Index: 43.8300 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.0145
Cell Significance Index: 2.3700 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.0110
Cell Significance Index: 0.2900 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0166
Cell Significance Index: -12.2800 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0177
Cell Significance Index: -1.8400 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0253
Cell Significance Index: -34.4200 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0411
Cell Significance Index: -25.6900 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0482
Cell Significance Index: -35.3300 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0485
Cell Significance Index: -36.7100 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0512
Cell Significance Index: -1.8000 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0646
Cell Significance Index: -36.4100 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1007
Cell Significance Index: -21.2000 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.1103
Cell Significance Index: -1.8900 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1192
Cell Significance Index: -17.3200 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.1304
Cell Significance Index: -14.1900 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.1319
Cell Significance Index: -3.8000 - Cell Name: subcutaneous adipocyte (CL0002521)
Fold Change: -0.1378
Cell Significance Index: -0.6000 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1391
Cell Significance Index: -14.2100 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1454
Cell Significance Index: -41.8300 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.1540
Cell Significance Index: -27.7600 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.1585
Cell Significance Index: -2.3400 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1676
Cell Significance Index: -19.7600 - Cell Name: keratocyte (CL0002363)
Fold Change: -0.1992
Cell Significance Index: -3.1600 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.2079
Cell Significance Index: -2.2600 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.2583
Cell Significance Index: -11.7100 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.2596
Cell Significance Index: -31.9200 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.2698
Cell Significance Index: -2.2000 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2751
Cell Significance Index: -31.5200 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.2972
Cell Significance Index: -15.4800 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.3322
Cell Significance Index: -5.1400 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.4134
Cell Significance Index: -29.2400 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.4183
Cell Significance Index: -25.1100 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.4285
Cell Significance Index: -26.3400 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.4302
Cell Significance Index: -29.7500 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.4314
Cell Significance Index: -29.0100 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.4388
Cell Significance Index: -10.9700 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.4766
Cell Significance Index: -13.6000 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.5084
Cell Significance Index: -31.1700 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5741
Cell Significance Index: -45.4700 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.6778
Cell Significance Index: -43.7300 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.6809
Cell Significance Index: -18.1800 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.7017
Cell Significance Index: -19.1000 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.7093
Cell Significance Index: -19.0100 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.7266
Cell Significance Index: -38.1500 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.7418
Cell Significance Index: -20.7300 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.7543
Cell Significance Index: -13.3300 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.7584
Cell Significance Index: -16.4300 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: -0.8512
Cell Significance Index: -12.9500 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.8874
Cell Significance Index: -55.9300 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.8920
Cell Significance Index: -12.1700 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: -0.8994
Cell Significance Index: -9.3900 - Cell Name: perivascular cell (CL4033054)
Fold Change: -0.9183
Cell Significance Index: -4.2400 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.9810
Cell Significance Index: -50.9600 - Cell Name: peg cell (CL4033014)
Fold Change: -1.0613
Cell Significance Index: -24.5200 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -1.0702
Cell Significance Index: -27.5100
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3053337526
Symbol: FGFR1_HUMAN
Name: Fibroblast growth factor receptor 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2162671
Title: The complete amino acid sequence of the shorter form of human basic fibroblast growth factor receptor deduced from its cDNA.
PubMed ID: 2162671
PubMed ID: 1697263
Title: Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors.
PubMed ID: 1697263
PubMed ID: 2167437
Title: Diverse forms of a receptor for acidic and basic fibroblast growth factors.
PubMed ID: 2167437
PubMed ID: 2159626
Title: Complete sequence of a human receptor for acidic and basic fibroblast growth factors.
PubMed ID: 2159626
PubMed ID: 1722683
Title: cDNA cloning and expression of a human FGF receptor which binds acidic and basic FGF.
PubMed ID: 1722683
PubMed ID: 1662973
Title: Molecular cloning of a human basic fibroblast growth factor receptor cDNA and expression of a biologically active extracellular domain in a baculovirus system.
PubMed ID: 1662973
PubMed ID: 1650441
Title: Alternative splicing generates at least five different isoforms of the human basic-FGF receptor.
PubMed ID: 1650441
PubMed ID: 1846977
Title: Fibroblast growth factor receptors from liver vary in three structural domains.
PubMed ID: 1846977
PubMed ID: 1317750
Title: K-sam-related gene, N-sam, encodes fibroblast growth factor receptor and is expressed in T-lymphocytic tumors.
PubMed ID: 1317750
PubMed ID: 20139426
Title: A case of Kallmann syndrome carrying a missense mutation in alternatively spliced exon 8A encoding the immunoglobulin-like domain IIIb of fibroblast growth factor receptor 1.
PubMed ID: 20139426
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16421571
Title: DNA sequence and analysis of human chromosome 8.
PubMed ID: 16421571
DOI: 10.1038/nature04406
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7520751
Title: Multivalent ligand-receptor binding interactions in the fibroblast growth factor system produce a cooperative growth factor and heparin mechanism for receptor dimerization.
PubMed ID: 7520751
DOI: 10.1021/bi00200a003
PubMed ID: 8074689
Title: Distinct role of 2-O-, N-, and 6-O-sulfate groups of heparin in the formation of the ternary complex with basic fibroblast growth factor and soluble FGF receptor-1.
PubMed ID: 8074689
PubMed ID: 1652059
Title: The human fibroblast growth factor receptor genes: a common structural arrangement underlies the mechanisms for generating receptor forms that differ in their third immunoglobulin domain.
PubMed ID: 1652059
PubMed ID: 1847500
Title: A novel c-fgr exon utilized in Epstein-Barr virus-infected B lymphocytes but not in normal monocytes.
PubMed ID: 1847500
PubMed ID: 1656221
Title: A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1.
PubMed ID: 1656221
PubMed ID: 1379697
Title: Point mutation of an FGF receptor abolishes phosphatidylinositol turnover and Ca2+ flux but not mitogenesis.
PubMed ID: 1379697
DOI: 10.1038/358678a0
PubMed ID: 1379698
Title: Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis.
PubMed ID: 1379698
DOI: 10.1038/358681a0
PubMed ID: 7516330
Title: Internalization of fibroblast growth factor receptor is inhibited by a point mutation at tyrosine 766.
PubMed ID: 7516330
PubMed ID: 8622701
Title: Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction.
PubMed ID: 8622701
DOI: 10.1128/mcb.16.3.977
PubMed ID: 8663044
Title: Receptor specificity of the fibroblast growth factor family.
PubMed ID: 8663044
PubMed ID: 9716603
Title: Consistent fusion of ZNF198 to the fibroblast growth factor receptor-1 in the t(8;13)(p11;q12) myeloproliferative syndrome.
PubMed ID: 9716603
PubMed ID: 9655399
Title: Structure of a heparin-linked biologically active dimer of fibroblast growth factor.
PubMed ID: 9655399
DOI: 10.1038/31741
PubMed ID: 9949182
Title: The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1.
PubMed ID: 9949182
PubMed ID: 10454568
Title: Grb10, a positive, stimulatory signaling adapter in platelet-derived growth factor BB-, insulin-like growth factor I-, and insulin-mediated mitogenesis.
PubMed ID: 10454568
PubMed ID: 10861678
Title: Clinical findings in a patient with FGFR1 P252R mutation and comparison with the literature.
PubMed ID: 10861678
DOI: 10.1002/1096-8628(20000703)93:1<22::aid-ajmg5>3.0.co;2-u
PubMed ID: 10688839
Title: FGFR1 is fused to the centrosome-associated protein CEP110 in the 8p12 stem cell myeloproliferative disorder with t(8;9)(p12;q33).
PubMed ID: 10688839
PubMed ID: 11353842
Title: Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins.
PubMed ID: 11353842
PubMed ID: 12181353
Title: The Shb adaptor protein binds to tyrosine 766 in the FGFR-1 and regulates the Ras/MEK/MAPK pathway via FRS2 phosphorylation in endothelial cells.
PubMed ID: 12181353
PubMed ID: 15034873
Title: Identification of a novel gene, FGFR1OP2, fused to FGFR1 in 8p11 myeloproliferative syndrome.
PubMed ID: 15034873
DOI: 10.1002/gcc.20023
PubMed ID: 15117958
Title: 90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in FGFR1 signaling.
PubMed ID: 15117958
PubMed ID: 16335952
Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
PubMed ID: 16335952
DOI: 10.1021/pr0502065
PubMed ID: 16946300
Title: Phosphotyrosine profiling identifies the KG-1 cell line as a model for the study of FGFR1 fusions in acute myeloid leukemia.
PubMed ID: 16946300
PubMed ID: 16597617
Title: Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.
PubMed ID: 16597617
PubMed ID: 16481405
Title: Factors controlling fibroblast growth factor receptor-1's cytoplasmic trafficking and its regulation as revealed by FRAP analysis.
PubMed ID: 16481405
PubMed ID: 16507368
Title: Autophosphorylation of FGFR1 kinase is mediated by a sequential and precisely ordered reaction.
PubMed ID: 16507368
PubMed ID: 17389761
Title: 14-3-3 integrates pro-survival signals mediated by the AKT and MAPK pathways in ZNF198-FGFR1 transformed hematopoietic cells.
PubMed ID: 17389761
PubMed ID: 17623664
Title: Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21.
PubMed ID: 17623664
PubMed ID: 17311277
Title: Fibroblast growth factor receptor-induced phosphorylation of STAT1 at the Golgi apparatus without translocation to the nucleus.
PubMed ID: 17311277
DOI: 10.1002/jcp.21014
PubMed ID: 18441324
Title: Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling.
PubMed ID: 18441324
PubMed ID: 18480409
Title: Ubiquitination of fibroblast growth factor receptor 1 is required for its intracellular sorting but not for its endocytosis.
PubMed ID: 18480409
PubMed ID: 19696444
Title: Novel mechanisms of fibroblast growth factor receptor 1 regulation by extracellular matrix protein anosmin-1.
PubMed ID: 19696444
PubMed ID: 19261810
Title: Fibroblast growth factor receptor-1 (FGFR1) nuclear dynamics reveal a novel mechanism in transcription control.
PubMed ID: 19261810
PubMed ID: 19224897
Title: The precise sequence of FGF receptor autophosphorylation is kinetically driven and is disrupted by oncogenic mutations.
PubMed ID: 19224897
PubMed ID: 20422052
Title: A novel fibroblast growth factor-1 (FGF1) mutant that acts as an FGF antagonist.
PubMed ID: 20422052
PubMed ID: 19966287
Title: Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation.
PubMed ID: 19966287
PubMed ID: 21765395
Title: Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function.
PubMed ID: 21765395
PubMed ID: 12141425
Title: The structure and function of vertebrate fibroblast growth factor receptor 1.
PubMed ID: 12141425
PubMed ID: 15863030
Title: Cellular signaling by fibroblast growth factor receptors.
PubMed ID: 15863030
PubMed ID: 20094046
Title: Fibroblast growth factor signalling: from development to cancer.
PubMed ID: 20094046
DOI: 10.1038/nrc2780
PubMed ID: 20117945
Title: Novel insights in FGFR1 regulation: lessons from Kallmann syndrome.
PubMed ID: 20117945
PubMed ID: 26942290
Title: Mosaic activating mutations in FGFR1 cause encephalocraniocutaneous lipomatosis.
PubMed ID: 26942290
PubMed ID: 8752212
Title: Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism.
PubMed ID: 8752212
PubMed ID: 9139660
Title: Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors.
PubMed ID: 9139660
PubMed ID: 10830168
Title: Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity.
PubMed ID: 10830168
PubMed ID: 11030354
Title: Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization.
PubMed ID: 11030354
PubMed ID: 19665973
Title: The selectivity of receptor tyrosine kinase signaling is controlled by a secondary SH2 domain binding site.
PubMed ID: 19665973
PubMed ID: 20133753
Title: Asymmetric receptor contact is required for tyrosine autophosphorylation of fibroblast growth factor receptor in living cells.
PubMed ID: 20133753
PubMed ID: 21454610
Title: A novel mode of protein kinase inhibition exploiting hydrophobic motifs of autoinhibited kinases: discovery of ATP-independent inhibitors of fibroblast growth factor receptor.
PubMed ID: 21454610
PubMed ID: 7874169
Title: A common mutation in the fibroblast growth factor receptor 1 gene in Pfeiffer syndrome.
PubMed ID: 7874169
DOI: 10.1038/ng1194-269
PubMed ID: 11173846
Title: An unusual FGFR1 mutation (fibroblast growth factor receptor 1 mutation) in a girl with non-syndromic trigonocephaly.
PubMed ID: 11173846
DOI: 10.1159/000056834
PubMed ID: 12627230
Title: Loss-of-function mutations in FGFR1 cause autosomal dominant Kallmann syndrome.
PubMed ID: 12627230
DOI: 10.1038/ng1122
PubMed ID: 15001591
Title: Clinical assessment and mutation analysis of Kallmann syndrome 1 (KAL1) and fibroblast growth factor receptor 1 (FGFR1, or KAL2) in five families and 18 sporadic patients.
PubMed ID: 15001591
PubMed ID: 15625620
Title: Mutations that cause osteoglophonic dysplasia define novel roles for FGFR1 in bone elongation.
PubMed ID: 15625620
DOI: 10.1086/427956
PubMed ID: 15605412
Title: Kallmann syndrome: 14 novel mutations in KAL1 and FGFR1 (KAL2).
PubMed ID: 15605412
DOI: 10.1002/humu.9298
PubMed ID: 15845591
Title: Gonadotrophin therapy in Kallmann syndrome caused by heterozygous mutations of the gene for fibroblast growth factor receptor 1: report of three families: case report.
PubMed ID: 15845591
PubMed ID: 16470795
Title: Extended mutational analyses of FGFR1 in osteoglophonic dysplasia.
PubMed ID: 16470795
DOI: 10.1002/ajmg.a.31106
PubMed ID: 16882753
Title: Novel fibroblast growth factor receptor 1 mutations in patients with congenital hypogonadotropic hypogonadism with and without anosmia.
PubMed ID: 16882753
DOI: 10.1210/jc.2005-2793
PubMed ID: 16764984
Title: Mutations in fibroblast growth factor receptor 1 cause Kallmann syndrome with a wide spectrum of reproductive phenotypes.
PubMed ID: 16764984
PubMed ID: 16757108
Title: Paediatric phenotype of Kallmann syndrome due to mutations of fibroblast growth factor receptor 1 (FGFR1).
PubMed ID: 16757108
PubMed ID: 16606836
Title: Mutations in fibroblast growth factor receptor 1 cause both Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism.
PubMed ID: 16606836
PubMed ID: 17154279
Title: Novel FGFR1 sequence variants in Kallmann syndrome, and genetic evidence that the FGFR1c isoform is required in olfactory bulb and palate morphogenesis.
PubMed ID: 17154279
DOI: 10.1002/humu.9470
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
PubMed ID: 19820032
Title: Impaired fibroblast growth factor receptor 1 signaling as a cause of normosmic idiopathic hypogonadotropic hypogonadism.
PubMed ID: 19820032
DOI: 10.1210/jc.2009-0179
PubMed ID: 21700882
Title: Heparan sulfate 6-O-sulfotransferase 1, a gene involved in extracellular sugar modifications, is mutated in patients with idiopathic hypogonadotrophic hypogonadism.
PubMed ID: 21700882
PubMed ID: 22927827
Title: SEMA3A, a gene involved in axonal pathfinding, is mutated in patients with Kallmann syndrome.
PubMed ID: 22927827
PubMed ID: 23643382
Title: Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism.
PubMed ID: 23643382
PubMed ID: 23812909
Title: FGFR1 mutations cause Hartsfield syndrome, the unique association of holoprosencephaly and ectrodactyly.
PubMed ID: 23812909
PubMed ID: 23041776
Title: A translocation t(2;8)(q12;p11) fuses FGFR1 to a novel partner gene, RANBP2/NUP358, in a myeloproliferative/myelodysplastic neoplasm.
PubMed ID: 23041776
DOI: 10.1038/leu.2012.286
PubMed ID: 24888332
Title: Novel de novo heterozygous FGFR1 mutation in two siblings with Hartsfield syndrome: A case of gonadal mosaicism.
PubMed ID: 24888332
DOI: 10.1002/ajmg.a.36621
PubMed ID: 25077900
Title: The prevalence of CHD7 missense versus truncating mutations is higher in patients with Kallmann syndrome than in typical CHARGE patients.
PubMed ID: 25077900
DOI: 10.1210/jc.2014-2110
PubMed ID: 26277103
Title: Novel FGFR1 mutations in Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism: evidence for the involvement of an alternatively spliced isoform.
PubMed ID: 26277103
Sequence Information:
- Length: 822
- Mass: 91868
- Checksum: 93A01B5D78C3E72C
- Sequence:
MWSWKCLLFW AVLVTATLCT ARPSPTLPEQ AQPWGAPVEV ESFLVHPGDL LQLRCRLRDD VQSINWLRDG VQLAESNRTR ITGEEVEVQD SVPADSGLYA CVTSSPSGSD TTYFSVNVSD ALPSSEDDDD DDDSSSEEKE TDNTKPNRMP VAPYWTSPEK MEKKLHAVPA AKTVKFKCPS SGTPNPTLRW LKNGKEFKPD HRIGGYKVRY ATWSIIMDSV VPSDKGNYTC IVENEYGSIN HTYQLDVVER SPHRPILQAG LPANKTVALG SNVEFMCKVY SDPQPHIQWL KHIEVNGSKI GPDNLPYVQI LKTAGVNTTD KEMEVLHLRN VSFEDAGEYT CLAGNSIGLS HHSAWLTVLE ALEERPAVMT SPLYLEIIIY CTGAFLISCM VGSVIVYKMK SGTKKSDFHS QMAVHKLAKS IPLRRQVTVS ADSSASMNSG VLLVRPSRLS SSGTPMLAGV SEYELPEDPR WELPRDRLVL GKPLGEGCFG QVVLAEAIGL DKDKPNRVTK VAVKMLKSDA TEKDLSDLIS EMEMMKMIGK HKNIINLLGA CTQDGPLYVI VEYASKGNLR EYLQARRPPG LEYCYNPSHN PEEQLSSKDL VSCAYQVARG MEYLASKKCI HRDLAARNVL VTEDNVMKIA DFGLARDIHH IDYYKKTTNG RLPVKWMAPE ALFDRIYTHQ SDVWSFGVLL WEIFTLGGSP YPGVPVEELF KLLKEGHRMD KPSNCTNELY MMMRDCWHAV PSQRPTFKQL VEDLDRIVAL TSNQEYLDLS MPLDQYSPSF PDTRSSTCSS GEDSVFSHEP LPEEPCLPRH PAQLANGGLK RR
Genular Protein ID: 3105612417
Symbol: A0A0S2Z3Q6_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11181995
PubMed ID: 26871637
Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
PubMed ID: 26871637
Sequence Information:
- Length: 820
- Mass: 91668
- Checksum: 16B07518ECFC98F5
- Sequence:
MWSWKCLLFW AVLVTATLCT ARPSPTLPEQ AQPWGAPVEV ESFLVHPGDL LQLRCRLRDD VQSINWLRDG VQLAESNRTR ITGEEVEVQD SVPADSGLYA CVTSSPSGSD TTYFSVNVSD ALPSSEDDDD DDDSSSEEKE TDNTKPNRMP VAPYWTSPEK MEKKLHAVPA AKTVKFKCPS SGTPNPTLRW LKNGKEFKPD HRIGGYKVRY ATWSIIMDSV VPSDKGNYTC IVENEYGSIN HTYQLDVVER SPHRPILQAG LPANKTVALG SNVEFMCKVY SDPQPHIQWL KHIEVNGSKI GPDNLPYVQI LKTAGVNTTD KEMEVLHLRN VSFEDAGEYT CLAGNSIGLS HHSAWLTVLE ALEERPAVMT SPLYLEIIIY CTGAFLISCM VGSVIVYKMK SGTKKSDFHS QMAVHKLAKS IPLRRQVSAD SSASMNSGVL LVRPSRLSSS GTPMLAGVSE YELPEDPRWE LPRDRLVLGK PLGEGCFGQV VLAEAIGLDK DKPNRVTKVA VKMLKSDATE KDLSDLISEM EMMKMIGKHK NIINLLGACT QDGPLYVIVE YASKGNLREY LQARRPPGLE YCYNPSHNPE EQLSSKDLVS CAYQVARGME YLASKKCIHR DLAARNVLVT EDNVMKIADF GLARDIHHID YYKKTTNGRL PVKWMAPEAL FDRIYTHQSD VWSFGVLLWE IFTLGGSPYP GVPVEELFKL LKEGHRMDKP SNCTNELYMM MRDCWHAVPS QRPTFKQLVE DLDRIVALTS NQEYLDLSMP LDQYSPSFPD TRSSTCSSGE DSVFSHEPLP EEPCLPRHPA QLANGGLKRR
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.