Details for: FOXG1

Gene ID: 2290

Symbol: FOXG1

Ensembl ID: ENSG00000176165

Description: forkhead box G1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 7.12
    Marker Score: 3947
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.85
    Marker Score: 38333
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.47
    Marker Score: 2482
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 2.27
    Marker Score: 6418
  • Cell Name: interneuron (CL0000099)
    Fold Change: 2.17
    Marker Score: 992
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.95
    Marker Score: 1029
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.93
    Marker Score: 2151
  • Cell Name: T cell (CL0000084)
    Fold Change: 1.85
    Marker Score: 3182
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.8
    Marker Score: 38377
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.79
    Marker Score: 7469
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.72
    Marker Score: 6655
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.5
    Marker Score: 56861
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.48
    Marker Score: 5497
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.48
    Marker Score: 5735
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.42
    Marker Score: 594
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.42
    Marker Score: 2190
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.4
    Marker Score: 20970
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.37
    Marker Score: 10467
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.27
    Marker Score: 10947
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.15
    Marker Score: 10966
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.11
    Marker Score: 68221
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.08
    Marker Score: 7191
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.05
    Marker Score: 9846
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71815
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48038
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.99
    Marker Score: 346.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.98
    Marker Score: 2478
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.96
    Marker Score: 836
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5355
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.94
    Marker Score: 34527
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.87
    Marker Score: 575
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.86
    Marker Score: 17069
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.86
    Marker Score: 3551
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.83
    Marker Score: 483
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.82
    Marker Score: 1338
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.77
    Marker Score: 437
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.71
    Marker Score: 1196
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.69
    Marker Score: 1137
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.66
    Marker Score: 3034.5
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.65
    Marker Score: 685.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.62
    Marker Score: 498
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.53
    Marker Score: 850
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.51
    Marker Score: 338
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.48
    Marker Score: 319
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.47
    Marker Score: 967
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.42
    Marker Score: 398
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.39
    Marker Score: 205
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.38
    Marker Score: 189
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.37
    Marker Score: 463
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.37
    Marker Score: 253
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.36
    Marker Score: 166
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.36
    Marker Score: 131
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.35
    Marker Score: 2622
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.35
    Marker Score: 1004
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.34
    Marker Score: 109
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.34
    Marker Score: 201
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.3
    Marker Score: 3047
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.3
    Marker Score: 800.5
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.28
    Marker Score: 968
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.27
    Marker Score: 156
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.25
    Marker Score: 368
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.25
    Marker Score: 448
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.2
    Marker Score: 370
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.19
    Marker Score: 174
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.19
    Marker Score: 205
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.19
    Marker Score: 129
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.18
    Marker Score: 729
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.18
    Marker Score: 109
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.18
    Marker Score: 310
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.16
    Marker Score: 125
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.16
    Marker Score: 46
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.16
    Marker Score: 195
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.15
    Marker Score: 357
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.15
    Marker Score: 48
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.15
    Marker Score: 37
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.15
    Marker Score: 295
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.14
    Marker Score: 38
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.14
    Marker Score: 165
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.14
    Marker Score: 227
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.14
    Marker Score: 200
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.13
    Marker Score: 35
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.13
    Marker Score: 136
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.13
    Marker Score: 36
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.13
    Marker Score: 38.5
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.13
    Marker Score: 31
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.12
    Marker Score: 228
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.12
    Marker Score: 143
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.12
    Marker Score: 34
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.12
    Marker Score: 38
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.12
    Marker Score: 71
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 0.12
    Marker Score: 38
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.12
    Marker Score: 222
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.12
    Marker Score: 28.5
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.11
    Marker Score: 132
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.11
    Marker Score: 108

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Other Information

**Key characteristics:** - FOXG1 is a transcription factor that belongs to the forkhead box (FOX) family of transcription factors. - It is a key regulator of the cell cycle, particularly in neural and hematopoietic cells. - FOXG1 is a key regulator of neuroblast proliferation and survival. - It is also involved in the regulation of cell cycle progression, differentiation, and apoptosis. **Pathways and functions:** - FOXG1 is involved in the regulation of the cell cycle through its interaction with the rna polymerase ii transcription factor. - It is a key regulator of neuroblast proliferation, survival, and differentiation. - It is also involved in the regulation of hematopoietic cell differentiation and function. - FOXG1 is a key regulator of the expression of cell cycle genes and the regulation of cell growth and differentiation. **Clinical significance:** - FOXG1 mutations have been linked to several human cancers, including neuroblastoma, leukemia, and breast cancer. - Targeting FOXG1 has emerged as a promising therapeutic strategy for these cancers. - Several drugs, such as GSK3β inhibitors and PD-1 antibodies, are currently being investigated in clinical trials for the treatment of cancer. **Additional information:** - FOXG1 is a conserved transcription factor that is found in all vertebrates. - It is a key regulator of the development of the central nervous system. - FOXG1 is a target for cancer therapy due to its role in the proliferation and survival of cancer cells.

Genular Protein ID: 1892437179

Symbol: FOXG1_HUMAN

Name: Forkhead box protein G1

UniProtKB Accession Codes:

P55316 A6NFY2 P55315 Q14488 Q86XT7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 2 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7959731

Title: Human brain factor 1, a new member of the fork head gene family.

PubMed ID: 7959731

DOI: 10.1006/geno.1994.1313

PubMed ID: 7599184

Title: The genes for human brain factor 1 and 2, members of the fork head gene family, are clustered on chromosome 14q.

PubMed ID: 7599184

DOI: 10.1016/0167-4781(95)00059-p

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12657635

Title: Human PLU-1 has transcriptional repression properties and interacts with the developmental transcription factors BF-1 and PAX9.

PubMed ID: 12657635

DOI: 10.1074/jbc.m301994200

PubMed ID: 17260156

Title: Comparative evolutionary analysis of the FoxG1 transcription factor from diverse vertebrates identifies conserved recognition sites for microRNA regulation.

PubMed ID: 17260156

DOI: 10.1007/s00427-006-0128-x

PubMed ID: 21280142

Title: A missense mutation within the fork-head domain of the forkhead box G1 Gene (FOXG1) affects its nuclear localization.

PubMed ID: 21280142

DOI: 10.1002/humu.21422

PubMed ID: 19578037

Title: Novel FOXG1 mutations associated with the congenital variant of Rett syndrome.

PubMed ID: 19578037

DOI: 10.1136/jmg.2009.067884

PubMed ID: 26993267

Title: Improving diagnosis and broadening the phenotypes in early-onset seizure and severe developmental delay disorders through gene panel analysis.

PubMed ID: 26993267

DOI: 10.1136/jmedgenet-2015-103263

Sequence Information:

  • Length: 489
  • Mass: 52352
  • Checksum: 897945F9CE4F2A71
  • Sequence:
    • MLDMGDRKEV KMIPKSSFSI NSLVPEAVQN DNHHASHGHH NSHHPQHHHH HHHHHHHPPP 
PAPQPPPPPQ QQQPPPPPPP APQPPQTRGA PAADDDKGPQ QLLLPPPPPP PPAAALDGAK 
ADGLGGKGEP GGGPGELAPV GPDEKEKGAG AGGEEKKGAG EGGKDGEGGK EGEKKNGKYE 
KPPFSYNALI MMAIRQSPEK RLTLNGIYEF IMKNFPYYRE NKQGWQNSIR HNLSLNKCFV 
KVPRHYDDPG KGNYWMLDPS SDDVFIGGTT GKLRRRSTTS RAKLAFKRGA RLTSTGLTFM 
DRAGSLYWPM SPFLSLHHPR ASSTLSYNGT TSAYPSHPMP YSSVLTQNSL GNNHSFSTAN 
GLSVDRLVNG EIPYATHHLT AAALAASVPC GLSVPCSGTY SLNPCSVNLL AGQTSYFFPH 
VPHPSMTSQS STSMSARAAS SSTSPQAPST LPCESLRPSL PSFTTGLSGG LSDYFTHQNQ 
GSSSNPLIH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.