Details for: FOXG1

Gene ID: 2290

Symbol: FOXG1

Ensembl ID: ENSG00000176165

Description: forkhead box G1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 6.1400
    Cell Significance Index: 64.1000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.8946
    Cell Significance Index: 116.4500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.4107
    Cell Significance Index: 62.4000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.3102
    Cell Significance Index: 49.6200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.2472
    Cell Significance Index: 29.9100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0588
    Cell Significance Index: 212.4000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0016
    Cell Significance Index: 359.2700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6046
    Cell Significance Index: 418.1400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.5522
    Cell Significance Index: 9.4400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.3031
    Cell Significance Index: 8.6500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1185
    Cell Significance Index: 7.9700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0295
    Cell Significance Index: -13.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0467
    Cell Significance Index: -26.3200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1221
    Cell Significance Index: -1.4300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1264
    Cell Significance Index: -8.9400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1280
    Cell Significance Index: -21.8600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1492
    Cell Significance Index: -42.9200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2295
    Cell Significance Index: -26.2900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.3173
    Cell Significance Index: -43.5700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6777
    Cell Significance Index: -38.0300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6872
    Cell Significance Index: -43.3100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7306
    Cell Significance Index: -23.9200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7721
    Cell Significance Index: -24.5900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.8133
    Cell Significance Index: -42.7000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.8247
    Cell Significance Index: -16.5600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8442
    Cell Significance Index: -29.5800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.9168
    Cell Significance Index: -43.0900
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.9463
    Cell Significance Index: -6.8800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.0043
    Cell Significance Index: -17.3700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.0195
    Cell Significance Index: -21.3400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.0841
    Cell Significance Index: -23.0100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -1.1011
    Cell Significance Index: -23.7900
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -1.1017
    Cell Significance Index: -10.9000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.1436
    Cell Significance Index: -41.9800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.2476
    Cell Significance Index: -31.1200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.2583
    Cell Significance Index: -40.3000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.2815
    Cell Significance Index: -25.3400
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -1.3244
    Cell Significance Index: -18.5200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -1.3496
    Cell Significance Index: -32.6900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -1.4522
    Cell Significance Index: -37.0000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.4604
    Cell Significance Index: -68.0900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -1.4633
    Cell Significance Index: -30.5400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -1.4658
    Cell Significance Index: -15.9700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.4955
    Cell Significance Index: -42.8700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -1.5293
    Cell Significance Index: -48.3700
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: -1.5545
    Cell Significance Index: -11.5100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -1.5972
    Cell Significance Index: -26.3200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -1.6010
    Cell Significance Index: -31.5100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -1.6378
    Cell Significance Index: -23.4600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.6507
    Cell Significance Index: -48.6200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -1.7261
    Cell Significance Index: -34.4200
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -1.7287
    Cell Significance Index: -23.0600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -1.7472
    Cell Significance Index: -26.3300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.7527
    Cell Significance Index: -46.8000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.7593
    Cell Significance Index: -46.2600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.7966
    Cell Significance Index: -48.1400
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -1.8125
    Cell Significance Index: -20.0200
  • Cell Name: neuron (CL0000540)
    Fold Change: -1.8398
    Cell Significance Index: -17.4400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -1.8425
    Cell Significance Index: -46.0200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -1.8803
    Cell Significance Index: -21.5200
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -1.8818
    Cell Significance Index: -38.2900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.9174
    Cell Significance Index: -40.9900
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -1.9404
    Cell Significance Index: -20.0800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -1.9563
    Cell Significance Index: -38.2500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -2.0154
    Cell Significance Index: -21.9100
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -2.0249
    Cell Significance Index: -26.2600
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -2.0497
    Cell Significance Index: -27.6600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -2.0515
    Cell Significance Index: -29.1500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -2.0671
    Cell Significance Index: -26.0900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -2.0677
    Cell Significance Index: -45.2800
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -2.1378
    Cell Significance Index: -21.1700
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -2.1789
    Cell Significance Index: -29.0500
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: -2.2313
    Cell Significance Index: -21.0000
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -2.2945
    Cell Significance Index: -21.9500
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -2.3475
    Cell Significance Index: -21.3400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -2.3627
    Cell Significance Index: -32.4000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -2.3650
    Cell Significance Index: -39.5800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -2.4143
    Cell Significance Index: -20.2800
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -2.4394
    Cell Significance Index: -28.7500
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -2.4810
    Cell Significance Index: -20.0900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -2.4928
    Cell Significance Index: -42.7200
  • Cell Name: glioblast (CL0000030)
    Fold Change: -2.4986
    Cell Significance Index: -15.6900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -2.5570
    Cell Significance Index: -47.2600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -2.5662
    Cell Significance Index: -41.1700
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -2.6055
    Cell Significance Index: -38.9800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -2.6121
    Cell Significance Index: -37.5100
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -2.6441
    Cell Significance Index: -31.6200
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -2.6593
    Cell Significance Index: -27.3400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -2.6682
    Cell Significance Index: -39.9800
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -2.6878
    Cell Significance Index: -29.4600
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: -2.7040
    Cell Significance Index: -25.5300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -2.7513
    Cell Significance Index: -44.5600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -2.7673
    Cell Significance Index: -33.6600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -2.8170
    Cell Significance Index: -47.3800
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -2.8557
    Cell Significance Index: -37.2700
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -2.9124
    Cell Significance Index: -40.2700
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -2.9157
    Cell Significance Index: -29.3700
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -2.9418
    Cell Significance Index: -24.3300
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -2.9746
    Cell Significance Index: -47.8300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -2.9763
    Cell Significance Index: -43.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** FOXG1 is a member of the forkhead box (FOX) family of transcription factors, characterized by the presence of a conserved forkhead domain. This domain is crucial for the recognition and binding to specific DNA sequences, allowing FOXG1 to regulate gene expression. FOXG1 is a multifunctional transcription factor, capable of both activating and repressing target gene expression, depending on the context and specific DNA sequences. Its expression is tightly regulated during development and is often restricted to specific cell types and tissues. **Pathways and Functions** FOXG1 is involved in various signaling pathways, including: 1. **Axon midline choice point recognition**: FOXG1 regulates the specification of axons and their guidance during neural development. 2. **Brain development**: FOXG1 is essential for the development of the cerebral cortex, particularly in the specification of pyramidal neurons. 3. **Chromatin remodeling**: FOXG1 interacts with chromatin remodeling complexes to regulate gene expression. 4. **DNA binding and transcriptional regulation**: FOXG1 binds to specific DNA sequences, either activating or repressing transcription of target genes. 5. **Neuroblast proliferation and differentiation**: FOXG1 regulates the proliferation and differentiation of neuroblasts, the precursors of neurons. FOXG1's functions can be broadly categorized into: 1. **Positive regulation**: promoting cell proliferation, differentiation, and survival. 2. **Negative regulation**: inhibiting cell proliferation, differentiation, and survival. **Clinical Significance** Dysregulation of FOXG1 has been implicated in several neurological disorders and cancers, including: 1. **Neurodevelopmental disorders**: FOXG1 mutations have been associated with intellectual disability, autism spectrum disorder, and schizophrenia. 2. **Cancer**: FOXG1 is often overexpressed in various types of cancer, including leukemia, lymphoma, and breast cancer. 3. **Neurodegenerative diseases**: FOXG1's role in regulating neuroinflammation and neuronal survival makes it a potential target for therapies in neurodegenerative diseases such as Alzheimer's and Parkinson's. In summary, FOXG1 is a multifunctional transcription factor that plays a critical role in regulating cell proliferation, differentiation, and survival across different cell types. Its dysregulation has been implicated in various neurological disorders and cancers, highlighting the importance of understanding FOXG1's mechanisms of action and its potential as a therapeutic target.

Genular Protein ID: 1892437179

Symbol: FOXG1_HUMAN

Name: Forkhead box protein G1

UniProtKB Accession Codes:

P55316 A6NFY2 P55315 Q14488 Q86XT7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 2 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7959731

Title: Human brain factor 1, a new member of the fork head gene family.

PubMed ID: 7959731

DOI: 10.1006/geno.1994.1313

PubMed ID: 7599184

Title: The genes for human brain factor 1 and 2, members of the fork head gene family, are clustered on chromosome 14q.

PubMed ID: 7599184

DOI: 10.1016/0167-4781(95)00059-p

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12657635

Title: Human PLU-1 has transcriptional repression properties and interacts with the developmental transcription factors BF-1 and PAX9.

PubMed ID: 12657635

DOI: 10.1074/jbc.m301994200

PubMed ID: 17260156

Title: Comparative evolutionary analysis of the FoxG1 transcription factor from diverse vertebrates identifies conserved recognition sites for microRNA regulation.

PubMed ID: 17260156

DOI: 10.1007/s00427-006-0128-x

PubMed ID: 21280142

Title: A missense mutation within the fork-head domain of the forkhead box G1 Gene (FOXG1) affects its nuclear localization.

PubMed ID: 21280142

DOI: 10.1002/humu.21422

PubMed ID: 19578037

Title: Novel FOXG1 mutations associated with the congenital variant of Rett syndrome.

PubMed ID: 19578037

DOI: 10.1136/jmg.2009.067884

PubMed ID: 26993267

Title: Improving diagnosis and broadening the phenotypes in early-onset seizure and severe developmental delay disorders through gene panel analysis.

PubMed ID: 26993267

DOI: 10.1136/jmedgenet-2015-103263

Sequence Information:

  • Length: 489
  • Mass: 52352
  • Checksum: 897945F9CE4F2A71
  • Sequence:
    • MLDMGDRKEV KMIPKSSFSI NSLVPEAVQN DNHHASHGHH NSHHPQHHHH HHHHHHHPPP 
PAPQPPPPPQ QQQPPPPPPP APQPPQTRGA PAADDDKGPQ QLLLPPPPPP PPAAALDGAK 
ADGLGGKGEP GGGPGELAPV GPDEKEKGAG AGGEEKKGAG EGGKDGEGGK EGEKKNGKYE 
KPPFSYNALI MMAIRQSPEK RLTLNGIYEF IMKNFPYYRE NKQGWQNSIR HNLSLNKCFV 
KVPRHYDDPG KGNYWMLDPS SDDVFIGGTT GKLRRRSTTS RAKLAFKRGA RLTSTGLTFM 
DRAGSLYWPM SPFLSLHHPR ASSTLSYNGT TSAYPSHPMP YSSVLTQNSL GNNHSFSTAN 
GLSVDRLVNG EIPYATHHLT AAALAASVPC GLSVPCSGTY SLNPCSVNLL AGQTSYFFPH 
VPHPSMTSQS STSMSARAAS SSTSPQAPST LPCESLRPSL PSFTTGLSGG LSDYFTHQNQ 
GSSSNPLIH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.