Details for: MLANA

Gene ID: 2315

Symbol: MLANA

Ensembl ID: ENSG00000120215

Description: melan-A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: 3.0988
    Cell Significance Index: 22.3000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.7089
    Cell Significance Index: 248.4100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.0840
    Cell Significance Index: 14.7900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.6287
    Cell Significance Index: 38.5500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.6159
    Cell Significance Index: 19.4800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.5434
    Cell Significance Index: 1023.1900
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.3228
    Cell Significance Index: 0.9600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2553
    Cell Significance Index: 6.8400
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.2221
    Cell Significance Index: 2.8700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1599
    Cell Significance Index: 4.1100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1538
    Cell Significance Index: 4.4300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1242
    Cell Significance Index: 12.2900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1229
    Cell Significance Index: 110.9400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1158
    Cell Significance Index: 22.0500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0967
    Cell Significance Index: 42.7400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0912
    Cell Significance Index: 1.7800
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.0798
    Cell Significance Index: 0.1800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0762
    Cell Significance Index: 1.5800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0665
    Cell Significance Index: 1.1400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.0510
    Cell Significance Index: 5.3100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0504
    Cell Significance Index: 1.7700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0503
    Cell Significance Index: 9.9900
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.0470
    Cell Significance Index: 0.4400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0451
    Cell Significance Index: 2.5300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0434
    Cell Significance Index: 8.7000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0413
    Cell Significance Index: 26.2500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0410
    Cell Significance Index: 3.1500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0352
    Cell Significance Index: 2.1700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0348
    Cell Significance Index: 4.2800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0316
    Cell Significance Index: 0.6900
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.0308
    Cell Significance Index: 0.1900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0301
    Cell Significance Index: 5.4200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0279
    Cell Significance Index: 4.5500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0165
    Cell Significance Index: 0.7500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0154
    Cell Significance Index: 23.7100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.0117
    Cell Significance Index: 0.2900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0108
    Cell Significance Index: 0.2700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0107
    Cell Significance Index: 3.8400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0101
    Cell Significance Index: 18.6000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0078
    Cell Significance Index: 10.5600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0060
    Cell Significance Index: 4.1300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0057
    Cell Significance Index: 0.6200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0052
    Cell Significance Index: 2.3800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0049
    Cell Significance Index: 0.2500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0032
    Cell Significance Index: -0.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0045
    Cell Significance Index: -3.3500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0056
    Cell Significance Index: -4.1000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0062
    Cell Significance Index: -3.5000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0062
    Cell Significance Index: -3.3900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0068
    Cell Significance Index: -1.9500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0099
    Cell Significance Index: -0.4600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0146
    Cell Significance Index: -1.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0195
    Cell Significance Index: -3.3400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0208
    Cell Significance Index: -4.3800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0216
    Cell Significance Index: -1.5000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0217
    Cell Significance Index: -2.2200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0256
    Cell Significance Index: -3.5100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0274
    Cell Significance Index: -0.6000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0276
    Cell Significance Index: -1.2200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0296
    Cell Significance Index: -0.3800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0305
    Cell Significance Index: -3.4900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0319
    Cell Significance Index: -2.1500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0325
    Cell Significance Index: -0.7800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0360
    Cell Significance Index: -0.6100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0457
    Cell Significance Index: -1.7300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0479
    Cell Significance Index: -2.4900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0503
    Cell Significance Index: -0.7200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0506
    Cell Significance Index: -3.1900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0545
    Cell Significance Index: -2.5600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0569
    Cell Significance Index: -0.8400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0569
    Cell Significance Index: -1.5900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0604
    Cell Significance Index: -3.1700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0654
    Cell Significance Index: -0.7800
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0683
    Cell Significance Index: -0.8600
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0688
    Cell Significance Index: -1.1100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0697
    Cell Significance Index: -1.4800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0699
    Cell Significance Index: -2.2900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0736
    Cell Significance Index: -1.5400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0737
    Cell Significance Index: -2.1700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0749
    Cell Significance Index: -1.8700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0751
    Cell Significance Index: -2.6300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0788
    Cell Significance Index: -2.5100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0789
    Cell Significance Index: -3.2300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0801
    Cell Significance Index: -2.1800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0878
    Cell Significance Index: -1.8700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0951
    Cell Significance Index: -2.5400
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0979
    Cell Significance Index: -1.3200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0981
    Cell Significance Index: -2.1200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0986
    Cell Significance Index: -1.2300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1013
    Cell Significance Index: -0.9600
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.1017
    Cell Significance Index: -0.8800
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.1071
    Cell Significance Index: -1.8400
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.1081
    Cell Significance Index: -1.0700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1106
    Cell Significance Index: -2.2200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1147
    Cell Significance Index: -2.8600
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1155
    Cell Significance Index: -2.3500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1188
    Cell Significance Index: -2.3500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1188
    Cell Significance Index: -1.5000
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.1195
    Cell Significance Index: -1.7000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1225
    Cell Significance Index: -3.5000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The melan-A gene is a non-coding gene that encodes for the melan-A protein, also known as MAR1_HUMAN. This protein is a transmembrane glycoprotein with a molecular weight of approximately 43 kDa. The melan-A protein is primarily expressed on the surface of melanocytes, which are responsible for producing melanin, the pigment responsible for skin and hair color. Interestingly, the melan-A protein is also expressed on other cell types, including retinal cells and intestinal epithelial cells, suggesting a broader role in the immune system. **Pathways and Functions:** The melan-A gene is involved in several cellular pathways, including: 1. **Endoplasmic reticulum membrane**: The melan-A protein is synthesized in the endoplasmic reticulum and is transported to the plasma membrane, where it plays a role in cell signaling and interaction with the immune system. 2. **Golgi apparatus**: The melan-A protein is also processed and modified in the Golgi apparatus, which is responsible for glycosylation and protein folding. 3. **Melanosome**: The melan-A protein is localized to melanosomes, which are organelles responsible for storing and transporting melanin. 4. **Plasma membrane**: The melan-A protein interacts with the plasma membrane, where it can bind to other proteins and receptors, modulating immune responses. 5. **Trans-golgi network**: The melan-A protein is also transported to the trans-golgi network, where it can interact with other proteins and influence cellular signaling. The melan-A protein plays a crucial role in the immune system, particularly in the context of cancer. It is recognized by cytotoxic T-cells, which can recognize and kill cancer cells expressing the melan-A protein. This recognition is mediated by the T-cell receptor (TCR) and is essential for the elimination of cancer cells. **Clinical Significance:** The melan-A gene has significant clinical implications, particularly in the context of cancer. The melan-A protein is recognized by cytotoxic T-cells, which can recognize and kill cancer cells expressing the melan-A protein. This recognition is mediated by the T-cell receptor (TCR) and is essential for the elimination of cancer cells. In melanoma, the expression of the melan-A protein is often used as a tumor antigen, which can be targeted by immunotherapy. Immunotherapies, such as checkpoint inhibitors, can enhance the recognition and killing of cancer cells expressing the melan-A protein. In addition to its role in cancer, the melan-A gene has implications in other diseases, including autoimmune disorders and neurodegenerative diseases. The melan-A protein has been implicated in the pathogenesis of autoimmune disorders, such as multiple sclerosis, and neurodegenerative diseases, such as Alzheimer's disease. In conclusion, the melan-A gene is a complex and multifunctional gene that plays a crucial role in the immune system, particularly in the context of cancer. Its clinical significance is significant, with implications in the development of immunotherapies and the understanding of autoimmune disorders and neurodegenerative diseases.

Genular Protein ID: 538799391

Symbol: MAR1_HUMAN

Name: Melanoma antigen recognized by T-cells 1

UniProtKB Accession Codes:

Q16655 Q6ICU4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 6 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 25 PDBsum 25 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8170938

Title: Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor.

PubMed ID: 8170938

DOI: 10.1073/pnas.91.9.3515

PubMed ID: 8006593

Title: A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas.

PubMed ID: 8006593

DOI: 10.1084/jem.180.1.35

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11551907

Title: Subcellular localization of the melanoma-associated protein Melan-AMART-1 influences the processing of its HLA-A2-restricted epitope.

PubMed ID: 11551907

DOI: 10.1074/jbc.m103221200

PubMed ID: 12191019

Title: The melanocytic protein Melan-A/MART-1 has a subcellular localization distinct from typical melanosomal proteins.

PubMed ID: 12191019

DOI: 10.1034/j.1600-0854.2002.30909.x

PubMed ID: 15695812

Title: MART-1 is required for the function of the melanosomal matrix protein PMEL17/GP100 and the maturation of melanosomes.

PubMed ID: 15695812

DOI: 10.1074/jbc.m413692200

PubMed ID: 19717472

Title: The ocular albinism type 1 (OA1) G-protein-coupled receptor functions with MART-1 at early stages of melanogenesis to control melanosome identity and composition.

PubMed ID: 19717472

DOI: 10.1093/hmg/ddp415

PubMed ID: 20417641

Title: Structural basis for the presentation of tumor-associated MHC class II-restricted phosphopeptides to CD4+ T cells.

PubMed ID: 20417641

DOI: 10.1016/j.jmb.2010.04.037

Sequence Information:

  • Length: 118
  • Mass: 13157
  • Checksum: B755BFF39CFCB16E
  • Sequence:
    • MPREDAHFIY GYPKKGHGHS YTTAEEAAGI GILTVILGVL LLIGCWYCRR RNGYRALMDK 
SLHVGTQCAL TRRCPQEGFD HRDSKVSLQE KNCEPVVPNA PPAYEKLSAE QSPPPYSP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.