Details for: FLOT2

Gene ID: 2319

Symbol: FLOT2

Ensembl ID: ENSG00000132589

Description: flotillin 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.63
    Marker Score: 6424.5
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.6
    Marker Score: 2354
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167086
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.45
    Marker Score: 81027
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.45
    Marker Score: 10763.5
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.44
    Marker Score: 1358
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.41
    Marker Score: 16346
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.35
    Marker Score: 1421
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.3
    Marker Score: 13402
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.29
    Marker Score: 3209.5
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.28
    Marker Score: 5489
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.25
    Marker Score: 11845
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.23
    Marker Score: 3869
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.21
    Marker Score: 10361
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.2
    Marker Score: 7670.5
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.2
    Marker Score: 1967
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.19
    Marker Score: 1051
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.18
    Marker Score: 692
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.17
    Marker Score: 269
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.15
    Marker Score: 1007
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.14
    Marker Score: 1986
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.12
    Marker Score: 23885
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.12
    Marker Score: 1645
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.11
    Marker Score: 58474
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.1
    Marker Score: 748
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.1
    Marker Score: 803
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.09
    Marker Score: 10295
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.09
    Marker Score: 351
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.09
    Marker Score: 790.5
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.09
    Marker Score: 1106
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.08
    Marker Score: 4405
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.08
    Marker Score: 66478
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.07
    Marker Score: 802
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.07
    Marker Score: 1865
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.06
    Marker Score: 2058
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.04
    Marker Score: 2548
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.04
    Marker Score: 14011
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.03
    Marker Score: 360
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.02
    Marker Score: 1157
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.01
    Marker Score: 767
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1
    Marker Score: 255
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1
    Marker Score: 964
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71650
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47872
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.99
    Marker Score: 2487
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.98
    Marker Score: 901
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30380
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.97
    Marker Score: 608
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.97
    Marker Score: 866
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.97
    Marker Score: 8506
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.97
    Marker Score: 3745
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.96
    Marker Score: 19187.5
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.96
    Marker Score: 35529
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.96
    Marker Score: 656
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.95
    Marker Score: 1523
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.95
    Marker Score: 2809
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2389
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.93
    Marker Score: 1950
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 479
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.93
    Marker Score: 645
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.92
    Marker Score: 222
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 436
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.92
    Marker Score: 2588
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.92
    Marker Score: 1423
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.92
    Marker Score: 555
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.92
    Marker Score: 1794.5
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.92
    Marker Score: 1105
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.91
    Marker Score: 984
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.91
    Marker Score: 394
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.91
    Marker Score: 945
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.9
    Marker Score: 738
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2688
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.9
    Marker Score: 656
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.9
    Marker Score: 34010.5
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.89
    Marker Score: 5432.5
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.89
    Marker Score: 1150
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.89
    Marker Score: 384
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.89
    Marker Score: 1181
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.89
    Marker Score: 489
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.89
    Marker Score: 607
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.88
    Marker Score: 308
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.87
    Marker Score: 603
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.87
    Marker Score: 2366
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.87
    Marker Score: 22246.5
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 312
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.86
    Marker Score: 3070.5
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.86
    Marker Score: 306
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.86
    Marker Score: 427
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.86
    Marker Score: 174
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.85
    Marker Score: 857
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.85
    Marker Score: 12762
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.85
    Marker Score: 737
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.84
    Marker Score: 1161
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.83
    Marker Score: 745
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.83
    Marker Score: 334
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.83
    Marker Score: 332
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.83
    Marker Score: 503
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.82
    Marker Score: 1337
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.82
    Marker Score: 249

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Other Information

**Key characteristics:** - Gene name: FLOT2 - Ensembl ID: ENSG00000132589 - Protein name: Flotillin-2 - Protein type: transmembrane protein - Expression: Highly expressed in various cell types in the human body - Function: Involved in cell adhesion, epidermal development, negative regulation of gene expression, neuronal system, programmed cell death, protein-protein interactions at synapses, protein binding, and signaling by rho gtpases **Pathways and functions:** - Cell adhesion: Flotillin-2 is expressed on the surface of epithelial cells and immune cells, where it plays a role in cell adhesion. - Epidermis development: Flotillin-2 is expressed in the skin and is involved in the development of the epidermis. - Negative regulation of gene expression: Flotillin-2 is a negative regulator of gene expression, and it has been shown to be involved in the regulation of skin development. - Neuronal system: Flotillin-2 is expressed in neurons and plays a role in neuronal development and function. - Programmed cell death: Flotillin-2 is involved in programmed cell death, a process known as apoptosis. - Protein-protein interactions at synapses: Flotillin-2 is involved in protein-protein interactions at synapses, which are essential for synaptic plasticity and learning and memory. - Protein binding: Flotillin-2 can bind to various proteins, including cadherins, integrins, and tetraspanins. These interactions are involved in cell adhesion, cell signaling, and tissue organization. - Signal transduction: Flotillin-2 is a substrate for several rho GTPases, including Rhoa, Rhob, and Rhoc. These GTPases are involved in various cellular processes, including cell adhesion, migration, and differentiation. **Clinical significance:** - Dysregulation of FLOT2 has been linked to various diseases, including cancer, autoimmune disorders, and neurodegenerative diseases. - In cancer, FLOT2 is overexpressed on tumor cells, where it promotes cell adhesion, migration, and invasion. - In autoimmune disorders, FLOT2 is expressed on immune cells and may contribute to the inflammatory response. - In neurodegenerative diseases, FLOT2 is involved in neuronal survival and differentiation.

Genular Protein ID: 639400985

Symbol: FLOT2_HUMAN

Name: Flotillin-2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 8051082

Title: Cloning and characterization of a novel epidermal cell surface antigen (ESA).

PubMed ID: 8051082

DOI: 10.1016/s0021-9258(17)32117-8

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20682791

Title: A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components.

PubMed ID: 20682791

DOI: 10.1074/jbc.m110.154120

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22081607

Title: DHHC5 protein palmitoylates flotillin-2 and is rapidly degraded on induction of neuronal differentiation in cultured cells.

PubMed ID: 22081607

DOI: 10.1074/jbc.m111.306183

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25255805

Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.

PubMed ID: 25255805

DOI: 10.1038/ncomms5919

Sequence Information:

  • Length: 428
  • Mass: 47064
  • Checksum: F690BFE0151D3BD7
  • Sequence:
  • MGNCHTVGPN EALVVSGGCC GSDYKQYVFG GWAWAWWCIS DTQRISLEIM TLQPRCEDVE 
    TAEGVALTVT GVAQVKIMTE KELLAVACEQ FLGKNVQDIK NVVLQTLEGH LRSILGTLTV 
    EQIYQDRDQF AKLVREVAAP DVGRMGIEIL SFTIKDVYDK VDYLSSLGKT QTAVVQRDAD 
    IGVAEAERDA GIREAECKKE MLDVKFMADT KIADSKRAFE LQKSAFSEEV NIKTAEAQLA 
    YELQGAREQQ KIRQEEIEIE VVQRKKQIAV EAQEILRTDK ELIATVRRPA EAEAHRIQQI 
    AEGEKVKQVL LAQAEAEKIR KIGEAEAAVI EAMGKAEAER MKLKAEAYQK YGDAAKMALV 
    LEALPQIAAK IAAPLTKVDE IVVLSGDNSK VTSEVNRLLA ELPASVHALT GVDLSKIPLI 
    KKATGVQV

Genular Protein ID: 1096289242

Symbol: J3QLD9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 428
  • Mass: 47142
  • Checksum: 45E24ED6EEE67EC8
  • Sequence:
  • MGNCHTVGPN EALVVSGGCC GSDYKQYVFG GWAWAWWCIS DTQRLSLEVM TILCRCENIE 
    TSEGVPLFVT GVAQVKIMTE KELLAVACEQ FLGKNVQDIK NVVLQTLEGH LRSILGTLTV 
    EQIYQDRDQF AKLVREVAAP DVGRMGIEIL SFTIKDVYDK VDYLSSLGKT QTAVVQRDAD 
    IGVAEAERDA GIREAECKKE MLDVKFMADT KIADSKRAFE LQKSAFSEEV NIKTAEAQLA 
    YELQGAREQQ KIRQEEIEIE VVQRKKQIAV EAQEILRTDK ELIATVRRPA EAEAHRIQQI 
    AEGEKVKQVL LAQAEAEKIR KIGEAEAAVI EAMGKAEAER MKLKAEAYQK YGDAAKMALV 
    LEALPQIAAK IAAPLTKVDE IVVLSGDNSK VTSEVNRLLA ELPASVHALT GVDLSKIPLI 
    KKATGVQV

Genular Protein ID: 3104798642

Symbol: Q6FG43_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 379
  • Mass: 41685
  • Checksum: 162A76D67CFEE4AE
  • Sequence:
  • MTLQPRCEDV ETAEGVALTV TGVAQVKIMT EKELLAVACE QFLGKNVQDI KNVVLQTLEG 
    HLRSILGTLT VEQIYQDRDQ FAKLVREVAA PDVGRMGIEI LSFTIKDVYD KVDYLSSLGK 
    TQTAVVQRDA DIGVAEAERD AGIREAECKK EMLDVKFMAD TKIADSKRAF ELQKSAFSEE 
    VNIKTAEAQL AYELQGAREQ QKIRQEEIEI EVVQRKKQIA VEAQEILRTD KELIATVRRP 
    AEAEAHRIQQ IAEGEKVKQV LLAQAEAEKI RKIGEAEAAV IEAMGKAEAE RMKLKAEAYQ 
    KYGDAAKMAL VLEALPQIAA KIAAPLTKVD EIVVLSGDNS KVTSEVNRLL AELPASVHAL 
    TGVDLSKIPL IKKATGVQV

Genular Protein ID: 3816744194

Symbol: Q9BTI6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 385
  • Mass: 42566
  • Checksum: F010273B5E0997F8
  • Sequence:
  • MGNCHTVGPN EALVVSGGCC GSDYKQYVFG GWAWAWWCIS DTQRISLEIM TLQPRCEDVE 
    TAEGVALTVT GVAQVKIMTE KELLAVACEQ FLGKNVQDIK NVVLQTLEGH LRSILGTLTV 
    EQIYQDRDQF AKLVREVAAP DVGRMGIEIL SFTIKDVYDK VDYLSSLGKT QTAVVQRDAD 
    IGVAEAERDA GIREAECKKE MLDVKFMADT KIADSKRAFE LQKSAFSEEV NIKTAEAQLA 
    YELQGAREQQ KIRQEEIEIE VVQRKKQIAV EAQEILRTDK ELIATVRRPA EAEAHRIQQI 
    AEGEKVKQVL LAQAEAEKIR KIGEAEATVI EAMGKAEAER MKLKAEAYQK YGDAAKMALV 
    LEALPQIAAK IAAPLPVPSG KIKNS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.