Details for: FLT4

Gene ID: 2324

Symbol: FLT4

Ensembl ID: ENSG00000037280

Description: fms related receptor tyrosine kinase 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 17.0318
    Cell Significance Index: -4.3200
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 2.8146
    Cell Significance Index: 10.4900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.9647
    Cell Significance Index: -4.3000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.7533
    Cell Significance Index: 42.4700
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.4167
    Cell Significance Index: 10.3900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.4051
    Cell Significance Index: 73.1900
  • Cell Name: endothelial stalk cell (CL0002671)
    Fold Change: 1.2556
    Cell Significance Index: 14.0700
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.1345
    Cell Significance Index: 11.7500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.0973
    Cell Significance Index: -4.3300
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.9266
    Cell Significance Index: 7.3200
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.5980
    Cell Significance Index: 5.6900
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.4958
    Cell Significance Index: 1.7300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.4519
    Cell Significance Index: 6.5000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.4393
    Cell Significance Index: 6.3000
  • Cell Name: dermis microvascular lymphatic vessel endothelial cell (CL2000041)
    Fold Change: 0.3068
    Cell Significance Index: 1.4800
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.2656
    Cell Significance Index: 1.6500
  • Cell Name: surface ectodermal cell (CL0000114)
    Fold Change: 0.2617
    Cell Significance Index: 2.0700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1386
    Cell Significance Index: 8.9400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1374
    Cell Significance Index: 0.8300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0780
    Cell Significance Index: 3.4500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0582
    Cell Significance Index: 1.5600
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.0579
    Cell Significance Index: 0.6200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0367
    Cell Significance Index: 1.3900
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.0265
    Cell Significance Index: 0.1900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0024
    Cell Significance Index: 0.4700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0018
    Cell Significance Index: -3.3700
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0022
    Cell Significance Index: -0.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0029
    Cell Significance Index: -5.3800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0037
    Cell Significance Index: -5.6700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0045
    Cell Significance Index: -6.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0055
    Cell Significance Index: -4.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0056
    Cell Significance Index: -4.1900
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: -0.0058
    Cell Significance Index: -0.0400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0063
    Cell Significance Index: -3.9800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0064
    Cell Significance Index: -1.2900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0070
    Cell Significance Index: -3.9200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0086
    Cell Significance Index: -3.1000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0090
    Cell Significance Index: -4.9000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0097
    Cell Significance Index: -4.3900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0102
    Cell Significance Index: -1.8300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0154
    Cell Significance Index: -4.4300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0184
    Cell Significance Index: -3.1500
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0209
    Cell Significance Index: -0.2100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0210
    Cell Significance Index: -4.4200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0248
    Cell Significance Index: -0.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0254
    Cell Significance Index: -3.6900
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: -0.0272
    Cell Significance Index: -0.1700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0282
    Cell Significance Index: -3.4700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0300
    Cell Significance Index: -3.0700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0304
    Cell Significance Index: -3.4900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0311
    Cell Significance Index: -0.4500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0318
    Cell Significance Index: -3.7100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0320
    Cell Significance Index: -4.1400
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0328
    Cell Significance Index: -0.4500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0355
    Cell Significance Index: -4.8800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0373
    Cell Significance Index: -0.6600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0396
    Cell Significance Index: -4.6700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0419
    Cell Significance Index: -4.3600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0448
    Cell Significance Index: -1.9500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0542
    Cell Significance Index: -0.7700
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0545
    Cell Significance Index: -0.6700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0552
    Cell Significance Index: -4.3700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0565
    Cell Significance Index: -4.3400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0574
    Cell Significance Index: -3.8600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0582
    Cell Significance Index: -4.3400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0607
    Cell Significance Index: -2.8600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0755
    Cell Significance Index: -3.5200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0786
    Cell Significance Index: -4.8300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0800
    Cell Significance Index: -4.4900
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.0819
    Cell Significance Index: -0.8900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0826
    Cell Significance Index: -2.8700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0914
    Cell Significance Index: -2.2800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0933
    Cell Significance Index: -1.0600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0980
    Cell Significance Index: -4.4400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0995
    Cell Significance Index: -2.9300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1025
    Cell Significance Index: -3.5900
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1060
    Cell Significance Index: -1.2900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1138
    Cell Significance Index: -1.7600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1150
    Cell Significance Index: -5.9800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1161
    Cell Significance Index: -3.8000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1162
    Cell Significance Index: -3.7000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1168
    Cell Significance Index: -3.1200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1198
    Cell Significance Index: -3.0800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1199
    Cell Significance Index: -3.3500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1212
    Cell Significance Index: -2.5900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1220
    Cell Significance Index: -6.1700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1267
    Cell Significance Index: -2.0100
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.1294
    Cell Significance Index: -1.4900
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1317
    Cell Significance Index: -2.6800
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.1383
    Cell Significance Index: -1.6300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1388
    Cell Significance Index: -3.9600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1452
    Cell Significance Index: -2.3300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1456
    Cell Significance Index: -1.8400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1462
    Cell Significance Index: -4.1900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1468
    Cell Significance Index: -5.3900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1470
    Cell Significance Index: -2.4600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1504
    Cell Significance Index: -2.5300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1517
    Cell Significance Index: -2.9600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1525
    Cell Significance Index: -4.4800
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1546
    Cell Significance Index: -2.1700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** FLT4 is a transmembrane receptor tyrosine kinase that belongs to the fms family of receptor tyrosine kinases. It is composed of an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain contains the ligand-binding site, while the intracellular domain contains the tyrosine kinase domain. FLT4 is activated by binding to its ligand, vascular endothelial growth factor (VEGF), which leads to receptor dimerization and the activation of downstream signaling pathways. **Pathways and Functions** FLT4 is involved in several signaling pathways that regulate various cellular processes, including: 1. **Angiogenesis**: FLT4 is a key player in the formation of new blood vessels, and its dysregulation can lead to increased angiogenesis and tumor growth. 2. **Lymphangiogenesis**: FLT4 is also involved in the formation of new lymphatic vessels, which are essential for the immune system's ability to detect and eliminate pathogens. 3. **Vasculature development**: FLT4 is expressed in endothelial cells during embryonic development, and its dysregulation can lead to defects in vasculature formation. 4. **Cell migration and proliferation**: FLT4 signaling pathways regulate cell migration and proliferation, which are essential for tissue repair and remodeling. 5. **Apoptosis regulation**: FLT4 has been shown to regulate apoptosis, or programmed cell death, in various cell types. **Clinical Significance** FLT4 has been implicated in several diseases, including: 1. **Cancer**: FLT4 overexpression has been observed in various types of cancer, including breast, lung, and colon cancer, where it contributes to increased angiogenesis and tumor growth. 2. **Cardiovascular disease**: FLT4 has been implicated in the development of cardiovascular disease, including atherosclerosis and cardiac hypertrophy. 3. **Neurological disorders**: FLT4 has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease, where it regulates cell migration and survival. 4. **Immune system disorders**: FLT4 has been implicated in immune system disorders, including rheumatoid arthritis and multiple sclerosis, where it regulates lymphangiogenesis and immune cell function. In conclusion, FLT4 is a critical receptor tyrosine kinase that plays a key role in various biological processes, including angiogenesis, lymphangiogenesis, and vasculature development. Its dysregulation has been implicated in several diseases, highlighting the importance of FLT4 in human health and disease.

Genular Protein ID: 406481364

Symbol: VGFR3_HUMAN

Name: Vascular endothelial growth factor receptor 3

UniProtKB Accession Codes:

P35916 A8K6L4 B5A926 Q16067 Q86W07 Q86W08

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 4 CORUM 1 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 16 DrugCentral 1 EC 2 EMBL 9 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 38 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 15 KEGG 1 MANE-Select 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PIRSF 1 PRINTS 2 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 7 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 2 RefSeq 2 Rhea 3 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1327515

Title: FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines.

PubMed ID: 1327515

PubMed ID: 1319394

Title: Chromosomal localization of FLT4, a novel receptor-type tyrosine kinase gene.

PubMed ID: 1319394

DOI: 10.1016/0888-7543(92)90277-y

PubMed ID: 8386825

Title: The FLT4 gene encodes a transmembrane tyrosine kinase related to the vascular endothelial growth factor receptor.

PubMed ID: 8386825

PubMed ID: 8700872

Title: Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4.

PubMed ID: 8700872

DOI: 10.1073/pnas.93.5.1988

PubMed ID: 18593464

Title: Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.

PubMed ID: 18593464

DOI: 10.1186/ar2447

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 1310071

Title: FLT4, a novel class III receptor tyrosine kinase in chromosome 5q33-qter.

PubMed ID: 1310071

PubMed ID: 7692369

Title: Two human FLT4 receptor tyrosine kinase isoforms with distinct carboxy terminal tails are produced by alternative processing of primary transcripts.

PubMed ID: 7692369

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 7898938

Title: Biochemical characterization of two isoforms of FLT4, a VEGF receptor-related tyrosine kinase.

PubMed ID: 7898938

PubMed ID: 7675451

Title: Mutation at tyrosine residue 1337 abrogates ligand-dependent transforming capacity of the FLT4 receptor.

PubMed ID: 7675451

PubMed ID: 9435229

Title: Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4).

PubMed ID: 9435229

DOI: 10.1073/pnas.95.2.548

PubMed ID: 11532940

Title: Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3.

PubMed ID: 11532940

DOI: 10.1093/emboj/20.17.4762

PubMed ID: 12881528

Title: Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites.

PubMed ID: 12881528

DOI: 10.1074/jbc.m304499200

PubMed ID: 15474514

Title: Heterodimerization with vascular endothelial growth factor receptor-2 (VEGFR-2) is necessary for VEGFR-3 activity.

PubMed ID: 15474514

DOI: 10.1016/j.bbrc.2004.08.237

PubMed ID: 15102829

Title: Activation of vascular endothelial growth factor receptor-3 and its downstream signaling promote cell survival under oxidative stress.

PubMed ID: 15102829

DOI: 10.1074/jbc.m314015200

PubMed ID: 16076871

Title: Direct recruitment of CRK and GRB2 to VEGFR-3 induces proliferation, migration, and survival of endothelial cells through the activation of ERK, AKT, and JNK pathways.

PubMed ID: 16076871

DOI: 10.1182/blood-2005-04-1388

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16452200

Title: Vascular endothelial growth factor receptor-3 and focal adhesion kinase bind and suppress apoptosis in breast cancer cells.

PubMed ID: 16452200

DOI: 10.1158/0008-5472.can-05-1661

PubMed ID: 17210781

Title: Cooperative and redundant roles of VEGFR-2 and VEGFR-3 signaling in adult lymphangiogenesis.

PubMed ID: 17210781

DOI: 10.1096/fj.06-6656com

PubMed ID: 19779139

Title: Autocrine loop between vascular endothelial growth factor (VEGF)-C and VEGF receptor-3 positively regulates tumor-associated lymphangiogenesis in oral squamoid cancer cells.

PubMed ID: 19779139

DOI: 10.2353/ajpath.2009.081139

PubMed ID: 19610651

Title: Small molecule chloropyramine hydrochloride (C4) targets the binding site of focal adhesion kinase and vascular endothelial growth factor receptor 3 and suppresses breast cancer growth in vivo.

PubMed ID: 19610651

DOI: 10.1021/jm900159g

PubMed ID: 20826270

Title: Protein tyrosine phosphatase PTPN14 is a regulator of lymphatic function and choanal development in humans.

PubMed ID: 20826270

DOI: 10.1016/j.ajhg.2010.08.008

PubMed ID: 20431062

Title: Endothelial cell adhesion to the extracellular matrix induces c-Src-dependent VEGFR-3 phosphorylation without the activation of the receptor intrinsic kinase activity.

PubMed ID: 20431062

DOI: 10.1161/circresaha.109.206326

PubMed ID: 20224550

Title: VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts.

PubMed ID: 20224550

DOI: 10.1038/emboj.2010.30

PubMed ID: 20445537

Title: Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis.

PubMed ID: 20445537

DOI: 10.1038/nature09002

PubMed ID: 21273538

Title: Combined blockade of VEGFR-2 and VEGFR-3 inhibits inflammatory lymphangiogenesis in early and middle stages.

PubMed ID: 21273538

DOI: 10.1167/iovs.10-6408

PubMed ID: 18680722

Title: VEGF receptor protein-tyrosine kinases: structure and regulation.

PubMed ID: 18680722

DOI: 10.1016/j.bbrc.2008.07.121

PubMed ID: 19230644

Title: VEGFs and receptors involved in angiogenesis versus lymphangiogenesis.

PubMed ID: 19230644

DOI: 10.1016/j.ceb.2008.12.012

PubMed ID: 21711246

Title: Signal transduction by vascular endothelial growth factor receptors.

PubMed ID: 21711246

DOI: 10.1042/bj20110301

PubMed ID: 21196198

Title: Lymphangiogenesis and cancer metastasis.

PubMed ID: 21196198

DOI: 10.2741/3715

PubMed ID: 23878260

Title: Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation.

PubMed ID: 23878260

DOI: 10.1073/pnas.1301415110

PubMed ID: 9817924

Title: Hereditary lymphedema: evidence for linkage and genetic heterogeneity.

PubMed ID: 9817924

DOI: 10.1093/hmg/7.13.2073

PubMed ID: 10856194

Title: Congenital hereditary lymphedema caused by a mutation that inactivates VEGFR3 tyrosine kinase.

PubMed ID: 10856194

DOI: 10.1086/303019

PubMed ID: 10835628

Title: Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema.

PubMed ID: 10835628

DOI: 10.1038/75997

PubMed ID: 11807987

Title: Somatic mutation of vascular endothelial growth factor receptors in juvenile hemangioma.

PubMed ID: 11807987

DOI: 10.1002/gcc.10028

PubMed ID: 16965327

Title: Hereditary lymphedema type I associated with VEGFR3 mutation: the first de novo case and atypical presentations.

PubMed ID: 16965327

DOI: 10.1111/j.1399-0004.2006.00687.x

PubMed ID: 16924388

Title: Wide clinical spectrum in a family with hereditary lymphedema type I due to a novel missense mutation in VEGFR3.

PubMed ID: 16924388

DOI: 10.1007/s10038-006-0031-3

PubMed ID: 17458866

Title: A novel VEGFR3 mutation causes Milroy disease.

PubMed ID: 17458866

DOI: 10.1002/ajmg.a.31703

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 19289394

Title: Recessive primary congenital lymphoedema caused by a VEGFR3 mutation.

PubMed ID: 19289394

DOI: 10.1136/jmg.2008.064469

PubMed ID: 26091405

Title: A novel missense mutation in FLT4 causes autosomal recessive hereditary lymphedema.

PubMed ID: 26091405

DOI: 10.1089/lrb.2014.0044

PubMed ID: 28991257

Title: Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands.

PubMed ID: 28991257

DOI: 10.1038/ng.3970

PubMed ID: 30232381

Title: Haploinsufficiency of vascular endothelial growth factor related signaling genes is associated with tetralogy of Fallot.

PubMed ID: 30232381

DOI: 10.1038/s41436-018-0260-9

Sequence Information:

  • Length: 1363
  • Mass: 152757
  • Checksum: B1473AAAC95E7E93
  • Sequence:
    • MQRGAALCLR LWLCLGLLDG LVSGYSMTPP TLNITEESHV IDTGDSLSIS CRGQHPLEWA 
WPGAQEAPAT GDKDSEDTGV VRDCEGTDAR PYCKVLLLHE VHANDTGSYV CYYKYIKARI 
EGTTAASSYV FVRDFEQPFI NKPDTLLVNR KDAMWVPCLV SIPGLNVTLR SQSSVLWPDG 
QEVVWDDRRG MLVSTPLLHD ALYLQCETTW GDQDFLSNPF LVHITGNELY DIQLLPRKSL 
ELLVGEKLVL NCTVWAEFNS GVTFDWDYPG KQAERGKWVP ERRSQQTHTE LSSILTIHNV 
SQHDLGSYVC KANNGIQRFR ESTEVIVHEN PFISVEWLKG PILEATAGDE LVKLPVKLAA 
YPPPEFQWYK DGKALSGRHS PHALVLKEVT EASTGTYTLA LWNSAAGLRR NISLELVVNV 
PPQIHEKEAS SPSIYSRHSR QALTCTAYGV PLPLSIQWHW RPWTPCKMFA QRSLRRRQQQ 
DLMPQCRDWR AVTTQDAVNP IESLDTWTEF VEGKNKTVSK LVIQNANVSA MYKCVVSNKV 
GQDERLIYFY VTTIPDGFTI ESKPSEELLE GQPVLLSCQA DSYKYEHLRW YRLNLSTLHD 
AHGNPLLLDC KNVHLFATPL AASLEEVAPG ARHATLSLSI PRVAPEHEGH YVCEVQDRRS 
HDKHCHKKYL SVQALEAPRL TQNLTDLLVN VSDSLEMQCL VAGAHAPSIV WYKDERLLEE 
KSGVDLADSN QKLSIQRVRE EDAGRYLCSV CNAKGCVNSS ASVAVEGSED KGSMEIVILV 
GTGVIAVFFW VLLLLIFCNM RRPAHADIKT GYLSIIMDPG EVPLEEQCEY LSYDASQWEF 
PRERLHLGRV LGYGAFGKVV EASAFGIHKG SSCDTVAVKM LKEGATASEH RALMSELKIL 
IHIGNHLNVV NLLGACTKPQ GPLMVIVEFC KYGNLSNFLR AKRDAFSPCA EKSPEQRGRF 
RAMVELARLD RRRPGSSDRV LFARFSKTEG GARRASPDQE AEDLWLSPLT MEDLVCYSFQ 
VARGMEFLAS RKCIHRDLAA RNILLSESDV VKICDFGLAR DIYKDPDYVR KGSARLPLKW 
MAPESIFDKV YTTQSDVWSF GVLLWEIFSL GASPYPGVQI NEEFCQRLRD GTRMRAPELA 
TPAIRRIMLN CWSGDPKARP AFSELVEILG DLLQGRGLQE EEEVCMAPRS SQSSEEGSFS 
QVSTMALHIA QADAEDSPPS LQRHSLAARY YNWVSFPGCL ARGAETRGSS RMKTFEEFPM 
TPTTYKGSVD NQTDSGMVLA SEEFEQIESR HRQESGFSCK GPGQNVAVTR AHPDSQGRRR 
RPERGARGGQ VFYNSEYGEL SEPSEEDHCS PSARVTFFTD NSY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.