Details for: MTOR

Gene ID: 2475

Symbol: MTOR

Ensembl ID: ENSG00000198793

Description: mechanistic target of rapamycin kinase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 194.1557
    Cell Significance Index: -30.2000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 119.7350
    Cell Significance Index: -30.3700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 63.8758
    Cell Significance Index: -25.9500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 27.2429
    Cell Significance Index: -26.0100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 25.3294
    Cell Significance Index: -31.2300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.4480
    Cell Significance Index: -30.6700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.9957
    Cell Significance Index: -27.6300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.9548
    Cell Significance Index: -31.3900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.0959
    Cell Significance Index: -15.5300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7403
    Cell Significance Index: 349.1100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0534
    Cell Significance Index: 377.8400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.9333
    Cell Significance Index: 41.2800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8757
    Cell Significance Index: 173.7800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8740
    Cell Significance Index: 67.0700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.8617
    Cell Significance Index: 32.6300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.8074
    Cell Significance Index: 558.4000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6993
    Cell Significance Index: 39.2400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.6532
    Cell Significance Index: 16.7900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6123
    Cell Significance Index: 66.6000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5805
    Cell Significance Index: 94.4200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5070
    Cell Significance Index: 30.4400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4977
    Cell Significance Index: 12.4400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4870
    Cell Significance Index: 13.6100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4376
    Cell Significance Index: 27.5800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3667
    Cell Significance Index: 24.6600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3471
    Cell Significance Index: 7.6000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3254
    Cell Significance Index: 58.6700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.3037
    Cell Significance Index: 3.6200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2634
    Cell Significance Index: 11.9400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2626
    Cell Significance Index: 5.6900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2500
    Cell Significance Index: 30.7400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2061
    Cell Significance Index: 39.2200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.2060
    Cell Significance Index: 5.8800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1990
    Cell Significance Index: 19.6900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1810
    Cell Significance Index: 21.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1782
    Cell Significance Index: 97.3200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1225
    Cell Significance Index: 5.7100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1191
    Cell Significance Index: 7.3200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1058
    Cell Significance Index: 199.2900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1020
    Cell Significance Index: 5.3000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0972
    Cell Significance Index: 2.8000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0970
    Cell Significance Index: 149.3100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0899
    Cell Significance Index: 1.5400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0895
    Cell Significance Index: 1.1100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0873
    Cell Significance Index: 161.0200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0772
    Cell Significance Index: 9.1000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0637
    Cell Significance Index: 57.5300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0512
    Cell Significance Index: 22.6200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0490
    Cell Significance Index: 22.2200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0477
    Cell Significance Index: 1.6800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0413
    Cell Significance Index: 26.2600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0357
    Cell Significance Index: 2.4700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0319
    Cell Significance Index: 43.3500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0288
    Cell Significance Index: 1.5000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0216
    Cell Significance Index: 2.9700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0195
    Cell Significance Index: 3.3300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0073
    Cell Significance Index: -0.1600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0137
    Cell Significance Index: -8.5700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0150
    Cell Significance Index: -11.0000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0185
    Cell Significance Index: -0.5000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0218
    Cell Significance Index: -3.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0221
    Cell Significance Index: -16.3500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0338
    Cell Significance Index: -0.6600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0371
    Cell Significance Index: -20.9400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0380
    Cell Significance Index: -28.7300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0612
    Cell Significance Index: -1.6400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0657
    Cell Significance Index: -4.6500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0756
    Cell Significance Index: -8.6600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0936
    Cell Significance Index: -26.9300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0940
    Cell Significance Index: -19.7900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1030
    Cell Significance Index: -6.6500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1202
    Cell Significance Index: -12.2800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1252
    Cell Significance Index: -16.0500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1622
    Cell Significance Index: -3.8900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1896
    Cell Significance Index: -24.5000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1917
    Cell Significance Index: -21.8800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1943
    Cell Significance Index: -4.0300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2010
    Cell Significance Index: -20.9300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2204
    Cell Significance Index: -3.1700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2230
    Cell Significance Index: -10.4800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2639
    Cell Significance Index: -3.6000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3082
    Cell Significance Index: -4.5500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3096
    Cell Significance Index: -6.5700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3125
    Cell Significance Index: -23.2900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3209
    Cell Significance Index: -4.6000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3235
    Cell Significance Index: -5.4500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3324
    Cell Significance Index: -26.3300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3484
    Cell Significance Index: -8.5000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3690
    Cell Significance Index: -19.3700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4296
    Cell Significance Index: -9.1500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.4407
    Cell Significance Index: -6.5100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.4483
    Cell Significance Index: -5.5900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4542
    Cell Significance Index: -14.8700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4562
    Cell Significance Index: -14.5300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4911
    Cell Significance Index: -9.8600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4993
    Cell Significance Index: -13.5900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5169
    Cell Significance Index: -31.6900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.5226
    Cell Significance Index: -10.3300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5245
    Cell Significance Index: -16.8000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.5451
    Cell Significance Index: -6.8800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Dual Functionality:** MTOR exhibits both autophagy- and anabolic-promoting activities, allowing it to fine-tune cellular metabolism in response to changing environmental conditions. 2. **Complex Interactions:** MTOR interacts with various proteins, including ribosomal proteins, transcription factors, and signaling molecules, to regulate gene expression and protein synthesis. 3. **Sensitivity to Nutrient Availability:** MTOR is sensitive to changes in nutrient availability, with insulin/IGF-1 signaling pathways regulating its activity. 4. **Inhibition by Rapamycin:** MTOR is inhibited by rapamycin, a natural product that has been used as an immunosuppressive agent, highlighting the importance of this pathway in regulating immune responses. **Pathways and Functions:** 1. **Autophagy:** MTOR promotes autophagy, a process by which cells recycle damaged or dysfunctional cellular components, under conditions of nutrient deprivation. 2. **Protein Synthesis:** MTOR regulates protein synthesis by controlling ribosome biogenesis and translation initiation. 3. **Cell Growth and Proliferation:** MTOR promotes cell growth and proliferation by regulating the expression of genes involved in cell cycle progression and metabolism. 4. **Immune Response:** MTOR regulates immune response by controlling the expression of genes involved in inflammation and immune cell function. 5. **Cancer:** MTOR is dysregulated in various types of cancer, including breast, lung, and colon cancer, contributing to tumor growth and metastasis. **Clinical Significance:** 1. **Cancer Therapy:** MTOR inhibitors, such as everolimus, have been approved as cancer therapies, demonstrating the potential of targeting this pathway in cancer treatment. 2. **Neurodegenerative Disorders:** MTOR dysregulation has been implicated in various neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease, highlighting the importance of this pathway in regulating neuronal function and survival. 3. **Metabolic Disorders:** MTOR dysregulation has been linked to metabolic disorders, including insulin resistance and type 2 diabetes, underscoring the importance of this pathway in regulating glucose and lipid metabolism. 4. **Immunosuppression:** MTOR inhibitors have been used as immunosuppressive agents to prevent organ rejection in transplant patients, demonstrating the potential of targeting this pathway in immunomodulation. In conclusion, the mechanistic target of rapamycin kinase (MTOR) is a critical regulator of cellular metabolism, growth, and survival, with implications for various human diseases. Further research is needed to fully elucidate the mechanisms of MTOR regulation and its role in disease pathogenesis, ultimately leading to the development of novel therapeutic strategies targeting this pathway.

Genular Protein ID: 2467388000

Symbol: MTOR_HUMAN

Name: FK506-binding protein 12-rapamycin complex-associated protein 1

UniProtKB Accession Codes:

P42345 Q4LE76 Q5TER1 Q6LE87 Q96QG3 Q9Y4I3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 30 CPTC 1 CTD 1 ChEBI 24 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 11 DrugCentral 1 EC 2 EMBL 9 EMDB 24 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 100 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 15 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 4 OrthoDB 1 PANTHER 2 PDB 49 PDBsum 49 PIR 1 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 13 RefSeq 2 Rhea 6 SABIO-RK 1 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8008069

Title: A mammalian protein targeted by G1-arresting rapamycin-receptor complex.

PubMed ID: 8008069

DOI: 10.1038/369756a0

PubMed ID: 9653645

Title: Molecular cloning and expression analysis of five novel genes in chromosome 1p36.

PubMed ID: 9653645

DOI: 10.1006/geno.1997.5186

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11426320

Title: The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome 1p36.2-3.

PubMed ID: 11426320

DOI: 10.1038/sj.gene.6363745

PubMed ID: 7809080

Title: RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex.

PubMed ID: 7809080

DOI: 10.1073/pnas.91.26.12574

PubMed ID: 9434772

Title: Expression, enzyme activity, and subcellular localization of mammalian target of rapamycin in insulin-responsive cells.

PubMed ID: 9434772

DOI: 10.1006/bbrc.1997.7878

PubMed ID: 11853878

Title: Characterization of ubiquilin 1, an mTOR-interacting protein.

PubMed ID: 11853878

DOI: 10.1016/s0167-4889(01)00164-1

PubMed ID: 12150925

Title: mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the growth machinery.

PubMed ID: 12150925

DOI: 10.1016/s0092-8674(02)00808-5

PubMed ID: 12150926

Title: Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action.

PubMed ID: 12150926

DOI: 10.1016/s0092-8674(02)00833-4

PubMed ID: 12231510

Title: The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase.

PubMed ID: 12231510

DOI: 10.1093/embo-reports/kvf197

PubMed ID: 12087098

Title: Regulation of ribosomal S6 kinase 2 by mammalian target of rapamycin.

PubMed ID: 12087098

DOI: 10.1074/jbc.m204080200

PubMed ID: 12408816

Title: Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control.

PubMed ID: 12408816

DOI: 10.1016/s1097-2765(02)00636-6

PubMed ID: 11930000

Title: FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction.

PubMed ID: 11930000

DOI: 10.1073/pnas.261702698

PubMed ID: 14651849

Title: TSC2 mediates cellular energy response to control cell growth and survival.

PubMed ID: 14651849

DOI: 10.1016/s0092-8674(03)00929-2

PubMed ID: 12718876

Title: GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR.

PubMed ID: 12718876

DOI: 10.1016/s1097-2765(03)00114-x

PubMed ID: 15268862

Title: Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton.

PubMed ID: 15268862

DOI: 10.1016/j.cub.2004.06.054

PubMed ID: 15545625

Title: Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex.

PubMed ID: 15545625

DOI: 10.1101/gad.1256804

PubMed ID: 14578359

Title: FKBP12-rapamycin-associated protein or mammalian target of rapamycin (FRAP/mTOR) localization in the endoplasmic reticulum and the Golgi apparatus.

PubMed ID: 14578359

DOI: 10.1074/jbc.m305912200

PubMed ID: 15467718

Title: Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive.

PubMed ID: 15467718

DOI: 10.1038/ncb1183

PubMed ID: 15905173

Title: Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase.

PubMed ID: 15905173

DOI: 10.1074/jbc.m504045200

PubMed ID: 15718470

Title: Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.

PubMed ID: 15718470

DOI: 10.1126/science.1106148

PubMed ID: 17517883

Title: The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1.

PubMed ID: 17517883

DOI: 10.1074/jbc.m702636200

PubMed ID: 17599906

Title: PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling.

PubMed ID: 17599906

DOI: 10.1074/jbc.m704343200

PubMed ID: 17386266

Title: PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase.

PubMed ID: 17386266

DOI: 10.1016/j.molcel.2007.03.003

PubMed ID: 18925875

Title: mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1).

PubMed ID: 18925875

DOI: 10.1042/bj20081668

PubMed ID: 18762023

Title: SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.

PubMed ID: 18762023

DOI: 10.1016/j.cmet.2008.07.007

PubMed ID: 18372248

Title: Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation.

PubMed ID: 18372248

DOI: 10.1074/jbc.m800723200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18497260

Title: The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.

PubMed ID: 18497260

DOI: 10.1126/science.1157535

PubMed ID: 19446321

Title: DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival.

PubMed ID: 19446321

DOI: 10.1016/j.cell.2009.03.046

PubMed ID: 19487463

Title: Site-specific mTOR phosphorylation promotes mTORC1-mediated signaling and cell growth.

PubMed ID: 19487463

DOI: 10.1128/mcb.01665-08

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 19145465

Title: mTOR phosphorylated at S2448 binds to raptor and rictor.

PubMed ID: 19145465

DOI: 10.1007/s00726-008-0230-7

PubMed ID: 20381137

Title: Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.

PubMed ID: 20381137

DOI: 10.1016/j.cell.2010.02.024

PubMed ID: 20537536

Title: DAP1, a novel substrate of mTOR, negatively regulates autophagy.

PubMed ID: 20537536

DOI: 10.1016/j.cub.2010.04.041

PubMed ID: 20810650

Title: A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.

PubMed ID: 20810650

DOI: 10.1101/gad.1934210

PubMed ID: 20801936

Title: Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes.

PubMed ID: 20801936

DOI: 10.1101/gad.1956410

PubMed ID: 20427287

Title: Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.

PubMed ID: 20427287

DOI: 10.1074/jbc.m110.121699

PubMed ID: 20516213

Title: mTORC1 directly phosphorylates and regulates human MAF1.

PubMed ID: 20516213

DOI: 10.1128/mcb.00319-10

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21576368

Title: mTOR kinase domain phosphorylation promotes mTORC1 signaling, cell growth, and cell cycle progression.

PubMed ID: 21576368

DOI: 10.1128/mcb.05437-11

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 21659604

Title: The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.

PubMed ID: 21659604

DOI: 10.1126/science.1199498

PubMed ID: 22576015

Title: MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB.

PubMed ID: 22576015

DOI: 10.4161/auto.19653

PubMed ID: 22343943

Title: A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB.

PubMed ID: 22343943

DOI: 10.1038/emboj.2012.32

PubMed ID: 22692423

Title: The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis.

PubMed ID: 22692423

DOI: 10.1126/scisignal.2002790

PubMed ID: 23027611

Title: 5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia.

PubMed ID: 23027611

DOI: 10.1002/emmm.201201410

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23394946

Title: mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state.

PubMed ID: 23394946

DOI: 10.1016/j.cell.2013.01.023

PubMed ID: 23426360

Title: Phosphorylation of lipin 1 and charge on the phosphatidic acid head group control its phosphatidic acid phosphatase activity and membrane association.

PubMed ID: 23426360

DOI: 10.1074/jbc.m112.441493

PubMed ID: 25657994

Title: The potential role of BRCA1-associated ATM activator-1 (BRAT1) in regulation of mTOR.

PubMed ID: 25657994

PubMed ID: 24247430

Title: Phosphorylation of the TOR ATP binding domain by AGC kinase constitutes a novel mode of TOR inhibition.

PubMed ID: 24247430

DOI: 10.1083/jcb.201305103

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23524951

Title: mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6.

PubMed ID: 23524951

DOI: 10.1038/ncb2708

PubMed ID: 23762398

Title: Interaction between NBS1 and the mTOR/Rictor/SIN1 complex through specific domains.

PubMed ID: 23762398

DOI: 10.1371/journal.pone.0065586

PubMed ID: 23429704

Title: Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis.

PubMed ID: 23429704

DOI: 10.1126/science.1228771

PubMed ID: 23429703

Title: Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1.

PubMed ID: 23429703

DOI: 10.1126/science.1228792

PubMed ID: 24403073

Title: Characterization of the Raptor/4E-BP1 interaction by chemical cross-linking coupled with mass spectrometry analysis.

PubMed ID: 24403073

DOI: 10.1074/jbc.m113.482067

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24448649

Title: The nutrient-responsive transcription factor TFE3 promotes autophagy, lysosomal biogenesis, and clearance of cellular debris.

PubMed ID: 24448649

DOI: 10.1126/scisignal.2004754

PubMed ID: 25851998

Title: A germline MTOR mutation in Aboriginal Australian siblings with intellectual disability, dysmorphism, macrocephaly, and small thoraces.

PubMed ID: 25851998

DOI: 10.1002/ajmg.a.37070

PubMed ID: 26018084

Title: Somatic mutations in the MTOR gene cause focal cortical dysplasia type IIb.

PubMed ID: 26018084

DOI: 10.1002/ana.24444

PubMed ID: 26542245

Title: Germline activating MTOR mutation arising through gonadal mosaicism in two brothers with megalencephaly and neurodevelopmental abnormalities.

PubMed ID: 26542245

DOI: 10.1186/s12881-015-0240-8

PubMed ID: 25438055

Title: AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation.

PubMed ID: 25438055

DOI: 10.1038/ncb3072

PubMed ID: 25799227

Title: Brain somatic mutations in MTOR cause focal cortical dysplasia type II leading to intractable epilepsy.

PubMed ID: 25799227

DOI: 10.1038/nm.3824

PubMed ID: 25561175

Title: SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.

PubMed ID: 25561175

DOI: 10.1038/nature14107

PubMed ID: 25878179

Title: Hemispheric cortical dysplasia secondary to a mosaic somatic mutation in MTOR.

PubMed ID: 25878179

DOI: 10.1212/wnl.0000000000001594

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 25567906

Title: Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.

PubMed ID: 25567906

DOI: 10.1126/science.1257132

PubMed ID: 26812014

Title: WAC regulates mTOR activity by acting as an adaptor for the TTT and Pontin/Reptin complexes.

PubMed ID: 26812014

DOI: 10.1016/j.devcel.2015.12.019

PubMed ID: 27623384

Title: PIKfyve Regulates Vacuole Maturation and Nutrient Recovery following Engulfment.

PubMed ID: 27623384

DOI: 10.1016/j.devcel.2016.08.001

PubMed ID: 27830187

Title: Germline and somatic mutations in the MTOR gene in focal cortical dysplasia and epilepsy.

PubMed ID: 27830187

DOI: 10.1212/nxg.0000000000000118

PubMed ID: 29750193

Title: Mammalian EAK-7 activates alternative mTOR signaling to regulate cell proliferation and migration.

PubMed ID: 29750193

DOI: 10.1126/sciadv.aao5838

PubMed ID: 29150432

Title: The IKK-related kinase TBK1 activates mTORC1 directly in response to growth factors and innate immune agonists.

PubMed ID: 29150432

DOI: 10.15252/embj.201696164

PubMed ID: 30956113

Title: Transmembrane 4 L six family member 5 senses arginine for mTORC1 signaling.

PubMed ID: 30956113

DOI: 10.1016/j.cmet.2019.03.005

PubMed ID: 30704899

Title: Pacer is a mediator of mTORC1 and GSK3-TIP60 signaling in regulation of autophagosome maturation and lipid metabolism.

PubMed ID: 30704899

DOI: 10.1016/j.molcel.2018.12.017

PubMed ID: 31112131

Title: GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor.

PubMed ID: 31112131

DOI: 10.7554/elife.43038

PubMed ID: 31695197

Title: Lipid signalling drives proteolytic rewiring of mitochondria by YME1L.

PubMed ID: 31695197

DOI: 10.1038/s41586-019-1738-6

PubMed ID: 31036939

Title: The lysosomal GPCR-like protein GPR137B regulates Rag and mTORC1 localization and activity.

PubMed ID: 31036939

DOI: 10.1038/s41556-019-0321-6

PubMed ID: 31601708

Title: Structural basis for the docking of mTORC1 on the lysosomal surface.

PubMed ID: 31601708

DOI: 10.1126/science.aay0166

PubMed ID: 33378666

Title: mTORC2 Assembly Is Regulated by USP9X-Mediated Deubiquitination of RICTOR.

PubMed ID: 33378666

DOI: 10.1016/j.celrep.2020.108564

PubMed ID: 32612235

Title: A substrate-specific mTORC1 pathway underlies Birt-Hogg-Dube syndrome.

PubMed ID: 32612235

DOI: 10.1038/s41586-020-2444-0

PubMed ID: 32561715

Title: Leucine regulates autophagy via acetylation of the mTORC1 component raptor.

PubMed ID: 32561715

DOI: 10.1038/s41467-020-16886-2

PubMed ID: 32647003

Title: HEM1 deficiency disrupts mTORC2 and F-actin control in inherited immunodysregulatory disease.

PubMed ID: 32647003

DOI: 10.1126/science.aay5663

PubMed ID: 34289345

Title: Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway.

PubMed ID: 34289345

DOI: 10.1016/j.cell.2021.06.028

PubMed ID: 35561222

Title: SNAT7 regulates mTORC1 via macropinocytosis.

PubMed ID: 35561222

DOI: 10.1073/pnas.2123261119

PubMed ID: 35904232

Title: TSPAN8 alleviates high glucose-induced apoptosis and autophagy via targeting mTORC2.

PubMed ID: 35904232

DOI: 10.1002/cbin.11870

PubMed ID: 36691768

Title: TORC1 phosphorylates and inhibits the ribosome preservation factor Stm1 to activate dormant ribosomes.

PubMed ID: 36691768

DOI: 10.15252/embj.2022112344

PubMed ID: 37057673

Title: De novo missense variants in RRAGC lead to a fatal mTORopathy of early childhood.

PubMed ID: 37057673

DOI: 10.1016/j.gim.2023.100838

PubMed ID: 36608670

Title: A central role for regulated protein stability in the control of TFE3 and MITF by nutrients.

PubMed ID: 36608670

DOI: 10.1016/j.molcel.2022.12.013

PubMed ID: 37751742

Title: Lysosomal cyst(e)ine storage potentiates tolerance to oxidative stress in cancer cells.

PubMed ID: 37751742

DOI: 10.1016/j.molcel.2023.08.032

PubMed ID: 8662507

Title: Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP.

PubMed ID: 8662507

DOI: 10.1126/science.273.5272.239

PubMed ID: 10089303

Title: Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution.

PubMed ID: 10089303

DOI: 10.1107/s0907444998014747

PubMed ID: 20060908

Title: Insights into the domain and repeat architecture of target of rapamycin.

PubMed ID: 20060908

DOI: 10.1016/j.jsb.2010.01.002

PubMed ID: 20542007

Title: Structure of the human mTOR complex I and its implications for rapamycin inhibition.

PubMed ID: 20542007

DOI: 10.1016/j.molcel.2010.05.017

PubMed ID: 23636326

Title: mTOR kinase structure, mechanism and regulation.

PubMed ID: 23636326

DOI: 10.1038/nature12122

Sequence Information:

  • Length: 2549
  • Mass: 288892
  • Checksum: 7D9AD6E784882AB4
  • Sequence:
    • MLGTGPAAAT TAATTSSNVS VLQQFASGLK SRNEETRAKA AKELQHYVTM ELREMSQEES 
TRFYDQLNHH IFELVSSSDA NERKGGILAI ASLIGVEGGN ATRIGRFANY LRNLLPSNDP 
VVMEMASKAI GRLAMAGDTF TAEYVEFEVK RALEWLGADR NEGRRHAAVL VLRELAISVP 
TFFFQQVQPF FDNIFVAVWD PKQAIREGAV AALRACLILT TQREPKEMQK PQWYRHTFEE 
AEKGFDETLA KEKGMNRDDR IHGALLILNE LVRISSMEGE RLREEMEEIT QQQLVHDKYC 
KDLMGFGTKP RHITPFTSFQ AVQPQQSNAL VGLLGYSSHQ GLMGFGTSPS PAKSTLVESR 
CCRDLMEEKF DQVCQWVLKC RNSKNSLIQM TILNLLPRLA AFRPSAFTDT QYLQDTMNHV 
LSCVKKEKER TAAFQALGLL SVAVRSEFKV YLPRVLDIIR AALPPKDFAH KRQKAMQVDA 
TVFTCISMLA RAMGPGIQQD IKELLEPMLA VGLSPALTAV LYDLSRQIPQ LKKDIQDGLL 
KMLSLVLMHK PLRHPGMPKG LAHQLASPGL TTLPEASDVG SITLALRTLG SFEFEGHSLT 
QFVRHCADHF LNSEHKEIRM EAARTCSRLL TPSIHLISGH AHVVSQTAVQ VVADVLSKLL 
VVGITDPDPD IRYCVLASLD ERFDAHLAQA ENLQALFVAL NDQVFEIREL AICTVGRLSS 
MNPAFVMPFL RKMLIQILTE LEHSGIGRIK EQSARMLGHL VSNAPRLIRP YMEPILKALI 
LKLKDPDPDP NPGVINNVLA TIGELAQVSG LEMRKWVDEL FIIIMDMLQD SSLLAKRQVA 
LWTLGQLVAS TGYVVEPYRK YPTLLEVLLN FLKTEQNQGT RREAIRVLGL LGALDPYKHK 
VNIGMIDQSR DASAVSLSES KSSQDSSDYS TSEMLVNMGN LPLDEFYPAV SMVALMRIFR 
DQSLSHHHTM VVQAITFIFK SLGLKCVQFL PQVMPTFLNV IRVCDGAIRE FLFQQLGMLV 
SFVKSHIRPY MDEIVTLMRE FWVMNTSIQS TIILLIEQIV VALGGEFKLY LPQLIPHMLR 
VFMHDNSPGR IVSIKLLAAI QLFGANLDDY LHLLLPPIVK LFDAPEAPLP SRKAALETVD 
RLTESLDFTD YASRIIHPIV RTLDQSPELR STAMDTLSSL VFQLGKKYQI FIPMVNKVLV 
RHRINHQRYD VLICRIVKGY TLADEEEDPL IYQHRMLRSG QGDALASGPV ETGPMKKLHV 
STINLQKAWG AARRVSKDDW LEWLRRLSLE LLKDSSSPSL RSCWALAQAY NPMARDLFNA 
AFVSCWSELN EDQQDELIRS IELALTSQDI AEVTQTLLNL AEFMEHSDKG PLPLRDDNGI 
VLLGERAAKC RAYAKALHYK ELEFQKGPTP AILESLISIN NKLQQPEAAA GVLEYAMKHF 
GELEIQATWY EKLHEWEDAL VAYDKKMDTN KDDPELMLGR MRCLEALGEW GQLHQQCCEK 
WTLVNDETQA KMARMAAAAA WGLGQWDSME EYTCMIPRDT HDGAFYRAVL ALHQDLFSLA 
QQCIDKARDL LDAELTAMAG ESYSRAYGAM VSCHMLSELE EVIQYKLVPE RREIIRQIWW 
ERLQGCQRIV EDWQKILMVR SLVVSPHEDM RTWLKYASLC GKSGRLALAH KTLVLLLGVD 
PSRQLDHPLP TVHPQVTYAY MKNMWKSARK IDAFQHMQHF VQTMQQQAQH AIATEDQQHK 
QELHKLMARC FLKLGEWQLN LQGINESTIP KVLQYYSAAT EHDRSWYKAW HAWAVMNFEA 
VLHYKHQNQA RDEKKKLRHA SGANITNATT AATTAATATT TASTEGSNSE SEAESTENSP 
TPSPLQKKVT EDLSKTLLMY TVPAVQGFFR SISLSRGNNL QDTLRVLTLW FDYGHWPDVN 
EALVEGVKAI QIDTWLQVIP QLIARIDTPR PLVGRLIHQL LTDIGRYHPQ ALIYPLTVAS 
KSTTTARHNA ANKILKNMCE HSNTLVQQAM MVSEELIRVA ILWHEMWHEG LEEASRLYFG 
ERNVKGMFEV LEPLHAMMER GPQTLKETSF NQAYGRDLME AQEWCRKYMK SGNVKDLTQA 
WDLYYHVFRR ISKQLPQLTS LELQYVSPKL LMCRDLELAV PGTYDPNQPI IRIQSIAPSL 
QVITSKQRPR KLTLMGSNGH EFVFLLKGHE DLRQDERVMQ LFGLVNTLLA NDPTSLRKNL 
SIQRYAVIPL STNSGLIGWV PHCDTLHALI RDYREKKKIL LNIEHRIMLR MAPDYDHLTL 
MQKVEVFEHA VNNTAGDDLA KLLWLKSPSS EVWFDRRTNY TRSLAVMSMV GYILGLGDRH 
PSNLMLDRLS GKILHIDFGD CFEVAMTREK FPEKIPFRLT RMLTNAMEVT GLDGNYRITC 
HTVMEVLREH KDSVMAVLEA FVYDPLLNWR LMDTNTKGNK RSRTRTDSYS AGQSVEILDG 
VELGEPAHKK TGTTVPESIH SFIGDGLVKP EALNKKAIQI INRVRDKLTG RDFSHDDTLD 
VPTQVELLIK QATSHENLCQ CYIGWCPFW

Genular Protein ID: 3439601957

Symbol: A0A8V8TQ52_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A8V8TQ52

Database IDs:

CTD 1 ChEBI 5 EC 1 EMBL 4 Ensembl 2 GO 2 Gene3D 1 GeneTree 1 HGNC 1 InterPro 6 NCBI Taxonomy 1 PANTHER 2 PROSITE 2 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 3 RuleBase 1 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 1590
  • Mass: 178743
  • Checksum: 2FE43AC7D0819C22
  • Sequence:
    • MLGTGPAAAT TAATTSSNVS VLQQFASGLK SRNEETRAKA AKELQHYVTM ELREMSQEES 
TRFYDQLNHH IFELVSSSDA NERKGGILAI ASLIGVEGGN ATRIGRFANY LRNLLPSNDP 
VVMEMASKAI GRLAMAGDTF TAEYVEFEVK RALEWLGADR NEGRRHAAVL VLRELAISVP 
TFFFQQVQPF FDNIFVAVWD PKQAIREGAV AALRACLILT TQREPKEMQK PQWYRHTFEE 
AEKGFDETLA KEKGMNRDDR IHGALLILNE LVRISSMEGE RLREEMEEIT QQQLVHDKYC 
KDLMGFGTKP RHITPFTSFQ AVQPQQSNAL VGLLGYSSHQ GLMGFGTSPS PAKSTLVESR 
CCRDLMEEKF DQVCQWVLKC RNSKNSLIQM TILNLLPRLA AFRPSAFTDT QYLQDTMNHV 
LSCVKKEKER TAAFQALGLL SVAVRSEFKV YLPRVLDIIR AALPPKDFAH KRQKAMQVDA 
TVFTCISMLA RAMGPGIQQD IKELLEPMLA VGLSPALTAV LYDLSRQIPQ LKKDIQDGLL 
KMLSLVLMHK PLRHPGMPKG LAHQLASPGL TTLPEASDVG SITLALRTLG SFEFEGHSLT 
QFVRHCADHF LNSEHKEIRM EAARTCSRLL TPSIHLISGH AHVVSQTAVQ VVADVLSKLL 
VVGITDPDPD IRYCVLASLD ERFDAHLAQA ENLQALFVAL NDQVFEIREL AICTVGRLSS 
MNPAFVMPFL RKMLIQILTE LEHSGIGRIK EQSARMLGHL VSNAPRLIRP YMEPILKALI 
LKLKDPDPDP NPGVINNVLA TIGELAQVSG LEMRKWVDEL FIIIMDMLQD SSLLAKRQVA 
LWTLGQLVAS TGYVVEPYRK YPTLLEVLLN FLKTEQNQGT RREAIRVLGL LGALDPYKHK 
VNIGMIDQSR DASAVSLSES KSSQDSSDYS TSEMLVNMGN LPLDEFYPAV SMVALMRIFR 
DQSLSHHHTM VVQAITFIFK SLGLKCVQFL PQVMPTFLNV IRVCDGAIRE FLFQQLGMLV 
SFVKSHIRPY MDEIVTLMRE FWVMNTSIQS TIILLIEQIV VALGGEFKLY LPQLIPHMLR 
VFMHDNSPGR IVSIKLLAAI QLFGANLDDY LHLLLPPIVK LFDAPEAPLP SRKAALETVD 
RLTESLDFTD YASRIIHPIV RTLDQSPELR STAMDTLSSL VFQLGKKYQI FIPMVNKVLV 
RHRINHQRYD VLICRIVKGY TLADEEEDPL IYQHRMLRSG QGDALASGPV ETGPMKKLHV 
STINLQKAWG AARRVSKDDW LEWLRRLSLE LLKDSSSPSL RSCWALAQAY NPMARDLFNA 
AFVSCWSELN EDQQDELIRS IELALTSQDI AEVTQTLLNL AEFMEHSDKG PLPLRDDNGI 
VLLGERAAKC RAYAKALHYK ELEFQKGPTP AILESLISIN NKLQQPEAAA GVLEYAMKHF 
GELEIQATWY EKLHEWEDAL VAYDKKMDTN KDDPELMLGR MRCLEALGEW GQLHQQCCEK 
WTLVNDETQA KMARMAAAAA WGLGQWDSME EYTCMIPRDT HDGAFYRAVL ALHQDLFSLA 
QQCIDKARDL LDAELTAMAG ESYSRAYGIP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.