Details for: MTOR
Associated with
Cells (max top 100)
(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: germ cell (CL0000586)
Fold Change: 2.71
Marker Score: 4738 - Cell Name: neuron (CL0000540)
Fold Change: 1.73
Marker Score: 7051 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 1.68
Marker Score: 25188 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.68
Marker Score: 1859 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.66
Marker Score: 17161 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 1.62
Marker Score: 12441 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.61
Marker Score: 59515 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.6
Marker Score: 98280 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.57
Marker Score: 59664 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.55
Marker Score: 14593 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.55
Marker Score: 13308 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.54
Marker Score: 5958 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.53
Marker Score: 6353 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.52
Marker Score: 14478 - Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 1.48
Marker Score: 621 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.47
Marker Score: 31423 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.45
Marker Score: 2242 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 1.44
Marker Score: 28709 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.36
Marker Score: 1647.5 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 1.34
Marker Score: 1802 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 1.28
Marker Score: 2809 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 1.27
Marker Score: 737 - Cell Name: oogonial cell (CL0000024)
Fold Change: 1.24
Marker Score: 1782 - Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 1.22
Marker Score: 387 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 1.18
Marker Score: 704 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.16
Marker Score: 4865.5 - Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 1.16
Marker Score: 610 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.15
Marker Score: 670 - Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 1.14
Marker Score: 312 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 1.09
Marker Score: 5064 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.08
Marker Score: 1247 - Cell Name: male germ cell (CL0000015)
Fold Change: 1.06
Marker Score: 305 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.05
Marker Score: 16394 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 1.04
Marker Score: 3715 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 1.02
Marker Score: 1954 - Cell Name: pyramidal neuron (CL0000598)
Fold Change: 1
Marker Score: 1687 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71731 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47955 - Cell Name: primordial germ cell (CL0000670)
Fold Change: 1
Marker Score: 1248 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30397 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 0.96
Marker Score: 21460 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2403 - Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 0.94
Marker Score: 528 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.94
Marker Score: 485 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.94
Marker Score: 31675 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.93
Marker Score: 441 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.92
Marker Score: 290 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.92
Marker Score: 2157 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2714 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.89
Marker Score: 5727 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5294 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 0.86
Marker Score: 2466 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.86
Marker Score: 309 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.86
Marker Score: 4900.5 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.86
Marker Score: 1953 - Cell Name: fat cell (CL0000136)
Fold Change: 0.86
Marker Score: 479 - Cell Name: oligodendrocyte (CL0000128)
Fold Change: 0.85
Marker Score: 2038 - Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.84
Marker Score: 407 - Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.83
Marker Score: 895 - Cell Name: oocyte (CL0000023)
Fold Change: 0.83
Marker Score: 204 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.82
Marker Score: 314 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 0.8
Marker Score: 3454 - Cell Name: cardiac neuron (CL0010022)
Fold Change: 0.8
Marker Score: 993 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.79
Marker Score: 248 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.79
Marker Score: 391 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.78
Marker Score: 229 - Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.78
Marker Score: 966 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.78
Marker Score: 312 - Cell Name: renal principal cell (CL0005009)
Fold Change: 0.78
Marker Score: 599 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.77
Marker Score: 592 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.77
Marker Score: 1933 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.77
Marker Score: 461 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.77
Marker Score: 4606 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.76
Marker Score: 1242 - Cell Name: astrocyte (CL0000127)
Fold Change: 0.76
Marker Score: 662 - Cell Name: stellate neuron (CL0000122)
Fold Change: 0.76
Marker Score: 4101 - Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 0.76
Marker Score: 3989 - Cell Name: taste receptor cell (CL0000209)
Fold Change: 0.76
Marker Score: 654 - Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 0.76
Marker Score: 506 - Cell Name: mesangial cell (CL0000650)
Fold Change: 0.74
Marker Score: 890 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.73
Marker Score: 379 - Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.73
Marker Score: 185 - Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 0.73
Marker Score: 422 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.72
Marker Score: 760 - Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.72
Marker Score: 573 - Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 0.71
Marker Score: 681 - Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.71
Marker Score: 1009 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.71
Marker Score: 804 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.71
Marker Score: 2958.5 - Cell Name: lens fiber cell (CL0011004)
Fold Change: 0.7
Marker Score: 223 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.7
Marker Score: 227 - Cell Name: Leydig cell (CL0000178)
Fold Change: 0.7
Marker Score: 758 - Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.7
Marker Score: 1721 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.69
Marker Score: 3716 - Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 0.68
Marker Score: 180 - Cell Name: brush cell (CL0002204)
Fold Change: 0.68
Marker Score: 623 - Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.68
Marker Score: 255 - Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.68
Marker Score: 216 - Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 0.68
Marker Score: 337 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 173
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Other Information
Genular Protein ID: 2467388000
Symbol: MTOR_HUMAN
Name: FK506-binding protein 12-rapamycin complex-associated protein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8008069
Title: A mammalian protein targeted by G1-arresting rapamycin-receptor complex.
PubMed ID: 8008069
DOI: 10.1038/369756a0
PubMed ID: 9653645
Title: Molecular cloning and expression analysis of five novel genes in chromosome 1p36.
PubMed ID: 9653645
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11426320
Title: The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome 1p36.2-3.
PubMed ID: 11426320
PubMed ID: 7809080
Title: RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex.
PubMed ID: 7809080
PubMed ID: 9434772
Title: Expression, enzyme activity, and subcellular localization of mammalian target of rapamycin in insulin-responsive cells.
PubMed ID: 9434772
PubMed ID: 11853878
Title: Characterization of ubiquilin 1, an mTOR-interacting protein.
PubMed ID: 11853878
PubMed ID: 12150925
Title: mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the growth machinery.
PubMed ID: 12150925
PubMed ID: 12150926
Title: Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action.
PubMed ID: 12150926
PubMed ID: 12231510
Title: The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase.
PubMed ID: 12231510
PubMed ID: 12087098
Title: Regulation of ribosomal S6 kinase 2 by mammalian target of rapamycin.
PubMed ID: 12087098
PubMed ID: 12408816
Title: Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control.
PubMed ID: 12408816
PubMed ID: 11930000
Title: FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction.
PubMed ID: 11930000
PubMed ID: 14651849
Title: TSC2 mediates cellular energy response to control cell growth and survival.
PubMed ID: 14651849
PubMed ID: 12718876
Title: GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR.
PubMed ID: 12718876
PubMed ID: 15268862
Title: Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton.
PubMed ID: 15268862
PubMed ID: 15545625
Title: Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex.
PubMed ID: 15545625
DOI: 10.1101/gad.1256804
PubMed ID: 14578359
Title: FKBP12-rapamycin-associated protein or mammalian target of rapamycin (FRAP/mTOR) localization in the endoplasmic reticulum and the Golgi apparatus.
PubMed ID: 14578359
PubMed ID: 15467718
Title: Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive.
PubMed ID: 15467718
DOI: 10.1038/ncb1183
PubMed ID: 15905173
Title: Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase.
PubMed ID: 15905173
PubMed ID: 15718470
Title: Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.
PubMed ID: 15718470
PubMed ID: 17517883
Title: The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1.
PubMed ID: 17517883
PubMed ID: 17599906
Title: PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling.
PubMed ID: 17599906
PubMed ID: 17386266
Title: PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase.
PubMed ID: 17386266
PubMed ID: 18925875
Title: mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1).
PubMed ID: 18925875
DOI: 10.1042/bj20081668
PubMed ID: 18762023
Title: SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.
PubMed ID: 18762023
PubMed ID: 18372248
Title: Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation.
PubMed ID: 18372248
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 18497260
Title: The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.
PubMed ID: 18497260
PubMed ID: 19446321
Title: DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival.
PubMed ID: 19446321
PubMed ID: 19487463
Title: Site-specific mTOR phosphorylation promotes mTORC1-mediated signaling and cell growth.
PubMed ID: 19487463
DOI: 10.1128/mcb.01665-08
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 19145465
Title: mTOR phosphorylated at S2448 binds to raptor and rictor.
PubMed ID: 19145465
PubMed ID: 20381137
Title: Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.
PubMed ID: 20381137
PubMed ID: 20537536
Title: DAP1, a novel substrate of mTOR, negatively regulates autophagy.
PubMed ID: 20537536
PubMed ID: 20810650
Title: A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.
PubMed ID: 20810650
DOI: 10.1101/gad.1934210
PubMed ID: 20801936
Title: Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes.
PubMed ID: 20801936
DOI: 10.1101/gad.1956410
PubMed ID: 20427287
Title: Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.
PubMed ID: 20427287
PubMed ID: 20516213
Title: mTORC1 directly phosphorylates and regulates human MAF1.
PubMed ID: 20516213
DOI: 10.1128/mcb.00319-10
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21576368
Title: mTOR kinase domain phosphorylation promotes mTORC1 signaling, cell growth, and cell cycle progression.
PubMed ID: 21576368
DOI: 10.1128/mcb.05437-11
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 21659604
Title: The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.
PubMed ID: 21659604
PubMed ID: 22576015
Title: MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB.
PubMed ID: 22576015
DOI: 10.4161/auto.19653
PubMed ID: 22343943
Title: A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB.
PubMed ID: 22343943
PubMed ID: 22692423
Title: The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis.
PubMed ID: 22692423
PubMed ID: 23027611
Title: 5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia.
PubMed ID: 23027611
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23394946
Title: mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state.
PubMed ID: 23394946
PubMed ID: 25657994
Title: The potential role of BRCA1-associated ATM activator-1 (BRAT1) in regulation of mTOR.
PubMed ID: 25657994
PubMed ID: 24247430
Title: Phosphorylation of the TOR ATP binding domain by AGC kinase constitutes a novel mode of TOR inhibition.
PubMed ID: 24247430
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 23524951
Title: mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6.
PubMed ID: 23524951
DOI: 10.1038/ncb2708
PubMed ID: 23762398
Title: Interaction between NBS1 and the mTOR/Rictor/SIN1 complex through specific domains.
PubMed ID: 23762398
PubMed ID: 23429704
Title: Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis.
PubMed ID: 23429704
PubMed ID: 23429703
Title: Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1.
PubMed ID: 23429703
PubMed ID: 24403073
Title: Characterization of the Raptor/4E-BP1 interaction by chemical cross-linking coupled with mass spectrometry analysis.
PubMed ID: 24403073
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24448649
Title: The nutrient-responsive transcription factor TFE3 promotes autophagy, lysosomal biogenesis, and clearance of cellular debris.
PubMed ID: 24448649
PubMed ID: 25851998
Title: A germline MTOR mutation in Aboriginal Australian siblings with intellectual disability, dysmorphism, macrocephaly, and small thoraces.
PubMed ID: 25851998
DOI: 10.1002/ajmg.a.37070
PubMed ID: 26018084
Title: Somatic mutations in the MTOR gene cause focal cortical dysplasia type IIb.
PubMed ID: 26018084
DOI: 10.1002/ana.24444
PubMed ID: 26542245
Title: Germline activating MTOR mutation arising through gonadal mosaicism in two brothers with megalencephaly and neurodevelopmental abnormalities.
PubMed ID: 26542245
PubMed ID: 25438055
Title: AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation.
PubMed ID: 25438055
DOI: 10.1038/ncb3072
PubMed ID: 25799227
Title: Brain somatic mutations in MTOR cause focal cortical dysplasia type II leading to intractable epilepsy.
PubMed ID: 25799227
DOI: 10.1038/nm.3824
PubMed ID: 25561175
Title: SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.
PubMed ID: 25561175
DOI: 10.1038/nature14107
PubMed ID: 25878179
Title: Hemispheric cortical dysplasia secondary to a mosaic somatic mutation in MTOR.
PubMed ID: 25878179
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 25567906
Title: Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.
PubMed ID: 25567906
PubMed ID: 26812014
Title: WAC regulates mTOR activity by acting as an adaptor for the TTT and Pontin/Reptin complexes.
PubMed ID: 26812014
PubMed ID: 27623384
Title: PIKfyve Regulates Vacuole Maturation and Nutrient Recovery following Engulfment.
PubMed ID: 27623384
PubMed ID: 27830187
Title: Germline and somatic mutations in the MTOR gene in focal cortical dysplasia and epilepsy.
PubMed ID: 27830187
PubMed ID: 29750193
Title: Mammalian EAK-7 activates alternative mTOR signaling to regulate cell proliferation and migration.
PubMed ID: 29750193
PubMed ID: 29150432
Title: The IKK-related kinase TBK1 activates mTORC1 directly in response to growth factors and innate immune agonists.
PubMed ID: 29150432
PubMed ID: 30956113
Title: Transmembrane 4 L six family member 5 senses arginine for mTORC1 signaling.
PubMed ID: 30956113
PubMed ID: 30704899
Title: Pacer is a mediator of mTORC1 and GSK3-TIP60 signaling in regulation of autophagosome maturation and lipid metabolism.
PubMed ID: 30704899
PubMed ID: 31112131
Title: GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor.
PubMed ID: 31112131
DOI: 10.7554/elife.43038
PubMed ID: 31036939
Title: The lysosomal GPCR-like protein GPR137B regulates Rag and mTORC1 localization and activity.
PubMed ID: 31036939
PubMed ID: 31601708
Title: Structural basis for the docking of mTORC1 on the lysosomal surface.
PubMed ID: 31601708
PubMed ID: 33378666
Title: mTORC2 Assembly Is Regulated by USP9X-Mediated Deubiquitination of RICTOR.
PubMed ID: 33378666
PubMed ID: 32612235
Title: A substrate-specific mTORC1 pathway underlies Birt-Hogg-Dube syndrome.
PubMed ID: 32612235
PubMed ID: 32561715
Title: Leucine regulates autophagy via acetylation of the mTORC1 component raptor.
PubMed ID: 32561715
PubMed ID: 32647003
Title: HEM1 deficiency disrupts mTORC2 and F-actin control in inherited immunodysregulatory disease.
PubMed ID: 32647003
PubMed ID: 34289345
Title: Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway.
PubMed ID: 34289345
PubMed ID: 35561222
Title: SNAT7 regulates mTORC1 via macropinocytosis.
PubMed ID: 35561222
PubMed ID: 36691768
Title: TORC1 phosphorylates and inhibits the ribosome preservation factor Stm1 to activate dormant ribosomes.
PubMed ID: 36691768
PubMed ID: 36608670
Title: A central role for regulated protein stability in the control of TFE3 and MITF by nutrients.
PubMed ID: 36608670
PubMed ID: 37751742
Title: Lysosomal cyst(e)ine storage potentiates tolerance to oxidative stress in cancer cells.
PubMed ID: 37751742
PubMed ID: 8662507
Title: Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP.
PubMed ID: 8662507
PubMed ID: 10089303
Title: Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution.
PubMed ID: 10089303
PubMed ID: 20060908
Title: Insights into the domain and repeat architecture of target of rapamycin.
PubMed ID: 20060908
PubMed ID: 20542007
Title: Structure of the human mTOR complex I and its implications for rapamycin inhibition.
PubMed ID: 20542007
PubMed ID: 23636326
Title: mTOR kinase structure, mechanism and regulation.
PubMed ID: 23636326
DOI: 10.1038/nature12122
PubMed ID: 27909983
Title: 4.4 Aa Resolution Cryo-EM structure of human mTOR Complex 1.
PubMed ID: 27909983
PubMed ID: 26678875
PubMed ID: 29236692
Title: Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.
PubMed ID: 29236692
DOI: 10.1038/nature25023
PubMed ID: 31601764
Title: Architecture of human Rag GTPase heterodimers and their complex with mTORC1.
PubMed ID: 31601764
Sequence Information:
- Length: 2549
- Mass: 288892
- Checksum: 7D9AD6E784882AB4
- Sequence:
MLGTGPAAAT TAATTSSNVS VLQQFASGLK SRNEETRAKA AKELQHYVTM ELREMSQEES TRFYDQLNHH IFELVSSSDA NERKGGILAI ASLIGVEGGN ATRIGRFANY LRNLLPSNDP VVMEMASKAI GRLAMAGDTF TAEYVEFEVK RALEWLGADR NEGRRHAAVL VLRELAISVP TFFFQQVQPF FDNIFVAVWD PKQAIREGAV AALRACLILT TQREPKEMQK PQWYRHTFEE AEKGFDETLA KEKGMNRDDR IHGALLILNE LVRISSMEGE RLREEMEEIT QQQLVHDKYC KDLMGFGTKP RHITPFTSFQ AVQPQQSNAL VGLLGYSSHQ GLMGFGTSPS PAKSTLVESR CCRDLMEEKF DQVCQWVLKC RNSKNSLIQM TILNLLPRLA AFRPSAFTDT QYLQDTMNHV LSCVKKEKER TAAFQALGLL SVAVRSEFKV YLPRVLDIIR AALPPKDFAH KRQKAMQVDA TVFTCISMLA RAMGPGIQQD IKELLEPMLA VGLSPALTAV LYDLSRQIPQ LKKDIQDGLL KMLSLVLMHK PLRHPGMPKG LAHQLASPGL TTLPEASDVG SITLALRTLG SFEFEGHSLT QFVRHCADHF LNSEHKEIRM EAARTCSRLL TPSIHLISGH AHVVSQTAVQ VVADVLSKLL VVGITDPDPD IRYCVLASLD ERFDAHLAQA ENLQALFVAL NDQVFEIREL AICTVGRLSS MNPAFVMPFL RKMLIQILTE LEHSGIGRIK EQSARMLGHL VSNAPRLIRP YMEPILKALI LKLKDPDPDP NPGVINNVLA TIGELAQVSG LEMRKWVDEL FIIIMDMLQD SSLLAKRQVA LWTLGQLVAS TGYVVEPYRK YPTLLEVLLN FLKTEQNQGT RREAIRVLGL LGALDPYKHK VNIGMIDQSR DASAVSLSES KSSQDSSDYS TSEMLVNMGN LPLDEFYPAV SMVALMRIFR DQSLSHHHTM VVQAITFIFK SLGLKCVQFL PQVMPTFLNV IRVCDGAIRE FLFQQLGMLV SFVKSHIRPY MDEIVTLMRE FWVMNTSIQS TIILLIEQIV VALGGEFKLY LPQLIPHMLR VFMHDNSPGR IVSIKLLAAI QLFGANLDDY LHLLLPPIVK LFDAPEAPLP SRKAALETVD RLTESLDFTD YASRIIHPIV RTLDQSPELR STAMDTLSSL VFQLGKKYQI FIPMVNKVLV RHRINHQRYD VLICRIVKGY TLADEEEDPL IYQHRMLRSG QGDALASGPV ETGPMKKLHV STINLQKAWG AARRVSKDDW LEWLRRLSLE LLKDSSSPSL RSCWALAQAY NPMARDLFNA AFVSCWSELN EDQQDELIRS IELALTSQDI AEVTQTLLNL AEFMEHSDKG PLPLRDDNGI VLLGERAAKC RAYAKALHYK ELEFQKGPTP AILESLISIN NKLQQPEAAA GVLEYAMKHF GELEIQATWY EKLHEWEDAL VAYDKKMDTN KDDPELMLGR MRCLEALGEW GQLHQQCCEK WTLVNDETQA KMARMAAAAA WGLGQWDSME EYTCMIPRDT HDGAFYRAVL ALHQDLFSLA QQCIDKARDL LDAELTAMAG ESYSRAYGAM VSCHMLSELE EVIQYKLVPE RREIIRQIWW ERLQGCQRIV EDWQKILMVR SLVVSPHEDM RTWLKYASLC GKSGRLALAH KTLVLLLGVD PSRQLDHPLP TVHPQVTYAY MKNMWKSARK IDAFQHMQHF VQTMQQQAQH AIATEDQQHK QELHKLMARC FLKLGEWQLN LQGINESTIP KVLQYYSAAT EHDRSWYKAW HAWAVMNFEA VLHYKHQNQA RDEKKKLRHA SGANITNATT AATTAATATT TASTEGSNSE SEAESTENSP TPSPLQKKVT EDLSKTLLMY TVPAVQGFFR SISLSRGNNL QDTLRVLTLW FDYGHWPDVN EALVEGVKAI QIDTWLQVIP QLIARIDTPR PLVGRLIHQL LTDIGRYHPQ ALIYPLTVAS KSTTTARHNA ANKILKNMCE HSNTLVQQAM MVSEELIRVA ILWHEMWHEG LEEASRLYFG ERNVKGMFEV LEPLHAMMER GPQTLKETSF NQAYGRDLME AQEWCRKYMK SGNVKDLTQA WDLYYHVFRR ISKQLPQLTS LELQYVSPKL LMCRDLELAV PGTYDPNQPI IRIQSIAPSL QVITSKQRPR KLTLMGSNGH EFVFLLKGHE DLRQDERVMQ LFGLVNTLLA NDPTSLRKNL SIQRYAVIPL STNSGLIGWV PHCDTLHALI RDYREKKKIL LNIEHRIMLR MAPDYDHLTL MQKVEVFEHA VNNTAGDDLA KLLWLKSPSS EVWFDRRTNY TRSLAVMSMV GYILGLGDRH PSNLMLDRLS GKILHIDFGD CFEVAMTREK FPEKIPFRLT RMLTNAMEVT GLDGNYRITC HTVMEVLREH KDSVMAVLEA FVYDPLLNWR LMDTNTKGNK RSRTRTDSYS AGQSVEILDG VELGEPAHKK TGTTVPESIH SFIGDGLVKP EALNKKAIQI INRVRDKLTG RDFSHDDTLD VPTQVELLIK QATSHENLCQ CYIGWCPFW
Genular Protein ID: 3439601957
Symbol: A0A8V8TQ52_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
Sequence Information:
- Length: 1590
- Mass: 178743
- Checksum: 2FE43AC7D0819C22
- Sequence:
MLGTGPAAAT TAATTSSNVS VLQQFASGLK SRNEETRAKA AKELQHYVTM ELREMSQEES TRFYDQLNHH IFELVSSSDA NERKGGILAI ASLIGVEGGN ATRIGRFANY LRNLLPSNDP VVMEMASKAI GRLAMAGDTF TAEYVEFEVK RALEWLGADR NEGRRHAAVL VLRELAISVP TFFFQQVQPF FDNIFVAVWD PKQAIREGAV AALRACLILT TQREPKEMQK PQWYRHTFEE AEKGFDETLA KEKGMNRDDR IHGALLILNE LVRISSMEGE RLREEMEEIT QQQLVHDKYC KDLMGFGTKP RHITPFTSFQ AVQPQQSNAL VGLLGYSSHQ GLMGFGTSPS PAKSTLVESR CCRDLMEEKF DQVCQWVLKC RNSKNSLIQM TILNLLPRLA AFRPSAFTDT QYLQDTMNHV LSCVKKEKER TAAFQALGLL SVAVRSEFKV YLPRVLDIIR AALPPKDFAH KRQKAMQVDA TVFTCISMLA RAMGPGIQQD IKELLEPMLA VGLSPALTAV LYDLSRQIPQ LKKDIQDGLL KMLSLVLMHK PLRHPGMPKG LAHQLASPGL TTLPEASDVG SITLALRTLG SFEFEGHSLT QFVRHCADHF LNSEHKEIRM EAARTCSRLL TPSIHLISGH AHVVSQTAVQ VVADVLSKLL VVGITDPDPD IRYCVLASLD ERFDAHLAQA ENLQALFVAL NDQVFEIREL AICTVGRLSS MNPAFVMPFL RKMLIQILTE LEHSGIGRIK EQSARMLGHL VSNAPRLIRP YMEPILKALI LKLKDPDPDP NPGVINNVLA TIGELAQVSG LEMRKWVDEL FIIIMDMLQD SSLLAKRQVA LWTLGQLVAS TGYVVEPYRK YPTLLEVLLN FLKTEQNQGT RREAIRVLGL LGALDPYKHK VNIGMIDQSR DASAVSLSES KSSQDSSDYS TSEMLVNMGN LPLDEFYPAV SMVALMRIFR DQSLSHHHTM VVQAITFIFK SLGLKCVQFL PQVMPTFLNV IRVCDGAIRE FLFQQLGMLV SFVKSHIRPY MDEIVTLMRE FWVMNTSIQS TIILLIEQIV VALGGEFKLY LPQLIPHMLR VFMHDNSPGR IVSIKLLAAI QLFGANLDDY LHLLLPPIVK LFDAPEAPLP SRKAALETVD RLTESLDFTD YASRIIHPIV RTLDQSPELR STAMDTLSSL VFQLGKKYQI FIPMVNKVLV RHRINHQRYD VLICRIVKGY TLADEEEDPL IYQHRMLRSG QGDALASGPV ETGPMKKLHV STINLQKAWG AARRVSKDDW LEWLRRLSLE LLKDSSSPSL RSCWALAQAY NPMARDLFNA AFVSCWSELN EDQQDELIRS IELALTSQDI AEVTQTLLNL AEFMEHSDKG PLPLRDDNGI VLLGERAAKC RAYAKALHYK ELEFQKGPTP AILESLISIN NKLQQPEAAA GVLEYAMKHF GELEIQATWY EKLHEWEDAL VAYDKKMDTN KDDPELMLGR MRCLEALGEW GQLHQQCCEK WTLVNDETQA KMARMAAAAA WGLGQWDSME EYTCMIPRDT HDGAFYRAVL ALHQDLFSLA QQCIDKARDL LDAELTAMAG ESYSRAYGIP
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.