Details for: FUT1

Gene ID: 2523

Symbol: FUT1

Ensembl ID: ENSG00000174951

Description: fucosyltransferase 1 (H blood group)

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 2.52
    Marker Score: 3616.5
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 865
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.08
    Marker Score: 787
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.03
    Marker Score: 1945.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71822
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48046
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 504
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5286
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.79
    Marker Score: 365
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1258
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 697
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 556
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.7
    Marker Score: 280
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.65
    Marker Score: 2731
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.61
    Marker Score: 876
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.56
    Marker Score: 1427
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.56
    Marker Score: 369
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.56
    Marker Score: 174
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.53
    Marker Score: 336
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.43
    Marker Score: 880
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.43
    Marker Score: 154
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.41
    Marker Score: 170
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.4
    Marker Score: 251
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.37
    Marker Score: 791
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.37
    Marker Score: 118
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 368
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.36
    Marker Score: 342
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.36
    Marker Score: 350
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.35
    Marker Score: 789
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.34
    Marker Score: 338
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.32
    Marker Score: 336
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.32
    Marker Score: 131
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.31
    Marker Score: 210
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.3
    Marker Score: 271
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.3
    Marker Score: 94
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.29
    Marker Score: 180
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.28
    Marker Score: 4379
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.28
    Marker Score: 209
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.28
    Marker Score: 400
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.28
    Marker Score: 296
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.27
    Marker Score: 71
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.27
    Marker Score: 293
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.26
    Marker Score: 126
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 89
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.24
    Marker Score: 208
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.23
    Marker Score: 229
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.22
    Marker Score: 72
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.22
    Marker Score: 436
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.22
    Marker Score: 52
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.21
    Marker Score: 141
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.21
    Marker Score: 205
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.2
    Marker Score: 115
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.2
    Marker Score: 43
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.2
    Marker Score: 53
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.2
    Marker Score: 86
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.19
    Marker Score: 137
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.19
    Marker Score: 175
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.19
    Marker Score: 241
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.19
    Marker Score: 112
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.19
    Marker Score: 112
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.19
    Marker Score: 47
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.16
    Marker Score: 165
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.16
    Marker Score: 37
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.16
    Marker Score: 79
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.16
    Marker Score: 155
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.15
    Marker Score: 193
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.15
    Marker Score: 37
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.15
    Marker Score: 102
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.14
    Marker Score: 60
  • Cell Name: parietal cell (CL0000162)
    Fold Change: 0.14
    Marker Score: 40
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.14
    Marker Score: 242
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.14
    Marker Score: 95
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.14
    Marker Score: 59
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.14
    Marker Score: 142
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.13
    Marker Score: 65
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.13
    Marker Score: 1808
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.13
    Marker Score: 54
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.13
    Marker Score: 34
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.13
    Marker Score: 58
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.13
    Marker Score: 940
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.12
    Marker Score: 42
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.12
    Marker Score: 29
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.12
    Marker Score: 28
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.12
    Marker Score: 46
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.12
    Marker Score: 348
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.12
    Marker Score: 220
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.12
    Marker Score: 120
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.12
    Marker Score: 29
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.12
    Marker Score: 36

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * The FUT1 gene is located on chromosome 15q26.2. * It is a large gene with a length of approximately 10.8 kb. * The protein encoded by FUT1 is a transmembrane protein with a molecular weight of approximately 140 kDa. * It is expressed in a variety of cell types, including respiratory cells, immune cells, and endothelial cells. **Pathways and functions:** * The FUT1 gene is involved in the biosynthesis of galactofuranose, a sugar that is an intermediate in the synthesis of blood group antigens. * It also plays a role in the regulation of endothelial cell migration and proliferation. * Defects in the FUT1 gene can lead to the formation of abnormal blood group substances, which can cause blood transfusions and other medical problems. **Clinical significance:** * Mutations in the FUT1 gene have been linked to the inheritance of blood group phenotypes. * These mutations can cause the production of abnormal blood group antigens, which can lead to blood transfusions and other medical problems. * Prenatal screening for FUT1 mutations is available to prevent these disorders. **Additional notes:** * The FUT1 gene is also involved in the regulation of cell-matrix adhesion and the migration of immune cells. * It is a key regulator of angiogenesis, the process by which new blood vessels form. * Mutations in the FUT1 gene have been linked to the development of several types of cancer.

Genular Protein ID: 2929264501

Symbol: FUT1_HUMAN

Name: Alpha(1,2)FT 1

UniProtKB Accession Codes:

P19526 O14505 O14506 O14507

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CDD 1 CTD 1 ChEBI 30 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 2 EMBL 8 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 21 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 2 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 3 Rhea 11 SABIO-RK 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UniPathway 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2118655

Title: Molecular cloning, sequence, and expression of a human GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase cDNA that can form the H blood group antigen.

PubMed ID: 2118655

DOI: 10.1073/pnas.87.17.6674

PubMed ID: 9122901

Title: Polymorphism of the h allele and the population frequency of sporadic nonfunctional alleles.

PubMed ID: 9122901

DOI: 10.1046/j.1537-2995.1997.37397240210.x

PubMed ID: 9226185

Title: Wide variety of point mutations in the H gene of Bombay and para-Bombay individuals which inactivate H enzyme.

PubMed ID: 9226185

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18205178

Title: Involvement of alpha 1-2-fucosyltransferase I (FUT1) and surface-expressed Lewis(y) (CD174) in first endothelial cell-cell contacts during angiogenesis.

PubMed ID: 18205178

DOI: 10.1002/jcp.21285

PubMed ID: 7912436

Title: Molecular basis for H blood group deficiency in Bombay (Oh) and para-Bombay individuals.

PubMed ID: 7912436

DOI: 10.1073/pnas.91.13.5843

PubMed ID: 9299444

Title: Missense mutation of FUT1 and deletion of FUT2 are responsible for Indian Bombay phenotype of ABO blood group system.

PubMed ID: 9299444

DOI: 10.1006/bbrc.1997.7232

Sequence Information:

  • Length: 365
  • Mass: 41251
  • Checksum: 4F4442EC375C9D9E
  • Sequence:
    • MWLRSHRQLC LAFLLVCVLS VIFFLHIHQD SFPHGLGLSI LCPDRRLVTP PVAIFCLPGT 
AMGPNASSSC PQHPASLSGT WTVYPNGRFG NQMGQYATLL ALAQLNGRRA FILPAMHAAL 
APVFRITLPV LAPEVDSRTP WRELQLHDWM SEEYADLRDP FLKLSGFPCS WTFFHHLREQ 
IRREFTLHDH LREEAQSVLG QLRLGRTGDR PRTFVGVHVR RGDYLQVMPQ RWKGVVGDSA 
YLRQAMDWFR ARHEAPVFVV TSNGMEWCKE NIDTSQGDVT FAGDGQEATP WKDFALLTQC 
NHTIMTIGTF GFWAAYLAGG DTVYLANFTL PDSEFLKIFK PEAAFLPEWV GINADLSPLW 
TLAKP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.