Details for: FUT1

Gene ID: 2523

Symbol: FUT1

Ensembl ID: ENSG00000174951

Description: fucosyltransferase 1 (H blood group)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 14.7845
    Cell Significance Index: -3.7500
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 7.9720
    Cell Significance Index: -1.2400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 2.8630
    Cell Significance Index: -3.5300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.6084
    Cell Significance Index: 51.5200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.5923
    Cell Significance Index: 12.9700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5550
    Cell Significance Index: 54.9100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.5438
    Cell Significance Index: 63.3700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.4940
    Cell Significance Index: 8.1400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4577
    Cell Significance Index: 413.3100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.3595
    Cell Significance Index: 5.2400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3374
    Cell Significance Index: 36.7000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3175
    Cell Significance Index: 19.0600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2936
    Cell Significance Index: 47.7600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2573
    Cell Significance Index: 3.5100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1835
    Cell Significance Index: 12.6900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1715
    Cell Significance Index: 4.9400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1620
    Cell Significance Index: 1.8400
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.1501
    Cell Significance Index: 1.2700
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: 0.1409
    Cell Significance Index: 1.9300
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.1377
    Cell Significance Index: 1.1700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.1130
    Cell Significance Index: 70.5400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1052
    Cell Significance Index: 2.2800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1005
    Cell Significance Index: 3.5300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0922
    Cell Significance Index: 17.5400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0885
    Cell Significance Index: 1.2600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0841
    Cell Significance Index: 2.2500
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.0567
    Cell Significance Index: 0.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0559
    Cell Significance Index: 11.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0527
    Cell Significance Index: 9.0000
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.0456
    Cell Significance Index: 0.1700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0447
    Cell Significance Index: 5.5000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0287
    Cell Significance Index: 1.4900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0278
    Cell Significance Index: 7.9900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0231
    Cell Significance Index: 0.4800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0207
    Cell Significance Index: 11.3200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0192
    Cell Significance Index: 3.4600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0160
    Cell Significance Index: 0.2300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0150
    Cell Significance Index: 0.3200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0143
    Cell Significance Index: 0.3900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0135
    Cell Significance Index: 5.9700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0080
    Cell Significance Index: 0.2000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0025
    Cell Significance Index: 0.9100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0002
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0010
    Cell Significance Index: -0.7200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0013
    Cell Significance Index: -0.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0017
    Cell Significance Index: -3.2100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0020
    Cell Significance Index: -0.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0023
    Cell Significance Index: -4.2500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0025
    Cell Significance Index: -3.8700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0028
    Cell Significance Index: -0.3200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0029
    Cell Significance Index: -1.6300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0033
    Cell Significance Index: -4.5100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0036
    Cell Significance Index: -2.7000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0044
    Cell Significance Index: -3.2200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0046
    Cell Significance Index: -0.2800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0056
    Cell Significance Index: -3.5500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0081
    Cell Significance Index: -1.7100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0102
    Cell Significance Index: -4.6300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0119
    Cell Significance Index: -0.1700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0124
    Cell Significance Index: -2.4600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0158
    Cell Significance Index: -0.2700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0195
    Cell Significance Index: -2.0000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0215
    Cell Significance Index: -0.3800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0224
    Cell Significance Index: -3.2600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0233
    Cell Significance Index: -0.6500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0245
    Cell Significance Index: -3.1700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0248
    Cell Significance Index: -0.1500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0265
    Cell Significance Index: -3.6400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0274
    Cell Significance Index: -2.0400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0323
    Cell Significance Index: -1.6800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0360
    Cell Significance Index: -1.0600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0372
    Cell Significance Index: -2.6300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0374
    Cell Significance Index: -2.3600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0413
    Cell Significance Index: -2.0900
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: -0.0414
    Cell Significance Index: -0.3000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0438
    Cell Significance Index: -0.6600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0443
    Cell Significance Index: -1.8100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0482
    Cell Significance Index: -3.7000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0510
    Cell Significance Index: -2.4000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0519
    Cell Significance Index: -3.1900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0541
    Cell Significance Index: -1.3100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0544
    Cell Significance Index: -3.6600
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.0545
    Cell Significance Index: -0.6200
  • Cell Name: duodenum glandular cell (CL1001589)
    Fold Change: -0.0551
    Cell Significance Index: -0.4000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0591
    Cell Significance Index: -3.8200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0597
    Cell Significance Index: -1.5700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0648
    Cell Significance Index: -3.4000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0690
    Cell Significance Index: -3.0000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0692
    Cell Significance Index: -3.8900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0702
    Cell Significance Index: -1.8800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0861
    Cell Significance Index: -2.1500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0880
    Cell Significance Index: -1.2600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0883
    Cell Significance Index: -3.2400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0922
    Cell Significance Index: -4.0800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0956
    Cell Significance Index: -3.1300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0968
    Cell Significance Index: -1.7900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0992
    Cell Significance Index: -3.1600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0993
    Cell Significance Index: -3.4800
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.0999
    Cell Significance Index: -1.1400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1004
    Cell Significance Index: -2.6800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** FUT1 is a member of the Fucosyltransferase family, which is responsible for the transfer of fucose moieties to specific glycoproteins and glycolipids. The gene is characterized by its ability to catalyze the formation of the ABO blood group antigens, which are critical for the proper functioning of the immune system. FUT1 is also involved in the regulation of cell adhesion, migration, and proliferation, making it a key player in various physiological and pathological processes. One of the unique characteristics of FUT1 is its ability to recognize and bind to specific substrates, including glycoproteins and glycolipids. This specificity is crucial for the proper functioning of the immune system and the maintenance of tissue homeostasis. Additionally, FUT1 is highly expressed in certain tissues, such as the respiratory tract and immune cells, where it plays a critical role in the regulation of immune responses. **Pathways and Functions** FUT1 is involved in several key pathways, including: 1. **ABO Blood Group Biosynthesis**: FUT1 is responsible for the transfer of fucose moieties to specific glycoproteins and glycolipids, which is essential for the formation of the ABO blood group antigens. 2. **Cell Adhesion**: FUT1 regulates cell adhesion by modifying the glycosylation pattern of cell surface proteins, which is critical for the proper functioning of the immune system. 3. **Immune Response**: FUT1 is involved in the regulation of immune responses by modifying the glycosylation pattern of immune cells and their surface proteins. 4. **Glycosylation**: FUT1 is involved in the transfer of fucose moieties to specific glycoproteins and glycolipids, which is essential for the proper functioning of the immune system and the maintenance of tissue homeostasis. 5. **Sphingolipid Metabolism**: FUT1 is involved in the regulation of sphingolipid metabolism by modifying the glycosylation pattern of sphingolipids. **Clinical Significance** FUT1 has been linked to several diseases, including: 1. **Cancer**: Abnormal expression or activity of FUT1 has been observed in various types of cancer, including colorectal, breast, and lung cancer. 2. **Autoimmune Disorders**: FUT1 has been linked to several autoimmune disorders, including rheumatoid arthritis, lupus, and multiple sclerosis. 3. **Cardiovascular Diseases**: FUT1 has been linked to cardiovascular diseases, including atherosclerosis and cardiac arrhythmias. 4. **Gastrointestinal Diseases**: FUT1 has been linked to gastrointestinal diseases, including inflammatory bowel disease and colon cancer. In conclusion, FUT1 is a critical gene that plays a key role in the biosynthesis of the ABO blood group antigens and the regulation of immune responses. Its abnormal expression or activity has been linked to several diseases, highlighting the importance of FUT1 in maintaining tissue homeostasis and preventing disease. Further research is needed to fully understand the role of FUT1 in human disease and to develop therapeutic strategies to target this gene.

Genular Protein ID: 2929264501

Symbol: FUT1_HUMAN

Name: Alpha(1,2)FT 1

UniProtKB Accession Codes:

P19526 O14505 O14506 O14507

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CDD 1 CTD 1 ChEBI 30 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 2 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 21 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 2 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 3 Rhea 11 SABIO-RK 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2118655

Title: Molecular cloning, sequence, and expression of a human GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase cDNA that can form the H blood group antigen.

PubMed ID: 2118655

DOI: 10.1073/pnas.87.17.6674

PubMed ID: 9122901

Title: Polymorphism of the h allele and the population frequency of sporadic nonfunctional alleles.

PubMed ID: 9122901

DOI: 10.1046/j.1537-2995.1997.37397240210.x

PubMed ID: 9226185

Title: Wide variety of point mutations in the H gene of Bombay and para-Bombay individuals which inactivate H enzyme.

PubMed ID: 9226185

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18205178

Title: Involvement of alpha 1-2-fucosyltransferase I (FUT1) and surface-expressed Lewis(y) (CD174) in first endothelial cell-cell contacts during angiogenesis.

PubMed ID: 18205178

DOI: 10.1002/jcp.21285

PubMed ID: 7912436

Title: Molecular basis for H blood group deficiency in Bombay (Oh) and para-Bombay individuals.

PubMed ID: 7912436

DOI: 10.1073/pnas.91.13.5843

PubMed ID: 9299444

Title: Missense mutation of FUT1 and deletion of FUT2 are responsible for Indian Bombay phenotype of ABO blood group system.

PubMed ID: 9299444

DOI: 10.1006/bbrc.1997.7232

Sequence Information:

  • Length: 365
  • Mass: 41251
  • Checksum: 4F4442EC375C9D9E
  • Sequence:
    • MWLRSHRQLC LAFLLVCVLS VIFFLHIHQD SFPHGLGLSI LCPDRRLVTP PVAIFCLPGT 
AMGPNASSSC PQHPASLSGT WTVYPNGRFG NQMGQYATLL ALAQLNGRRA FILPAMHAAL 
APVFRITLPV LAPEVDSRTP WRELQLHDWM SEEYADLRDP FLKLSGFPCS WTFFHHLREQ 
IRREFTLHDH LREEAQSVLG QLRLGRTGDR PRTFVGVHVR RGDYLQVMPQ RWKGVVGDSA 
YLRQAMDWFR ARHEAPVFVV TSNGMEWCKE NIDTSQGDVT FAGDGQEATP WKDFALLTQC 
NHTIMTIGTF GFWAAYLAGG DTVYLANFTL PDSEFLKIFK PEAAFLPEWV GINADLSPLW 
TLAKP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.