Details for: SLC37A4

Gene ID: 2542

Symbol: SLC37A4

Ensembl ID: ENSG00000137700

Description: solute carrier family 37 member 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.67
    Marker Score: 2573
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.62
    Marker Score: 1683
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.49
    Marker Score: 995
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.38
    Marker Score: 6613
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.38
    Marker Score: 555
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.22
    Marker Score: 1086
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.2
    Marker Score: 4262
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.2
    Marker Score: 2820
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.18
    Marker Score: 883
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.11
    Marker Score: 1157
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.08
    Marker Score: 2262
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.08
    Marker Score: 2556
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.07
    Marker Score: 1134
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71776
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48001
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30404
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 488
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 442
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5305
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.91
    Marker Score: 614
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.89
    Marker Score: 3838
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.88
    Marker Score: 2773
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.87
    Marker Score: 1415
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 312
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.87
    Marker Score: 326
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.86
    Marker Score: 208
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.84
    Marker Score: 3287
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.79
    Marker Score: 185
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.77
    Marker Score: 1070
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.76
    Marker Score: 1292
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 578
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.74
    Marker Score: 189
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 380.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.72
    Marker Score: 290
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 459
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.72
    Marker Score: 702
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 651
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.71
    Marker Score: 204
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.7
    Marker Score: 882
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.69
    Marker Score: 380.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.66
    Marker Score: 659
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.63
    Marker Score: 2662
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.62
    Marker Score: 341
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.62
    Marker Score: 3326
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.62
    Marker Score: 1305
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.61
    Marker Score: 303
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.59
    Marker Score: 739.5
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.58
    Marker Score: 3738
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.56
    Marker Score: 529
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.55
    Marker Score: 159
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.54
    Marker Score: 862.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 431
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.54
    Marker Score: 18649
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.53
    Marker Score: 758
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.53
    Marker Score: 562
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.52
    Marker Score: 168
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.52
    Marker Score: 1188
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.51
    Marker Score: 342
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.5
    Marker Score: 143
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5
    Marker Score: 123
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.49
    Marker Score: 183
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.49
    Marker Score: 335
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.49
    Marker Score: 1115
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.49
    Marker Score: 183
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.48
    Marker Score: 282
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.48
    Marker Score: 107
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 0.47
    Marker Score: 267
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.47
    Marker Score: 377
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.47
    Marker Score: 175
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.47
    Marker Score: 621
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.47
    Marker Score: 146
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.46
    Marker Score: 123
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.45
    Marker Score: 489
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.45
    Marker Score: 118
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.45
    Marker Score: 185
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.44
    Marker Score: 181
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.44
    Marker Score: 727
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.43
    Marker Score: 187
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.43
    Marker Score: 1170
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.42
    Marker Score: 623
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.42
    Marker Score: 1130
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.42
    Marker Score: 954
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.42
    Marker Score: 176
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.41
    Marker Score: 1126.5
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.41
    Marker Score: 659
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.41
    Marker Score: 80
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.41
    Marker Score: 431
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.41
    Marker Score: 391
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.4
    Marker Score: 1653
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.4
    Marker Score: 216
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.4
    Marker Score: 87
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.4
    Marker Score: 392
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.39
    Marker Score: 965.5
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.39
    Marker Score: 989
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.39
    Marker Score: 180
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.39
    Marker Score: 206

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Other Information

**Key characteristics:** - SLC37A4 is a member of the solute carrier family 37, which is involved in the transport of organic anions across biological membranes. - It is a type of glucose transporter, which is responsible for the transport of glucose into cells. - It is expressed in high levels in the colon, where it is involved in the absorption of glucose from the lumen of the intestine. - It is also expressed in the pancreas, kidney, and extravillous trophoblast, where it is involved in the transport of glucose into cells. **Pathways and functions:** - SLC37A4 is involved in the following pathways: - Carbohydrate transport - Endoplasmic reticulum - Endoplasmic reticulum membrane - Gluconeogenesis - Glucose-6-phosphate transport - Glucose metabolic process - It is responsible for the transport of glucose into cells, where it is used for energy. - It is also involved in the regulation of blood glucose levels. **Clinical significance:** - Mutations in SLC37A4 have been linked to several human diseases, including glucose-6-phosphate dehydrogenase deficiency, which is an inherited disorder characterized by low levels of glucose-6-phosphate dehydrogenase, an enzyme involved in the metabolism of glucose. - SLC37A4 inhibitors are being investigated as potential treatments for these diseases.

Genular Protein ID: 4253170008

Symbol: G6PT1_HUMAN

Name: Glucose-5-phosphate transporter

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9428641

Title: Sequence of a putative glucose 6-phosphate translocase, mutated in glycogen storage disease type Ib.

PubMed ID: 9428641

DOI: 10.1016/s0014-5793(97)01463-4

PubMed ID: 9856496

Title: Genomic structure of the human glucose 6-phosphate translocase gene and novel mutations in the gene of a Japanese patient with glycogen storage disease type Ib.

PubMed ID: 9856496

DOI: 10.1007/s004390050856

PubMed ID: 10026167

Title: Inactivation of the glucose 6-phosphate transporter causes glycogen storage disease type 1b.

PubMed ID: 10026167

DOI: 10.1074/jbc.274.9.5532

PubMed ID: 10023055

Title: Structure of the gene mutated in glycogen storage disease type Ib.

PubMed ID: 10023055

DOI: 10.1016/s0378-1119(98)00614-3

PubMed ID: 10323254

Title: Molecular diagnosis of type 1c glycogen storage disease.

PubMed ID: 10323254

DOI: 10.1007/s004390050948

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21949678

Title: SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate antiporters.

PubMed ID: 21949678

DOI: 10.1371/journal.pone.0023157

PubMed ID: 11949931

Title: Type I glycogen storage diseases: disorders of the glucose-6-phosphatase complex.

PubMed ID: 11949931

DOI: 10.2174/1566524024605798

PubMed ID: 9758626

Title: A gene on chromosome 11q23 coding for a putative glucose-6-phosphate translocase is mutated in glycogen-storage disease types Ib and Ic.

PubMed ID: 9758626

DOI: 10.1086/302068

PubMed ID: 9781688

Title: Structure and mutation analysis of the glycogen storage disease type 1b gene.

PubMed ID: 9781688

DOI: 10.1016/s0014-5793(98)01129-6

PubMed ID: 10482962

Title: The putative glucose 6-phosphate translocase gene is mutated in essentially all cases of glycogen storage disease type I non-a.

PubMed ID: 10482962

DOI: 10.1038/sj.ejhg.5200366

PubMed ID: 10518030

Title: Mutations in the glucose-6-phosphate transporter (G6PT) gene in patients with glycogen storage diseases type 1b and 1c.

PubMed ID: 10518030

DOI: 10.1016/s0014-5793(99)01248-x

PubMed ID: 9675154

Title: Molecular analysis of glycogen storage disease type Ib: identification of a prevalent mutation among Japanese patients and assignment of a putative glucose-6-phosphate translocase gene to chromosome 11.

PubMed ID: 9675154

DOI: 10.1006/bbrc.1998.8985

PubMed ID: 10482875

Title: Glycogen storage disease type Ib: structural and mutational analysis of the microsomal glucose-6-phosphate transporter gene.

PubMed ID: 10482875

DOI: 10.1002/(sici)1096-8628(19990917)86:3<253::aid-ajmg11>3.0.co;2-7

PubMed ID: 11071391

Title: Mutation analysis in glycogen storage disease type 1 non-a.

PubMed ID: 11071391

DOI: 10.1007/s004390000371

PubMed ID: 10874322

Title: A novel missense mutation (P191L) in the glucose-6-phosphate translocase gene identified in a Chinese family with glycogen storage disease 1b.

PubMed ID: 10874322

DOI: 10.1002/1098-1004(200007)16:1<94::aid-humu26>3.0.co;2-q

PubMed ID: 10923042

Title: Molecular analysis in glycogen storage disease 1 non-A: DHPLC detection of the highly prevalent exon 8 mutations of the G6PT1 gene in German patients.

PubMed ID: 10923042

DOI: 10.1002/1098-1004(200008)16:2<177::aid-humu13>3.0.co;2-8

PubMed ID: 10931421

Title: Glycogen storage disease type Ib without neutropenia.

PubMed ID: 10931421

DOI: 10.1067/mpd.2000.107472

PubMed ID: 12409273

Title: Novel missense mutation (Y24H) in the G6PT1 gene causing glycogen storage disease type 1b.

PubMed ID: 12409273

DOI: 10.1016/s1096-7192(02)00110-5

PubMed ID: 15669677

Title: Allelic heterogeneity of glycogen storage disease type Ib in French patients: a study of 11 cases.

PubMed ID: 15669677

DOI: 10.1023/b:boli.0000042987.43395.c6

PubMed ID: 15059622

Title: Genetic testing of glycogen storage disease type Ib in Japan: five novel G6PT1 mutations and a rapid detection method for a prevalent mutation W118R.

PubMed ID: 15059622

DOI: 10.1016/j.ymgme.2003.12.004

PubMed ID: 15953877

Title: A novel mutation (A148V) in the glucose 6-phosphate translocase (SLC37A4) gene in a Korean patient with glycogen storage disease type 1b.

PubMed ID: 15953877

DOI: 10.3346/jkms.2005.20.3.499

PubMed ID: 19579760

Title: Glycogen storage disease type Ib: the first case in Taiwan.

PubMed ID: 19579760

DOI: 10.1016/s1875-9572(09)60048-6

PubMed ID: 21629566

Title: A novel mutation in SLC37A4 gene in a Sri Lankan boy with glycogen storage disease type Ib associated with very early onset neutropenia.

PubMed ID: 21629566

DOI: 10.4172/1747-0862.1000046

PubMed ID: 32884905

Title: SLC37A4-CDG: Mislocalization of the glucose-6-phosphate transporter to the Golgi causes a new congenital disorder of glycosylation.

PubMed ID: 32884905

DOI: 10.1016/j.ymgmr.2020.100636

PubMed ID: 33964207

Title: A mutation in SLC37A4 causes a dominantly inherited congenital disorder of glycosylation characterized by liver dysfunction.

PubMed ID: 33964207

DOI: 10.1016/j.ajhg.2021.04.013

PubMed ID: 33728255

Title: SLC37A4-CDG: Second patient.

PubMed ID: 33728255

DOI: 10.1002/jmd2.12195

Sequence Information:

  • Length: 429
  • Mass: 46360
  • Checksum: C0399332FE72694B
  • Sequence:
  • MAAQGYGYYR TVIFSAMFGG YSLYYFNRKT FSFVMPSLVE EIPLDKDDLG FITSSQSAAY 
    AISKFVSGVL SDQMSARWLF SSGLLLVGLV NIFFAWSSTV PVFAALWFLN GLAQGLGWPP 
    CGKVLRKWFE PSQFGTWWAI LSTSMNLAGG LGPILATILA QSYSWRSTLA LSGALCVVVS 
    FLCLLLIHNE PADVGLRNLD PMPSEGKKGS LKEESTLQEL LLSPYLWVLS TGYLVVFGVK 
    TCCTDWGQFF LIQEKGQSAL VGSSYMSALE VGGLVGSIAA GYLSDRAMAK AGLSNYGNPR 
    HGLLLFMMAG MTVSMYLFRV TVTSDSPKLW ILVLGAVFGF SSYGPIALFG VIANESAPPN 
    LCGTSHAIVG LMANVGGFLA GLPFSTIAKH YSWSTAFWVA EVICAASTAA FFLLRNIRTK 
    MGRVSKKAE

Genular Protein ID: 3878422

Symbol: A8K0S7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 428
  • Mass: 46273
  • Checksum: D7B6136B0FDB521F
  • Sequence:
  • MAAQGYGYYR TVIFSAMFGG YSLYYFNRKT FSFVMPSLVE EIPLDKDDLG FITSSQSAAY 
    AISKFVSGVL SDQMSARWLF SSGLLLVGLV NIFFAWSSTV PVFAALWFLN GLAQGLGWPP 
    CGKVLRKWFE PSQFGTWWAI LSTSMNLAGG LGPILATILA QSYSWRSTLA LSGALCVVVS 
    FLCLLLIHNE PADVGLRNLD PMPSEGKKGS LKEESTLQEL LLSPYLWVLS TGYLVVFGVK 
    TCCTDWGQFF LIQEKGQSAL VGSSYMSALE VGGLVGSIAA GYLSDRAMAK AGLSNYGNPR 
    HGLLLFMMAG MTVSMYLFRV TVTSDSPKLW ILVLGAVFGF SSYGPIALFG VIANESAPPN 
    LCGTSHAIVG LMANVGGFLA GLPFSTIAKH YSWSTAFWVA EVICAATAAF FLLRNIRTKM 
    GRVSKKAE

Genular Protein ID: 1979311634

Symbol: B4DUH2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 356
  • Mass: 38229
  • Checksum: F8709A95C038C872
  • Sequence:
  • MSARWLFSSG LLLVGLVNIF FAWSSTVPVF AALWFLNGLA QGLGWPPCGK VLRKWFEPSQ 
    FGTWWAILST SMNLAGGLGP ILATILAQSY SWRSTLALSG ALCVVVSFLC LLLIHNEPAD 
    VGLRNLDPMP SEGKKGSLKE ESTLQELLLS PYLWVLSTGY LVVFGVKTCC TDWGQFFLIQ 
    EKGQSALVGS SYMSALEVGG LVGSIAAGYL SDRAMAKAGL SNYGNPRHGL LLFMMAGMTV 
    SMYLFRVTVT SDSPKLWILV LGAVFGFSSY GPIALFGVIA NESAPPNLCG TSHAIVGLMA 
    NVGGFLAGLP FSTIAKHYSW STAFWVAEVI CAASTAAFFL LRNIRTKMGR VSKKAE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.