Details for: KLK5

Gene ID: 25818

Symbol: KLK5

Ensembl ID: ENSG00000167754

Description: kallikrein related peptidase 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 12.7877
    Cell Significance Index: 84.8900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 4.1912
    Cell Significance Index: 81.9500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.1622
    Cell Significance Index: -2.5400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.9475
    Cell Significance Index: 122.4100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.5553
    Cell Significance Index: 13.4500
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: 0.5186
    Cell Significance Index: 6.4400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4955
    Cell Significance Index: 219.0900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4855
    Cell Significance Index: 22.8200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4055
    Cell Significance Index: 28.6800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1913
    Cell Significance Index: 2.7200
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.1312
    Cell Significance Index: 0.3000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1060
    Cell Significance Index: 73.3100
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.0512
    Cell Significance Index: 0.4400
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.0435
    Cell Significance Index: 0.5600
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.0311
    Cell Significance Index: 0.4300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0019
    Cell Significance Index: -0.3800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0032
    Cell Significance Index: -0.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0041
    Cell Significance Index: -7.6300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0076
    Cell Significance Index: -14.0500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0092
    Cell Significance Index: -6.7700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0100
    Cell Significance Index: -6.3300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0106
    Cell Significance Index: -16.2800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0123
    Cell Significance Index: -9.1400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0123
    Cell Significance Index: -16.7100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0127
    Cell Significance Index: -6.9400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0136
    Cell Significance Index: -0.3400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0155
    Cell Significance Index: -5.5500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0155
    Cell Significance Index: -11.7400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0163
    Cell Significance Index: -9.1800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0196
    Cell Significance Index: -8.9000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0227
    Cell Significance Index: -1.6900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0283
    Cell Significance Index: -8.1300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0308
    Cell Significance Index: -0.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0370
    Cell Significance Index: -6.6700
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0381
    Cell Significance Index: -0.4100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0426
    Cell Significance Index: -6.1900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0432
    Cell Significance Index: -8.5700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0473
    Cell Significance Index: -8.0800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0536
    Cell Significance Index: -6.5900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0536
    Cell Significance Index: -7.3700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0681
    Cell Significance Index: -3.4400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0711
    Cell Significance Index: -2.9100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0761
    Cell Significance Index: -1.4900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0775
    Cell Significance Index: -8.8800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0838
    Cell Significance Index: -8.5600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0859
    Cell Significance Index: -8.9400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0860
    Cell Significance Index: -2.2100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1099
    Cell Significance Index: -2.3000
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.1281
    Cell Significance Index: -2.2000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1312
    Cell Significance Index: -8.8300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1503
    Cell Significance Index: -9.2400
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.1519
    Cell Significance Index: -1.7900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1537
    Cell Significance Index: -2.0100
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.1538
    Cell Significance Index: -1.3300
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.1547
    Cell Significance Index: -2.2000
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.1773
    Cell Significance Index: -2.2700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1775
    Cell Significance Index: -2.9900
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.1823
    Cell Significance Index: -2.2000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1924
    Cell Significance Index: -6.6900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1999
    Cell Significance Index: -2.9500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2051
    Cell Significance Index: -6.0400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2114
    Cell Significance Index: -7.4100
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.2143
    Cell Significance Index: -2.0400
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.2214
    Cell Significance Index: -2.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2218
    Cell Significance Index: -9.8100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2233
    Cell Significance Index: -6.4000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2265
    Cell Significance Index: -7.4200
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: -0.2308
    Cell Significance Index: -2.2000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2351
    Cell Significance Index: -8.6300
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.2422
    Cell Significance Index: -2.3500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2494
    Cell Significance Index: -14.0000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2583
    Cell Significance Index: -9.7800
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.2607
    Cell Significance Index: -2.7500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2623
    Cell Significance Index: -7.0100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2716
    Cell Significance Index: -8.6500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2878
    Cell Significance Index: -6.3000
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.2988
    Cell Significance Index: -2.3800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3036
    Cell Significance Index: -6.4900
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.3094
    Cell Significance Index: -3.5600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3095
    Cell Significance Index: -7.7300
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.3128
    Cell Significance Index: -4.5800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3128
    Cell Significance Index: -8.9300
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.3189
    Cell Significance Index: -2.2900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3226
    Cell Significance Index: -5.7000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3264
    Cell Significance Index: -8.7500
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.3341
    Cell Significance Index: -3.0200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3438
    Cell Significance Index: -8.5800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3605
    Cell Significance Index: -2.4400
  • Cell Name: eosinophil (CL0000771)
    Fold Change: -0.3644
    Cell Significance Index: -3.2300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3751
    Cell Significance Index: -10.0400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.3786
    Cell Significance Index: -4.4700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3833
    Cell Significance Index: -10.0800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3986
    Cell Significance Index: -8.4600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4022
    Cell Significance Index: -8.6900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.4074
    Cell Significance Index: -10.3800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.4089
    Cell Significance Index: -6.9500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4120
    Cell Significance Index: -7.0600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4139
    Cell Significance Index: -8.3100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4162
    Cell Significance Index: -8.2300
  • Cell Name: respiratory suprabasal cell (CL4033048)
    Fold Change: -0.4190
    Cell Significance Index: -3.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** KLK5 is a serine-type peptidase that belongs to the kallikrein-related peptidase family. The gene is characterized by its ability to cleave various substrates, including proteins and peptides, through its active site. KLK5 is also known for its involvement in the regulation of cellular processes, such as keratinization, cornification, and the formation of the cornified envelope, which are critical for the development and maintenance of epithelial tissues. One of the key features of KLK5 is its ability to regulate the production of antimicrobial peptides and its positive regulation of g protein-coupled receptor signaling pathways. This suggests that KLK5 plays a role in the immune response and the regulation of cellular signaling pathways. **Pathways and Functions** KLK5 is involved in several key pathways, including: 1. **Keratinization**: KLK5 is essential for the regulation of keratinization, a process by which epithelial cells undergo a series of changes to form a cornified envelope, which provides structural support and protection to the skin. 2. **Cornification**: KLK5 is involved in the regulation of cornification, a process by which epithelial cells undergo a series of changes to form a cornified envelope. 3. **Proteolysis**: KLK5 is a serine-type endopeptidase that cleaves various substrates, including proteins and peptides, through its active site. 4. **Antimicrobial peptide production**: KLK5 regulates the production of antimicrobial peptides, which are essential for the immune response against pathogens. 5. **G protein-coupled receptor signaling pathway**: KLK5 positively regulates the g protein-coupled receptor signaling pathway, which is involved in various cellular processes, including cell signaling and differentiation. **Clinical Significance** KLK5 has been implicated in several diseases and disorders, including: 1. **Psoriasis**: KLK5 is overexpressed in psoriatic skin lesions, suggesting its role in the development of psoriasis. 2. **Alopecia areata**: KLK5 is involved in the regulation of hair follicle development and maintenance, and its dysregulation may contribute to alopecia areata. 3. **Cancer**: KLK5 is overexpressed in various types of cancer, including breast, lung, and colon cancer, suggesting its role in tumorigenesis and cancer progression. 4. **Neurological disorders**: KLK5 is involved in the regulation of neural development and maintenance, and its dysregulation may contribute to neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, KLK5 is a multifunctional gene that plays a critical role in various physiological and pathological processes. Its dysregulation may contribute to the development of various diseases and disorders, highlighting the importance of further research into the role of KLK5 in human health and disease.

Genular Protein ID: 2628678519

Symbol: KLK5_HUMAN

Name: Kallikrein-like protein 2

UniProtKB Accession Codes:

Q9Y337 A0A024R4G4 Q53ZR3 Q9HBG8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 15 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 5 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10514489

Title: Purification, molecular cloning, and expression of a human stratum corneum trypsin-like serine protease with possible function in desquamation.

PubMed ID: 10514489

DOI: 10.1074/jbc.274.42.30033

PubMed ID: 10652563

Title: Identification of novel human kallikrein-like genes on chromosome 19q13.3-q13.4.

PubMed ID: 10652563

PubMed ID: 11054574

Title: Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region.

PubMed ID: 11054574

DOI: 10.1016/s0378-1119(00)00382-6

PubMed ID: 15361712

Title: Differential expression of a human kallikrein 5 (KLK5) splice variant in ovarian and prostate cancer.

PubMed ID: 15361712

DOI: 10.1159/000079147

PubMed ID: 28224083

Title: Comparative genomic analysis of eutherian kallikrein genes.

PubMed ID: 28224083

DOI: 10.1016/j.ymgmr.2017.01.009

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19194479

Title: SPINK9: a selective, skin-specific Kazal-type serine protease inhibitor.

PubMed ID: 19194479

DOI: 10.1038/jid.2008.448

PubMed ID: 19190773

Title: Identification of lympho-epithelial Kazal-type inhibitor 2 in human skin as a kallikrein-related peptidase 5-specific protease inhibitor.

PubMed ID: 19190773

DOI: 10.1371/journal.pone.0004372

PubMed ID: 17881000

Title: Structural basis of the zinc inhibition of human tissue kallikrein 5.

PubMed ID: 17881000

DOI: 10.1016/j.jmb.2007.08.042

Sequence Information:

  • Length: 293
  • Mass: 32020
  • Checksum: D92C92F5609E5946
  • Sequence:
    • MATARPPWMW VLCALITALL LGVTEHVLAN NDVSCDHPSN TVPSGSNQDL GAGAGEDARS 
DDSSSRIING SDCDMHTQPW QAALLLRPNQ LYCGAVLVHP QWLLTAAHCR KKVFRVRLGH 
YSLSPVYESG QQMFQGVKSI PHPGYSHPGH SNDLMLIKLN RRIRPTKDVR PINVSSHCPS 
AGTKCLVSGW GTTKSPQVHF PKVLQCLNIS VLSQKRCEDA YPRQIDDTMF CAGDKAGRDS 
CQGDSGGPVV CNGSLQGLVS WGDYPCARPN RPGVYTNLCK FTKWIQETIQ ANS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.