Details for: GAP43

Gene ID: 2596

Symbol: GAP43

Ensembl ID: ENSG00000172020

Description: growth associated protein 43

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 120.2095
    Cell Significance Index: -49.5200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 94.4882
    Cell Significance Index: -44.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.8146
    Cell Significance Index: 564.6100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 2.7764
    Cell Significance Index: 47.5800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.5258
    Cell Significance Index: 155.2500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.4680
    Cell Significance Index: 54.0400
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 2.3836
    Cell Significance Index: 24.8300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.8784
    Cell Significance Index: 45.0500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.4891
    Cell Significance Index: 42.5000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.2839
    Cell Significance Index: 86.3300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.1103
    Cell Significance Index: 49.1100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.0397
    Cell Significance Index: 39.3700
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.6432
    Cell Significance Index: 8.5800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5683
    Cell Significance Index: 393.0500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3336
    Cell Significance Index: 42.7700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.2351
    Cell Significance Index: 34.1700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1511
    Cell Significance Index: 54.1900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1487
    Cell Significance Index: 2.3000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1352
    Cell Significance Index: 26.8300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0928
    Cell Significance Index: 5.2100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0068
    Cell Significance Index: -4.2400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0228
    Cell Significance Index: -42.9800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0241
    Cell Significance Index: -17.8700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0273
    Cell Significance Index: -50.3500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0313
    Cell Significance Index: -48.2600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0352
    Cell Significance Index: -19.8300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0359
    Cell Significance Index: -48.8400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0371
    Cell Significance Index: -23.5400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0669
    Cell Significance Index: -50.6500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0815
    Cell Significance Index: -44.5400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0960
    Cell Significance Index: -2.0100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0976
    Cell Significance Index: -44.3100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1096
    Cell Significance Index: -18.7100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1124
    Cell Significance Index: -23.6700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1201
    Cell Significance Index: -34.5500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1267
    Cell Significance Index: -1.3800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1512
    Cell Significance Index: -2.9900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1757
    Cell Significance Index: -5.6000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.2171
    Cell Significance Index: -39.1400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2581
    Cell Significance Index: -13.5500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2741
    Cell Significance Index: -7.6600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3134
    Cell Significance Index: -36.5200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.3164
    Cell Significance Index: -43.4500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3170
    Cell Significance Index: -10.3800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.3205
    Cell Significance Index: -39.4100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3368
    Cell Significance Index: -43.5100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3901
    Cell Significance Index: -46.0000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4112
    Cell Significance Index: -46.9400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4330
    Cell Significance Index: -45.0900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.4336
    Cell Significance Index: -44.2900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4443
    Cell Significance Index: -50.9100
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.4577
    Cell Significance Index: -5.3400
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.5580
    Cell Significance Index: -3.6300
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.5585
    Cell Significance Index: -4.6100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.5676
    Cell Significance Index: -5.3800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5846
    Cell Significance Index: -43.5700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6021
    Cell Significance Index: -12.7800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.6028
    Cell Significance Index: -46.2600
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.6472
    Cell Significance Index: -5.0300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6500
    Cell Significance Index: -22.7700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.6563
    Cell Significance Index: -16.3700
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.6590
    Cell Significance Index: -6.2700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.6983
    Cell Significance Index: -10.0000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.7374
    Cell Significance Index: -38.4100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.8038
    Cell Significance Index: -50.6600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.8632
    Cell Significance Index: -17.3300
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.8693
    Cell Significance Index: -9.6500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.8720
    Cell Significance Index: -18.2000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.8928
    Cell Significance Index: -41.9600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.9223
    Cell Significance Index: -11.4400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.9278
    Cell Significance Index: -23.8500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -1.0255
    Cell Significance Index: -24.8400
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -1.0680
    Cell Significance Index: -10.9800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.0891
    Cell Significance Index: -50.7800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -1.1689
    Cell Significance Index: -14.7500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -1.1715
    Cell Significance Index: -25.3100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.3163
    Cell Significance Index: -45.7400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.3256
    Cell Significance Index: -48.6600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -1.3654
    Cell Significance Index: -18.2000
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -1.3867
    Cell Significance Index: -13.7200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.4566
    Cell Significance Index: -38.3000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.4568
    Cell Significance Index: -41.7600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -1.4776
    Cell Significance Index: -51.9200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.5251
    Cell Significance Index: -32.6000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -1.5290
    Cell Significance Index: -48.3600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.5380
    Cell Significance Index: -45.3000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -1.5860
    Cell Significance Index: -39.5500
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -1.6124
    Cell Significance Index: -17.7900
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -1.6324
    Cell Significance Index: -21.1700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -1.6415
    Cell Significance Index: -48.2100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -1.6626
    Cell Significance Index: -33.8300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.7111
    Cell Significance Index: -45.6900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.7157
    Cell Significance Index: -43.8300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.7195
    Cell Significance Index: -29.7300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -1.7282
    Cell Significance Index: -21.5500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -1.7283
    Cell Significance Index: -11.7100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -1.7903
    Cell Significance Index: -20.3400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -1.7951
    Cell Significance Index: -51.7200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.8003
    Cell Significance Index: -48.2400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -1.8083
    Cell Significance Index: -35.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GAP43 is a cytoplasmic protein that is specifically expressed in neurons and certain glial cells, including astrocytes and radial glial cells. It is characterized by its ability to interact with various proteins, including L1CAM, calmodulin, and phosphatidylinositol phosphate, and is involved in regulating the formation and maintenance of growth cones, filopodia, and synapses. GAP43 is also a substrate for protein kinase C (PKC) and has been implicated in the regulation of axonal outgrowth, branching, and regeneration. **Pathways and Functions:** GAP43 is involved in several key pathways, including: 1. **Axon guidance**: GAP43 plays a crucial role in regulating axonal growth and guidance, particularly during the formation of synapses and the establishment of neural circuits. 2. **Axon regeneration**: GAP43 is involved in the regulation of axonal regeneration, particularly during the formation of new growth cones and the re-establishment of neural connections. 3. **Cell fate commitment**: GAP43 is required for the commitment of neural stem cells to a neuronal fate and the regulation of neural differentiation. 4. **Regulation of filopodium assembly**: GAP43 is involved in the regulation of filopodium assembly, which is essential for the formation of growth cones and the establishment of neural connections. 5. **Regulation of postsynaptic specialization assembly**: GAP43 is required for the regulation of postsynaptic specialization, which is essential for the formation of synapses and the transmission of neural signals. **Clinical Significance:** Dysregulation of GAP43 has been implicated in various neurological disorders, including: 1. **Neurodegenerative diseases**: GAP43 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Spinal cord injury**: GAP43 is required for the regulation of axonal regeneration and the establishment of neural connections following spinal cord injury. 3. **Stroke**: GAP43 has been implicated in the regulation of axonal growth and guidance following stroke, and its dysregulation may contribute to the development of stroke-related cognitive impairments. In conclusion, GAP43 is a critical regulator of axonal growth, guidance, and regeneration, and its dysregulation has been implicated in various neurological disorders. Further research is needed to fully understand the mechanisms by which GAP43 regulates neural development and function, and to explore its potential as a therapeutic target for the treatment of neurological disorders.

Genular Protein ID: 1319294179

Symbol: NEUM_HUMAN

Name: Neuromodulin

UniProtKB Accession Codes:

P17677 A8K0Y4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 11 Ensembl 2 ExpressionAtlas 1 GO 25 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3272162

Title: Human GAP-43: its deduced amino acid sequence and chromosomal localization in mouse and human.

PubMed ID: 3272162

DOI: 10.1016/0896-6273(88)90196-1

PubMed ID: 3272163

Title: Cloning of human GAP-43: growth association and ischemic resurgence.

PubMed ID: 3272163

DOI: 10.1016/0896-6273(88)90197-3

PubMed ID: 8231732

Title: Structure of the human gene for the neural phosphoprotein B-50 (GAP-43).

PubMed ID: 8231732

DOI: 10.1016/0169-328x(93)90128-c

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14978216

Title: Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs.

PubMed ID: 14978216

DOI: 10.1091/mbc.e03-07-0493

PubMed ID: 21152083

Title: Acyl-protein thioesterase 2 catalyzes the deacylation of peripheral membrane-associated GAP-43.

PubMed ID: 21152083

DOI: 10.1371/journal.pone.0015045

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

Sequence Information:

  • Length: 238
  • Mass: 24803
  • Checksum: B3536D012A127CC8
  • Sequence:
    • MLCCMRRTKQ VEKNDDDQKI EQDGIKPEDK AHKAATKIQA SFRGHITRKK LKGEKKDDVQ 
AAEAEANKKD EAPVADGVEK KGEGTTTAEA APATGSKPDE PGKAGETPSE EKKGEGDAAT 
EQAAPQAPAS SEEKAGSAET ESATKASTDN SPSSKAEDAP AKEEPKQADV PAAVTAAAAT 
TPAAEDAAAK ATAQPPTETG ESSQAEENIE AVDETKPKES ARQDEGKEEE PEADQEHA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.