Gene GAP43 - ENSG00000172020 | NCBI Gene ID: 2596

Details for: GAP43

Gene ID: 2596

Symbol: GAP43

Ensembl ID: ENSG00000172020

Description: growth associated protein 43

Associated with

Axon guidance
(R-HSA-422475)
Developmental biology
(R-HSA-1266738)
L1cam interactions
(R-HSA-373760)
Nervous system development
(R-HSA-9675108)
Astrocyte differentiation
(GO:0048708)
Axon choice point recognition
(GO:0016198)
Axon regeneration
(GO:0031103)
Calmodulin binding
(GO:0005516)
Cell fate commitment
(GO:0045165)
Cytoplasm
(GO:0005737)
Dendrite
(GO:0030425)
Filopodium membrane
(GO:0031527)
Gaba-ergic synapse
(GO:0098982)
Growth cone membrane
(GO:0032584)
Lysophosphatidic acid binding
(GO:0035727)
Perikaryon
(GO:0043204)
Phosphatidylinositol phosphate binding
(GO:1901981)
Phosphatidylserine binding
(GO:0001786)
Plasma membrane
(GO:0005886)
Postsynaptic density
(GO:0014069)
Presynapse
(GO:0098793)
Protein binding
(GO:0005515)
Protein kinase c-activating g protein-coupled receptor signaling pathway
(GO:0007205)
Radial glial cell differentiation
(GO:0060019)
Regulation of filopodium assembly
(GO:0051489)
Regulation of growth
(GO:0040008)
Regulation of postsynaptic specialization assembly
(GO:0099150)
Response to wounding
(GO:0009611)
Tissue regeneration
(GO:0042246)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 6.05
Marker Score: 31742
Cell Name: chromaffin cell (CL0000166)
Fold Change: 5.55
Marker Score: 7807
Cell Name: macroglial cell (CL0000126)
Fold Change: 3.65
Marker Score: 8383
Cell Name: granule cell (CL0000120)
Fold Change: 3.34
Marker Score: 25194
Cell Name: Purkinje cell (CL0000121)
Fold Change: 3.2
Marker Score: 108240
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 3.17
Marker Score: 13226
Cell Name: stellate neuron (CL0000122)
Fold Change: 3.12
Marker Score: 16741
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 2.68
Marker Score: 902
Cell Name: radial glial cell (CL0000681)
Fold Change: 2.66
Marker Score: 980
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 2.6
Marker Score: 2915
Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 2.43
Marker Score: 1412
Cell Name: motor neuron (CL0000100)
Fold Change: 2.19
Marker Score: 1298
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 2.19
Marker Score: 43479
Cell Name: inhibitory motor neuron (CL0008015)
Fold Change: 2.06
Marker Score: 973.5
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 2.03
Marker Score: 20944
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 2.03
Marker Score: 2526.5
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 2.02
Marker Score: 4177.5
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.98
Marker Score: 18608
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.93
Marker Score: 118393
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.88
Marker Score: 7807.5
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.86
Marker Score: 715.5
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.83
Marker Score: 17380
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 1.81
Marker Score: 7020
Cell Name: neuron (CL0000540)
Fold Change: 1.79
Marker Score: 7290
Cell Name: ganglion interneuron (CL0000397)
Fold Change: 1.68
Marker Score: 510
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.62
Marker Score: 13893
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.59
Marker Score: 2448
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 1.58
Marker Score: 3219
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.58
Marker Score: 2990
Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 1.42
Marker Score: 797.5
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.37
Marker Score: 869
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.19
Marker Score: 2427
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.19
Marker Score: 43913
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.16
Marker Score: 18105
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.07
Marker Score: 640
Cell Name: goblet cell (CL0000160)
Fold Change: 1.05
Marker Score: 6985
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 1.05
Marker Score: 4859
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251802
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 1.02
Marker Score: 2924
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71819
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1
Marker Score: 2537
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48044
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.99
Marker Score: 314.5
Cell Name: visceromotor neuron (CL0005025)
Fold Change: 0.98
Marker Score: 287
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30408
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5350
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2742
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.89
Marker Score: 680
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.88
Marker Score: 33292
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5286
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 0.87
Marker Score: 816.5
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.86
Marker Score: 454.5
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 0.84
Marker Score: 8482
Cell Name: neuronal brush cell (CL0000555)
Fold Change: 0.83
Marker Score: 2785
Cell Name: neural crest cell (CL0011012)
Fold Change: 0.81
Marker Score: 870
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 0.81
Marker Score: 1362
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1264
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 710
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 397
Cell Name: CNS interneuron (CL0000402)
Fold Change: 0.75
Marker Score: 358
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.74
Marker Score: 909
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.72
Marker Score: 4346
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.7
Marker Score: 179
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.69
Marker Score: 688
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.69
Marker Score: 330
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.66
Marker Score: 438
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.6
Marker Score: 476
Cell Name: glial cell (CL0000125)
Fold Change: 0.57
Marker Score: 631
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.57
Marker Score: 582
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.56
Marker Score: 149
Cell Name: meningeal macrophage (CL0000879)
Fold Change: 0.56
Marker Score: 158
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 0.54
Marker Score: 338
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 0.53
Marker Score: 170
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.53
Marker Score: 7885.5
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.52
Marker Score: 231
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 0.5
Marker Score: 1201
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.48
Marker Score: 236
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.48
Marker Score: 200
Cell Name: microglial cell (CL0000129)
Fold Change: 0.48
Marker Score: 868
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.48
Marker Score: 3653.5
Cell Name: mature astrocyte (CL0002627)
Fold Change: 0.47
Marker Score: 307
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.46
Marker Score: 319
Cell Name: erythroid lineage cell (CL0000764)
Fold Change: 0.46
Marker Score: 229
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.46
Marker Score: 1080
Cell Name: renal principal cell (CL0005009)
Fold Change: 0.45
Marker Score: 347.5
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 0.45
Marker Score: 421
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.44
Marker Score: 1690
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.43
Marker Score: 419
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.43
Marker Score: 111
Cell Name: enteric neuron (CL0007011)
Fold Change: 0.42
Marker Score: 224
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.42
Marker Score: 130
Cell Name: mature microglial cell (CL0002629)
Fold Change: 0.4
Marker Score: 146
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.4
Marker Score: 479
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.39
Marker Score: 127
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.37
Marker Score: 372
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.37
Marker Score: 153
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.37
Marker Score: 996
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.36
Marker Score: 348
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.35
Marker Score: 144
Cell Name: retinal cone cell (CL0000573)
Fold Change: 0.35
Marker Score: 998

Hover over a box to see details here...

**Key characteristics:** * GAP43 is a transmembrane protein that is found in the cell membrane. * It is a member of the GAP family of proteins, which are involved in the regulation of cell growth and differentiation. * GAP43 is a highly conserved protein, with a similar sequence found in organisms from flies to humans. * It is a key regulator of neurite outgrowth and guidance, and is essential for the survival of neurons in the central nervous system. **Pathways and functions:** * GAP43 is involved in a variety of cellular processes, including growth, development, and differentiation. * It is a key regulator of neurite outgrowth and guidance, and is essential for the survival of neurons in the central nervous system. * It is also involved in synaptic plasticity and learning and memory. * It is a target for a number of neurotoxins, suggesting that it is involved in neuronal death. **Clinical significance:** * Mutations in the GAP43 gene have been linked to a number of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. * Targeting GAP43 has been shown to be a potential therapeutic strategy for these diseases. **Other important points:** * GAP43 is a highly dynamic protein, with its expression levels changing in response to a variety of factors, including growth factors, neurotransmitters, and cytokines. * It is a key regulator of the expression of other genes involved in neuronal development and function. * It is a promising target for the development of new therapies for neurodegenerative diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Neuromodulin

Genular Protein ID: 1319294179

Symbol: NEUM_HUMAN

Name: Neuromodulin

UniProtKB Accession Codes:

P17677 A8K0Y4

Database IDs:

Citations:

PubMed ID: 3272162

Title: Human GAP-43: its deduced amino acid sequence and chromosomal localization in mouse and human.

PubMed ID: 3272162

DOI: 10.1016/0896-6273(88)90196-1

PubMed ID: 3272163

Title: Cloning of human GAP-43: growth association and ischemic resurgence.

PubMed ID: 3272163

DOI: 10.1016/0896-6273(88)90197-3

PubMed ID: 8231732

Title: Structure of the human gene for the neural phosphoprotein B-50 (GAP-43).

PubMed ID: 8231732

DOI: 10.1016/0169-328x(93)90128-c

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14978216

Title: Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs.

PubMed ID: 14978216

DOI: 10.1091/mbc.e03-07-0493

PubMed ID: 21152083

Title: Acyl-protein thioesterase 2 catalyzes the deacylation of peripheral membrane-associated GAP-43.

PubMed ID: 21152083

DOI: 10.1371/journal.pone.0015045

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

Sequence Information:

Length: 238
Mass: 24803
Checksum: B3536D012A127CC8
Sequence:

MLCCMRRTKQ VEKNDDDQKI EQDGIKPEDK AHKAATKIQA SFRGHITRKK LKGEKKDDVQ 
AAEAEANKKD EAPVADGVEK KGEGTTTAEA APATGSKPDE PGKAGETPSE EKKGEGDAAT 
EQAAPQAPAS SEEKAGSAET ESATKASTDN SPSSKAEDAP AKEEPKQADV PAAVTAAAAT 
TPAAEDAAAK ATAQPPTETG ESSQAEENIE AVDETKPKES ARQDEGKEEE PEADQEHA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: GAP43

Associated with

Cells (max top 100)

Other Information

Human GAP-43: its deduced amino acid sequence and chromosomal localization in mouse and human. PubMed ID: 3272162

Cloning of human GAP-43: growth association and ischemic resurgence. PubMed ID: 3272163

Structure of the human gene for the neural phosphoprotein B-50 (GAP-43). PubMed ID: 8231732

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence, annotation and analysis of human chromosome 3. PubMed ID: 16641997

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs. PubMed ID: 14978216

Acyl-protein thioesterase 2 catalyzes the deacylation of peripheral membrane-associated GAP-43. PubMed ID: 21152083

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Characterization of single-nucleotide polymorphisms in coding regions of human genes. PubMed ID: 10391209