Gene KAT2A - ENSG00000108773 | NCBI Gene ID: 2648

Details for: KAT2A

Gene ID: 2648

Symbol: KAT2A

Ensembl ID: ENSG00000108773

Description: lysine acetyltransferase 2A

Associated with

B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Cardiogenesis
(R-HSA-9733709)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Constitutive signaling by notch1 hd+pest domain mutants
(R-HSA-2894862)
Constitutive signaling by notch1 pest domain mutants
(R-HSA-2644606)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Epigenetic regulation of gene expression
(R-HSA-212165)
Formation of paraxial mesoderm
(R-HSA-9793380)
Formation of wdr5-containing histone-modifying complexes
(R-HSA-9772755)
Gastrulation
(R-HSA-9758941)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Hats acetylate histones
(R-HSA-3214847)
Metabolism of proteins
(R-HSA-392499)
Notch-hlh transcription pathway
(R-HSA-350054)
Notch1 intracellular domain regulates transcription
(R-HSA-2122947)
Notch3 intracellular domain regulates transcription
(R-HSA-9013508)
Notch4 intracellular domain regulates transcription
(R-HSA-9013695)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Post-translational protein modification
(R-HSA-597592)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Regulation of beta-cell development
(R-HSA-186712)
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
(R-HSA-210744)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i transcription
(R-HSA-73864)
Rna polymerase i transcription initiation
(R-HSA-73762)
Runx3 regulates notch signaling
(R-HSA-8941856)
Signaling by notch
(R-HSA-157118)
Signaling by notch1
(R-HSA-1980143)
Signaling by notch1 hd+pest domain mutants in cancer
(R-HSA-2894858)
Signaling by notch1 in cancer
(R-HSA-2644603)
Signaling by notch1 pest domain mutants in cancer
(R-HSA-2644602)
Signaling by notch3
(R-HSA-9012852)
Signaling by notch4
(R-HSA-9013694)
Signal transduction
(R-HSA-162582)
Transcriptional regulation by runx3
(R-HSA-8878159)
Ub-specific processing proteases
(R-HSA-5689880)
Cellular response to tumor necrosis factor
(GO:0071356)
Chromatin binding
(GO:0003682)
Chromatin remodeling
(GO:0006338)
Dna-binding transcription factor binding
(GO:0140297)
Fibroblast proliferation
(GO:0048144)
Gluconeogenesis
(GO:0006094)
Heart development
(GO:0007507)
Histone acetyltransferase activity
(GO:0004402)
Histone deacetylase binding
(GO:0042826)
Histone glutaryltransferase activity
(GO:0106229)
Histone h3 acetyltransferase activity
(GO:0010484)
Histone h3k9 acetyltransferase activity
(GO:0043992)
Histone h3k18 acetyltransferase activity
(GO:0043993)
Histone h4k12 acetyltransferase activity
(GO:0043997)
Histone succinyltransferase activity
(GO:0106078)
Internal peptidyl-lysine acetylation
(GO:0018393)
Intracellular distribution of mitochondria
(GO:0048312)
In utero embryonic development
(GO:0001701)
Limb development
(GO:0060173)
Long-term memory
(GO:0007616)
Metencephalon development
(GO:0022037)
Midbrain development
(GO:0030901)
Multicellular organism growth
(GO:0035264)
Negative regulation of centriole replication
(GO:0046600)
Negative regulation of gluconeogenesis
(GO:0045721)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neural tube closure
(GO:0001843)
Peptide-lysine-n-acetyltransferase activity
(GO:0061733)
Positive regulation of cell projection organization
(GO:0031346)
Positive regulation of cytokine production
(GO:0001819)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of gluconeogenesis
(GO:0045722)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein phosphatase binding
(GO:0019903)
Regulation of cartilage development
(GO:0061035)
Regulation of cell cycle
(GO:0051726)
Regulation of cell division
(GO:0051302)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of dna repair
(GO:0006282)
Regulation of embryonic development
(GO:0045995)
Regulation of protein stability
(GO:0031647)
Regulation of regulatory t cell differentiation
(GO:0045589)
Regulation of rna splicing
(GO:0043484)
Regulation of synaptic plasticity
(GO:0048167)
Regulation of t cell activation
(GO:0050863)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Regulation of tubulin deacetylation
(GO:0090043)
Response to nutrient levels
(GO:0031667)
Response to organic cyclic compound
(GO:0014070)
Somitogenesis
(GO:0001756)
Telencephalon development
(GO:0021537)
Transcription coactivator activity
(GO:0003713)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: lung endothelial cell (CL1001567)
Fold Change: 2.21
Marker Score: 19368
Cell Name: mature astrocyte (CL0002627)
Fold Change: 1.57
Marker Score: 1033
Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 168756
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 1.35
Marker Score: 654
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 1.31
Marker Score: 1045
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.22
Marker Score: 11500
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 1.21
Marker Score: 1080
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.19
Marker Score: 73471
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.19
Marker Score: 25306
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 1.17
Marker Score: 5424.5
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.17
Marker Score: 43124
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.17
Marker Score: 10039
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.16
Marker Score: 11043
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 1.15
Marker Score: 15270.5
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.15
Marker Score: 1770
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 1.14
Marker Score: 1378
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 1.13
Marker Score: 1899
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.1
Marker Score: 1244
Cell Name: Leydig cell (CL0000178)
Fold Change: 1.08
Marker Score: 1168
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.05
Marker Score: 4070
Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 1.02
Marker Score: 372
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1
Marker Score: 4153
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30401
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.96
Marker Score: 36412
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.95
Marker Score: 14225
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2403
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.94
Marker Score: 484
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.93
Marker Score: 438
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.93
Marker Score: 18431
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.92
Marker Score: 7030
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2716
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5291
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.87
Marker Score: 4940
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.86
Marker Score: 309
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.85
Marker Score: 357
Cell Name: follicular B cell (CL0000843)
Fold Change: 0.84
Marker Score: 908
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.84
Marker Score: 1359
Cell Name: Sertoli cell (CL0000216)
Fold Change: 0.84
Marker Score: 4954.5
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.8
Marker Score: 2149
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.76
Marker Score: 7641
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.74
Marker Score: 298
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.74
Marker Score: 566.5
Cell Name: male germ cell (CL0000015)
Fold Change: 0.74
Marker Score: 213
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.74
Marker Score: 2894
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.73
Marker Score: 774
Cell Name: mature microglial cell (CL0002629)
Fold Change: 0.72
Marker Score: 260
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.72
Marker Score: 4655
Cell Name: brush cell (CL0002204)
Fold Change: 0.7
Marker Score: 642
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.7
Marker Score: 871
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.69
Marker Score: 189
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 0.69
Marker Score: 401
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 0.69
Marker Score: 259
Cell Name: primordial germ cell (CL0000670)
Fold Change: 0.68
Marker Score: 858.5
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.68
Marker Score: 2857
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 0.68
Marker Score: 2413
Cell Name: Unknown (CL0002371)
Fold Change: 0.67
Marker Score: 708
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.66
Marker Score: 170
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.65
Marker Score: 596
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 0.64
Marker Score: 280
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.64
Marker Score: 1733
Cell Name: oogonial cell (CL0000024)
Fold Change: 0.63
Marker Score: 911
Cell Name: astrocyte (CL0000127)
Fold Change: 0.63
Marker Score: 543
Cell Name: fat cell (CL0000136)
Fold Change: 0.62
Marker Score: 344
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.61
Marker Score: 366
Cell Name: stem cell (CL0000034)
Fold Change: 0.61
Marker Score: 1445
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.61
Marker Score: 9493
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.6
Marker Score: 402
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 0.6
Marker Score: 364
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.58
Marker Score: 1186
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 0.58
Marker Score: 1150
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.57
Marker Score: 1421
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 0.57
Marker Score: 533
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.57
Marker Score: 2096
Cell Name: proerythroblast (CL0000547)
Fold Change: 0.56
Marker Score: 380
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 0.56
Marker Score: 374.5
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.55
Marker Score: 2234
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 0.55
Marker Score: 191
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.54
Marker Score: 432
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 0.53
Marker Score: 1344
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 0.52
Marker Score: 474
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.51
Marker Score: 323
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.5
Marker Score: 277
Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: 0.5
Marker Score: 304
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.5
Marker Score: 329
Cell Name: theca cell (CL0000503)
Fold Change: 0.49
Marker Score: 354
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.49
Marker Score: 1042
Cell Name: neuron (CL0000540)
Fold Change: 0.49
Marker Score: 2007
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 0.49
Marker Score: 437
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.49
Marker Score: 724
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.49
Marker Score: 129
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 0.48
Marker Score: 558
Cell Name: memory B cell (CL0000787)
Fold Change: 0.48
Marker Score: 362
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 0.48
Marker Score: 180
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 0.48
Marker Score: 237
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.48
Marker Score: 121
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: 0.47
Marker Score: 265
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.47
Marker Score: 1117
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.47
Marker Score: 979
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.47
Marker Score: 299
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.47
Marker Score: 2795

Hover over a box to see details here...

**Key characteristics:** * The KAT2A gene is located on chromosome 17q21.1. * It is a member of the KAT2 family of lysine acetyltransferases. * KAT2A is expressed in high levels in early-stage heart development, and its expression is later downregulated. * KAT2A is a key regulator of cardiac differentiation and function. **Pathways and functions:** * KAT2A is involved in a variety of cellular processes, including cardiac differentiation, migration, and proliferation. * It plays a role in the regulation of cardiac remodeling in response to injury or disease. * KAT2A also has a role in the regulation of blood pressure and heart rate. **Clinical significance:** * Mutations in the KAT2A gene have been linked to a number of human diseases, including congenital heart defects, stroke, and hypertension. * Targeting KAT2A has been investigated as a therapeutic strategy for these diseases. **Additional information:** * KAT2A is a highly conserved protein, with a similar gene found in other mammals. * KAT2A is a ubiquitin-dependent protein, which means that it is targeted for degradation by the proteasome. * KAT2A has been shown to be a tumor suppressor in some cancer cells.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Histone acetyltransferase KAT2A

Genular Protein ID: 2762387134

Symbol: KAT2A_HUMAN

Name: Histone acetyltransferase KAT2A

UniProtKB Accession Codes:

Q92830 Q8N1A2 Q9UCW1

Database IDs:

Citations:

PubMed ID: 8552087

Title: Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5.

PubMed ID: 8552087

DOI: 10.1128/mcb.16.2.593

PubMed ID: 9611240

Title: Cloning of Drosophila GCN5: conserved features among metazoan GCN5 family members.

PubMed ID: 9611240

DOI: 10.1093/nar/26.12.2948

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8684459

Title: A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A.

PubMed ID: 8684459

DOI: 10.1038/382319a0

PubMed ID: 11564863

Title: Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo.

PubMed ID: 11564863

DOI: 10.1128/mcb.21.20.6782-6795.2001

PubMed ID: 10373431

Title: Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction.

PubMed ID: 10373431

DOI: 10.1074/jbc.274.26.18285

PubMed ID: 10611234

Title: The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc.

PubMed ID: 10611234

DOI: 10.1128/mcb.20.2.556-562.2000

PubMed ID: 11384967

Title: The histone acetyltransferase, hGCN5, interacts with and acetylates the HIV transactivator, Tat.

PubMed ID: 11384967

DOI: 10.1074/jbc.m101385200

PubMed ID: 11438666

Title: The TFIID components human TAFII140 and Drosophila BIP2 (TAFII155) are novel metazoan homologues of yeast TAFII47 containing a histone fold and a PHD finger.

PubMed ID: 11438666

DOI: 10.1128/mcb.21.15.5109-5121.2001

PubMed ID: 14767476

Title: The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases.

PubMed ID: 14767476

DOI: 10.1038/sj.onc.1207424

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 16753578

Title: GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1alpha.

PubMed ID: 16753578

DOI: 10.1016/j.cmet.2006.04.013

PubMed ID: 17301242

Title: Glucocorticoid-stimulated preadipocyte differentiation is mediated through acetylation of C/EBPbeta by GCN5.

PubMed ID: 17301242

DOI: 10.1073/pnas.0607378104

PubMed ID: 18206972

Title: A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing.

PubMed ID: 18206972

DOI: 10.1016/j.molcel.2007.12.011

PubMed ID: 19103755

Title: The double-histone-acetyltransferase complex ATAC is essential for mammalian development.

PubMed ID: 19103755

DOI: 10.1128/mcb.01599-08

PubMed ID: 23142079

Title: The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis.

PubMed ID: 23142079

DOI: 10.1016/j.molcel.2012.09.030

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 25593309

Title: Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.

PubMed ID: 25593309

DOI: 10.1101/gad.252189.114

PubMed ID: 27796307

Title: KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification.

PubMed ID: 27796307

DOI: 10.1038/ncomms13227

PubMed ID: 29174768

Title: Acetylation of TBX5 by KAT2B and KAT2A regulates heart and limb development.

PubMed ID: 29174768

DOI: 10.1016/j.yjmcc.2017.11.013

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 30109122

Title: Supramolecular assembly of KAT2A with succinyl-CoA for histone succinylation.

PubMed ID: 30109122

DOI: 10.1038/s41421-018-0048-8

PubMed ID: 29973595

Title: XPC is an RNA polymerase II cofactor recruiting ATAC to promoters by interacting with E2F1.

PubMed ID: 29973595

DOI: 10.1038/s41467-018-05010-0

PubMed ID: 31542297

Title: Glutarylation of histone H4 lysine 91 regulates chromatin dynamics.

PubMed ID: 31542297

DOI: 10.1016/j.molcel.2019.08.018

PubMed ID: 31527837

Title: DNA repair complex licenses acetylation of H2A.Z.1 by KAT2A during transcription.

PubMed ID: 31527837

DOI: 10.1038/s41589-019-0354-y

PubMed ID: 30894545

Title: Functional interplay between TFIIH and KAT2A regulates higher-order chromatin structure and class II gene expression.

PubMed ID: 30894545

DOI: 10.1038/s41467-019-09270-2

PubMed ID: 35995428

Title: The Acyl-CoA Specificity of Human Lysine Acetyltransferase KAT2A.

PubMed ID: 35995428

DOI: 10.1021/acs.biochem.2c00308

PubMed ID: 11090279

Title: Solution structure and acetyl-lysine binding activity of the GCN5 bromodomain.

PubMed ID: 11090279

DOI: 10.1006/jmbi.2000.4207

PubMed ID: 17410582

Title: Crystal structure of a binary complex between human GCN5 histone acetyltransferase domain and acetyl coenzyme A.

PubMed ID: 17410582

DOI: 10.1002/prot.21407

PubMed ID: 22464331

Title: Histone recognition and large-scale structural analysis of the human bromodomain family.

PubMed ID: 22464331

DOI: 10.1016/j.cell.2012.02.013

PubMed ID: 27377381

Title: Structural basis for acyl-group discrimination by human Gcn5L2.

PubMed ID: 27377381

DOI: 10.1107/s2059798316007907

PubMed ID: 29211711

Title: KAT2A coupled with the alpha-KGDH complex acts as a histone H3 succinyltransferase.

PubMed ID: 29211711

DOI: 10.1038/nature25003

Sequence Information:

Length: 837
Mass: 93926
Checksum: 728CC8ACF08600EA
Sequence:

MAEPSQAPTP APAAQPRPLQ SPAPAPTPTP APSPASAPIP TPTPAPAPAP AAAPAGSTGT 
GGPGVGSGGA GSGGDPARPG LSQQQRASQR KAQVRGLPRA KKLEKLGVFS ACKANETCKC 
NGWKNPKPPT APRMDLQQPA ANLSELCRSC EHPLADHVSH LENVSEDEIN RLLGMVVDVE 
NLFMSVHKEE DTDTKQVYFY LFKLLRKCIL QMTRPVVEGS LGSPPFEKPN IEQGVLNFVQ 
YKFSHLAPRE RQTMFELSKM FLLCLNYWKL ETPAQFRQRS QAEDVATYKV NYTRWLCYCH 
VPQSCDSLPR YETTHVFGRS LLRSIFTVTR RQLLEKFRVE KDKLVPEKRT LILTHFPKFL 
SMLEEEIYGA NSPIWESGFT MPPSEGTQLV PRPASVSAAV VPSTPIFSPS MGGGSNSSLS 
LDSAGAEPMP GEKRTLPENL TLEDAKRLRV MGDIPMELVN EVMLTITDPA AMLGPETSLL 
SANAARDETA RLEERRGIIE FHVIGNSLTP KANRRVLLWL VGLQNVFSHQ LPRMPKEYIA 
RLVFDPKHKT LALIKDGRVI GGICFRMFPT QGFTEIVFCA VTSNEQVKGY GTHLMNHLKE 
YHIKHNILYF LTYADEYAIG YFKKQGFSKD IKVPKSRYLG YIKDYEGATL MECELNPRIP 
YTELSHIIKK QKEIIKKLIE RKQAQIRKVY PGLSCFKEGV RQIPVESVPG IRETGWKPLG 
KEKGKELKDP DQLYTTLKNL LAQIKSHPSA WPFMEPVKKS EAPDYYEVIR FPIDLKTMTE 
RLRSRYYVTR KLFVADLQRV IANCREYNPP DSEYCRCASA LEKFFYFKLK EGGLIDK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: KAT2A

Associated with

Cells (max top 100)

Other Information

Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5. PubMed ID: 8552087

Cloning of Drosophila GCN5: conserved features among metazoan GCN5 family members. PubMed ID: 9611240

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. PubMed ID: 8684459

Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo. PubMed ID: 11564863

Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction. PubMed ID: 10373431

The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc. PubMed ID: 10611234

The histone acetyltransferase, hGCN5, interacts with and acetylates the HIV transactivator, Tat. PubMed ID: 11384967

The TFIID components human TAFII140 and Drosophila BIP2 (TAFII155) are novel metazoan homologues of yeast TAFII47 containing a histone fold and a PHD finger. PubMed ID: 11438666

The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases. PubMed ID: 14767476

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. PubMed ID: 15592455

GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1alpha. PubMed ID: 16753578

Glucocorticoid-stimulated preadipocyte differentiation is mediated through acetylation of C/EBPbeta by GCN5. PubMed ID: 17301242

A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing. PubMed ID: 18206972

The double-histone-acetyltransferase complex ATAC is essential for mammalian development. PubMed ID: 19103755

The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis. PubMed ID: 23142079

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination. PubMed ID: 25593309

KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification. PubMed ID: 27796307

Acetylation of TBX5 by KAT2B and KAT2A regulates heart and limb development. PubMed ID: 29174768

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Supramolecular assembly of KAT2A with succinyl-CoA for histone succinylation. PubMed ID: 30109122

XPC is an RNA polymerase II cofactor recruiting ATAC to promoters by interacting with E2F1. PubMed ID: 29973595

Glutarylation of histone H4 lysine 91 regulates chromatin dynamics. PubMed ID: 31542297

DNA repair complex licenses acetylation of H2A.Z.1 by KAT2A during transcription. PubMed ID: 31527837

Functional interplay between TFIIH and KAT2A regulates higher-order chromatin structure and class II gene expression. PubMed ID: 30894545

The Acyl-CoA Specificity of Human Lysine Acetyltransferase KAT2A. PubMed ID: 35995428

Solution structure and acetyl-lysine binding activity of the GCN5 bromodomain. PubMed ID: 11090279

Crystal structure of a binary complex between human GCN5 histone acetyltransferase domain and acetyl coenzyme A. PubMed ID: 17410582

Histone recognition and large-scale structural analysis of the human bromodomain family. PubMed ID: 22464331

Structural basis for acyl-group discrimination by human Gcn5L2. PubMed ID: 27377381

KAT2A coupled with the alpha-KGDH complex acts as a histone H3 succinyltransferase. PubMed ID: 29211711