Details for: KAT2A
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 126.1369
Cell Significance Index: -19.6200 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 70.4138
Cell Significance Index: -17.8600 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 46.9581
Cell Significance Index: -22.1700 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 42.0177
Cell Significance Index: -17.0700 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 33.1509
Cell Significance Index: -22.2500 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 18.6595
Cell Significance Index: -17.8200 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 16.3834
Cell Significance Index: -20.2000 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 7.6899
Cell Significance Index: -16.8300 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 7.6077
Cell Significance Index: -20.3800 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 5.1697
Cell Significance Index: -20.4000 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 3.1491
Cell Significance Index: 164.0300 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.5192
Cell Significance Index: 150.2800 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.2184
Cell Significance Index: 34.0500 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.0330
Cell Significance Index: 207.2200 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.7728
Cell Significance Index: 22.2700 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.7587
Cell Significance Index: 123.3900 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.5520
Cell Significance Index: 33.1400 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.5487
Cell Significance Index: 196.8200 - Cell Name: type I muscle cell (CL0002211)
Fold Change: 0.5246
Cell Significance Index: 12.8000 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.4252
Cell Significance Index: 22.0900 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4231
Cell Significance Index: 382.0100 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.4205
Cell Significance Index: 19.0600 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.3922
Cell Significance Index: 77.8300 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.3604
Cell Significance Index: 18.9200 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3527
Cell Significance Index: 67.1300 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.3476
Cell Significance Index: 240.3900 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.3283
Cell Significance Index: 9.3700 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3138
Cell Significance Index: 21.7000 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.2260
Cell Significance Index: 28.9700 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.2000
Cell Significance Index: 27.4700 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.1782
Cell Significance Index: 4.8500 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.1275
Cell Significance Index: 16.4700 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.1261
Cell Significance Index: 1.7200 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1139
Cell Significance Index: 62.1900 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.1118
Cell Significance Index: 7.5200 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.0956
Cell Significance Index: 6.1700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0746
Cell Significance Index: 13.4400 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.0691
Cell Significance Index: 5.3000 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0631
Cell Significance Index: 27.9200 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0568
Cell Significance Index: 2.6500 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.0549
Cell Significance Index: 2.5800 - Cell Name: subcutaneous adipocyte (CL0002521)
Fold Change: 0.0528
Cell Significance Index: 0.2300 - Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: 0.0458
Cell Significance Index: 0.6400 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.0422
Cell Significance Index: 1.1100 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.0318
Cell Significance Index: 0.6600 - Cell Name: slow muscle cell (CL0000189)
Fold Change: 0.0207
Cell Significance Index: 0.3100 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0203
Cell Significance Index: 2.4900 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0161
Cell Significance Index: 30.2700 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0102
Cell Significance Index: 0.3600 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0023
Cell Significance Index: 4.2900 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0001
Cell Significance Index: -0.0900 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0020
Cell Significance Index: -0.3500 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0032
Cell Significance Index: -0.1400 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0067
Cell Significance Index: -9.0900 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0068
Cell Significance Index: -4.3000 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0119
Cell Significance Index: -8.7500 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0139
Cell Significance Index: -10.5300 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0220
Cell Significance Index: -9.9900 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0269
Cell Significance Index: -19.9600 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0329
Cell Significance Index: -18.5600 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0355
Cell Significance Index: -4.1900 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0368
Cell Significance Index: -23.0000 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0486
Cell Significance Index: -4.9600 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0495
Cell Significance Index: -7.1900 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0503
Cell Significance Index: -1.0900 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.0550
Cell Significance Index: -1.9100 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.0586
Cell Significance Index: -0.7500 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0656
Cell Significance Index: -7.5200 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0704
Cell Significance Index: -20.2500 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0717
Cell Significance Index: -1.2000 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0729
Cell Significance Index: -2.7600 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0976
Cell Significance Index: -11.3700 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0998
Cell Significance Index: -7.4400 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1104
Cell Significance Index: -23.2600 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1345
Cell Significance Index: -9.5100 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1609
Cell Significance Index: -4.1100 - Cell Name: type II muscle cell (CL0002212)
Fold Change: -0.1624
Cell Significance Index: -2.6200 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.1667
Cell Significance Index: -3.5500 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1708
Cell Significance Index: -5.4700 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.1806
Cell Significance Index: -1.8700 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1858
Cell Significance Index: -11.3900 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1873
Cell Significance Index: -19.5000 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1897
Cell Significance Index: -11.6600 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1932
Cell Significance Index: -5.1600 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.2037
Cell Significance Index: -5.8400 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2121
Cell Significance Index: -13.3700 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.2252
Cell Significance Index: -6.0300 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.2253
Cell Significance Index: -4.8200 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.2328
Cell Significance Index: -4.9400 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.2337
Cell Significance Index: -4.0400 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.2369
Cell Significance Index: -4.0600 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2381
Cell Significance Index: -18.8600 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2449
Cell Significance Index: -13.7400 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.3285
Cell Significance Index: -4.9500 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.3291
Cell Significance Index: -10.4800 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.3621
Cell Significance Index: -7.1600 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.3645
Cell Significance Index: -9.3700 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3845
Cell Significance Index: -12.5900 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.3879
Cell Significance Index: -8.3800 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: -0.4034
Cell Significance Index: -5.0900
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2762387134
Symbol: KAT2A_HUMAN
Name: Histone acetyltransferase KAT2A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8552087
Title: Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5.
PubMed ID: 8552087
DOI: 10.1128/mcb.16.2.593
PubMed ID: 9611240
Title: Cloning of Drosophila GCN5: conserved features among metazoan GCN5 family members.
PubMed ID: 9611240
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8684459
Title: A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A.
PubMed ID: 8684459
DOI: 10.1038/382319a0
PubMed ID: 11564863
Title: Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo.
PubMed ID: 11564863
PubMed ID: 10373431
Title: Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction.
PubMed ID: 10373431
PubMed ID: 10611234
Title: The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc.
PubMed ID: 10611234
PubMed ID: 11384967
Title: The histone acetyltransferase, hGCN5, interacts with and acetylates the HIV transactivator, Tat.
PubMed ID: 11384967
PubMed ID: 11438666
Title: The TFIID components human TAFII140 and Drosophila BIP2 (TAFII155) are novel metazoan homologues of yeast TAFII47 containing a histone fold and a PHD finger.
PubMed ID: 11438666
PubMed ID: 14767476
Title: The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases.
PubMed ID: 14767476
PubMed ID: 15592455
Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
PubMed ID: 15592455
DOI: 10.1038/nbt1046
PubMed ID: 16753578
Title: GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1alpha.
PubMed ID: 16753578
PubMed ID: 17301242
Title: Glucocorticoid-stimulated preadipocyte differentiation is mediated through acetylation of C/EBPbeta by GCN5.
PubMed ID: 17301242
PubMed ID: 18206972
Title: A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing.
PubMed ID: 18206972
PubMed ID: 19103755
Title: The double-histone-acetyltransferase complex ATAC is essential for mammalian development.
PubMed ID: 19103755
DOI: 10.1128/mcb.01599-08
PubMed ID: 21131905
Title: Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation.
PubMed ID: 21131905
PubMed ID: 23142079
Title: The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis.
PubMed ID: 23142079
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 25593309
Title: Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.
PubMed ID: 25593309
PubMed ID: 27796307
Title: KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification.
PubMed ID: 27796307
DOI: 10.1038/ncomms13227
PubMed ID: 29174768
Title: Acetylation of TBX5 by KAT2B and KAT2A regulates heart and limb development.
PubMed ID: 29174768
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 30109122
Title: Supramolecular assembly of KAT2A with succinyl-CoA for histone succinylation.
PubMed ID: 30109122
PubMed ID: 29973595
Title: XPC is an RNA polymerase II cofactor recruiting ATAC to promoters by interacting with E2F1.
PubMed ID: 29973595
PubMed ID: 31542297
Title: Glutarylation of histone H4 lysine 91 regulates chromatin dynamics.
PubMed ID: 31542297
PubMed ID: 31527837
Title: DNA repair complex licenses acetylation of H2A.Z.1 by KAT2A during transcription.
PubMed ID: 31527837
PubMed ID: 30894545
Title: Functional interplay between TFIIH and KAT2A regulates higher-order chromatin structure and class II gene expression.
PubMed ID: 30894545
PubMed ID: 35995428
Title: The Acyl-CoA Specificity of Human Lysine Acetyltransferase KAT2A.
PubMed ID: 35995428
PubMed ID: 38128537
Title: Metabolic regulation of homologous recombination repair by MRE11 lactylation.
PubMed ID: 38128537
PubMed ID: 11090279
Title: Solution structure and acetyl-lysine binding activity of the GCN5 bromodomain.
PubMed ID: 11090279
PubMed ID: 17410582
Title: Crystal structure of a binary complex between human GCN5 histone acetyltransferase domain and acetyl coenzyme A.
PubMed ID: 17410582
DOI: 10.1002/prot.21407
PubMed ID: 22464331
Title: Histone recognition and large-scale structural analysis of the human bromodomain family.
PubMed ID: 22464331
PubMed ID: 27377381
Title: Structural basis for acyl-group discrimination by human Gcn5L2.
PubMed ID: 27377381
PubMed ID: 29211711
Title: KAT2A coupled with the alpha-KGDH complex acts as a histone H3 succinyltransferase.
PubMed ID: 29211711
DOI: 10.1038/nature25003
Sequence Information:
- Length: 837
- Mass: 93926
- Checksum: 728CC8ACF08600EA
- Sequence:
MAEPSQAPTP APAAQPRPLQ SPAPAPTPTP APSPASAPIP TPTPAPAPAP AAAPAGSTGT GGPGVGSGGA GSGGDPARPG LSQQQRASQR KAQVRGLPRA KKLEKLGVFS ACKANETCKC NGWKNPKPPT APRMDLQQPA ANLSELCRSC EHPLADHVSH LENVSEDEIN RLLGMVVDVE NLFMSVHKEE DTDTKQVYFY LFKLLRKCIL QMTRPVVEGS LGSPPFEKPN IEQGVLNFVQ YKFSHLAPRE RQTMFELSKM FLLCLNYWKL ETPAQFRQRS QAEDVATYKV NYTRWLCYCH VPQSCDSLPR YETTHVFGRS LLRSIFTVTR RQLLEKFRVE KDKLVPEKRT LILTHFPKFL SMLEEEIYGA NSPIWESGFT MPPSEGTQLV PRPASVSAAV VPSTPIFSPS MGGGSNSSLS LDSAGAEPMP GEKRTLPENL TLEDAKRLRV MGDIPMELVN EVMLTITDPA AMLGPETSLL SANAARDETA RLEERRGIIE FHVIGNSLTP KANRRVLLWL VGLQNVFSHQ LPRMPKEYIA RLVFDPKHKT LALIKDGRVI GGICFRMFPT QGFTEIVFCA VTSNEQVKGY GTHLMNHLKE YHIKHNILYF LTYADEYAIG YFKKQGFSKD IKVPKSRYLG YIKDYEGATL MECELNPRIP YTELSHIIKK QKEIIKKLIE RKQAQIRKVY PGLSCFKEGV RQIPVESVPG IRETGWKPLG KEKGKELKDP DQLYTTLKNL LAQIKSHPSA WPFMEPVKKS EAPDYYEVIR FPIDLKTMTE RLRSRYYVTR KLFVADLQRV IANCREYNPP DSEYCRCASA LEKFFYFKLK EGGLIDK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.