Details for: GCNT1

Gene ID: 2650

Symbol: GCNT1

Ensembl ID: ENSG00000187210

Description: glucosaminyl (N-acetyl) transferase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 99.0709
    Cell Significance Index: -15.4100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 49.5972
    Cell Significance Index: -12.5800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 31.1634
    Cell Significance Index: -16.0300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 23.7921
    Cell Significance Index: -15.9700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.6039
    Cell Significance Index: -15.5400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.6778
    Cell Significance Index: -15.2100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.2223
    Cell Significance Index: -16.0400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.6697
    Cell Significance Index: -10.2200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.9964
    Cell Significance Index: -15.7700
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 2.6229
    Cell Significance Index: 26.4600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.0319
    Cell Significance Index: 44.0200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.9652
    Cell Significance Index: 117.9800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.8740
    Cell Significance Index: 304.7900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.8559
    Cell Significance Index: 183.5900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.7586
    Cell Significance Index: 2391.2500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.6275
    Cell Significance Index: 46.8900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.5032
    Cell Significance Index: 163.5000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.3894
    Cell Significance Index: 1254.4900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.1849
    Cell Significance Index: 52.4100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.1437
    Cell Significance Index: 43.3100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9154
    Cell Significance Index: 181.6700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8289
    Cell Significance Index: 57.3300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.6638
    Cell Significance Index: 13.7700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.6564
    Cell Significance Index: 16.7700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.5105
    Cell Significance Index: 5.2900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.4279
    Cell Significance Index: 12.2100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.3957
    Cell Significance Index: 179.5900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3944
    Cell Significance Index: 8.4000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3762
    Cell Significance Index: 17.0500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3653
    Cell Significance Index: 199.5100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3431
    Cell Significance Index: 22.1400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3407
    Cell Significance Index: 64.8400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.2804
    Cell Significance Index: 29.2000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2473
    Cell Significance Index: 465.5800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2151
    Cell Significance Index: 77.1700
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.2141
    Cell Significance Index: 2.2300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2092
    Cell Significance Index: 6.7000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2074
    Cell Significance Index: 12.7500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2005
    Cell Significance Index: 40.2200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1875
    Cell Significance Index: 12.6100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.1812
    Cell Significance Index: 2.2600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0998
    Cell Significance Index: 1.7100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0994
    Cell Significance Index: 12.8400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0971
    Cell Significance Index: 12.4500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0959
    Cell Significance Index: 4.5100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0958
    Cell Significance Index: 10.9400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0890
    Cell Significance Index: 16.0500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0858
    Cell Significance Index: 10.1200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0744
    Cell Significance Index: 114.5000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0646
    Cell Significance Index: 1.0000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0316
    Cell Significance Index: 58.2100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0302
    Cell Significance Index: 1.0600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: 0.0071
    Cell Significance Index: 0.0900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0006
    Cell Significance Index: -0.3500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0011
    Cell Significance Index: -0.7000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0022
    Cell Significance Index: -1.6500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0073
    Cell Significance Index: -2.1000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0074
    Cell Significance Index: -0.9100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0161
    Cell Significance Index: -0.4300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0176
    Cell Significance Index: -9.9400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0192
    Cell Significance Index: -14.5000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0197
    Cell Significance Index: -2.8600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0197
    Cell Significance Index: -14.4700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0259
    Cell Significance Index: -2.6500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0274
    Cell Significance Index: -12.1200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0340
    Cell Significance Index: -5.8000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0347
    Cell Significance Index: -0.5200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0353
    Cell Significance Index: -7.4400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0438
    Cell Significance Index: -5.1100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0521
    Cell Significance Index: -1.2500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0524
    Cell Significance Index: -0.8400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0715
    Cell Significance Index: -9.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0793
    Cell Significance Index: -9.0800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0847
    Cell Significance Index: -6.3100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0924
    Cell Significance Index: -2.3100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1149
    Cell Significance Index: -3.0800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1672
    Cell Significance Index: -2.5200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1672
    Cell Significance Index: -12.8300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1712
    Cell Significance Index: -4.5800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1773
    Cell Significance Index: -10.8700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1791
    Cell Significance Index: -4.7100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1858
    Cell Significance Index: -2.5400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1876
    Cell Significance Index: -1.5300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2008
    Cell Significance Index: -11.2700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2096
    Cell Significance Index: -10.8900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2419
    Cell Significance Index: -3.0000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2439
    Cell Significance Index: -6.6400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2456
    Cell Significance Index: -15.4800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2634
    Cell Significance Index: -12.2800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2777
    Cell Significance Index: -7.7600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2806
    Cell Significance Index: -8.2400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2990
    Cell Significance Index: -9.7900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3035
    Cell Significance Index: -5.6100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3160
    Cell Significance Index: -16.5900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3184
    Cell Significance Index: -10.0700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3327
    Cell Significance Index: -10.6000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3360
    Cell Significance Index: -11.7700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.3647
    Cell Significance Index: -15.8600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3793
    Cell Significance Index: -13.1800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4088
    Cell Significance Index: -15.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GCNT1 is a member of the glycosyltransferase family, specifically belonging to the Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity. The enzyme is predominantly expressed in various cell types, including epithelial, muscle, and neuronal cells, where it is involved in the production of O-glycans on mucins, glycoproteins, and glycolipids. GCNT1 exhibits high specificity for core 2 O-glycans, which are critical for the formation of beta-1,6-GlcNAc linkages. The enzyme's activity is regulated by various factors, including insulin, which modulates GCNT1 expression and activity in response to metabolic cues. **Pathways and Functions:** GCNT1 is integral to several cellular processes, including: 1. **Glycoprotein biosynthesis:** GCNT1 facilitates the transfer of GlcNAc to specific core glycan structures, enabling the formation of O-glycans on glycoproteins and mucins. 2. **Cell adhesion:** O-glycans on cell surface glycoproteins and mucins interact with specific ligands, modulating cell adhesion and migration. 3. **Signaling:** Glycoproteins and glycolipids modified by GCNT1 can interact with specific receptors, influencing signaling pathways involved in development, immune responses, and disease states. 4. **Morphogenesis:** GCNT1 plays a role in tissue morphogenesis, particularly in the development of epithelial and neural tissues. **Clinical Significance:** Dysregulation of GCNT1 has been implicated in various disease states, including: 1. **Neurological disorders:** Mutations in GCNT1 have been associated with neurodevelopmental disorders, such as intellectual disability and autism spectrum disorder. 2. **Cancer:** Altered GCNT1 expression and activity have been linked to cancer progression and metastasis. 3. **Immunological disorders:** GCNT1 plays a role in the regulation of leukocyte tethering and rolling, which is critical in the development of inflammatory diseases, such as atherosclerosis and arthritis. 4. **Metabolic disorders:** Insulin signaling pathways modulated by GCNT1 have been implicated in the regulation of glucose metabolism and the development of insulin resistance. In conclusion, GCNT1 is a vital component of the glycosylation machinery, playing a crucial role in various cellular processes, including glycoprotein biosynthesis, cell adhesion, signaling, and morphogenesis. Its dysregulation has been implicated in various disease states, highlighting the importance of GCNT1 in maintaining cellular homeostasis and its potential as a therapeutic target for disease intervention.

Genular Protein ID: 1724406744

Symbol: GCNT1_HUMAN

Name: Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

UniProtKB Accession Codes:

Q02742 Q6DJZ4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CTD 1 ChEBI 37 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 8 Ensembl 3 GO 15 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 7 Rhea 12 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1329093

Title: Expression cloning of a cDNA encoding UDP-GlcNAc:Gal beta 1-3-GalNAc-R (GlcNAc to GalNAc) beta 1-6GlcNAc transferase by gene transfer into CHO cells expressing polyoma large tumor antigen.

PubMed ID: 1329093

DOI: 10.1073/pnas.89.19.9326

PubMed ID: 7579796

Title: Genomic organization of core 2 and I branching beta-1,6-N-acetylglucosaminyltransferases. Implication for evolution of the beta-1,6-N-acetylglucosaminyltransferase gene family.

PubMed ID: 7579796

DOI: 10.1093/glycob/5.4.417

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23027862

Title: Golgi phosphoprotein 3 determines cell binding properties under dynamic flow by controlling Golgi localization of core 2 N-acetylglucosaminyltransferase 1.

PubMed ID: 23027862

DOI: 10.1074/jbc.m112.346528

Sequence Information:

  • Length: 428
  • Mass: 49799
  • Checksum: 71D71A251874E1F0
  • Sequence:
    • MLRTLLRRRL FSYPTKYYFM VLVLSLITFS VLRIHQKPEF VSVRHLELAG ENPSSDINCT 
KVLQGDVNEI QKVKLEILTV KFKKRPRWTP DDYINMTSDC SSFIKRRKYI VEPLSKEEAE 
FPIAYSIVVH HKIEMLDRLL RAIYMPQNFY CIHVDTKSED SYLAAVMGIA SCFSNVFVAS 
RLESVVYASW SRVQADLNCM KDLYAMSANW KYLINLCGMD FPIKTNLEIV RKLKLLMGEN 
NLETERMPSH KEERWKKRYE VVNGKLTNTG TVKMLPPLET PLFSGSAYFV VSREYVGYVL 
QNEKIQKLME WAQDTYSPDE YLWATIQRIP EVPGSLPASH KYDLSDMQAV ARFVKWQYFE 
GDVSKGAPYP PCDGVHVRSV CIFGAGDLNW MLRKHHLFAN KFDVDVDLFA IQCLDEHLRH 
KALETLKH

Genular Protein ID: 818596117

Symbol: Q86T81_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q86T81

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CAZy 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 InterPro 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 5

Sequence Information:

  • Length: 428
  • Mass: 49848
  • Checksum: CA0D2136BAF3988A
  • Sequence:
    • MLRTLLRRRL FSYPTKYYFM VLVLSLITFS VLRIHQKPEF VSVRHLELAG ENPSSDINCT 
KVLQGDVNEI QKVKLEILTV KFKKRPRWTP DDYINMTSDC SSFIKRRKYI VEPLSKEEAE 
FPIAYSIVVH HKIEMLDRLL RAIYMPQNFY CIHVDTKSED SYLAAVMGIA SCFSNVFVAS 
RLESVVYASW SRVQADLNCM KDLYAMSANW KYLINLCGMD FPIKTNLEIV RKLKLLMGEN 
NLETERMPSH KEERWKKRYE VVYGKLTNTG TVKMLPPLET PLFSGSAYFV VSREYVGYVL 
QNEKIQKLME WAQDTYSPDE YLWATIQRIP EVPGSLPASH KYDLSDMQAV ARFVKWQYFE 
GDVSKGAPYP PCDGVHVRSV CIFGAGDLNW MLRKHHLFAN KFDVDVDLFA IQCLDEHLRH 
KALETLKH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.