Details for: OR10H1

Gene ID: 26539

Symbol: OR10H1

Ensembl ID: ENSG00000186723

Description: olfactory receptor family 10 subfamily H member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 7.9720
    Cell Significance Index: -1.2400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 4.7311
    Cell Significance Index: -1.2000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.8285
    Cell Significance Index: 146.9300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.7081
    Cell Significance Index: 17.7000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.4800
    Cell Significance Index: 6.6600
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.4725
    Cell Significance Index: 5.9400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.4406
    Cell Significance Index: 27.0200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.4300
    Cell Significance Index: 3.9600
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.3045
    Cell Significance Index: 4.2100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1771
    Cell Significance Index: 2.8100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1723
    Cell Significance Index: 32.7900
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: 0.1620
    Cell Significance Index: 1.1300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1561
    Cell Significance Index: 3.3300
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.1430
    Cell Significance Index: 0.7800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.1409
    Cell Significance Index: 1.7800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1209
    Cell Significance Index: 7.2600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1183
    Cell Significance Index: 5.3600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0812
    Cell Significance Index: 8.0300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0807
    Cell Significance Index: 8.7800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0643
    Cell Significance Index: 58.0400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0636
    Cell Significance Index: 4.0100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0573
    Cell Significance Index: 0.7500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0512
    Cell Significance Index: 8.3400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0426
    Cell Significance Index: 5.4600
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.0415
    Cell Significance Index: 0.8500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0409
    Cell Significance Index: 2.8300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0403
    Cell Significance Index: 0.6900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0185
    Cell Significance Index: 0.4000
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.0179
    Cell Significance Index: 0.1100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0167
    Cell Significance Index: 2.0500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0155
    Cell Significance Index: 0.3400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0124
    Cell Significance Index: 0.5800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0117
    Cell Significance Index: 2.1100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0097
    Cell Significance Index: 1.1300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0087
    Cell Significance Index: 0.2000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0084
    Cell Significance Index: 0.2300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0083
    Cell Significance Index: 0.2400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0075
    Cell Significance Index: 0.2400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0059
    Cell Significance Index: 0.4200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0036
    Cell Significance Index: 0.0600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0031
    Cell Significance Index: 0.1100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0029
    Cell Significance Index: 0.0600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0023
    Cell Significance Index: 1.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0022
    Cell Significance Index: 0.7900
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: 0.0019
    Cell Significance Index: 0.0100
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.0013
    Cell Significance Index: 0.0100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0002
    Cell Significance Index: -0.3400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0003
    Cell Significance Index: -0.5200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0005
    Cell Significance Index: -0.9200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0006
    Cell Significance Index: -0.4300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0007
    Cell Significance Index: -0.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0010
    Cell Significance Index: -0.2100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0017
    Cell Significance Index: -1.0800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0020
    Cell Significance Index: -1.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0021
    Cell Significance Index: -1.1800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0023
    Cell Significance Index: -0.0400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0024
    Cell Significance Index: -0.4800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0026
    Cell Significance Index: -1.1900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0031
    Cell Significance Index: -0.6500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0041
    Cell Significance Index: -0.1200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0044
    Cell Significance Index: -0.0600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0044
    Cell Significance Index: -0.2200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0064
    Cell Significance Index: -0.7300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0076
    Cell Significance Index: -1.1100
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0077
    Cell Significance Index: -0.1000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0080
    Cell Significance Index: -1.1000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0081
    Cell Significance Index: -0.3500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0081
    Cell Significance Index: -0.9600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0086
    Cell Significance Index: -0.1300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0086
    Cell Significance Index: -0.3500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0097
    Cell Significance Index: -1.2500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0097
    Cell Significance Index: -0.7200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0111
    Cell Significance Index: -1.1300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0114
    Cell Significance Index: -0.2100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0129
    Cell Significance Index: -0.2700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0132
    Cell Significance Index: -1.0100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0141
    Cell Significance Index: -0.1600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0174
    Cell Significance Index: -0.5600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0174
    Cell Significance Index: -0.6100
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0177
    Cell Significance Index: -0.1500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0181
    Cell Significance Index: -1.1700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0181
    Cell Significance Index: -0.3900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0183
    Cell Significance Index: -0.6000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0201
    Cell Significance Index: -1.1300
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0231
    Cell Significance Index: -0.2800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0247
    Cell Significance Index: -1.1600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0262
    Cell Significance Index: -1.1600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0273
    Cell Significance Index: -0.6800
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0282
    Cell Significance Index: -0.2400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0285
    Cell Significance Index: -1.0800
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0285
    Cell Significance Index: -0.3800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0287
    Cell Significance Index: -0.6100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0289
    Cell Significance Index: -0.4200
  • Cell Name: deuterosomal cell (CL4033044)
    Fold Change: -0.0293
    Cell Significance Index: -0.2300
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0309
    Cell Significance Index: -0.3400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0320
    Cell Significance Index: -0.6700
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0331
    Cell Significance Index: -0.3200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0354
    Cell Significance Index: -0.7100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0360
    Cell Significance Index: -0.3800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** OR10H1 is a G protein-coupled receptor (GPCR) that belongs to the olfactory receptor family, which is responsible for detecting odorant molecules in the air. This receptor is characterized by its high expression in the olfactory epithelium, where it is involved in the perception of smell. OR10H1 is also expressed in other tissues, including the immune system, where it may play a role in modulating immune responses. **Pathways and Functions:** OR10H1 is involved in several signaling pathways, including: 1. **Detection of chemical stimulus involved in sensory perception of smell:** OR10H1 binds to odorant molecules, triggering a signaling cascade that ultimately leads to the perception of smell. 2. **Expression and translocation of olfactory receptors:** OR10H1 regulates the expression and translocation of other olfactory receptors, ensuring that the correct odorant molecules are detected. 3. **G protein-coupled receptor activity:** OR10H1 activates a G protein, which in turn modulates various downstream signaling pathways. 4. **G protein-coupled receptor signaling pathway:** OR10H1 is involved in the activation of a G protein-coupled receptor signaling pathway, which regulates various cellular processes. 5. **Olfactory receptor activity:** OR10H1 is a key player in the olfactory receptor activity, enabling the detection of odorant molecules. 6. **Olfactory signaling pathway:** OR10H1 is part of the olfactory signaling pathway, which transmits signals from the olfactory epithelium to the brain. **Clinical Significance:** OR10H1 has been implicated in various diseases, including: 1. **Mucosal immune disorders:** OR10H1 is expressed in the intestinal epithelium, where it may play a role in modulating the mucosal immune response. 2. **Neurological disorders:** OR10H1 is expressed in the cerebral cortex, where it may be involved in the regulation of olfactory perception and other neurological processes. 3. **Cancer:** OR10H1 has been implicated in the development and progression of certain types of cancer, including colon cancer. 4. **Neurodegenerative disorders:** OR10H1 may be involved in the regulation of olfactory perception in neurodegenerative disorders, such as Alzheimer's disease. In conclusion, OR10H1 is a complex gene that plays a crucial role in the detection of chemical stimuli involved in sensory perception of smell. Its expression in various tissues and involvement in multiple signaling pathways highlight its importance in multiple physiological processes. Further research is needed to fully elucidate the clinical significance of OR10H1 and its role in various diseases.

Genular Protein ID: 1447726165

Symbol: O10H1_HUMAN

Name: Olfactory receptor 10H1

UniProtKB Accession Codes:

Q9Y4A9 Q6IFQ2 Q96R59

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12213199

Title: DEFOG: a practical scheme for deciphering families of genes.

PubMed ID: 12213199

DOI: 10.1006/geno.2002.6830

PubMed ID: 14983052

Title: The human olfactory receptor gene family.

PubMed ID: 14983052

DOI: 10.1073/pnas.0307882100

Sequence Information:

  • Length: 318
  • Mass: 35254
  • Checksum: D289E18D8A56FC57
  • Sequence:
    • MQRANHSTVT QFILVGFSVF PHLQLMLFLL FLLMYLFTLL GNLLIMATVW SERSLHTPMY 
LFLCALSVSE ILYTVAIIPR MLADLLSTQR SIAFLACASQ MFFSFSFGFT HSFLLTVMGY 
DRYVAICHPL RYNVLMSPRG CACLVGCSWA GGLVMGMVVT SAIFHLAFCG HKEIHHFACH 
VPPLLKLACG DDVLVVAKGV GLVCITALLG CFLLILLSYA FIVAAILKIP SAEGRNKAFS 
TCASHLTVVV VHYGFASVIY LKPKSPQSLE GDTLMGITYT VLTPFLSPII FSLRNKELKV 
AMKKTFFSKL YPEKNVMM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.