Details for: GDI2

Gene ID: 2665

Symbol: GDI2

Ensembl ID: ENSG00000057608

Description: GDP dissociation inhibitor 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.97
    Marker Score: 39217
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.91
    Marker Score: 33816
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 2.89
    Marker Score: 1756
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.78
    Marker Score: 155707
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.77
    Marker Score: 3345.5
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.71
    Marker Score: 27496
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 2.67
    Marker Score: 2384
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.66
    Marker Score: 17329
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.65
    Marker Score: 5158
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.65
    Marker Score: 4615
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.56
    Marker Score: 7593
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.52
    Marker Score: 2632.5
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.5
    Marker Score: 3541
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.5
    Marker Score: 5220
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.48
    Marker Score: 10159
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.47
    Marker Score: 10632
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.43
    Marker Score: 1195
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.39
    Marker Score: 2557
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.39
    Marker Score: 2558
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.38
    Marker Score: 32026
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 2.38
    Marker Score: 2810.5
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.38
    Marker Score: 1496
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.35
    Marker Score: 5672
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.33
    Marker Score: 3954
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.31
    Marker Score: 1217
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.28
    Marker Score: 2148
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.28
    Marker Score: 2296
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.27
    Marker Score: 2267
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.26
    Marker Score: 6149
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.25
    Marker Score: 538
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.24
    Marker Score: 5272.5
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 2.22
    Marker Score: 2092
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.19
    Marker Score: 4450
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.19
    Marker Score: 1654
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.18
    Marker Score: 5426
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.18
    Marker Score: 55783
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.17
    Marker Score: 24452
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 2.15
    Marker Score: 2078
  • Cell Name: oocyte (CL0000023)
    Fold Change: 2.14
    Marker Score: 530
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 2.14
    Marker Score: 1254
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 2.14
    Marker Score: 5814
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.14
    Marker Score: 2397.5
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.12
    Marker Score: 2252
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.12
    Marker Score: 18249
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 2.11
    Marker Score: 1320
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.11
    Marker Score: 3743
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 2.11
    Marker Score: 2231
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 2.1
    Marker Score: 1392
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.1
    Marker Score: 1399
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.1
    Marker Score: 72598
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.09
    Marker Score: 2395
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.09
    Marker Score: 5417
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.09
    Marker Score: 1512
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.08
    Marker Score: 1491
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 2.08
    Marker Score: 2562
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.07
    Marker Score: 2972
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.07
    Marker Score: 3885
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.06
    Marker Score: 16111.5
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.06
    Marker Score: 8097
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 2.06
    Marker Score: 4034.5
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.06
    Marker Score: 70017
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.05
    Marker Score: 1497
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.05
    Marker Score: 3150
  • Cell Name: stem cell (CL0000034)
    Fold Change: 2.03
    Marker Score: 4832
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 2.02
    Marker Score: 955
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.02
    Marker Score: 9701
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 2.02
    Marker Score: 4236
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 2
    Marker Score: 1365
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.98
    Marker Score: 19973.5
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.98
    Marker Score: 1054
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 1.98
    Marker Score: 1358
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.98
    Marker Score: 5175
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.98
    Marker Score: 1127
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.97
    Marker Score: 1172
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.97
    Marker Score: 104279
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.97
    Marker Score: 1310
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.97
    Marker Score: 1904
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.97
    Marker Score: 1083
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.96
    Marker Score: 2291
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.95
    Marker Score: 12491
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.95
    Marker Score: 2595
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.95
    Marker Score: 655
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.94
    Marker Score: 2509
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.94
    Marker Score: 3184
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.93
    Marker Score: 445
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1.93
    Marker Score: 712
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.93
    Marker Score: 4379
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.93
    Marker Score: 476
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.92
    Marker Score: 2088
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.92
    Marker Score: 663
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.92
    Marker Score: 1365
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.92
    Marker Score: 939
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.91
    Marker Score: 1320
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.91
    Marker Score: 668
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.9
    Marker Score: 452
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.89
    Marker Score: 18759
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.89
    Marker Score: 607
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.89
    Marker Score: 5930
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.88
    Marker Score: 2766
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 1.88
    Marker Score: 430

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Other Information

**Key characteristics:** * GDI2 is a protein that is involved in the regulation of protein trafficking. * It is a negative regulator of cilium assembly and protein localization to the cilium. * It is involved in the negative regulation of protein localization to the cilium. * It is involved in the regulation of Rab GDP dissociation factor activity. * It is a key regulator of small GTPase-mediated signal transduction. **Pathways and functions:** * GDI2 inhibits the activity of Rab GDP dissociation factor. * Rab GDP dissociation factor is a protein that is involved in the trafficking of proteins between the endoplasmic reticulum and the cell. * When Rab GDP dissociation factor is bound by GDP, it dissociates from its GDP-bound form and becomes active. * The activated Rab GDP dissociation factor then dissociates GDP and activates the small GTPase. * The small GTPase then recruits a guanosine exchange protein (GEFS) to the GTP-bound Rab GDP. * The GEFS exchange GTP for GDP on the Rab, which then dissociates from the Rab GDP and becomes active. * The active Rab GDP dissociation factor then dissociates GDP and activates the small GTPase. * This leads to the activation of downstream signaling pathways, which can lead to cell cycle arrest or apoptosis. **Clinical significance:** GDI2 is a potential therapeutic target for cancer. Studies have shown that GDI2 inhibitors can inhibit the growth of cancer cells in vitro and in vivo. However, further research is needed to determine the optimal dose and schedule of GDI2 inhibitors for clinical use.

Genular Protein ID: 897842098

Symbol: GDIB_HUMAN

Name: Rab GDP dissociation inhibitor beta

UniProtKB Accession Codes:

P50395 O43928 Q5SX88 Q9UQM6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CPTAC 2 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 18 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 21 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRIDE 1 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 2 RNAct 1 Reactome 2 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9434952

Title: The human rab GDI beta gene with long retroposon-rich introns maps to 10p15 and its pseudogene to 7p11-p13.

PubMed ID: 9434952

DOI: 10.1007/s003359900685

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10996854

Title: Impairment of bile salt-dependent lipase secretion in human pancreatic tumoral SOJ-6 cells.

PubMed ID: 10996854

DOI: 10.1002/1097-4644(20001215)79:4<628::aid-jcb120>3.0.co;2-t

PubMed ID: 7543319

Title: Expression patterns of two human genes coding for different rab GDP-dissociation inhibitors (GDIs), extremely conserved proteins involved in cellular transport.

PubMed ID: 7543319

DOI: 10.1093/hmg/4.4.701

PubMed ID: 11809807

Title: The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function.

PubMed ID: 11809807

DOI: 10.1128/mcb.22.4.1158-1171.2002

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25860027

Title: GSK3beta-Dzip1-Rab8 cascade regulates ciliogenesis after mitosis.

PubMed ID: 25860027

DOI: 10.1371/journal.pbio.1002129

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26824392

Title: Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases.

PubMed ID: 26824392

DOI: 10.7554/elife.12813

PubMed ID: 29125462

Title: Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.

PubMed ID: 29125462

DOI: 10.7554/elife.31012

Sequence Information:

  • Length: 445
  • Mass: 50663
  • Checksum: CE186A2E3A47FCC9
  • Sequence:
    • MNEEYDVIVL GTGLTECILS GIMSVNGKKV LHMDRNPYYG GESASITPLE DLYKRFKIPG 
SPPESMGRGR DWNVDLIPKF LMANGQLVKM LLYTEVTRYL DFKVTEGSFV YKGGKIYKVP 
STEAEALASS LMGLFEKRRF RKFLVYVANF DEKDPRTFEG IDPKKTTMRD VYKKFDLGQD 
VIDFTGHALA LYRTDDYLDQ PCYETINRIK LYSESLARYG KSPYLYPLYG LGELPQGFAR 
LSAIYGGTYM LNKPIEEIIV QNGKVIGVKS EGEIARCKQL ICDPSYVKDR VEKVGQVIRV 
ICILSHPIKN TNDANSCQII IPQNQVNRKS DIYVCMISFA HNVAAQGKYI AIVSTTVETK 
EPEKEIRPAL ELLEPIEQKF VSISDLLVPK DLGTESQIFI SRTYDATTHF ETTCDDIKNI 
YKRMTGSEFD FEEMKRKKND IYGED

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.