Details for: STEAP1

Gene ID: 26872

Symbol: STEAP1

Ensembl ID: ENSG00000164647

Description: STEAP family member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 63.7509
    Cell Significance Index: -16.1700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 32.6822
    Cell Significance Index: -15.4300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 22.9948
    Cell Significance Index: -15.4300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.3982
    Cell Significance Index: -17.1400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.0902
    Cell Significance Index: -16.1400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.3495
    Cell Significance Index: 122.0500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.8012
    Cell Significance Index: 26.9900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.3572
    Cell Significance Index: 134.2600
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.0664
    Cell Significance Index: 11.0000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.9382
    Cell Significance Index: 15.4600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8925
    Cell Significance Index: 805.9000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.8026
    Cell Significance Index: 19.4400
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.5228
    Cell Significance Index: 5.4100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4889
    Cell Significance Index: 22.1600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4609
    Cell Significance Index: 31.8800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4432
    Cell Significance Index: 87.9600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4252
    Cell Significance Index: 12.1900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2835
    Cell Significance Index: 51.1000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1933
    Cell Significance Index: 6.1900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1799
    Cell Significance Index: 4.8200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1551
    Cell Significance Index: 7.2900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1518
    Cell Significance Index: 82.8800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1437
    Cell Significance Index: 4.1400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1305
    Cell Significance Index: 2.7800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1028
    Cell Significance Index: 45.4700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0992
    Cell Significance Index: 18.8800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0924
    Cell Significance Index: 11.3600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0899
    Cell Significance Index: 18.0300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0895
    Cell Significance Index: 4.5200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0755
    Cell Significance Index: 5.6300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0615
    Cell Significance Index: 1.4200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0614
    Cell Significance Index: 0.5700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0534
    Cell Significance Index: 6.8500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0496
    Cell Significance Index: 1.2400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0454
    Cell Significance Index: 7.7600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0451
    Cell Significance Index: 0.9400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0250
    Cell Significance Index: 0.7000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0165
    Cell Significance Index: 5.9300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0031
    Cell Significance Index: 0.4300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0045
    Cell Significance Index: -0.5800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0048
    Cell Significance Index: -0.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0068
    Cell Significance Index: -12.8000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0069
    Cell Significance Index: -4.2800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0088
    Cell Significance Index: -0.3100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0096
    Cell Significance Index: -7.1200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0105
    Cell Significance Index: -5.9300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0108
    Cell Significance Index: -19.9400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0114
    Cell Significance Index: -0.5300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0132
    Cell Significance Index: -20.3000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0154
    Cell Significance Index: -11.6900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0169
    Cell Significance Index: -23.0400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0196
    Cell Significance Index: -14.4000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0214
    Cell Significance Index: -6.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0218
    Cell Significance Index: -13.8300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0302
    Cell Significance Index: -3.5200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0333
    Cell Significance Index: -7.0100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0386
    Cell Significance Index: -17.5200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0411
    Cell Significance Index: -0.8900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0575
    Cell Significance Index: -0.6000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0582
    Cell Significance Index: -3.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0756
    Cell Significance Index: -8.6600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0863
    Cell Significance Index: -6.1000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0905
    Cell Significance Index: -13.1600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1051
    Cell Significance Index: -12.0000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1054
    Cell Significance Index: -2.7100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1115
    Cell Significance Index: -2.7800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1290
    Cell Significance Index: -13.1800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1342
    Cell Significance Index: -2.6200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1565
    Cell Significance Index: -16.3000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1900
    Cell Significance Index: -2.9400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1907
    Cell Significance Index: -15.1000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1941
    Cell Significance Index: -13.0500
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1981
    Cell Significance Index: -1.9100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2070
    Cell Significance Index: -8.4800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2252
    Cell Significance Index: -17.2800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2280
    Cell Significance Index: -2.5900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2325
    Cell Significance Index: -6.3300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2490
    Cell Significance Index: -3.9500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2496
    Cell Significance Index: -4.2100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2524
    Cell Significance Index: -15.9100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2564
    Cell Significance Index: -16.5400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2647
    Cell Significance Index: -5.5400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2717
    Cell Significance Index: -16.7000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2759
    Cell Significance Index: -15.4800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2788
    Cell Significance Index: -4.1200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.3163
    Cell Significance Index: -5.0800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3234
    Cell Significance Index: -16.9800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3360
    Cell Significance Index: -11.7700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3637
    Cell Significance Index: -13.3500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3667
    Cell Significance Index: -10.8000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3690
    Cell Significance Index: -2.5000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3807
    Cell Significance Index: -10.0100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3928
    Cell Significance Index: -12.5100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.3932
    Cell Significance Index: -17.1000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3968
    Cell Significance Index: -17.5500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4127
    Cell Significance Index: -14.3400
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.4141
    Cell Significance Index: -3.5200
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.4144
    Cell Significance Index: -2.1700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4486
    Cell Significance Index: -6.1200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4538
    Cell Significance Index: -12.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular localization:** STEAP1 is localized to the plasma membrane and is involved in cell-cell junctions. 2. **Protein structure:** The STEAP1 protein is a transmembrane protein with a characteristic structure, which allows it to interact with other proteins and lipids. 3. **Metal ion binding:** STEAP1 has the ability to bind metal ions, such as iron and zinc, which is essential for its function. 4. **Endosomal function:** STEAP1 is involved in the regulation of endosomal function, which is critical for cellular homeostasis. 5. **Cell type specificity:** STEAP1 expression is tissue-specific, with different cell types expressing the protein in distinct patterns. **Pathways and Functions:** 1. **Cell-cell junctions:** STEAP1 plays a role in maintaining the integrity of cell-cell junctions, which is essential for tissue function and homeostasis. 2. **Endosomal function:** STEAP1 regulates endosomal function, which is critical for the sorting and degradation of cellular waste and the uptake of nutrients. 3. **Ferric-chelate reductase activity:** STEAP1 has the ability to reduce ferric-chelates, which is essential for the regulation of iron homeostasis. 4. **Heme binding:** STEAP1 binds heme, which is essential for the regulation of cellular homeostasis and the maintenance of cellular function. 5. **Membrane and metal ion binding:** STEAP1 interacts with other proteins and lipids at the plasma membrane, which is essential for its function. **Clinical Significance:** 1. **Cancer:** STEAP1 has been implicated in the development and progression of several types of cancer, including prostate cancer, breast cancer, and lung cancer. 2. **Inflammatory disorders:** STEAP1 has been implicated in the pathogenesis of inflammatory disorders, such as rheumatoid arthritis and atherosclerosis. 3. **Neurological disorders:** STEAP1 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Metabolic disorders:** STEAP1 has been implicated in the regulation of glucose and lipid metabolism, which is essential for maintaining cellular homeostasis. 5. **Infectious diseases:** STEAP1 has been implicated in the pathogenesis of infectious diseases, such as tuberculosis and malaria. In conclusion, STEAP1 is a multifunctional gene that plays a critical role in maintaining cellular homeostasis and has been implicated in several diseases, including cancer, inflammatory disorders, and metabolic disorders. Further research is needed to fully understand the mechanisms by which STEAP1 regulates cellular processes and to explore its potential as a therapeutic target.

Genular Protein ID: 2770374877

Symbol: STEA1_HUMAN

Name: STEAP1 protein

UniProtKB Accession Codes:

Q9UHE8 A4D1E0 O95034

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 10 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EMDB 1 Ensembl 1 ExpressionAtlas 1 GO 7 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10588738

Title: STEAP: a prostate-specific cell-surface antigen highly expressed in human prostate tumors.

PubMed ID: 10588738

DOI: 10.1073/pnas.96.25.14523

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16609065

Title: The Steap proteins are metalloreductases.

PubMed ID: 16609065

DOI: 10.1182/blood-2006-02-003681

PubMed ID: 32409586

Title: Cryo-electron microscopy structure and potential enzymatic function of human six-transmembrane epithelial antigen of the prostate 1 (STEAP1).

PubMed ID: 32409586

DOI: 10.1074/jbc.ra120.013690

Sequence Information:

  • Length: 339
  • Mass: 39851
  • Checksum: 55443A170C870387
  • Sequence:
    • MESRKDITNQ EELWKMKPRR NLEEDDYLHK DTGETSMLKR PVLLHLHQTA HADEFDCPSE 
LQHTQELFPQ WHLPIKIAAI IASLTFLYTL LREVIHPLAT SHQQYFYKIP ILVINKVLPM 
VSITLLALVY LPGVIAAIVQ LHNGTKYKKF PHWLDKWMLT RKQFGLLSFF FAVLHAIYSL 
SYPMRRSYRY KLLNWAYQQV QQNKEDAWIE HDVWRMEIYV SLGIVGLAIL ALLAVTSIPS 
VSDSLTWREF HYIQSKLGIV SLLLGTIHAL IFAWNKWIDI KQFVWYTPPT FMIAVFLPIV 
VLIFKSILFL PCLRKKILKI RHGWEDVTKI NKTEICSQL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.