Details for: CHORDC1

Gene ID: 26973

Symbol: CHORDC1

Ensembl ID: ENSG00000110172

Description: cysteine and histidine rich domain containing 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 296.5054
    Cell Significance Index: -46.1200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 184.9250
    Cell Significance Index: -46.9100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 120.5008
    Cell Significance Index: -49.6400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 113.9958
    Cell Significance Index: -53.8200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 109.0442
    Cell Significance Index: -44.3000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 97.5728
    Cell Significance Index: -50.1900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 80.2060
    Cell Significance Index: -53.8200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 47.0231
    Cell Significance Index: -44.9000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 40.0501
    Cell Significance Index: -49.3800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.0226
    Cell Significance Index: -48.2800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.7229
    Cell Significance Index: -50.2100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.4566
    Cell Significance Index: -38.2600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 3.6080
    Cell Significance Index: 27.8100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.1814
    Cell Significance Index: 62.5300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5797
    Cell Significance Index: 316.8900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.1858
    Cell Significance Index: 25.6900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.1171
    Cell Significance Index: 29.3800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9563
    Cell Significance Index: 26.0300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8575
    Cell Significance Index: 101.1300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8225
    Cell Significance Index: 38.6600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7660
    Cell Significance Index: 152.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7598
    Cell Significance Index: 272.5200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6769
    Cell Significance Index: 92.9600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6475
    Cell Significance Index: 18.6600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5733
    Cell Significance Index: 36.9900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5596
    Cell Significance Index: 91.0100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5541
    Cell Significance Index: 383.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5173
    Cell Significance Index: 63.6100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5040
    Cell Significance Index: 275.2500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4035
    Cell Significance Index: 178.4000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3571
    Cell Significance Index: 64.3800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3370
    Cell Significance Index: 20.2300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3349
    Cell Significance Index: 15.1800
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.3285
    Cell Significance Index: 1.9300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3109
    Cell Significance Index: 39.8500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2932
    Cell Significance Index: 4.0000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2927
    Cell Significance Index: 264.2500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2781
    Cell Significance Index: 27.5100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2154
    Cell Significance Index: 10.8900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2055
    Cell Significance Index: 10.7900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1088
    Cell Significance Index: 3.7800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0585
    Cell Significance Index: 4.1400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0382
    Cell Significance Index: 2.9300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0305
    Cell Significance Index: 57.3600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0202
    Cell Significance Index: 0.7100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0097
    Cell Significance Index: 0.2600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0053
    Cell Significance Index: 0.3000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0037
    Cell Significance Index: 0.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0066
    Cell Significance Index: -12.1100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0100
    Cell Significance Index: -6.3700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0132
    Cell Significance Index: -20.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0174
    Cell Significance Index: -7.9100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0218
    Cell Significance Index: -29.6600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0357
    Cell Significance Index: -26.4400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0386
    Cell Significance Index: -28.3200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0387
    Cell Significance Index: -29.2900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0480
    Cell Significance Index: -29.9900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0635
    Cell Significance Index: -9.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0636
    Cell Significance Index: -35.8500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0778
    Cell Significance Index: -13.2900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0857
    Cell Significance Index: -11.0700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1014
    Cell Significance Index: -10.3600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1208
    Cell Significance Index: -1.4400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1236
    Cell Significance Index: -7.7900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.1306
    Cell Significance Index: -24.8600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1444
    Cell Significance Index: -30.4100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1536
    Cell Significance Index: -44.1900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1544
    Cell Significance Index: -8.0400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1835
    Cell Significance Index: -21.3900
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.2174
    Cell Significance Index: -2.2700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2184
    Cell Significance Index: -9.6600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2230
    Cell Significance Index: -15.4200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2502
    Cell Significance Index: -11.6700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2734
    Cell Significance Index: -7.6400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3124
    Cell Significance Index: -11.8300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3153
    Cell Significance Index: -23.5000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3587
    Cell Significance Index: -41.1000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4365
    Cell Significance Index: -49.8300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4451
    Cell Significance Index: -46.3500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4768
    Cell Significance Index: -12.7600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5080
    Cell Significance Index: -8.5000
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.5365
    Cell Significance Index: -5.7000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.5852
    Cell Significance Index: -12.2500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5905
    Cell Significance Index: -46.7700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.6281
    Cell Significance Index: -3.8000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.6606
    Cell Significance Index: -14.1200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7396
    Cell Significance Index: -19.0100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.7486
    Cell Significance Index: -17.3000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7629
    Cell Significance Index: -46.7700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.7630
    Cell Significance Index: -20.4500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.7658
    Cell Significance Index: -31.3800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.8373
    Cell Significance Index: -21.3900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.8635
    Cell Significance Index: -25.3600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.8653
    Cell Significance Index: -9.8300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.8947
    Cell Significance Index: -18.9900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.9090
    Cell Significance Index: -29.7600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.9115
    Cell Significance Index: -29.0300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9652
    Cell Significance Index: -30.9200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -1.0117
    Cell Significance Index: -8.2500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.0136
    Cell Significance Index: -35.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The CHORDC1 gene is characterized by its expression in multiple cell types, including those of connective tissue, epithelial cells, and immune cells. The protein encoded by this gene, CHRD1_HUMAN, is composed of a cysteine and histidine-rich domain, which is thought to be essential for its function. The gene is also associated with various cellular processes, including centrosome duplication, chaperone-mediated protein folding, and regulation of cellular responses to heat. **Pathways and Functions:** The CHORDC1 gene is involved in several key pathways, including: 1. **Centrosome duplication:** The CHORDC1 protein is thought to play a role in the regulation of centrosome duplication, a process crucial for cell division and cytokinesis. 2. **Chaperone-mediated protein folding:** The cysteine and histidine-rich domain of the CHORDC1 protein is believed to facilitate chaperone-mediated protein folding, a process essential for protein stability and function. 3. **Regulation of cellular response to heat:** The CHORDC1 protein is also involved in the regulation of cellular responses to heat stress, a process that is critical for cell survival and adaptation. 4. **Hsp90 protein binding:** The CHORDC1 protein interacts with heat shock protein 90 (Hsp90), a chaperone that plays a crucial role in protein folding and degradation. **Clinical Significance:** The CHORDC1 gene has been associated with various diseases, including cancer and autoimmune disorders. For example, alterations in the expression of CHORDC1 have been observed in prostate cancer and breast cancer, suggesting a potential role in tumorigenesis. Additionally, CHORDC1 has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus, where dysregulation of the immune response can lead to tissue damage and inflammation. In conclusion, the CHORDC1 gene is a multifaceted gene that plays a critical role in various cellular processes, including centrosome duplication, chaperone-mediated protein folding, and regulation of cellular responses to heat. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the molecular mechanisms underlying CHORDC1 function and its clinical significance. **Recommendations:** Future studies should aim to: 1. Elucidate the molecular mechanisms underlying CHORDC1 function, particularly in the context of centrosome duplication and chaperone-mediated protein folding. 2. Investigate the role of CHORDC1 in cancer and autoimmune diseases, with a focus on its potential as a therapeutic target. 3. Explore the expression patterns of CHORDC1 in different cell types and tissues, with a view to understanding its role in various physiological and pathological processes. By further investigating the CHORDC1 gene, we can gain a deeper understanding of its role in cellular processes and its potential as a therapeutic target for various diseases.

Genular Protein ID: 3190881488

Symbol: CHRD1_HUMAN

Name: Cysteine and histidine-rich domain-containing protein 1

UniProtKB Accession Codes:

Q9UHD1 B2R6P8 Q6IN49 Q8WVL9 Q9H3D6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 16 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10571178

Title: A novel class of eukaryotic zinc-binding proteins is required for disease resistance signaling in barley and development in C. elegans.

PubMed ID: 10571178

DOI: 10.1016/s0092-8674(00)81522-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20230755

Title: Morgana/chp-1, a ROCK inhibitor involved in centrosome duplication and tumorigenesis.

PubMed ID: 20230755

DOI: 10.1016/j.devcel.2009.12.020

PubMed ID: 19875381

Title: A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein.

PubMed ID: 19875381

DOI: 10.1074/mcp.m900261-mcp200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 32053105

Title: The CHORD protein CHP-1 regulates EGF receptor trafficking and signaling in C. elegans and in human cells.

PubMed ID: 32053105

DOI: 10.7554/elife.50986

Sequence Information:

  • Length: 332
  • Mass: 37490
  • Checksum: 3142D8EC8A879155
  • Sequence:
    • MALLCYNRGC GQRFDPETNS DDACTYHPGV PVFHDALKGW SCCKRRTTDF SDFLSIVGCT 
KGRHNSEKPP EPVKPEVKTT EKKELCELKP KFQEHIIQAP KPVEAIKRPS PDEPMTNLEL 
KISASLKQAL DKLKLSSGNE ENKKEEDNDE IKIGTSCKNG GCSKTYQGLE SLEEVCVYHS 
GVPIFHEGMK YWSCCRRKTS DFNTFLAQEG CTKGKHMWTK KDAGKKVVPC RHDWHQTGGE 
VTISVYAKNS LPELSRVEAN STLLNVHIVF EGEKEFDQNV KLWGVIDVKR SYVTMTATKI 
EITMRKAEPM QWASLELPAA KKQEKQKDAT TD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.