Details for: USP21

Gene ID: 27005

Symbol: USP21

Ensembl ID: ENSG00000143258

Description: ubiquitin specific peptidase 21

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 48.3782
    Cell Significance Index: -7.5300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 31.3432
    Cell Significance Index: -7.9500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 18.3997
    Cell Significance Index: -7.4800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 18.1627
    Cell Significance Index: -8.5800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 7.8555
    Cell Significance Index: -7.5000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.6426
    Cell Significance Index: -8.1900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.9527
    Cell Significance Index: -7.9100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.1160
    Cell Significance Index: -8.3500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.1097
    Cell Significance Index: -6.4800
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.4919
    Cell Significance Index: 9.2300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.0144
    Cell Significance Index: -2.2200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5629
    Cell Significance Index: 35.4800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5539
    Cell Significance Index: 500.1400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4629
    Cell Significance Index: 27.7900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.4619
    Cell Significance Index: 5.9200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4499
    Cell Significance Index: 48.9400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3823
    Cell Significance Index: 62.1700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3503
    Cell Significance Index: 9.7900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2922
    Cell Significance Index: 7.8300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2676
    Cell Significance Index: 7.7100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2390
    Cell Significance Index: 16.5300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2077
    Cell Significance Index: 4.5000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1986
    Cell Significance Index: 19.6500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1972
    Cell Significance Index: 22.9800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1840
    Cell Significance Index: 8.3400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1808
    Cell Significance Index: 36.2600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1426
    Cell Significance Index: 28.2900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1323
    Cell Significance Index: 2.7700
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.1226
    Cell Significance Index: 1.7200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1036
    Cell Significance Index: 19.7100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0932
    Cell Significance Index: 12.8000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0932
    Cell Significance Index: 4.8400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0876
    Cell Significance Index: 31.4400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0802
    Cell Significance Index: 14.4500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0773
    Cell Significance Index: 1.2400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0642
    Cell Significance Index: 0.9200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0598
    Cell Significance Index: 26.4400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0583
    Cell Significance Index: 6.8800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0571
    Cell Significance Index: 1.2500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0556
    Cell Significance Index: 30.3500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0436
    Cell Significance Index: 1.2800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0405
    Cell Significance Index: 0.5800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0394
    Cell Significance Index: 0.6600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0384
    Cell Significance Index: 1.7900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0342
    Cell Significance Index: 4.3900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0327
    Cell Significance Index: 1.1500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0275
    Cell Significance Index: 1.4300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0273
    Cell Significance Index: 18.9000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0233
    Cell Significance Index: 2.8600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0160
    Cell Significance Index: 0.3400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0037
    Cell Significance Index: 6.9000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0026
    Cell Significance Index: 4.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0016
    Cell Significance Index: 2.9700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0011
    Cell Significance Index: -0.0300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0013
    Cell Significance Index: -0.1000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0022
    Cell Significance Index: -2.9900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0031
    Cell Significance Index: -0.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0059
    Cell Significance Index: -3.7500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0076
    Cell Significance Index: -5.5900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0084
    Cell Significance Index: -6.3300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0101
    Cell Significance Index: -7.5100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0112
    Cell Significance Index: -5.0900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0132
    Cell Significance Index: -7.4600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0144
    Cell Significance Index: -9.0000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0169
    Cell Significance Index: -0.2300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0206
    Cell Significance Index: -0.5200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0208
    Cell Significance Index: -5.9900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0215
    Cell Significance Index: -3.1300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0234
    Cell Significance Index: -2.4000
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.0244
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0251
    Cell Significance Index: -2.8800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0283
    Cell Significance Index: -0.4300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0287
    Cell Significance Index: -0.7800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0312
    Cell Significance Index: -5.3200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0316
    Cell Significance Index: -2.0400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0414
    Cell Significance Index: -2.9300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0416
    Cell Significance Index: -2.5600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0428
    Cell Significance Index: -9.0200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0448
    Cell Significance Index: -5.7900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0509
    Cell Significance Index: -1.7700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0534
    Cell Significance Index: -0.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0549
    Cell Significance Index: -3.0800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0556
    Cell Significance Index: -2.9200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0574
    Cell Significance Index: -2.7000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0680
    Cell Significance Index: -5.0700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0699
    Cell Significance Index: -4.7000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0712
    Cell Significance Index: -1.9000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0752
    Cell Significance Index: -7.8300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0899
    Cell Significance Index: -5.5100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0944
    Cell Significance Index: -1.7500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0985
    Cell Significance Index: -7.8000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1093
    Cell Significance Index: -3.2200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1107
    Cell Significance Index: -0.7500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1180
    Cell Significance Index: -5.2200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1241
    Cell Significance Index: -3.1900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1348
    Cell Significance Index: -1.4000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1369
    Cell Significance Index: -3.9300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1378
    Cell Significance Index: -3.6900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1400
    Cell Significance Index: -5.3000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1666
    Cell Significance Index: -2.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** USP21 exhibits the following key characteristics: 1. **Deubiquitinating enzyme**: USP21 is a cysteine-type deubiquitinase enzyme, capable of removing ubiquitin chains from target proteins, thereby regulating their activity and localization. 2. **Tissue-specific expression**: USP21 is expressed in various tissues, including the pulmonary interstitial fibroblast, neural progenitor cell, germ cell, and intestinal epithelial cell, suggesting its involvement in different cellular processes. 3. **Cellular localization**: USP21 is found in both the cytosol and nucleus, highlighting its role in regulating protein activity and transcription. 4. **Interactions with signaling pathways**: USP21 interacts with multiple signaling pathways, including death receptor signaling, Tnfr1-induced NF-κB signaling, and Tnfr1-induced proapoptotic signaling, underscoring its role in regulating immune responses and cellular homeostasis. **Pathways and Functions:** USP21 is involved in several key pathways, including: 1. **Cysteine-type deubiquitinase activity**: USP21 regulates protein degradation by removing ubiquitin chains from target proteins. 2. **Death receptor signaling**: USP21 modulates the activity of death receptors, influencing apoptosis and immune responses. 3. **Tnfr1-induced NF-κB signaling**: USP21 regulates the activation of NF-κB, a transcription factor involved in immune responses and inflammation. 4. **Tnfr1-induced proapoptotic signaling**: USP21 modulates the activity of proapoptotic proteins, influencing cell survival and apoptosis. 5. **Protein binding and regulation**: USP21 regulates protein-protein interactions, influencing the activity of various proteins involved in cellular processes. **Clinical Significance:** The USP21 gene has significant implications for various diseases and conditions, including: 1. **Autoimmune disorders**: Dysregulation of USP21 may contribute to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer**: USP21 may play a role in cancer development and progression, particularly in the regulation of apoptosis and cellular homeostasis. 3. **Neurodegenerative diseases**: USP21 may be involved in neurodegenerative diseases, such as Alzheimer's and Parkinson's, through its regulation of protein degradation and transcription. 4. **Inflammatory disorders**: USP21 modulates inflammatory responses, making it a potential target for the treatment of inflammatory disorders, such as psoriasis and inflammatory bowel disease. In conclusion, the USP21 gene plays a critical role in regulating immune responses, cellular homeostasis, and protein degradation. Its dysregulation may contribute to various diseases and conditions, highlighting the need for further research into the mechanisms and functions of USP21.

Genular Protein ID: 2061928269

Symbol: UBP21_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10786635

Title: Sequencing, tissue distribution and chromosomal assignment of a novel ubiquitin-specific protease USP23.

PubMed ID: 10786635

DOI: 10.1016/s0167-4781(99)00233-x

PubMed ID: 10799498

Title: Identification of a novel isopeptidase with dual specificity for ubiquitin- and NEDD8-conjugated proteins.

PubMed ID: 10799498

DOI: 10.1074/jbc.275.19.14212

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15498874

Title: Large-scale cDNA transfection screening for genes related to cancer development and progression.

PubMed ID: 15498874

DOI: 10.1073/pnas.0404089101

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21888622

Title: A global survey of CRM1-dependent nuclear export sequences in the human deubiquitinase family.

PubMed ID: 21888622

DOI: 10.1042/bj20111300

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26100909

Title: BEND3 represses rDNA transcription by stabilizing a NoRC component via USP21 deubiquitinase.

PubMed ID: 26100909

DOI: 10.1073/pnas.1424705112

PubMed ID: 32011234

Title: Distinct regulatory ribosomal ubiquitylation events are reversible and hierarchically organized.

PubMed ID: 32011234

DOI: 10.7554/elife.54023

PubMed ID: 21399617

Title: Polyubiquitin binding and cross-reactivity in the USP domain deubiquitinase USP21.

PubMed ID: 21399617

DOI: 10.1038/embor.2011.17

Sequence Information:

  • Length: 565
  • Mass: 62656
  • Checksum: 8A13ED34C03B2330
  • Sequence:
  • MPQASEHRLG RTREPPVNIQ PRVGSKLPFA PRARSKERRN PASGPNPMLR PLPPRPGLPD 
    ERLKKLELGR GRTSGPRPRG PLRADHGVPL PGSPPPTVAL PLPSRTNLAR SKSVSSGDLR 
    PMGIALGGHR GTGELGAALS RLALRPEPPT LRRSTSLRRL GGFPGPPTLF SIRTEPPASH 
    GSFHMISARS SEPFYSDDKM AHHTLLLGSG HVGLRNLGNT CFLNAVLQCL SSTRPLRDFC 
    LRRDFRQEVP GGGRAQELTE AFADVIGALW HPDSCEAVNP TRFRAVFQKY VPSFSGYSQQ 
    DAQEFLKLLM ERLHLEINRR GRRAPPILAN GPVPSPPRRG GALLEEPELS DDDRANLMWK 
    RYLEREDSKI VDLFVGQLKS CLKCQACGYR STTFEVFCDL SLPIPKKGFA GGKVSLRDCF 
    NLFTKEEELE SENAPVCDRC RQKTRSTKKL TVQRFPRILV LHLNRFSASR GSIKKSSVGV 
    DFPLQRLSLG DFASDKAGSP VYQLYALCNH SGSVHYGHYT ALCRCQTGWH VYNDSRVSPV 
    SENQVASSEG YVLFYQLMQE PPRCL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.