Details for: USP21
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 48.3782
Cell Significance Index: -7.5300 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 31.3432
Cell Significance Index: -7.9500 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 18.3997
Cell Significance Index: -7.4800 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 18.1627
Cell Significance Index: -8.5800 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 7.8555
Cell Significance Index: -7.5000 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 6.6426
Cell Significance Index: -8.1900 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 2.9527
Cell Significance Index: -7.9100 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 2.1160
Cell Significance Index: -8.3500 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 2.1097
Cell Significance Index: -6.4800 - Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 1.4919
Cell Significance Index: 9.2300 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 1.0144
Cell Significance Index: -2.2200 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.5629
Cell Significance Index: 35.4800 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.5539
Cell Significance Index: 500.1400 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.4629
Cell Significance Index: 27.7900 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.4619
Cell Significance Index: 5.9200 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.4499
Cell Significance Index: 48.9400 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.3823
Cell Significance Index: 62.1700 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.3503
Cell Significance Index: 9.7900 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.2922
Cell Significance Index: 7.8300 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.2676
Cell Significance Index: 7.7100 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2390
Cell Significance Index: 16.5300 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2077
Cell Significance Index: 4.5000 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1986
Cell Significance Index: 19.6500 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.1972
Cell Significance Index: 22.9800 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1840
Cell Significance Index: 8.3400 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.1808
Cell Significance Index: 36.2600 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.1426
Cell Significance Index: 28.2900 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.1323
Cell Significance Index: 2.7700 - Cell Name: Sertoli cell (CL0000216)
Fold Change: 0.1226
Cell Significance Index: 1.7200 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1036
Cell Significance Index: 19.7100 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0932
Cell Significance Index: 12.8000 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0932
Cell Significance Index: 4.8400 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0876
Cell Significance Index: 31.4400 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0802
Cell Significance Index: 14.4500 - Cell Name: decidual cell (CL2000002)
Fold Change: 0.0773
Cell Significance Index: 1.2400 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.0642
Cell Significance Index: 0.9200 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0598
Cell Significance Index: 26.4400 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0583
Cell Significance Index: 6.8800 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.0571
Cell Significance Index: 1.2500 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0556
Cell Significance Index: 30.3500 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.0436
Cell Significance Index: 1.2800 - Cell Name: proerythroblast (CL0000547)
Fold Change: 0.0405
Cell Significance Index: 0.5800 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0394
Cell Significance Index: 0.6600 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0384
Cell Significance Index: 1.7900 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0342
Cell Significance Index: 4.3900 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0327
Cell Significance Index: 1.1500 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.0275
Cell Significance Index: 1.4300 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0273
Cell Significance Index: 18.9000 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0233
Cell Significance Index: 2.8600 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0160
Cell Significance Index: 0.3400 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0037
Cell Significance Index: 6.9000 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0026
Cell Significance Index: 4.0600 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0016
Cell Significance Index: 2.9700 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0011
Cell Significance Index: -0.0300 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0013
Cell Significance Index: -0.1000 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0022
Cell Significance Index: -2.9900 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0031
Cell Significance Index: -0.1000 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0059
Cell Significance Index: -3.7500 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0076
Cell Significance Index: -5.5900 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0084
Cell Significance Index: -6.3300 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0101
Cell Significance Index: -7.5100 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0112
Cell Significance Index: -5.0900 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0132
Cell Significance Index: -7.4600 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0144
Cell Significance Index: -9.0000 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0169
Cell Significance Index: -0.2300 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0206
Cell Significance Index: -0.5200 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0208
Cell Significance Index: -5.9900 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0215
Cell Significance Index: -3.1300 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0234
Cell Significance Index: -2.4000 - Cell Name: epidermal cell (CL0000362)
Fold Change: -0.0244
Cell Significance Index: -0.0600 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0251
Cell Significance Index: -2.8800 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.0283
Cell Significance Index: -0.4300 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0287
Cell Significance Index: -0.7800 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0312
Cell Significance Index: -5.3200 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0316
Cell Significance Index: -2.0400 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0414
Cell Significance Index: -2.9300 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0416
Cell Significance Index: -2.5600 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0428
Cell Significance Index: -9.0200 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0448
Cell Significance Index: -5.7900 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.0509
Cell Significance Index: -1.7700 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.0534
Cell Significance Index: -0.5800 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0549
Cell Significance Index: -3.0800 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0556
Cell Significance Index: -2.9200 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0574
Cell Significance Index: -2.7000 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0680
Cell Significance Index: -5.0700 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0699
Cell Significance Index: -4.7000 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0712
Cell Significance Index: -1.9000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0752
Cell Significance Index: -7.8300 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0899
Cell Significance Index: -5.5100 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.0944
Cell Significance Index: -1.7500 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0985
Cell Significance Index: -7.8000 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.1093
Cell Significance Index: -3.2200 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.1107
Cell Significance Index: -0.7500 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1180
Cell Significance Index: -5.2200 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1241
Cell Significance Index: -3.1900 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.1348
Cell Significance Index: -1.4000 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.1369
Cell Significance Index: -3.9300 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.1378
Cell Significance Index: -3.6900 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.1400
Cell Significance Index: -5.3000 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.1666
Cell Significance Index: -2.5100
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2061928269
Symbol: UBP21_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10786635
Title: Sequencing, tissue distribution and chromosomal assignment of a novel ubiquitin-specific protease USP23.
PubMed ID: 10786635
PubMed ID: 10799498
Title: Identification of a novel isopeptidase with dual specificity for ubiquitin- and NEDD8-conjugated proteins.
PubMed ID: 10799498
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15498874
Title: Large-scale cDNA transfection screening for genes related to cancer development and progression.
PubMed ID: 15498874
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 21888622
Title: A global survey of CRM1-dependent nuclear export sequences in the human deubiquitinase family.
PubMed ID: 21888622
DOI: 10.1042/bj20111300
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 26100909
Title: BEND3 represses rDNA transcription by stabilizing a NoRC component via USP21 deubiquitinase.
PubMed ID: 26100909
PubMed ID: 32011234
Title: Distinct regulatory ribosomal ubiquitylation events are reversible and hierarchically organized.
PubMed ID: 32011234
DOI: 10.7554/elife.54023
PubMed ID: 21399617
Title: Polyubiquitin binding and cross-reactivity in the USP domain deubiquitinase USP21.
PubMed ID: 21399617
Sequence Information:
- Length: 565
- Mass: 62656
- Checksum: 8A13ED34C03B2330
- Sequence:
MPQASEHRLG RTREPPVNIQ PRVGSKLPFA PRARSKERRN PASGPNPMLR PLPPRPGLPD ERLKKLELGR GRTSGPRPRG PLRADHGVPL PGSPPPTVAL PLPSRTNLAR SKSVSSGDLR PMGIALGGHR GTGELGAALS RLALRPEPPT LRRSTSLRRL GGFPGPPTLF SIRTEPPASH GSFHMISARS SEPFYSDDKM AHHTLLLGSG HVGLRNLGNT CFLNAVLQCL SSTRPLRDFC LRRDFRQEVP GGGRAQELTE AFADVIGALW HPDSCEAVNP TRFRAVFQKY VPSFSGYSQQ DAQEFLKLLM ERLHLEINRR GRRAPPILAN GPVPSPPRRG GALLEEPELS DDDRANLMWK RYLEREDSKI VDLFVGQLKS CLKCQACGYR STTFEVFCDL SLPIPKKGFA GGKVSLRDCF NLFTKEEELE SENAPVCDRC RQKTRSTKKL TVQRFPRILV LHLNRFSASR GSIKKSSVGV DFPLQRLSLG DFASDKAGSP VYQLYALCNH SGSVHYGHYT ALCRCQTGWH VYNDSRVSPV SENQVASSEG YVLFYQLMQE PPRCL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.