Details for: FGF22

Gene ID: 27006

Symbol: FGF22

Ensembl ID: ENSG00000070388

Description: fibroblast growth factor 22

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 30.9878
    Cell Significance Index: -4.8200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 19.0031
    Cell Significance Index: -4.8200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.2265
    Cell Significance Index: -4.8400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.8243
    Cell Significance Index: 20.6100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 0.7879
    Cell Significance Index: -2.4200
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.3812
    Cell Significance Index: 3.2400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2607
    Cell Significance Index: 15.6500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2129
    Cell Significance Index: 40.5200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2061
    Cell Significance Index: 10.8200
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.1962
    Cell Significance Index: 2.2600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.1801
    Cell Significance Index: 1.2200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1697
    Cell Significance Index: 4.8900
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.1567
    Cell Significance Index: 1.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1415
    Cell Significance Index: 28.3900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1411
    Cell Significance Index: 7.3300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1383
    Cell Significance Index: 6.2700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1379
    Cell Significance Index: 1.9800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1105
    Cell Significance Index: 12.0200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0836
    Cell Significance Index: 2.1500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0826
    Cell Significance Index: 1.7900
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.0754
    Cell Significance Index: 0.1700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0591
    Cell Significance Index: 21.1900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0541
    Cell Significance Index: 0.8100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0410
    Cell Significance Index: 2.8400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0330
    Cell Significance Index: 1.1600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0309
    Cell Significance Index: 0.6600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0281
    Cell Significance Index: 1.3100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0269
    Cell Significance Index: 3.7000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0202
    Cell Significance Index: 2.9300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0149
    Cell Significance Index: 1.4700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0141
    Cell Significance Index: 0.8900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0140
    Cell Significance Index: 2.2800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0126
    Cell Significance Index: 1.6100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0097
    Cell Significance Index: 4.3100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0084
    Cell Significance Index: 15.7400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0062
    Cell Significance Index: 3.9400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0055
    Cell Significance Index: 0.9900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0028
    Cell Significance Index: 2.5000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0026
    Cell Significance Index: 0.5200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0013
    Cell Significance Index: 2.4300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0008
    Cell Significance Index: 0.4400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0008
    Cell Significance Index: -1.2400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0011
    Cell Significance Index: -0.0500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0018
    Cell Significance Index: -0.2100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0018
    Cell Significance Index: -0.0700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0034
    Cell Significance Index: -0.1100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0036
    Cell Significance Index: -4.9400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0044
    Cell Significance Index: -3.1900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0059
    Cell Significance Index: -4.4300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0065
    Cell Significance Index: -2.9500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0070
    Cell Significance Index: -5.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0090
    Cell Significance Index: -5.0600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0097
    Cell Significance Index: -2.8000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0102
    Cell Significance Index: -6.3700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0103
    Cell Significance Index: -1.0500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0128
    Cell Significance Index: -1.5800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0128
    Cell Significance Index: -0.2200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0160
    Cell Significance Index: -0.3500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0165
    Cell Significance Index: -1.0100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0245
    Cell Significance Index: -4.1800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0267
    Cell Significance Index: -3.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0288
    Cell Significance Index: -6.0700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0323
    Cell Significance Index: -0.8800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0331
    Cell Significance Index: -2.3400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0336
    Cell Significance Index: -3.8600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0346
    Cell Significance Index: -2.6600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0353
    Cell Significance Index: -2.6300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0355
    Cell Significance Index: -0.4400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0372
    Cell Significance Index: -1.0400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0405
    Cell Significance Index: -0.8400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0422
    Cell Significance Index: -4.3900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0437
    Cell Significance Index: -5.1500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0463
    Cell Significance Index: -3.1100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0471
    Cell Significance Index: -2.0500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0473
    Cell Significance Index: -2.9100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0491
    Cell Significance Index: -0.7400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0491
    Cell Significance Index: -1.4000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0515
    Cell Significance Index: -4.0800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0556
    Cell Significance Index: -3.5900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0616
    Cell Significance Index: -0.8400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0656
    Cell Significance Index: -3.0900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0683
    Cell Significance Index: -0.9700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0702
    Cell Significance Index: -3.9400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0740
    Cell Significance Index: -1.2200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0747
    Cell Significance Index: -2.3800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0831
    Cell Significance Index: -2.7200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0831
    Cell Significance Index: -2.9100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0859
    Cell Significance Index: -2.5300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0899
    Cell Significance Index: -2.4000
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0972
    Cell Significance Index: -0.9400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0984
    Cell Significance Index: -1.4100
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.1032
    Cell Significance Index: -0.9300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1066
    Cell Significance Index: -1.7100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1102
    Cell Significance Index: -3.8300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1151
    Cell Significance Index: -2.4100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1153
    Cell Significance Index: -1.8300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1179
    Cell Significance Index: -3.3800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1215
    Cell Significance Index: -3.0300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1253
    Cell Significance Index: -2.1600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1271
    Cell Significance Index: -2.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FGF22 is a 22-kDa protein that belongs to the fibroblast growth factor family. It is highly conserved across species, with high sequence similarity to other members of the family. FGF22 is primarily expressed in the kidney, colon, and brain, where it is involved in various cellular processes, including cell differentiation, proliferation, and migration. Notably, FGF22 has been shown to have a high degree of homology to FGF21, a well-studied member of the FGF family, suggesting that FGF22 may have similar functions in the body. **Pathways and Functions:** FGF22 is involved in several signaling pathways, including the fibroblast growth factor receptor (FGFR) pathway, the insulin receptor signaling cascade, and the phospholipase C-mediated cascade. FGF22 binds to FGFRs, activating downstream signaling pathways that regulate cell proliferation, differentiation, and migration. Additionally, FGF22 has been shown to interact with other growth factors, including insulin-like growth factor 1 (IGF-1), to regulate cell growth and survival. FGF22 has also been implicated in the regulation of the PI3K/AKT signaling pathway, which is a key regulator of cell survival and proliferation. **Clinical Significance:** FGF22 has been implicated in several diseases, including cancer, metabolic disorders, and autoimmune diseases. In cancer, FGF22 has been shown to promote tumor growth, metastasis, and angiogenesis. In metabolic disorders, FGF22 has been implicated in the regulation of glucose and lipid metabolism. In autoimmune diseases, FGF22 has been shown to regulate the immune response and inflammation. Notably, FGF22 has been identified as a biomarker for several diseases, including cancer and metabolic disorders, suggesting that it may have potential as a therapeutic target. **Conclusion:** FGF22 is a complex and multifaceted protein that plays a crucial role in various cellular processes, including cell differentiation, proliferation, and migration. Despite its widespread expression in various tissues, FGF22 remains poorly understood, and its exact role in the immune system is still unclear. Further research is needed to fully elucidate the mechanisms by which FGF22 regulates cellular processes and to explore its potential as a therapeutic target for various diseases. **Recommendations for Future Research:** 1. Investigate the specific mechanisms by which FGF22 regulates cellular processes, including cell differentiation, proliferation, and migration. 2. Explore the role of FGF22 in the immune system, including its interactions with other immune cells and its regulation of immune responses. 3. Investigate the potential of FGF22 as a therapeutic target for various diseases, including cancer, metabolic disorders, and autoimmune diseases. 4. Develop novel assays and techniques to study FGF22 and its interactions with other proteins and signaling pathways. By addressing these questions and exploring the mysteries of FGF22, we may uncover new insights into the regulation of cellular processes and the development of novel therapeutic strategies for various diseases.

Genular Protein ID: 4269616893

Symbol: FGF22_HUMAN

Name: Fibroblast growth factor 22

UniProtKB Accession Codes:

Q9HCT0 B2RPH4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 21 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11342227

Title: Identification of a novel fibroblast growth factor, FGF-22, preferentially expressed in the inner root sheath of the hair follicle.

PubMed ID: 11342227

DOI: 10.1016/s0167-4781(00)00302-x

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15806171

Title: The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair.

PubMed ID: 15806171

DOI: 10.1038/sj.onc.1208560

PubMed ID: 16597617

Title: Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.

PubMed ID: 16597617

DOI: 10.1074/jbc.m601252200

PubMed ID: 20094046

Title: Fibroblast growth factor signalling: from development to cancer.

PubMed ID: 20094046

DOI: 10.1038/nrc2780

Sequence Information:

  • Length: 170
  • Mass: 19663
  • Checksum: CB88918C2D5A4CE7
  • Sequence:
    • MRRRLWLGLA WLLLARAPDA AGTPSASRGP RSYPHLEGDV RWRRLFSSTH FFLRVDPGGR 
VQGTRWRHGQ DSILEIRSVH VGVVVIKAVS SGFYVAMNRR GRLYGSRLYT VDCRFRERIE 
ENGHNTYASQ RWRRRGQPMF LALDRRGGPR PGGRTRRYHL SAHFLPVLVS

Genular Protein ID: 1175798729

Symbol: K7ELB9_HUMAN

Name: N/A

UniProtKB Accession Codes:

K7ELB9

Database IDs:

ARBA 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 2 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 1 Proteomes 2 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 165
  • Mass: 18205
  • Checksum: CF1F21CAF2EC8925
  • Sequence:
    • MRRRLWLGLA WLLLARAPDA AGTPSASRGP RSYPHLEGDV RWRRLFSSTH FFLRVDPGGR 
VQGTRWRHGQ DSILEIRSVH VGVVVIKAVS SGFYVAMNRR GRLYGSVPGA HRRERPQHLR 
LTALAPPRPA HVPGAGQEGG APARRPDAAV PPVRPLPARP GLLRP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.