Details for: CNPPD1

Gene ID: 27013

Symbol: CNPPD1

Ensembl ID: ENSG00000115649

Description: cyclin Pas1/PHO80 domain containing 1

Associated with

  • Cyclin-dependent protein kinase holoenzyme complex
    (GO:0000307)
  • Cyclin-dependent protein serine/threonine kinase regulator activity
    (GO:0016538)
  • Membrane
    (GO:0016020)
  • Nucleus
    (GO:0005634)
  • Protein kinase binding
    (GO:0019901)
  • Regulation of cyclin-dependent protein serine/threonine kinase activity
    (GO:0000079)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 119.2901
    Cell Significance Index: -18.5600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 74.3958
    Cell Significance Index: -18.8700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 58.3812
    Cell Significance Index: -24.0500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 55.0883
    Cell Significance Index: -22.3800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 50.3259
    Cell Significance Index: -23.7600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 47.8435
    Cell Significance Index: -24.6100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 23.6503
    Cell Significance Index: -22.5800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.8562
    Cell Significance Index: -19.5500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.8929
    Cell Significance Index: -18.4700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.7830
    Cell Significance Index: -22.8200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.9227
    Cell Significance Index: -15.1200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.0842
    Cell Significance Index: -6.7500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.3689
    Cell Significance Index: 159.5300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.3138
    Cell Significance Index: 38.5900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0877
    Cell Significance Index: 176.9100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.0027
    Cell Significance Index: 118.2500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.9128
    Cell Significance Index: 58.8900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8971
    Cell Significance Index: 12.2400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7307
    Cell Significance Index: 50.5300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6504
    Cell Significance Index: 587.3000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5996
    Cell Significance Index: 12.9900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5779
    Cell Significance Index: 30.1000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5160
    Cell Significance Index: 93.0100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3685
    Cell Significance Index: 45.3100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3540
    Cell Significance Index: 16.0500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3438
    Cell Significance Index: 16.0300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2851
    Cell Significance Index: 7.7600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.2527
    Cell Significance Index: 4.6700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2512
    Cell Significance Index: 111.0400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2489
    Cell Significance Index: 11.7000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2426
    Cell Significance Index: 12.6000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2377
    Cell Significance Index: 32.6400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2149
    Cell Significance Index: 117.3800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2129
    Cell Significance Index: 36.3500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1935
    Cell Significance Index: 2.9000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1914
    Cell Significance Index: 24.5300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1911
    Cell Significance Index: 18.9000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1722
    Cell Significance Index: 4.9600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1715
    Cell Significance Index: 32.6300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1051
    Cell Significance Index: 20.8500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0983
    Cell Significance Index: 6.9500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0869
    Cell Significance Index: 17.4300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0553
    Cell Significance Index: 1.7700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0459
    Cell Significance Index: 3.4200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0357
    Cell Significance Index: 24.6700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0292
    Cell Significance Index: 0.7800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0256
    Cell Significance Index: 0.9000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0188
    Cell Significance Index: 6.7300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0130
    Cell Significance Index: 0.6800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0128
    Cell Significance Index: 24.0800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0048
    Cell Significance Index: 0.6200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0020
    Cell Significance Index: 1.4800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0019
    Cell Significance Index: -1.4100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0043
    Cell Significance Index: -0.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0053
    Cell Significance Index: -3.9000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0057
    Cell Significance Index: -0.5800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0068
    Cell Significance Index: -4.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0128
    Cell Significance Index: -23.6100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0154
    Cell Significance Index: -23.7600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0171
    Cell Significance Index: -0.4500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0174
    Cell Significance Index: -23.6900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0248
    Cell Significance Index: -1.5600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0258
    Cell Significance Index: -14.5300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0265
    Cell Significance Index: -0.7400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0266
    Cell Significance Index: -16.8700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0369
    Cell Significance Index: -0.3400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0395
    Cell Significance Index: -8.3300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0457
    Cell Significance Index: -20.7300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0578
    Cell Significance Index: -6.6000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0581
    Cell Significance Index: -0.6600
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0672
    Cell Significance Index: -0.5100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0685
    Cell Significance Index: -19.7200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0759
    Cell Significance Index: -1.9400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0759
    Cell Significance Index: -8.7000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0821
    Cell Significance Index: -2.2000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0876
    Cell Significance Index: -1.8700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1036
    Cell Significance Index: -15.0600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1324
    Cell Significance Index: -3.3100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1488
    Cell Significance Index: -1.5400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1568
    Cell Significance Index: -2.6300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1586
    Cell Significance Index: -12.1700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2085
    Cell Significance Index: -21.7100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2237
    Cell Significance Index: -13.7500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2462
    Cell Significance Index: -19.5000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2535
    Cell Significance Index: -6.7800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2814
    Cell Significance Index: -17.2600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2844
    Cell Significance Index: -5.9000
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2894
    Cell Significance Index: -2.4600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2948
    Cell Significance Index: -19.8300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2974
    Cell Significance Index: -10.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3447
    Cell Significance Index: -19.3400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4019
    Cell Significance Index: -11.5200
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.4392
    Cell Significance Index: -6.1600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4417
    Cell Significance Index: -7.5700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4515
    Cell Significance Index: -13.3000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4598
    Cell Significance Index: -10.0700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4598
    Cell Significance Index: -11.8200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4748
    Cell Significance Index: -24.0000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4903
    Cell Significance Index: -21.6900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.5169
    Cell Significance Index: -8.9100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The CNPPD1 gene is characterized by its unique domain structure, which comprises a cyclin Pas1/PHO80 domain. This domain is essential for the protein's ability to interact with cyclin-dependent protein kinases (CDKs) and regulate their activity. CNPPD1 is highly expressed in various cell types, including germ cells, B cells, and epithelial cells, suggesting its involvement in multiple biological processes. Notably, CNPPD1 is significantly expressed in immune cells, such as class-switched memory B cells, CD4-positive, alpha-beta memory T cells, and tonsil germinal center B cells, highlighting its potential role in immune function and regulation. **Pathways and Functions:** The CNPPD1 gene is intricately involved in several cellular pathways, including: 1. **Cyclin-dependent protein kinase holoenzyme complex**: CNPPD1 interacts with CDKs to form a holoenzyme complex, which regulates the cell cycle and mitosis. 2. **Cyclin-dependent protein serine/threonine kinase regulator activity**: CNPPD1 modulates the activity of CDKs, influencing cell proliferation, differentiation, and survival. 3. **Membrane and nucleus**: CNPPD1 is localized to both the membrane and nucleus, suggesting its role in regulating cellular processes that involve membrane trafficking and gene expression. **Clinical Significance:** The CNPPD1 gene has significant implications for various diseases, particularly those related to immune dysfunction and cancer. Some potential clinical applications of CNPPD1 include: 1. **Immunotherapy**: CNPPD1 may play a role in modulating immune responses, making it a potential target for immunotherapies aimed at cancer treatment. 2. **Autoimmune diseases**: CNPPD1's involvement in immune function suggests its potential role in autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Cancer research**: CNPPD1's involvement in cell cycle regulation and protein kinase interactions makes it a potential target for cancer research and therapy. In conclusion, the CNPPD1 gene is a complex and multifaceted gene that plays a crucial role in regulating cellular processes, including cell cycle, protein kinase interactions, and immune function. Further research is necessary to fully elucidate the mechanisms by which CNPPD1 functions and to explore its potential clinical applications.

Genular Protein ID: 3991949616

Symbol: CNPD1_HUMAN

Name: Protein CNPPD1

UniProtKB Accession Codes:

Q9BV87 B2RC77 O75548 Q9H4N0 Q9UQN0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 4 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 410
  • Mass: 45456
  • Checksum: 9C0C75F7BF026C6A
  • Sequence:
    • MDLTGLLLDE EGTFSLAGFQ DFTFLPGHQK LSARIRRRLY YGWDWEADCS LEELSSPVAD 
IAVELLQKAA PSPIRRLQKK YVAHVSREAC ISPCAMMLAL VYIERLRHRN PDYLQHVSSS 
DLFLISMMVA SKYLYDEGEE EEVFNDEWGA AGGVAVPTLN ALERGFLSAM DWHLYTDPRE 
IFEVLSWLES CVAEQQGRWR GWYTYTDLCV LLEQPTWQLA LGSLCQRLVK LSCLLAVAYV 
SSVALAVASV AVIHQSLGLS CIPTPGPPDL GLTSRCLLEP CIPSVPQCLP SLANVSSCLE 
GSMGLRSLWG SLLASLTPPP LPPPDPPAPP TLLHNCHLCQ KLQRDSPTCH ACLHPNRTVP 
TALSSPWYHT YGLAPPWPWS PVLLSLPQPQ QCSLFSVMEL ARLKSFVFPG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.