Details for: SIGLEC7

Gene ID: 27036

Symbol: SIGLEC7

Ensembl ID: ENSG00000168995

Description: sialic acid binding Ig like lectin 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 22.8872
    Cell Significance Index: -3.5600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 2.8955
    Cell Significance Index: -3.5700
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.1584
    Cell Significance Index: 12.3300
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.9986
    Cell Significance Index: 2.6800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.7350
    Cell Significance Index: 13.5900
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 0.6805
    Cell Significance Index: 1.8000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.2992
    Cell Significance Index: 4.8000
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.0683
    Cell Significance Index: 0.7300
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.0599
    Cell Significance Index: 0.4900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0009
    Cell Significance Index: -0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0017
    Cell Significance Index: -3.2700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0019
    Cell Significance Index: -1.4400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0023
    Cell Significance Index: -1.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0026
    Cell Significance Index: -3.9600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0040
    Cell Significance Index: -3.0200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0058
    Cell Significance Index: -3.7200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0059
    Cell Significance Index: -1.6900
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.0077
    Cell Significance Index: -0.0700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0084
    Cell Significance Index: -3.8000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0087
    Cell Significance Index: -0.8900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0093
    Cell Significance Index: -3.3400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0101
    Cell Significance Index: -0.4100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0113
    Cell Significance Index: -2.2400
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0130
    Cell Significance Index: -0.1900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0167
    Cell Significance Index: -3.3500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0169
    Cell Significance Index: -0.8500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0182
    Cell Significance Index: -2.5100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0211
    Cell Significance Index: -3.8100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0214
    Cell Significance Index: -3.6500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0254
    Cell Significance Index: -3.6900
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0263
    Cell Significance Index: -0.3500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0266
    Cell Significance Index: -1.6800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0300
    Cell Significance Index: -1.4000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0304
    Cell Significance Index: -3.7400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0306
    Cell Significance Index: -3.6100
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0310
    Cell Significance Index: -0.4000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0327
    Cell Significance Index: -3.7500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0335
    Cell Significance Index: -0.4700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0356
    Cell Significance Index: -0.2900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0367
    Cell Significance Index: -4.7000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0453
    Cell Significance Index: -3.4800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0454
    Cell Significance Index: -1.2700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0496
    Cell Significance Index: -3.7000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0519
    Cell Significance Index: -2.4400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0556
    Cell Significance Index: -2.8900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0565
    Cell Significance Index: -3.8000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0570
    Cell Significance Index: -3.6800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0579
    Cell Significance Index: -3.5600
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.0601
    Cell Significance Index: -0.5500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0606
    Cell Significance Index: -1.0300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0610
    Cell Significance Index: -1.5700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0667
    Cell Significance Index: -3.7500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0690
    Cell Significance Index: -1.3500
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: -0.0703
    Cell Significance Index: -0.1800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0718
    Cell Significance Index: -1.7400
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0784
    Cell Significance Index: -0.8000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0846
    Cell Significance Index: -3.7400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0888
    Cell Significance Index: -3.1100
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0944
    Cell Significance Index: -0.8400
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0958
    Cell Significance Index: -0.8100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0985
    Cell Significance Index: -2.6300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0985
    Cell Significance Index: -3.7300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0988
    Cell Significance Index: -1.6600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1017
    Cell Significance Index: -2.7300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1067
    Cell Significance Index: -3.5000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1071
    Cell Significance Index: -3.7200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1109
    Cell Significance Index: -1.6100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1130
    Cell Significance Index: -3.6000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1175
    Cell Significance Index: -3.4600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1267
    Cell Significance Index: -3.7200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1284
    Cell Significance Index: -3.6800
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: -0.1321
    Cell Significance Index: -0.5500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1326
    Cell Significance Index: -1.9000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1332
    Cell Significance Index: -3.8000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1383
    Cell Significance Index: -2.1400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1386
    Cell Significance Index: -3.5300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1400
    Cell Significance Index: -3.6800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1400
    Cell Significance Index: -2.0100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1408
    Cell Significance Index: -3.5100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1425
    Cell Significance Index: -3.5600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1447
    Cell Significance Index: -3.6100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1451
    Cell Significance Index: -3.9500
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1463
    Cell Significance Index: -1.8100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1482
    Cell Significance Index: -3.7900
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1486
    Cell Significance Index: -1.7100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1526
    Cell Significance Index: -3.6600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1529
    Cell Significance Index: -2.0000
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.1624
    Cell Significance Index: -1.6800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1624
    Cell Significance Index: -3.3900
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1633
    Cell Significance Index: -1.5200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1644
    Cell Significance Index: -3.6000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1648
    Cell Significance Index: -3.5600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1658
    Cell Significance Index: -4.0500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1701
    Cell Significance Index: -2.0000
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1702
    Cell Significance Index: -1.5000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1715
    Cell Significance Index: -3.6400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1731
    Cell Significance Index: -4.0000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1775
    Cell Significance Index: -3.5400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1776
    Cell Significance Index: -3.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SIGLEC7 is a member of the sialic acid binding Ig-like lectin family, which are carbohydrate-binding proteins that recognize and bind to sialic acid residues on the surface of cells. The SIGLEC7 protein is characterized by its ability to bind to sialic acid residues, which are commonly found on the surface of immune cells, such as T cells, B cells, and dendritic cells. This binding is thought to play a key role in modulating immune cell interactions, including cell adhesion, migration, and signaling. **Pathways and Functions:** SIGLEC7 is involved in several key pathways, including: 1. **Adaptive Immunity:** SIGLEC7 plays a crucial role in regulating T cell responses, particularly in the context of autoimmune diseases. It binds to sialic acid residues on the surface of antigen-presenting cells, which helps to modulate T cell activation and proliferation. 2. **Innate Immunity:** SIGLEC7 is also involved in the recognition of pathogens by innate immune cells, such as dendritic cells and macrophages. It helps to regulate the production of pro-inflammatory cytokines and the activation of immune cells. 3. **Cell Adhesion:** SIGLEC7 binds to sialic acid residues on the surface of cells, which helps to regulate cell adhesion and migration. This is particularly important in the context of immune cell migration to sites of inflammation. 4. **Signaling:** SIGLEC7 is also involved in the regulation of signaling pathways, including the JAK/STAT pathway, which is important for the regulation of immune cell responses. **Clinical Significance:** SIGLEC7 has been implicated in several autoimmune and inflammatory diseases, including: 1. **Autoimmune Diseases:** SIGLEC7 has been shown to play a role in the development of autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer:** SIGLEC7 has been implicated in the development and progression of certain types of cancer, including colon cancer and breast cancer. 3. **Neurological Disorders:** SIGLEC7 has been implicated in the development of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Infectious Diseases:** SIGLEC7 has been shown to play a role in the regulation of immune responses to infections, including those caused by bacteria and viruses. In conclusion, SIGLEC7 is an important gene that plays a crucial role in regulating immune cell interactions, particularly in the context of adaptive and innate immunity. Its dysregulation has been implicated in several autoimmune and inflammatory diseases, highlighting the importance of further research into the mechanisms by which SIGLEC7 regulates immune cell responses.

Genular Protein ID: 3622649850

Symbol: SIGL7_HUMAN

Name: Sialic acid-binding Ig-like lectin 7

UniProtKB Accession Codes:

Q9Y286 Q9NZQ1 Q9UJ86 Q9UJ87 Q9Y502

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CPTC 1 CTD 1 ChEBI 2 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 8 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 1 RefSeq 3 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniLectin 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10567377

Title: Identification and characterization of a novel siglec, siglec-7, expressed by human natural killer cells and monocytes.

PubMed ID: 10567377

DOI: 10.1074/jbc.274.48.34089

PubMed ID: 10499918

Title: Identification and molecular cloning of p75/AIRM1, a novel member of the sialoadhesin family that functions as an inhibitory receptor in human natural killer cells.

PubMed ID: 10499918

DOI: 10.1084/jem.190.6.793

PubMed ID: 10764831

Title: Siglec-7: a sialic acid-binding lectin of the immunoglobulin superfamily.

PubMed ID: 10764831

DOI: 10.1093/glycob/10.4.431

PubMed ID: 10611343

Title: Engagement of p75/AIRM1 or CD33 inhibits the proliferation of normal or leukemic myeloid cells.

PubMed ID: 10611343

DOI: 10.1073/pnas.96.26.15091

PubMed ID: 11389909

Title: Binding specificity of siglec7 to disialogangliosides of renal cell carcinoma: possible role of disialogangliosides in tumor progression.

PubMed ID: 11389909

DOI: 10.1016/s0014-5793(01)02476-0

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 12438315

Title: High resolution crystal structures of Siglec-7. Insights into ligand specificity in the Siglec family.

PubMed ID: 12438315

DOI: 10.1074/jbc.m210602200

PubMed ID: 14747738

Title: Structure of the saccharide-binding domain of the human natural killer cell inhibitory receptor p75/AIRM1.

PubMed ID: 14747738

DOI: 10.1107/s0907444903028439

PubMed ID: 16623661

Title: The structure of siglec-7 in complex with sialosides: leads for rational structure-based inhibitor design.

PubMed ID: 16623661

DOI: 10.1042/bj20060103

PubMed ID: 16895906

Title: Siglec-7 undergoes a major conformational change when complexed with the alpha(2,8)-disialylganglioside GT1b.

PubMed ID: 16895906

DOI: 10.1074/jbc.m601714200

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 467
  • Mass: 51143
  • Checksum: 8AFE44462B001F52
  • Sequence:
    • MLLLLLLPLL WGRERVEGQK SNRKDYSLTM QSSVTVQEGM CVHVRCSFSY PVDSQTDSDP 
VHGYWFRAGN DISWKAPVAT NNPAWAVQEE TRDRFHLLGD PQTKNCTLSI RDARMSDAGR 
YFFRMEKGNI KWNYKYDQLS VNVTALTHRP NILIPGTLES GCFQNLTCSV PWACEQGTPP 
MISWMGTSVS PLHPSTTRSS VLTLIPQPQH HGTSLTCQVT LPGAGVTTNR TIQLNVSYPP 
QNLTVTVFQG EGTASTALGN SSSLSVLEGQ SLRLVCAVDS NPPARLSWTW RSLTLYPSQP 
SNPLVLELQV HLGDEGEFTC RAQNSLGSQH VSLNLSLQQE YTGKMRPVSG VLLGAVGGAG 
ATALVFLSFC VIFIVVRSCR KKSARPAADV GDIGMKDANT IRGSASQGNL TESWADDNPR 
HHGLAAHSSG EEREIQYAPL SFHKGEPQDL SGQEATNNEY SEIKIPK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.