Details for: B3GAT1

Gene ID: 27087

Symbol: B3GAT1

Ensembl ID: ENSG00000109956

Description: beta-1,3-glucuronyltransferase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.1325
    Cell Significance Index: 46.2000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.8838
    Cell Significance Index: 45.6300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.8416
    Cell Significance Index: 369.4200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.8210
    Cell Significance Index: 82.5400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.6950
    Cell Significance Index: 48.3700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.4525
    Cell Significance Index: 276.4300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.2510
    Cell Significance Index: 84.1200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.1746
    Cell Significance Index: 25.7200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1383
    Cell Significance Index: 408.2800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.9835
    Cell Significance Index: 31.5000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8778
    Cell Significance Index: 86.8300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8021
    Cell Significance Index: 724.2500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.5673
    Cell Significance Index: 82.4700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4994
    Cell Significance Index: 22.0900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4169
    Cell Significance Index: 67.8000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3507
    Cell Significance Index: 242.5600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2942
    Cell Significance Index: 32.0100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2793
    Cell Significance Index: 17.1700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2647
    Cell Significance Index: 13.9000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0053
    Cell Significance Index: 0.3700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0013
    Cell Significance Index: 0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0000
    Cell Significance Index: 0.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0046
    Cell Significance Index: -7.1500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0054
    Cell Significance Index: -0.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0054
    Cell Significance Index: -9.9600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0135
    Cell Significance Index: -0.3900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0135
    Cell Significance Index: -0.5900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0180
    Cell Significance Index: -24.4900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0278
    Cell Significance Index: -17.6700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0341
    Cell Significance Index: -25.2300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0356
    Cell Significance Index: -26.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0412
    Cell Significance Index: -31.1500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0465
    Cell Significance Index: -26.2400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0473
    Cell Significance Index: -25.8100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0520
    Cell Significance Index: -9.3800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0554
    Cell Significance Index: -25.1500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0750
    Cell Significance Index: -4.6000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0780
    Cell Significance Index: -4.6800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0782
    Cell Significance Index: -2.9600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0821
    Cell Significance Index: -23.6200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1146
    Cell Significance Index: -2.3000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1373
    Cell Significance Index: -28.9200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1400
    Cell Significance Index: -27.7800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1451
    Cell Significance Index: -8.1400
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1545
    Cell Significance Index: -1.4700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1696
    Cell Significance Index: -20.8600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1740
    Cell Significance Index: -22.3100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1744
    Cell Significance Index: -29.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1874
    Cell Significance Index: -25.7300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1969
    Cell Significance Index: -6.2700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2100
    Cell Significance Index: -27.1300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2426
    Cell Significance Index: -2.8300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2467
    Cell Significance Index: -28.7500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2468
    Cell Significance Index: -29.1100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2608
    Cell Significance Index: -8.5400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2617
    Cell Significance Index: -26.7300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2652
    Cell Significance Index: -30.3800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2678
    Cell Significance Index: -27.8800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2705
    Cell Significance Index: -7.5600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2759
    Cell Significance Index: -14.3300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2929
    Cell Significance Index: -7.5300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3268
    Cell Significance Index: -3.5600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3406
    Cell Significance Index: -21.4700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.3761
    Cell Significance Index: -4.6700
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.3771
    Cell Significance Index: -5.0300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3772
    Cell Significance Index: -28.1100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3782
    Cell Significance Index: -29.0200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3803
    Cell Significance Index: -8.2200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4024
    Cell Significance Index: -8.5700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4513
    Cell Significance Index: -15.8100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4538
    Cell Significance Index: -23.6400
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.4882
    Cell Significance Index: -4.0300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.4988
    Cell Significance Index: -6.2200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5084
    Cell Significance Index: -10.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.5288
    Cell Significance Index: -24.8600
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.5316
    Cell Significance Index: -5.7000
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.5511
    Cell Significance Index: -4.2400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5684
    Cell Significance Index: -11.7900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.5771
    Cell Significance Index: -5.4700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5823
    Cell Significance Index: -27.1500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.6012
    Cell Significance Index: -9.0600
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.6408
    Cell Significance Index: -8.3100
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.6426
    Cell Significance Index: -8.1100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.6580
    Cell Significance Index: -12.9500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.6619
    Cell Significance Index: -11.4500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6794
    Cell Significance Index: -24.9400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.7297
    Cell Significance Index: -15.2300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7586
    Cell Significance Index: -26.3600
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.8745
    Cell Significance Index: -9.1100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8776
    Cell Significance Index: -25.8500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.8946
    Cell Significance Index: -17.6900
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.9039
    Cell Significance Index: -12.6400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.9084
    Cell Significance Index: -22.6600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.9257
    Cell Significance Index: -23.0900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.9283
    Cell Significance Index: -29.3600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.9467
    Cell Significance Index: -12.6200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.9578
    Cell Significance Index: -28.1300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.9719
    Cell Significance Index: -19.3800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.9817
    Cell Significance Index: -28.1400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -1.0097
    Cell Significance Index: -14.4600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** B3GAT1 is a tetrasaccharide linker sequence-specific glucuronyltransferase that catalyzes the transfer of glucuronic acid to galactose residues in GAGs and glycoproteins. This enzyme is essential for the formation of chondroitin sulfate and dermatan sulfate, two critical GAGs involved in various biological processes. B3GAT1 is specifically expressed in plasmacytoid dendritic cells, GABAergic cortical interneurons, and other cell types, suggesting its role in immune response and neuronal function. **Pathways and Functions:** B3GAT1 is involved in several key pathways, including: 1. **Glycosaminoglycan biosynthesis:** B3GAT1 is essential for the synthesis of chondroitin sulfate and dermatan sulfate, which are critical components of the extracellular matrix and play a role in cell-cell interactions and signaling. 2. **Endoplasmic reticulum membrane:** B3GAT1 is localized to the endoplasmic reticulum membrane, where it participates in the glycosylation of proteins and lipids. 3. **Glycosaminoglycan metabolism:** B3GAT1 is involved in the degradation and recycling of GAGs, which is essential for maintaining cellular homeostasis. 4. **Protein glycosylation:** B3GAT1 is responsible for the addition of tetrasaccharide linker sequences to glycoproteins, which is critical for protein function and stability. **Clinical Significance:** Dysregulation of B3GAT1 has been implicated in various diseases, including: 1. **Immunological disorders:** Alterations in B3GAT1 expression have been observed in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, suggesting its role in immune response regulation. 2. **Neurological disorders:** B3GAT1 has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease, where dysregulation of glycosaminoglycan metabolism is thought to contribute to disease progression. 3. **Cancer:** B3GAT1 has been implicated in cancer progression, where altered glycosylation patterns can influence tumor cell adhesion, migration, and invasion. In conclusion, B3GAT1 is a critical enzyme involved in the synthesis of tetrasaccharide linker sequences, which play a pivotal role in glycosaminoglycan and glycoprotein formation. Its dysregulation has been implicated in various diseases, highlighting the importance of B3GAT1 in maintaining cellular homeostasis and function. Further research is needed to elucidate the full extent of B3GAT1's role in the immune system and beyond.

Genular Protein ID: 2393342967

Symbol: B3GA1_HUMAN

Name: Beta-1,3-glucuronyltransferase 1

UniProtKB Accession Codes:

Q9P2W7 B7Z5Z8 Q96FS7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CDD 1 CTD 1 ChEBI 13 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 1 EMBL 4 Ensembl 3 EvolutionaryTrace 1 GO 12 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 7 Rhea 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10783264

Title: Cloning and chromosomal mapping of human glucuronyltransferase involved in biosynthesis of the HNK-1 carbohydrate epitope.

PubMed ID: 10783264

DOI: 10.1006/geno.2000.6152

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14993226

Title: Structural basis for acceptor substrate recognition of a human glucuronyltransferase, GlcAT-P, an enzyme critical in the biosynthesis of the carbohydrate epitope HNK-1.

PubMed ID: 14993226

DOI: 10.1074/jbc.m400622200

Sequence Information:

  • Length: 334
  • Mass: 38256
  • Checksum: 0DF42399D19701B3
  • Sequence:
    • MPKRRDILAI VLIVLPWTLL ITVWHQSTLA PLLAVHKDEG SDPRRETPPG ADPREYCTSD 
RDIVEVVRTE YVYTRPPPWS DTLPTIHVVT PTYSRPVQKA ELTRMANTLL HVPNLHWLVV 
EDAPRRTPLT ARLLRDTGLN YTHLHVETPR NYKLRGDARD PRIPRGTMQR NLALRWLRET 
FPRNSSQPGV VYFADDDNTY SLELFEEMRS TRRVSVWPVA FVGGLRYEAP RVNGAGKVVG 
WKTVFDPHRP FAIDMAGFAV NLRLILQRSQ AYFKLRGVKG GYQESSLLRE LVTLNDLEPK 
AANCTKILVW HTRTEKPVLV NEGKKGFTDP SVEI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.