Details for: CACNG4

Gene ID: 27092

Symbol: CACNG4

Ensembl ID: ENSG00000075461

Description: calcium voltage-gated channel auxiliary subunit gamma 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.8356
    Cell Significance Index: 173.8500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.7116
    Cell Significance Index: 59.3800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.5945
    Cell Significance Index: 114.7600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.3210
    Cell Significance Index: 87.8900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.7743
    Cell Significance Index: 38.4400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.5395
    Cell Significance Index: 36.9200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.3687
    Cell Significance Index: 84.1300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0977
    Cell Significance Index: 393.7400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.9969
    Cell Significance Index: 31.9300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4438
    Cell Significance Index: 43.9000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4265
    Cell Significance Index: 385.1300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3381
    Cell Significance Index: 18.9700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2697
    Cell Significance Index: 186.5300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.2683
    Cell Significance Index: 3.8200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2167
    Cell Significance Index: 35.2500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1444
    Cell Significance Index: 3.6100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0648
    Cell Significance Index: 7.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0512
    Cell Significance Index: 10.2700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0379
    Cell Significance Index: 7.2100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0196
    Cell Significance Index: 0.6900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0119
    Cell Significance Index: 2.3700
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.0106
    Cell Significance Index: 0.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0106
    Cell Significance Index: 5.8000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0031
    Cell Significance Index: -0.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0098
    Cell Significance Index: -18.5100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0106
    Cell Significance Index: -4.6800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0171
    Cell Significance Index: -31.5700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0208
    Cell Significance Index: -32.0700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0234
    Cell Significance Index: -31.8500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0344
    Cell Significance Index: -21.8300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0350
    Cell Significance Index: -25.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0359
    Cell Significance Index: -27.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0392
    Cell Significance Index: -29.0100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0475
    Cell Significance Index: -29.6400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0489
    Cell Significance Index: -27.5900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0578
    Cell Significance Index: -26.2200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0643
    Cell Significance Index: -11.6000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0662
    Cell Significance Index: -19.0400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0723
    Cell Significance Index: -5.0000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0816
    Cell Significance Index: -3.7000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0923
    Cell Significance Index: -1.8300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0967
    Cell Significance Index: -4.5100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0981
    Cell Significance Index: -1.9700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1124
    Cell Significance Index: -1.6100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1177
    Cell Significance Index: -3.2900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1234
    Cell Significance Index: -17.9400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1399
    Cell Significance Index: -29.4800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1430
    Cell Significance Index: -17.5800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1620
    Cell Significance Index: -27.6600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1690
    Cell Significance Index: -23.2100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1807
    Cell Significance Index: -23.3400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1891
    Cell Significance Index: -11.3500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2139
    Cell Significance Index: -24.9300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2159
    Cell Significance Index: -16.0900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2343
    Cell Significance Index: -24.4000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2715
    Cell Significance Index: -31.1100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2717
    Cell Significance Index: -4.1000
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.2831
    Cell Significance Index: -1.6800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2855
    Cell Significance Index: -6.0600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3095
    Cell Significance Index: -6.4200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3186
    Cell Significance Index: -8.1900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3281
    Cell Significance Index: -25.1800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3360
    Cell Significance Index: -11.0000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.3527
    Cell Significance Index: -4.1200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3567
    Cell Significance Index: -8.6400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3620
    Cell Significance Index: -24.3400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.4082
    Cell Significance Index: -8.5200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4249
    Cell Significance Index: -9.1800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4258
    Cell Significance Index: -12.1500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.4294
    Cell Significance Index: -4.0700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4454
    Cell Significance Index: -9.4900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4570
    Cell Significance Index: -8.9200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4617
    Cell Significance Index: -24.2400
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.4761
    Cell Significance Index: -2.9900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4779
    Cell Significance Index: -22.4600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4954
    Cell Significance Index: -10.3700
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -0.5457
    Cell Significance Index: -4.2800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5590
    Cell Significance Index: -29.0400
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.5733
    Cell Significance Index: -3.7300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5966
    Cell Significance Index: -20.9000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.6389
    Cell Significance Index: -17.0600
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.6698
    Cell Significance Index: -10.0200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6813
    Cell Significance Index: -21.7000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7102
    Cell Significance Index: -26.0700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.7164
    Cell Significance Index: -14.1000
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.7220
    Cell Significance Index: -10.2700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7422
    Cell Significance Index: -25.7900
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.7498
    Cell Significance Index: -9.8200
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.7538
    Cell Significance Index: -5.4800
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.7630
    Cell Significance Index: -9.9600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.7858
    Cell Significance Index: -21.3900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.7923
    Cell Significance Index: -15.8000
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.7931
    Cell Significance Index: -10.2900
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.8045
    Cell Significance Index: -10.9400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.8079
    Cell Significance Index: -10.2000
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.8093
    Cell Significance Index: -10.3600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.8454
    Cell Significance Index: -22.2300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.8461
    Cell Significance Index: -14.5000
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.8481
    Cell Significance Index: -7.7100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.8514
    Cell Significance Index: -14.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Calcium Channel Auxiliary Subunit:** The CACNG4 gene encodes a gamma subunit of calcium voltage-gated channels, which are essential for the regulation of calcium influx into cells. 2. **Regulation of Neuronal Excitability:** The CACNG4 gene is involved in modulating neuronal excitability, particularly in the Purkinje cells of the cerebellum, where it regulates the amplitude and frequency of action potentials. 3. **Synaptic Plasticity:** The CACNG4 gene is also implicated in synaptic plasticity, a process critical for learning and memory. It interacts with AMPA receptors to regulate synaptic transmission and long-term potentiation. 4. **Muscle Contraction:** The CACNG4 gene is expressed in muscle cells, where it contributes to the regulation of muscle contraction and relaxation. 5. **Conservation Across Species:** The CACNG4 gene is conserved across species, from humans to mice, highlighting its essential role in maintaining cellular homeostasis. **Pathways and Functions:** 1. **Ampa Glutamate Receptor Complex:** The CACNG4 gene interacts with AMPA receptors to regulate synaptic transmission and long-term potentiation. 2. **Calcium Channel Regulator Activity:** The CACNG4 gene modulates calcium influx into cells, influencing neuronal excitability and muscle contraction. 3. **Cardiac Conduction:** The CACNG4 gene is involved in regulating cardiac conduction, particularly in the sinoatrial node, where it influences the generation of cardiac impulses. 4. **Neurotransmitter Receptor Internalization:** The CACNG4 gene is involved in the internalization of neurotransmitter receptors, regulating synaptic transmission and plasticity. 5. **Muscle Contraction:** The CACNG4 gene contributes to the regulation of muscle contraction and relaxation, particularly in skeletal muscle cells. **Clinical Significance:** 1. **Neurological Disorders:** The CACNG4 gene has been implicated in various neurological disorders, including epilepsy, Parkinson's disease, and Alzheimer's disease. 2. **Muscular Dystrophy:** Mutations in the CACNG4 gene have been associated with muscular dystrophy, a group of genetic disorders characterized by progressive muscle weakness and degeneration. 3. **Cancer:** The CACNG4 gene has been implicated in cancer development and progression, particularly in glioblastoma and breast cancer. 4. **Cardiovascular Disease:** The CACNG4 gene is involved in regulating cardiac conduction, and its dysfunction may contribute to the development of cardiovascular disease. In conclusion, the CACNG4 gene plays a crucial role in regulating various cellular processes, including neuronal excitability, synaptic plasticity, and muscle contraction. Its involvement in multiple signaling pathways and its conservation across species highlight its importance in maintaining cellular homeostasis. Further research is necessary to fully elucidate the functions and clinical significance of the CACNG4 gene.

Genular Protein ID: 299718136

Symbol: CCG4_HUMAN

Name: Voltage-dependent calcium channel gamma-4 subunit

UniProtKB Accession Codes:

Q9UBN1 B2RCK0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 7 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 5 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10613843

Title: Identification of three novel Ca(2+) channel gamma subunit genes reveals molecular diversification by tandem and chromosome duplication.

PubMed ID: 10613843

DOI: 10.1101/gr.9.12.1204

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21172611

Title: Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins.

PubMed ID: 21172611

DOI: 10.1016/j.neuron.2010.11.026

PubMed ID: 21127204

Title: Cardiac L-type calcium channel (Cav1.2) associates with gamma subunits.

PubMed ID: 21127204

DOI: 10.1096/fj.10-172353

Sequence Information:

  • Length: 327
  • Mass: 36579
  • Checksum: 79630ACC03B1DAE6
  • Sequence:
    • MVRCDRGLQM LLTTAGAFAA FSLMAIAIGT DYWLYSSAHI CNGTNLTMDD GPPPRRARGD 
LTHSGLWRVC CIEGIYKGHC FRINHFPEDN DYDHDSSEYL LRIVRASSVF PILSTILLLL 
GGLCIGAGRI YSRKNNIVLS AGILFVAAGL SNIIGIIVYI SSNTGDPSDK RDEDKKNHYN 
YGWSFYFGAL SFIVAETVGV LAVNIYIEKN KELRFKTKRE FLKASSSSPY ARMPSYRYRR 
RRSRSSSRST EASPSRDVSP MGLKITGAIP MGELSMYTLS REPLKVTTAA SYSPDQEASF 
LQVHDFFQQD LKEGFHVSML NRRTTPV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.