Details for: KCNMB3

Gene ID: 27094

Symbol: KCNMB3

Ensembl ID: ENSG00000171121

Description: potassium calcium-activated channel subfamily M regulatory beta subunit 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 45.2601
    Cell Significance Index: -7.0400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 27.3613
    Cell Significance Index: -6.9400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 15.1136
    Cell Significance Index: -6.1400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.8558
    Cell Significance Index: -7.2200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.3278
    Cell Significance Index: 142.7200
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.7483
    Cell Significance Index: 6.3600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5745
    Cell Significance Index: 56.8300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5011
    Cell Significance Index: 99.4500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4035
    Cell Significance Index: 364.2900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3363
    Cell Significance Index: 9.0100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3231
    Cell Significance Index: 19.4000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3184
    Cell Significance Index: 34.6400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2794
    Cell Significance Index: 45.4400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.2779
    Cell Significance Index: 4.5800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2525
    Cell Significance Index: 15.9200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2089
    Cell Significance Index: 74.9200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2017
    Cell Significance Index: 40.4600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1916
    Cell Significance Index: 14.7100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1898
    Cell Significance Index: 10.6500
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.1743
    Cell Significance Index: 2.3500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1538
    Cell Significance Index: 29.2600
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.1533
    Cell Significance Index: 1.9300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1367
    Cell Significance Index: 9.4600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.1208
    Cell Significance Index: 1.8200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1071
    Cell Significance Index: 12.4800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1035
    Cell Significance Index: 2.0200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0911
    Cell Significance Index: 5.6000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0838
    Cell Significance Index: 15.1100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0833
    Cell Significance Index: 2.4000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0826
    Cell Significance Index: 12.0100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0768
    Cell Significance Index: 9.8400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0740
    Cell Significance Index: 8.7300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0563
    Cell Significance Index: 1.2200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0507
    Cell Significance Index: 2.3000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0499
    Cell Significance Index: 6.1300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0424
    Cell Significance Index: 1.0600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0329
    Cell Significance Index: 0.4800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0260
    Cell Significance Index: 0.9200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0248
    Cell Significance Index: 0.1500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0166
    Cell Significance Index: 2.8300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0112
    Cell Significance Index: 6.1100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0091
    Cell Significance Index: 0.5900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0042
    Cell Significance Index: 0.5800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0025
    Cell Significance Index: 3.9200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0023
    Cell Significance Index: 4.4100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0022
    Cell Significance Index: 0.1500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0018
    Cell Significance Index: 3.3100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0012
    Cell Significance Index: 0.1400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0006
    Cell Significance Index: 0.0300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0004
    Cell Significance Index: 0.2600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0002
    Cell Significance Index: 0.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0004
    Cell Significance Index: -0.5400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0008
    Cell Significance Index: -0.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0020
    Cell Significance Index: -0.9300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0054
    Cell Significance Index: -3.9700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0062
    Cell Significance Index: -4.5600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0063
    Cell Significance Index: -2.8000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0068
    Cell Significance Index: -5.1700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0081
    Cell Significance Index: -0.6000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0082
    Cell Significance Index: -4.6500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0093
    Cell Significance Index: -0.9500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0115
    Cell Significance Index: -7.1700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0117
    Cell Significance Index: -0.2800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0136
    Cell Significance Index: -0.1900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0178
    Cell Significance Index: -0.3800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0180
    Cell Significance Index: -5.1700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0235
    Cell Significance Index: -3.0400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0278
    Cell Significance Index: -0.4000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0329
    Cell Significance Index: -6.9200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0343
    Cell Significance Index: -1.1000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0491
    Cell Significance Index: -1.3100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0526
    Cell Significance Index: -2.4700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0565
    Cell Significance Index: -5.8800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0608
    Cell Significance Index: -0.5600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0623
    Cell Significance Index: -1.7400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0698
    Cell Significance Index: -4.9400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0731
    Cell Significance Index: -1.0400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0742
    Cell Significance Index: -1.1000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0794
    Cell Significance Index: -2.7600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0820
    Cell Significance Index: -1.7400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0839
    Cell Significance Index: -6.6500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0886
    Cell Significance Index: -1.9400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0971
    Cell Significance Index: -4.9100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1069
    Cell Significance Index: -1.5400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1071
    Cell Significance Index: -2.8700
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1104
    Cell Significance Index: -1.5500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1110
    Cell Significance Index: -3.0200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1213
    Cell Significance Index: -6.3700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1230
    Cell Significance Index: -5.4400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1295
    Cell Significance Index: -1.8600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1307
    Cell Significance Index: -2.2400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1357
    Cell Significance Index: -1.7400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1367
    Cell Significance Index: -1.6300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1387
    Cell Significance Index: -4.5400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1471
    Cell Significance Index: -2.6000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1481
    Cell Significance Index: -5.6100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1518
    Cell Significance Index: -2.5400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1526
    Cell Significance Index: -4.8600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1539
    Cell Significance Index: -5.3900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1563
    Cell Significance Index: -3.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** KCNMB3 is a member of the KCNMB family of potassium channel regulatory subunits, which are known to modulate the activity of calcium-activated potassium channels. The KCNMB3 subunit is characterized by its ability to interact with the KCNMB1 subunit, forming a heteromeric channel complex that regulates potassium ion transport. The KCNMB3 subunit is also known to interact with other proteins, such as the calcium-calmodulin complex, to modulate channel activity. **Pathways and Functions** The KCNMB3 gene is involved in several signaling pathways, including: 1. **Calcium homeostasis**: KCNMB3 regulates calcium-activated potassium channels, which are essential for maintaining calcium homeostasis in various cells, including neurons and intestinal epithelial cells. 2. **Neuronal excitability**: KCNMB3 modulates the activity of calcium-activated potassium channels in neurons, influencing neuronal excitability and synaptic transmission. 3. **Potassium ion transport**: KCNMB3 regulates potassium ion transport across cell membranes, influencing various cellular processes, including muscle contraction and cell volume regulation. 4. **Hemostasis**: KCNMB3 is involved in platelet homeostasis, regulating platelet activation and aggregation. **Clinical Significance** Dysregulation of the KCNMB3 gene has been implicated in several diseases, including: 1. **Neurological disorders**: KCNMB3 mutations have been associated with neurological disorders, such as epilepsy and intellectual disability. 2. **Cardiovascular disease**: KCNMB3 dysfunction has been linked to cardiovascular disease, including hypertension and arrhythmias. 3. **Gastrointestinal disorders**: KCNMB3 dysregulation has been implicated in gastrointestinal disorders, such as inflammatory bowel disease and cancer. In conclusion, the KCNMB3 gene plays a crucial role in regulating various cellular processes, including calcium homeostasis, neuronal excitability, and potassium ion transport. Dysregulation of this gene has been implicated in several diseases, highlighting the importance of this gene in maintaining cellular homeostasis and overall health.

Genular Protein ID: 2612418363

Symbol: KCMB3_HUMAN

Name: Calcium-activated potassium channel subunit beta-3

UniProtKB Accession Codes:

Q9NPA1 B7Z9C9 D3DNR2 E9PER5 Q9NPG7 Q9NRM9 Q9UHN3

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 EMBL 13 Ensembl 6 ExpressionAtlas 1 GO 8 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 5 SMR 1 STRING 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 10585773

Title: Identification of a putative regulatory subunit of a calcium-activated potassium channel in the dup(3q) syndrome region and a related sequence on 22q11.2.

PubMed ID: 10585773

DOI: 10.1006/geno.1999.5975

PubMed ID: 10692449

Title: Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4.

PubMed ID: 10692449

DOI: 10.1074/jbc.275.9.6453

PubMed ID: 10766764

Title: Cloning and functional expression of two families of Beta-subunits of the large conductance calcium-activated potassium channel.

PubMed ID: 10766764

DOI: 10.1074/jbc.m910187199

PubMed ID: 10792058

Title: A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin.

PubMed ID: 10792058

DOI: 10.1073/pnas.100118597

PubMed ID: 10828459

Title: hKCNMB3 and hKCNMB4, cloning and characterization of two members of the large-conductance calcium-activated potassium channel beta subunit family.

PubMed ID: 10828459

DOI: 10.1016/s0014-5793(00)01584-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 10864947

Title: Rectification and rapid activation at low Ca2+ of Ca2+-activated, voltage-dependent BK currents: consequences of rapid inactivation by a novel beta subunit.

PubMed ID: 10864947

DOI: 10.1523/jneurosci.20-13-04890.2000

PubMed ID: 11382808

Title: Inactivation of BK channels mediated by the NH(2) terminus of the beta3b auxiliary subunit involves a two-step mechanism: possible separation of binding and blockade.

PubMed ID: 11382808

DOI: 10.1085/jgp.117.6.583

PubMed ID: 11382809

Title: Gating properties conferred on BK channels by the beta3b auxiliary subunit in the absence of its NH(2)- and COOH termini.

PubMed ID: 11382809

DOI: 10.1085/jgp.117.6.607

PubMed ID: 14612589

Title: Variants of the KCNMB3 regulatory subunit of maxi BK channels affect channel inactivation.

PubMed ID: 14612589

DOI: 10.1152/physiolgenomics.00110.2003

PubMed ID: 12740608

Title: Redox-sensitive extracellular gates formed by auxiliary beta subunits of calcium-activated potassium channels.

PubMed ID: 12740608

DOI: 10.1038/nsb932

PubMed ID: 12136044

Title: New disguises for an old channel: MaxiK channel beta-subunits.

PubMed ID: 12136044

DOI: 10.1152/nips.01387.2002

Sequence Information:

  • Length: 279
  • Mass: 31604
  • Checksum: EC5F0D5D3E040C4C
  • Sequence:
    • MDFSPSSELG FHFVAFILLT RHRTAFPASG KKRETDYSDG DPLDVHKRLP SSAGEDRAVM 
LGFAMMGFSV LMFFLLGTTI LKPFMLSIQR EESTCTAIHT DIMDDWLDCA FTCGVHCHGQ 
GKYPCLQVFV NLSHPGQKAL LHYNEEAVQI NPKCFYTPKC HQDRNDLLNS ALDIKEFFDH 
KNGTPFSCFY SPASQSEDVI LIKKYDQMAI FHCLFWPSLT LLGGALIVGM VRLTQHLSLL 
CEKYSTVVRD EVGGKVPYIE QHQFKLCIMR RSKGRAEKS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.