Details for: ARRDC2

Gene ID: 27106

Symbol: ARRDC2

Ensembl ID: ENSG00000105643

Description: arrestin domain containing 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 98.7494
    Cell Significance Index: -15.3600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 59.9661
    Cell Significance Index: -15.2100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 37.5009
    Cell Significance Index: -15.2400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 33.2630
    Cell Significance Index: -17.1100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 24.8129
    Cell Significance Index: -16.6500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 16.3290
    Cell Significance Index: -15.5900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.6201
    Cell Significance Index: -15.5600
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 6.5120
    Cell Significance Index: 24.2700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.6106
    Cell Significance Index: -15.0300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.2548
    Cell Significance Index: -16.1400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.4120
    Cell Significance Index: -17.4100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.2859
    Cell Significance Index: -9.3800
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 2.0700
    Cell Significance Index: 33.4000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.4693
    Cell Significance Index: 35.8500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.9975
    Cell Significance Index: 64.3600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.9130
    Cell Significance Index: 47.5600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.8022
    Cell Significance Index: 12.8700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7271
    Cell Significance Index: 19.7900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6580
    Cell Significance Index: 594.1000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.6324
    Cell Significance Index: 11.1800
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.5143
    Cell Significance Index: 2.3000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4341
    Cell Significance Index: 20.4000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3984
    Cell Significance Index: 64.8000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3765
    Cell Significance Index: 40.9500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3570
    Cell Significance Index: 67.9300
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.3399
    Cell Significance Index: 1.2800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2585
    Cell Significance Index: 15.5200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2405
    Cell Significance Index: 10.9000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2292
    Cell Significance Index: 22.6700
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.2192
    Cell Significance Index: 2.2700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1839
    Cell Significance Index: 12.7200
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.1825
    Cell Significance Index: 1.8300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1768
    Cell Significance Index: 5.1000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1763
    Cell Significance Index: 22.7800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1334
    Cell Significance Index: 2.8900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1326
    Cell Significance Index: 2.4500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1214
    Cell Significance Index: 24.3600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1131
    Cell Significance Index: 13.3400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1047
    Cell Significance Index: 13.4200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1036
    Cell Significance Index: 2.7700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0810
    Cell Significance Index: 11.1200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0766
    Cell Significance Index: 41.8300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0586
    Cell Significance Index: 7.2100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0498
    Cell Significance Index: 1.7500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0445
    Cell Significance Index: 8.0300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0431
    Cell Significance Index: 3.2100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0192
    Cell Significance Index: 26.1600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0057
    Cell Significance Index: 2.5400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0026
    Cell Significance Index: 0.2700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0033
    Cell Significance Index: -5.1000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0043
    Cell Significance Index: -7.8400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0074
    Cell Significance Index: -13.9100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0178
    Cell Significance Index: -13.4700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0208
    Cell Significance Index: -15.2600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0210
    Cell Significance Index: -7.5300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0223
    Cell Significance Index: -16.5000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0244
    Cell Significance Index: -15.5100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0285
    Cell Significance Index: -16.1000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0288
    Cell Significance Index: -13.0600
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0299
    Cell Significance Index: -0.2000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0314
    Cell Significance Index: -19.6000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0438
    Cell Significance Index: -12.5900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0447
    Cell Significance Index: -8.8700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0450
    Cell Significance Index: -2.1000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0533
    Cell Significance Index: -0.4300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0713
    Cell Significance Index: -8.3100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0716
    Cell Significance Index: -12.2200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0718
    Cell Significance Index: -3.7300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0755
    Cell Significance Index: -8.6500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0906
    Cell Significance Index: -4.5800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0924
    Cell Significance Index: -19.4600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1010
    Cell Significance Index: -14.6800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1035
    Cell Significance Index: -1.7400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1109
    Cell Significance Index: -2.3600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1258
    Cell Significance Index: -7.7100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1326
    Cell Significance Index: -2.7500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1634
    Cell Significance Index: -17.0200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1779
    Cell Significance Index: -5.1000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1795
    Cell Significance Index: -5.7500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1977
    Cell Significance Index: -5.5300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2022
    Cell Significance Index: -5.0600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2060
    Cell Significance Index: -2.8100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2080
    Cell Significance Index: -14.7100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2093
    Cell Significance Index: -16.5800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2154
    Cell Significance Index: -16.5300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2275
    Cell Significance Index: -15.3000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2403
    Cell Significance Index: -2.7300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2541
    Cell Significance Index: -4.3800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2684
    Cell Significance Index: -16.5000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2694
    Cell Significance Index: -16.9800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2783
    Cell Significance Index: -12.1000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2893
    Cell Significance Index: -15.1900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3190
    Cell Significance Index: -8.2000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3218
    Cell Significance Index: -18.0600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3355
    Cell Significance Index: -13.7500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3545
    Cell Significance Index: -10.4100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3608
    Cell Significance Index: -12.6400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3625
    Cell Significance Index: -9.2600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3677
    Cell Significance Index: -11.7100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3787
    Cell Significance Index: -12.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ARRDC2 is a gene that encodes a protein with an arrestin domain, which is a protein-binding domain that regulates the activity of G protein-coupled receptors (GPCRs). The ARRD2 protein is highly expressed in endothelial cells, which are critical for maintaining vascular homeostasis and immune function. The protein is also expressed in immune cells, including B cells and innate lymphoid cells, suggesting a role in regulating immune responses. **Pathways and Functions:** ARRDC2 is involved in several key pathways that regulate immune function and endothelial function. These include: 1. **GPCR signaling:** ARRD2 regulates the activity of GPCRs, which are critical for transmitting signals from receptors to downstream effectors. In endothelial cells, GPCR signaling is involved in regulating vascular tone and immune responses. 2. **Protein transport:** ARRD2 is involved in regulating the transport of proteins across cellular membranes. This is critical for maintaining endothelial function and immune cell function. 3. **Immune cell regulation:** ARRD2 regulates the function of immune cells, including B cells and innate lymphoid cells. This is critical for maintaining immune homeostasis and preventing autoimmune disease. **Clinical Significance:** ARRDC2 has been implicated in several immune-related disorders, including: 1. **Autoimmune diseases:** Variants in the ARRDC2 gene have been associated with autoimmune diseases, including rheumatoid arthritis and lupus. 2. **Inflammatory disorders:** ARRDC2 is involved in regulating inflammation, and variants in the gene have been associated with inflammatory disorders, including asthma and rheumatoid arthritis. 3. **Endothelial dysfunction:** ARRDC2 is critical for maintaining endothelial function, and variants in the gene have been associated with endothelial dysfunction, which is a key feature of cardiovascular disease. In conclusion, ARRDC2 is a critical gene that regulates immune responses and endothelial function. Variants in the gene have been associated with several immune-related disorders, and understanding the role of ARRDC2 in these disorders may provide new therapeutic targets for treating these diseases. **Future Directions:** Further research is needed to fully understand the role of ARRDC2 in immune regulation and endothelial function. This includes: 1. **Functional studies:** Further functional studies are needed to understand the role of ARRD2 in regulating GPCR signaling and protein transport. 2. **Clinical studies:** Clinical studies are needed to understand the role of ARRDC2 in immune-related disorders and to identify potential therapeutic targets. 3. **Genetic studies:** Genetic studies are needed to understand the genetic basis of ARRDC2 and to identify potential genetic variants that contribute to disease. Overall, ARRDC2 is a critical gene that plays a key role in regulating immune responses and endothelial function. Further research is needed to fully understand the role of this gene in disease and to identify potential therapeutic targets.

Genular Protein ID: 2459589677

Symbol: ARRD2_HUMAN

Name: Arrestin domain-containing protein 2

UniProtKB Accession Codes:

Q8TBH0 B2RBG9 O95895 Q6ZRV9 Q8WYG6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15498874

Title: Large-scale cDNA transfection screening for genes related to cancer development and progression.

PubMed ID: 15498874

DOI: 10.1073/pnas.0404089101

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21191027

Title: Multiple interactions between the ESCRT machinery and arrestin-related proteins: implications for PPXY-dependent budding.

PubMed ID: 21191027

DOI: 10.1128/jvi.02045-10

Sequence Information:

  • Length: 407
  • Mass: 44379
  • Checksum: AC11194410C31BD8
  • Sequence:
    • MLFDKVKAFS VQLDGATAGV EPVFSGGQAV AGRVLLELSS AARVGALRLR ARGRAHVHWT 
ESRSAGSSTA YTQSYSERVE VVSHRATLLA PDTGETTTLP PGRHEFLFSF QLPPTLVTSF 
EGKHGSVRYC IKATLHRPWV PARRARKVFT VIEPVDINTP ALLAPQAGAR EKVARSWYCN 
RGLVSLSAKI DRKGYTPGEV IPVFAEIDNG STRPVLPRAA VVQTQTFMAR GARKQKRAVV 
ASLAGEPVGP GQRALWQGRA LRIPPVGPSI LHCRVLHVDY ALKVCVDIPG TSKLLLELPL 
VIGTIPLHPF GSRSSSVGSH ASFLLDWRLG ALPERPEAPP EYSEVVADTE EAALGQSPFP 
LPQDPDMSLE GPFFAYIQEF RYRPPPLYSE EDPNPLLGDM RPRCMTC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.