Details for: PDE7B

Gene ID: 27115

Symbol: PDE7B

Ensembl ID: ENSG00000171408

Description: phosphodiesterase 7B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 229.9010
    Cell Significance Index: -35.7600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 142.0695
    Cell Significance Index: -36.0400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 72.2905
    Cell Significance Index: -34.1300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 67.0511
    Cell Significance Index: -27.2400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 29.0440
    Cell Significance Index: -35.8100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.1535
    Cell Significance Index: -36.1200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 8.0818
    Cell Significance Index: 172.7500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 5.6597
    Cell Significance Index: 250.3400
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 5.4736
    Cell Significance Index: 76.5400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 5.2174
    Cell Significance Index: 197.5700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 3.9652
    Cell Significance Index: 57.0300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.6751
    Cell Significance Index: 33.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2113
    Cell Significance Index: 242.9900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.0632
    Cell Significance Index: 20.7500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.0466
    Cell Significance Index: 80.3200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.0218
    Cell Significance Index: 706.7100
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.7592
    Cell Significance Index: 8.8300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.7006
    Cell Significance Index: 317.9800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.6892
    Cell Significance Index: 22.0800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6581
    Cell Significance Index: 236.0600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3694
    Cell Significance Index: 20.7300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.3318
    Cell Significance Index: 5.5900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.3299
    Cell Significance Index: 8.0500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.2400
    Cell Significance Index: 4.1500
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.2235
    Cell Significance Index: 3.4000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2145
    Cell Significance Index: 38.6700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.2145
    Cell Significance Index: 3.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1487
    Cell Significance Index: 94.4700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1440
    Cell Significance Index: 23.4300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1293
    Cell Significance Index: 238.4800
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.1147
    Cell Significance Index: 1.2800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1056
    Cell Significance Index: 20.0900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0752
    Cell Significance Index: 9.2500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0614
    Cell Significance Index: 94.4900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0516
    Cell Significance Index: 97.1700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0093
    Cell Significance Index: 5.0800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0021
    Cell Significance Index: 0.3000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0019
    Cell Significance Index: 2.6500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0171
    Cell Significance Index: -3.4000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0305
    Cell Significance Index: -22.3400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0465
    Cell Significance Index: -34.4600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0474
    Cell Significance Index: -4.6900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0491
    Cell Significance Index: -37.1300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0592
    Cell Significance Index: -36.9600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0601
    Cell Significance Index: -26.5800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0620
    Cell Significance Index: -34.9800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0788
    Cell Significance Index: -4.0900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1010
    Cell Significance Index: -29.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1162
    Cell Significance Index: -15.9600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1485
    Cell Significance Index: -4.2800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1654
    Cell Significance Index: -3.3200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.1672
    Cell Significance Index: -18.1900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1690
    Cell Significance Index: -10.3900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1707
    Cell Significance Index: -35.9600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1714
    Cell Significance Index: -2.5300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1870
    Cell Significance Index: -31.9300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2074
    Cell Significance Index: -12.4500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2140
    Cell Significance Index: -21.8600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2381
    Cell Significance Index: -3.4100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2491
    Cell Significance Index: -32.1800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2523
    Cell Significance Index: -29.7500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2638
    Cell Significance Index: -13.8500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2727
    Cell Significance Index: -6.5400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2822
    Cell Significance Index: -19.5200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2838
    Cell Significance Index: -19.0800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2884
    Cell Significance Index: -36.9700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3030
    Cell Significance Index: -34.7100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3038
    Cell Significance Index: -35.4000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3074
    Cell Significance Index: -32.0100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3086
    Cell Significance Index: -13.9900
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.3762
    Cell Significance Index: -3.3900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3800
    Cell Significance Index: -5.6100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3821
    Cell Significance Index: -30.2700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3956
    Cell Significance Index: -9.8900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4170
    Cell Significance Index: -8.8500
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.4171
    Cell Significance Index: -5.5600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4332
    Cell Significance Index: -27.9500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4365
    Cell Significance Index: -32.5300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4406
    Cell Significance Index: -9.5500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4450
    Cell Significance Index: -27.2900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4522
    Cell Significance Index: -9.3800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4673
    Cell Significance Index: -9.2400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5063
    Cell Significance Index: -26.3800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.5103
    Cell Significance Index: -23.9900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5308
    Cell Significance Index: -24.7500
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.5355
    Cell Significance Index: -8.0100
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.5513
    Cell Significance Index: -7.2200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5719
    Cell Significance Index: -9.8000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.5732
    Cell Significance Index: -7.3500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.5779
    Cell Significance Index: -20.3100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6013
    Cell Significance Index: -37.9000
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.6221
    Cell Significance Index: -7.1200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.6385
    Cell Significance Index: -5.8800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.6564
    Cell Significance Index: -12.9200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6579
    Cell Significance Index: -16.9100
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.6799
    Cell Significance Index: -9.0700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.6883
    Cell Significance Index: -14.8700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.6939
    Cell Significance Index: -9.8600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.7074
    Cell Significance Index: -18.6000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7171
    Cell Significance Index: -25.1200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PDE7B is a type VII phosphodiesterase, which is distinct from other phosphodiesterases due to its unique substrate specificity and tissue distribution. It is primarily expressed in the heart, kidneys, and nervous system, where it regulates the levels of cAMP and cGMP. PDE7B is also involved in the regulation of various signaling pathways, including those mediated by G-protein coupled receptors (GPCRs) and the adenylate cyclase-cAMP pathway. **Pathways and Functions:** PDE7B is involved in several key signaling pathways, including: 1. **G-protein coupled receptor signaling**: PDE7B regulates the levels of cAMP and cGMP in response to GPCR activation, which is essential for the transmission of signals from the cell surface to the intracellular space. 2. **Camp-mediated signaling**: PDE7B is involved in the regulation of the adenylate cyclase-cAMP pathway, which is critical for the production of cAMP and the activation of downstream signaling pathways. 3. **Cyclic nucleotide signaling**: PDE7B regulates the levels of cAMP and cGMP, which are essential for various cellular processes, including gene expression, cellular differentiation, and immune responses. **Clinical Significance:** PDE7B has been implicated in various diseases and disorders, including: 1. **Cardiovascular disease**: PDE7B has been shown to play a role in the regulation of cardiac function and the development of cardiovascular disease. 2. **Renal disease**: PDE7B has been implicated in the regulation of renal function and the development of renal disease. 3. **Neurological disorders**: PDE7B has been shown to play a role in the regulation of neuronal function and the development of neurological disorders, including epilepsy and Parkinson's disease. 4. **Immune responses**: PDE7B has been implicated in the regulation of immune responses, including the activation of immune cells and the production of cytokines. In conclusion, PDE7B is a critical regulator of cyclic nucleotide levels and signaling pathways, and its dysregulation has been implicated in various diseases and disorders. Further research is needed to fully understand the role of PDE7B in immunological and cellular processes, and to explore its potential as a therapeutic target. **Signaling Pathways and Functions:** 1. **3',5'-cyclic-AMP phosphodiesterase activity**: PDE7B regulates the breakdown of cAMP, which is essential for the activation of downstream signaling pathways. 2. **3',5'-cyclic-GMP phosphodiesterase activity**: PDE7B regulates the breakdown of cGMP, which is essential for the activation of downstream signaling pathways. 3. **Camp-mediated signaling**: PDE7B is involved in the regulation of the adenylate cyclase-cAMP pathway, which is critical for the production of cAMP and the activation of downstream signaling pathways. 4. **G alpha (s) signaling events**: PDE7B regulates the levels of cAMP in response to G alpha (s) signaling events, which is essential for the transmission of signals from the cell surface to the intracellular space. 5. **Gpcr downstream signalling**: PDE7B regulates the levels of cAMP and cGMP in response to GPCR activation, which is essential for the transmission of signals from the cell surface to the intracellular space. 6. **Signal transduction**: PDE7B regulates the levels of cAMP and cGMP, which are essential for the activation of downstream signaling pathways. 7. **Synapse**: PDE7B regulates the levels of cAMP and cGMP in response to synaptic activity, which is essential for the transmission of signals between neurons. **Significantly Expressed Cells:** 1. **Cardiac muscle cell**: PDE7B is expressed in cardiac muscle cells, where it regulates cardiac function and the development of cardiovascular disease. 2. **Renal principal cell**: PDE7B is expressed in renal principal cells, where it regulates renal function and the development of renal disease. 3. **Vascular leptomeningeal cell**: PDE7B is expressed in vascular leptomeningeal cells, where it regulates vascular function and the development of vascular disease. 4. **Ciliary muscle cell**: PDE7B is expressed in ciliary muscle cells, where it regulates smooth muscle function and the development of ocular disease. 5. **Astrocyte of the cerebral cortex**: PDE7B is expressed in astrocytes of the cerebral cortex, where it regulates neuronal function and the development of neurological disorders. 6. **Mature astrocyte**: PDE7B is expressed in mature astrocytes, where it regulates neuronal function and the development of neurological disorders. 7. **Sncg GABAergic cortical interneuron**: PDE7B is expressed in Sncg GABAergic cortical interneurons, where it regulates neuronal function and the development of neurological disorders. 8. **Kidney interstitial fibroblast**: PDE7B is expressed in kidney interstitial fibroblasts, where it regulates renal function and the development of renal disease. 9. **A2 amacrine cell**: PDE7B is expressed in A2 amacrine cells, where it regulates retinal function and the development of ocular disease. 10. **Taste receptor cell**: PDE7B is expressed in taste receptor cells, where it regulates taste perception and the development of taste disorders.

Genular Protein ID: 3525327051

Symbol: PDE7B_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9NP56 Q5W154

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 10 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EC 1 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10814504

Title: Identification of human PDE7B, a cAMP-specific phosphodiesterase.

PubMed ID: 10814504

DOI: 10.1006/bbrc.2000.2661

PubMed ID: 10872825

Title: Cloning and characterisation of the human and mouse PDE7B, a novel cAMP-specific nucleotide phosphodiesterase.

PubMed ID: 10872825

DOI: 10.1006/bbrc.2000.2743

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

Sequence Information:

  • Length: 450
  • Mass: 51835
  • Checksum: EC142BF3E28D0028
  • Sequence:
    • MSCLMVERCG EILFENPDQN AKCVCMLGDI RLRGQTGVRA ERRGSYPFID FRLLNSTTYS 
GEIGTKKKVK RLLSFQRYFH ASRLLRGIIP QAPLHLLDED YLGQARHMLS KVGMWDFDIF 
LFDRLTNGNS LVTLLCHLFN THGLIHHFKL DMVTLHRFLV MVQEDYHSQN PYHNAVHAAD 
VTQAMHCYLK EPKLASFLTP LDIMLGLLAA AAHDVDHPGV NQPFLIKTNH HLANLYQNMS 
VLENHHWRST IGMLRESRLL AHLPKEMTQD IEQQLGSLIL ATDINRQNEF LTRLKAHLHN 
KDLRLEDAQD RHFMLQIALK CADICNPCRI WEMSKQWSER VCEEFYRQGE LEQKFELEIS 
PLCNQQKDSI PSIQIGFMSY IVEPLFREWA HFTGNSTLSE NMLGHLAHNK AQWKSLLPRQ 
HRSRGSSGSG PDHDHAGQGT ESEEQEGDSP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.