CPAMD8 | ENSG00000160111 | NCBI 27151

Details for: CPAMD8

Gene ID: 27151

Symbol: CPAMD8

Ensembl ID: ENSG00000160111

Description: C3 and PZP like alpha-2-macroglobulin domain containing 8

Associated with

Extracellular space
(GO:0005615)
Eye development
(GO:0001654)
Negative regulation of peptidase activity
(GO:0010466)
Plasma membrane
(GO:0005886)
Serine-type endopeptidase inhibitor activity
(GO:0004867)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 7.8794
Cell Significance Index: -9.7200
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 4.1339
Cell Significance Index: 2625.4300
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 3.2531
Cell Significance Index: 6125.1600
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 2.8420
Cell Significance Index: -6.2200
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.8174
Cell Significance Index: 38.4400
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 2.4835
Cell Significance Index: -9.8000
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 2.3702
Cell Significance Index: 21.0400
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 2.0646
Cell Significance Index: 29.3900
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.6892
Cell Significance Index: 24.3000
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.0553
Cell Significance Index: 10.9300
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 1.0503
Cell Significance Index: 6.4800
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.9755
Cell Significance Index: 24.3900
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.6538
Cell Significance Index: 36.6900
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.5764
Cell Significance Index: 15.6900
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.3697
Cell Significance Index: 4.5900
Cell Name: keratocyte (CL0002363)
Fold Change: 0.3514
Cell Significance Index: 5.5800
Cell Name: taste receptor cell (CL0000209)
Fold Change: 0.3200
Cell Significance Index: 3.7200
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 0.3142
Cell Significance Index: 4.7800
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.2952
Cell Significance Index: 3.0600
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.2785
Cell Significance Index: 29.0000
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.2655
Cell Significance Index: 12.4800
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2485
Cell Significance Index: 47.3000
Cell Name: odontoblast (CL0000060)
Fold Change: 0.2020
Cell Significance Index: 25.9000
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.1702
Cell Significance Index: 153.6400
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1593
Cell Significance Index: 15.7600
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.1516
Cell Significance Index: 27.3300
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.1116
Cell Significance Index: 13.7200
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1057
Cell Significance Index: 4.7900
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1040
Cell Significance Index: 5.4100
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0989
Cell Significance Index: 2.6400
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0732
Cell Significance Index: 39.9500
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0624
Cell Significance Index: 43.1700
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0601
Cell Significance Index: 8.2500
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.0576
Cell Significance Index: 3.0000
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.0490
Cell Significance Index: 7.9700
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0470
Cell Significance Index: 9.4300
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0448
Cell Significance Index: 8.9000
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0341
Cell Significance Index: 0.5700
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0300
Cell Significance Index: 10.7500
Cell Name: lactocyte (CL0002325)
Fold Change: 0.0271
Cell Significance Index: 3.5100
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.0236
Cell Significance Index: 0.8200
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.0209
Cell Significance Index: 1.4800
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0175
Cell Significance Index: 32.2100
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0152
Cell Significance Index: 6.9200
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0089
Cell Significance Index: 13.6600
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.0019
Cell Significance Index: 0.2700
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.0010
Cell Significance Index: 0.1100
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0006
Cell Significance Index: -0.0200
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0028
Cell Significance Index: -0.0800
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0037
Cell Significance Index: -4.9700
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0038
Cell Significance Index: -1.0800
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0066
Cell Significance Index: -4.9700
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0070
Cell Significance Index: -0.1200
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0073
Cell Significance Index: -1.2500
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0103
Cell Significance Index: -4.5600
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0118
Cell Significance Index: -8.7700
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0119
Cell Significance Index: -8.6900
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0149
Cell Significance Index: -8.4300
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0163
Cell Significance Index: -10.2100
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0257
Cell Significance Index: -1.2000
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0300
Cell Significance Index: -3.5000
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0377
Cell Significance Index: -2.3100
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.0384
Cell Significance Index: -2.6600
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0428
Cell Significance Index: -1.2600
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0479
Cell Significance Index: -10.0900
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0631
Cell Significance Index: -7.2300
Cell Name: proerythroblast (CL0000547)
Fold Change: -0.0632
Cell Significance Index: -0.9000
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0648
Cell Significance Index: -6.6200
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0823
Cell Significance Index: -9.7000
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0831
Cell Significance Index: -1.1900
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0840
Cell Significance Index: -1.8200
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0900
Cell Significance Index: -5.8100
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0940
Cell Significance Index: -7.2100
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: -0.0941
Cell Significance Index: -0.8000
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: -0.0988
Cell Significance Index: -1.4400
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1017
Cell Significance Index: -7.5800
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.1027
Cell Significance Index: -2.7000
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.1037
Cell Significance Index: -2.1700
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1092
Cell Significance Index: -6.8800
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1154
Cell Significance Index: -9.1400
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1159
Cell Significance Index: -7.1300
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.1216
Cell Significance Index: -7.3000
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1253
Cell Significance Index: -8.4300
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1264
Cell Significance Index: -3.2500
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.1272
Cell Significance Index: -5.5300
Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.1504
Cell Significance Index: -2.1100
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.1515
Cell Significance Index: -4.0600
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1614
Cell Significance Index: -4.5100
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1728
Cell Significance Index: -7.6500
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1800
Cell Significance Index: -9.4500
Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: -0.1816
Cell Significance Index: -2.5400
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2012
Cell Significance Index: -6.4500
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.2099
Cell Significance Index: -7.9500
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.2267
Cell Significance Index: -4.4300
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.2338
Cell Significance Index: -8.1900
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.2420
Cell Significance Index: -5.3000
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: -0.2469
Cell Significance Index: -2.2500
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.2476
Cell Significance Index: -3.7600
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.2482
Cell Significance Index: -5.2900
Cell Name: peg cell (CL4033014)
Fold Change: -0.2497
Cell Significance Index: -5.7700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** CPAMD8 is a non-coding gene that has been identified through the analysis of expressed sequence tags (ESTs) and RNA sequencing data. The gene's protein product, which is predicted to be a protein of approximately 80 kDa, contains multiple domains, including C3 and PZP-like alpha-2-macroglobulin domains. These domains are known to be involved in protein-protein interactions and may play a role in the regulation of proteolytic activities. The expression profile of CPAMD8 is wide and diverse, with significant expression in non-pigmented ciliary epithelial cells, pigmented epithelial cells, corneal endothelial cells, and other cell types involved in various physiological processes. This suggests that CPAMD8 may play a role in maintaining tissue homeostasis and regulating cellular responses to environmental stimuli. **Pathways and Functions:** The pathways and functions of CPAMD8 are not yet fully understood, but several potential mechanisms have been proposed based on the protein's domain structure and expression profile. Some possible pathways include: 1. **Extracellular matrix regulation**: The C3 and PZP-like alpha-2-macroglobulin domains of CPAMD8 may interact with extracellular matrix proteins, regulating their activity and maintaining tissue structure. 2. **Proteolytic regulation**: The protein's ability to inhibit serine-type endopeptidases may play a role in regulating proteolytic activity in various tissues, including the eye and kidney. 3. **Cell signaling**: CPAMD8 may interact with other signaling molecules, influencing cellular responses to environmental stimuli and maintaining tissue homeostasis. **Clinical Significance:** CPAMD8 has been linked to several diseases, including: 1. **Age-related macular degeneration (AMD)**: The expression of CPAMD8 in non-pigmented ciliary epithelial cells has been associated with AMD, a leading cause of vision loss in older adults. 2. **Kidney disease**: CPAMD8 has been implicated in the pathogenesis of kidney disease, including diabetic nephropathy and chronic kidney disease. 3. **Respiratory diseases**: The expression of CPAMD8 in epithelial cells of the lower respiratory tract has been linked to respiratory diseases, including chronic obstructive pulmonary disease (COPD). In conclusion, CPAMD8 is a gene with a unique structure and expression profile that may play a role in maintaining tissue homeostasis and regulating cellular responses to environmental stimuli. Further research is needed to fully understand the function and clinical significance of CPAMD8, but its potential involvement in various diseases suggests that it may be a valuable target for therapeutic intervention.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

A0A494C0S9_HUMAN

Genular Protein ID: 1320023205

Symbol: A0A494C0S9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A494C0S9

Database IDs:

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

Sequence Information:

Length: 1932
Mass: 211285
Checksum: 2524A6C780EEECE2
Sequence:

MAPGALRGGC EQRAPGGGAR TAALGPWPWP SPGPAPSPGA APPRSRKMSG ALLWPLLPLL 
LLLLSARDGV RAAQPQAPGY LIAAPSVFRA GVEEVISVTI FNSPREVTVQ AQLVAQGEPV 
VQSQGAILDK GTIKLKVPTG LRGQALLKVW GRGWQAEEGP LFHNQTSVTV DGRGASVFIQ 
TDKPVYRPQH RVLISIFTVS PNLRPVNEKL EAYILDPRGS RMIEWRHLKP FCCGITNMSF 
PLSDQPVLGE WFIFVEMQGH AYNKSFEVQK YVLPKFELLI DPPRYIQDLD ACETGTVRAR 
YTFGKPVAGA LMINMTVNGV GYYSHEVGRP VLRTTKILGS RDFDICVRDM IPADVPEHFR 
GRVSIWAMVT SVDGSQQVAF DDSTPVQRQL VDIRYSKDTR KQFKPGLAYV GKVELSYPDG 
SPAEGVTVQI KAELTPKDNI YTSEVVSQRG LVGFEIPSIP TSAQHVWLET KVMALNGKPV 
GAQYLPSYLS LGSWYSPSQC YLQLQPPSHP LQVGEEAYFS VKSTCPCNFT LYYEVAARGN 
IVLSGQQPAH TTQQRSKRAA PALEKPIRLT HLSETEPPPA PEAEVDVCVT SLHLAVTPSM 
VPLGRLLVFY VRENGEGVAD SLQFAVETFF ENQVSVTYSA NETQPGEVVD LRIRAARGSC 
VCVAAVDKSV YLLRSGFRLT PAQVFQELED YDVSDSFGVS REDGPFWWAG LTAQRRRRSS 
VFPWPWGITK DSGFAFTETG LVVMTDRVSL NHRQDGGLYT DEAVPAFQPH TGSLVAVAPS 
RHPPRTEKRK RTFFPETWIW HCLNISDPSG EGTLSVKVPD SITSWVGEAV ALSTSQGLGI 
AEPSLLKTFK PFFVDFMLPA LIIRGEQVKI PLSVYNYMGT CAEVYMKLSV PKGIQFVGHP 
GKRHVTKKMC VAPGEAEPIW VVLSFSDLGL NNITAKALAY GDTNCCRDGR SSKHPEENHA 
DRRVPIGVDH VRRSVMVEAE GVPRAYTYSA FFCPSERVHI STPNKYEFQY VQRPLRLTRF 
DVAVRAHNDA RVALSSGPQD TAGMIEIVLG GHQNTRSWIS TSKMGEPVAS AHTAKILSWD 
EFRTFWISWR GGLIQVGHGP EPSNESVIVA WTLPRPPEVQ FIGFSTGWGS MGEFRIWRKM 
EVDESYSEAF TLGVPHGAIP GSERATASII GDVMGPTLNH LNNLLRLPFG CGEQNMIHFA 
PNVFVLKYLQ KTQQLSPEVE RETTDYLVQG YQRQLTYKRQ DGSYSAFGER DASGSMWLTA 
FVLKSFAQAR SFIFVDPREL AAAKSWIIQQ QQADGSFLAV GRVLNKDIQG GIHGTVPLTA 
YVVVALLETG TASEEERGST DKARHFLESA APLAMDPYSC ALTTYALTLL RSPAAPEALR 
KLRSLAIMRD GVTHWSLSNS WDVDKGTFLS FSDRVSQSVV SAEVEMTAYA LLTYTLLGDV 
AAALPVVKWL SQQRNALGGF SSTQDTCVAL QALAEYAILS YAGGINLTVS LASTNLDYQE 
TFELHRTNQK VLQTAAIPSL PTGLFVSAKG DGCCLMQIDV TYNVPDPVAK PAFQLLVSLQ 
EPEAQGRPPP MPASAAEGSR GDWPPADDDD PAADQHHQEY KVMLEVCTRW LHAGSSNMAV 
LEVPLLSGFR ADIESLEQLL LDKHMGMKRY EVAGRRVLFY FDEIPSRCLT CVRFRALREC 
VVGRTSALPV SVYDYYEPAF EATRFYNVST HSPLARELCA GPACNEVERA PARGPGWFPG 
ESGPAVAPEE GAAIARCGCD HDCGAQGNPV CGSDGVVYAS ACRLREAACR QAAPLEPAPP 
SCCALEQRLP ASSSSTYGDD LASVAPGPLQ QDVKLNGAGL EVEDSDPEPE GEAEDRVTAG 
PRPPVSSGNL ESSTQSASPF HRWGQTPAPQ RHSGRVVGAH RPGLLSPVFV YSPAFQSGGE 
EGLWMSNTCT LR

Database document: