Details for: BRPF3

Gene ID: 27154

Symbol: BRPF3

Ensembl ID: ENSG00000096070

Description: bromodomain and PHD finger containing 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 92.5133
    Cell Significance Index: -14.3900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 59.6901
    Cell Significance Index: -15.1400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 34.0801
    Cell Significance Index: -16.0900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 33.4517
    Cell Significance Index: -13.5900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 23.9187
    Cell Significance Index: -16.0500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 14.2761
    Cell Significance Index: -13.6300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.4092
    Cell Significance Index: -15.3000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.9102
    Cell Significance Index: -15.4300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.4171
    Cell Significance Index: -5.2900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.2215
    Cell Significance Index: 59.5300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2485
    Cell Significance Index: 74.9600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.2203
    Cell Significance Index: 16.6500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1387
    Cell Significance Index: 123.8600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9317
    Cell Significance Index: 42.2300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8997
    Cell Significance Index: 146.3300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8851
    Cell Significance Index: 799.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8347
    Cell Significance Index: 165.6500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7338
    Cell Significance Index: 147.1900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4998
    Cell Significance Index: 14.4000
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.4926
    Cell Significance Index: 6.9100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.4431
    Cell Significance Index: 6.6400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3697
    Cell Significance Index: 8.0100
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.3426
    Cell Significance Index: 3.6400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2935
    Cell Significance Index: 16.4700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2699
    Cell Significance Index: 96.8100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2563
    Cell Significance Index: 13.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2555
    Cell Significance Index: 13.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2436
    Cell Significance Index: 43.9100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2329
    Cell Significance Index: 14.6800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2211
    Cell Significance Index: 10.3100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2101
    Cell Significance Index: 20.7800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2057
    Cell Significance Index: 5.6000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1755
    Cell Significance Index: 33.3900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1602
    Cell Significance Index: 19.6900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1228
    Cell Significance Index: 3.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1118
    Cell Significance Index: 61.0400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1095
    Cell Significance Index: 18.7000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1042
    Cell Significance Index: 14.3100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0981
    Cell Significance Index: 67.8500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0774
    Cell Significance Index: 2.7200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0732
    Cell Significance Index: 1.9300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0703
    Cell Significance Index: 31.0900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0593
    Cell Significance Index: 6.7900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0531
    Cell Significance Index: 1.1300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0490
    Cell Significance Index: 3.0100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0189
    Cell Significance Index: 2.4200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0145
    Cell Significance Index: 1.1100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0082
    Cell Significance Index: 0.5500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0058
    Cell Significance Index: 0.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0021
    Cell Significance Index: -3.9200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0027
    Cell Significance Index: -1.9700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0027
    Cell Significance Index: -0.1200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0054
    Cell Significance Index: -3.3600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0063
    Cell Significance Index: -11.6000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0072
    Cell Significance Index: -11.0200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0080
    Cell Significance Index: -5.0500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0087
    Cell Significance Index: -6.4100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0094
    Cell Significance Index: -12.8200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0103
    Cell Significance Index: -0.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0126
    Cell Significance Index: -7.1100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0137
    Cell Significance Index: -10.3900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0140
    Cell Significance Index: -0.2900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0147
    Cell Significance Index: -6.6900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0150
    Cell Significance Index: -0.4000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0215
    Cell Significance Index: -1.0100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0283
    Cell Significance Index: -0.7900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0319
    Cell Significance Index: -4.6400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0385
    Cell Significance Index: -8.1100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0416
    Cell Significance Index: -11.9600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0418
    Cell Significance Index: -1.5800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0541
    Cell Significance Index: -6.3000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0599
    Cell Significance Index: -6.1200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0611
    Cell Significance Index: -7.2100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0627
    Cell Significance Index: -1.0500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0632
    Cell Significance Index: -8.1700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0724
    Cell Significance Index: -8.2600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0883
    Cell Significance Index: -6.5800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0959
    Cell Significance Index: -6.1900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1076
    Cell Significance Index: -7.6100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1439
    Cell Significance Index: -3.1500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1449
    Cell Significance Index: -15.0900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1584
    Cell Significance Index: -3.8000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1672
    Cell Significance Index: -13.2400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1720
    Cell Significance Index: -4.4200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1724
    Cell Significance Index: -1.7900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2050
    Cell Significance Index: -5.8500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2060
    Cell Significance Index: -10.8200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2077
    Cell Significance Index: -2.9800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2093
    Cell Significance Index: -2.6800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2166
    Cell Significance Index: -13.2800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2235
    Cell Significance Index: -3.8300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2305
    Cell Significance Index: -7.3400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2396
    Cell Significance Index: -3.6100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2412
    Cell Significance Index: -8.3800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2540
    Cell Significance Index: -5.3900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2566
    Cell Significance Index: -8.4000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2613
    Cell Significance Index: -5.1000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.2735
    Cell Significance Index: -3.9200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2926
    Cell Significance Index: -6.7600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3093
    Cell Significance Index: -6.1200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Histone Acetyltransferase Activity**: BRPF3 possesses HAT activity, which enables it to acetylate histones, particularly histones H3, H4, and H12. 2. **Bromodomain and PHD Finger**: The protein's unique structure, comprising a bromodomain and PHD finger, allows it to recognize and bind to acetylated histones, facilitating its interaction with chromatin. 3. **Widespread Expression**: BRPF3 is expressed in various cell types, including germ cells, neurons, kidney proximal straight tubule epithelial cells, and others, indicating its involvement in diverse cellular processes. 4. **Chromatin Remodeling**: By acetylating histones, BRPF3 contributes to chromatin remodeling, which is essential for regulating gene expression and transcriptional activity. **Pathways and Functions:** 1. **Chromatin Modifying Enzymes**: BRPF3 is involved in the regulation of chromatin modifying enzymes, which are crucial for maintaining chromatin structure and transcriptional activity. 2. **Chromatin Organization**: The protein's ability to acetylate histones and remodel chromatin is essential for maintaining chromatin organization and facilitating gene expression. 3. **Gene Expression (Transcription)**: BRPF3 plays a critical role in regulating gene expression by modulating chromatin structure and transcriptional activity. 4. **Histone Acetylation**: The protein's HAT activity is essential for acetylating histones, which is a key event in regulating chromatin structure and transcriptional activity. 5. **Regulation of Developmental Process**: BRPF3's expression in germ cells and other tissues suggests its involvement in regulating developmental processes. 6. **Regulation of Hemopoiesis**: The protein's expression in hematopoietic cells implies its role in regulating hemopoiesis. **Clinical Significance:** 1. **Cancer**: BRPF3's involvement in regulating chromatin structure and transcriptional activity makes it a potential target for cancer therapy. 2. **Neurological Disorders**: The protein's expression in neurons and its role in regulating gene expression and chromatin structure suggest its potential involvement in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Cardiovascular Diseases**: BRPF3's expression in platelet cells and its role in regulating platelet activation and aggregation imply its potential involvement in cardiovascular diseases. 4. **Hematological Disorders**: The protein's expression in hematopoietic cells and its role in regulating hemopoiesis suggest its potential involvement in hematological disorders, such as leukemia and lymphoma. In conclusion, BRPF3 is a critical regulator of gene expression and chromatin remodeling in various tissues, and its dysregulation may contribute to various diseases. Further research is necessary to fully elucidate the protein's role in different cellular processes and its potential as a therapeutic target.

Genular Protein ID: 3571655482

Symbol: BRPF3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10574462

Title: Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10574462

DOI: 10.1093/dnares/6.5.337

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16387653

Title: ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation.

PubMed ID: 16387653

DOI: 10.1016/j.molcel.2005.12.007

PubMed ID: 18794358

Title: Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes.

PubMed ID: 18794358

DOI: 10.1128/mcb.01297-08

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25593309

Title: Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.

PubMed ID: 25593309

DOI: 10.1101/gad.252189.114

PubMed ID: 26620551

Title: BRPF3-HBO1 regulates replication origin activation and histone H3K14 acetylation.

PubMed ID: 26620551

DOI: 10.15252/embj.201591293

PubMed ID: 26677226

Title: The chromatin regulator BRPF3 preferentially activates the HBO1 acetyltransferase but is dispensable for mouse development and survival.

PubMed ID: 26677226

DOI: 10.1074/jbc.m115.703041

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 21720545

Title: Structural and histone binding ability characterizations of human PWWP domains.

PubMed ID: 21720545

DOI: 10.1371/journal.pone.0018919

Sequence Information:

  • Length: 1205
  • Mass: 135745
  • Checksum: F51DCAB253ED35C7
  • Sequence:
  • MRKPRRKSRQ NAEGRRSPSP YSLKCSPTRE TLTYAQAQRI VEVDIDGRLH RISIYDPLKI 
    ITEDELTAQD ITECNSNKEN SEQPQFPGKS KKPSSKGKKK ESCSKHASGT SFHLPQPSFR 
    MVDSGIQPEA PPLPAAYYRY IEKPPEDLDA EVEYDMDEED LAWLDMVNEK RRVDGHSLVS 
    ADTFELLVDR LEKESYLESR SSGAQQSLID EDAFCCVCLD DECHNSNVIL FCDICNLAVH 
    QECYGVPYIP EGQWLCRCCL QSPSRPVDCI LCPNKGGAFK QTSDGHWAHV VCAIWIPEVC 
    FANTVFLEPI EGIDNIPPAR WKLTCYICKQ KGLGAAIQCH KVNCYTAFHV TCAQRAGLFM 
    KIEPMRETSL NGTIFTVRKT AYCEAHSPPG AATARRKGDS PRSISETGDE EGLKEGDGEE 
    EEEEEVEEEE QEAQGGVSGS LKGVPKKSKM SLKQKIKKEP EEAGQDTPST LPMLAVPQIP 
    SYRLNKICSG LSFQRKNQFM QRLHNYWLLK RQARNGVPLI RRLHSHLQSQ RNAEQREQDE 
    KTSAVKEELK YWQKLRHDLE RARLLIELIR KREKLKREQV KVQQAAMELE LMPFNVLLRT 
    TLDLLQEKDP AHIFAEPVNL SEVPDYLEFI SKPMDFSTMR RKLESHLYRT LEEFEEDFNL 
    IVTNCMKYNA KDTIFHRAAV RLRDLGGAIL RHARRQAENI GYDPERGTHL PESPKLEDFY 
    RFSWEDVDNI LIPENRAHLS PEVQLKELLE KLDLVSAMRS SGARTRRVRL LRREINALRQ 
    KLAQPPPPQP PSLNKTVSNG ELPAGPQGDA AVLEQALQEE PEDDGDRDDS KLPPPPTLEP 
    TGPAPSLSEQ ESPPEPPTLK PINDSKPPSR FLKPRKVEED ELLEKSPLQL GNEPLQRLLS 
    DNGINRLSLM APDTPAGTPL SGVGRRTSVL FKKAKNGVKL QRSPDRVLEN GEDHGVAGSP 
    ASPASIEEER HSRKRPRSRS CSESEGERSP QQEEETGMTN GFGKHTESGS DSECSLGLSG 
    GLAFEACSGL TPPKRSRGKP ALSRVPFLEG VNGDSDYNGS GRSLLLPFED RGDLEPLELV 
    WAKCRGYPSY PALIIDPKMP REGLLHNGVP IPVPPLDVLK LGEQKQAEAG EKLFLVLFFD 
    NKRTWQWLPR DKVLPLGVED TVDKLKMLEG RKTSIRKSVQ VAYDRAMIHL SRVRGPHSFV 
    TSSYL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.