Details for: TUBG2

Gene ID: 27175

Symbol: TUBG2

Ensembl ID: ENSG00000037042

Description: tubulin gamma 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 109.1644
    Cell Significance Index: -16.9800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 69.2311
    Cell Significance Index: -17.5600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.3476
    Cell Significance Index: -17.6900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.5308
    Cell Significance Index: -17.5000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.4931
    Cell Significance Index: -17.7300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.0171
    Cell Significance Index: 580.3800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.8066
    Cell Significance Index: 343.8100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.5381
    Cell Significance Index: 79.9000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0682
    Cell Significance Index: 105.6700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8246
    Cell Significance Index: 165.4200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8234
    Cell Significance Index: 148.4400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5560
    Cell Significance Index: 90.4400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.5383
    Cell Significance Index: 15.3600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5152
    Cell Significance Index: 102.2400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4824
    Cell Significance Index: 25.3300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4504
    Cell Significance Index: 49.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3810
    Cell Significance Index: 136.6600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3464
    Cell Significance Index: 9.6800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3361
    Cell Significance Index: 39.1700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3209
    Cell Significance Index: 6.8400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3184
    Cell Significance Index: 39.1500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2967
    Cell Significance Index: 7.9500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2818
    Cell Significance Index: 10.6700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2763
    Cell Significance Index: 12.2200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2649
    Cell Significance Index: 183.1900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2445
    Cell Significance Index: 16.9100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2434
    Cell Significance Index: 6.6300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1694
    Cell Significance Index: 21.7200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1612
    Cell Significance Index: 12.3700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1470
    Cell Significance Index: 8.8300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1451
    Cell Significance Index: 19.9200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1288
    Cell Significance Index: 2.7900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0979
    Cell Significance Index: 16.7200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0918
    Cell Significance Index: 82.9200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0898
    Cell Significance Index: 6.0400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0897
    Cell Significance Index: 1.9700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0682
    Cell Significance Index: 0.9300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0633
    Cell Significance Index: 2.8700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0625
    Cell Significance Index: 27.6500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0555
    Cell Significance Index: 3.4100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0555
    Cell Significance Index: 1.6000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0506
    Cell Significance Index: 1.0600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0470
    Cell Significance Index: 25.6500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0445
    Cell Significance Index: 0.7500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0406
    Cell Significance Index: 0.7000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0375
    Cell Significance Index: 1.7500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0284
    Cell Significance Index: 18.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0263
    Cell Significance Index: 49.4700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0182
    Cell Significance Index: 0.6400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0158
    Cell Significance Index: 29.1800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0117
    Cell Significance Index: 18.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0051
    Cell Significance Index: 2.3100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0004
    Cell Significance Index: 0.5000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0017
    Cell Significance Index: -0.1300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0025
    Cell Significance Index: -1.5400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0028
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0046
    Cell Significance Index: -3.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0122
    Cell Significance Index: -6.8700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0149
    Cell Significance Index: -2.1600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0149
    Cell Significance Index: -10.9500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0186
    Cell Significance Index: -14.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0257
    Cell Significance Index: -2.9500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0267
    Cell Significance Index: -3.4500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0332
    Cell Significance Index: -0.4300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0402
    Cell Significance Index: -4.1100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0416
    Cell Significance Index: -8.7700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0503
    Cell Significance Index: -5.9300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0715
    Cell Significance Index: -1.8800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0912
    Cell Significance Index: -6.4500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0937
    Cell Significance Index: -10.7000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0971
    Cell Significance Index: -6.1200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1076
    Cell Significance Index: -2.6900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1236
    Cell Significance Index: -5.8100
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1260
    Cell Significance Index: -1.7000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1276
    Cell Significance Index: -1.1800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1333
    Cell Significance Index: -2.8300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1336
    Cell Significance Index: -3.2100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1342
    Cell Significance Index: -1.9100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1417
    Cell Significance Index: -1.1900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1485
    Cell Significance Index: -15.4700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1656
    Cell Significance Index: -9.2900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1918
    Cell Significance Index: -15.1900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2039
    Cell Significance Index: -4.2300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2045
    Cell Significance Index: -6.5500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2131
    Cell Significance Index: -4.1600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2148
    Cell Significance Index: -13.8600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.2249
    Cell Significance Index: -3.0000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2255
    Cell Significance Index: -13.8300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2440
    Cell Significance Index: -7.7700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2564
    Cell Significance Index: -8.9100
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.2614
    Cell Significance Index: -3.0100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2621
    Cell Significance Index: -8.5800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2772
    Cell Significance Index: -3.0200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2852
    Cell Significance Index: -4.5300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2900
    Cell Significance Index: -10.1600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3151
    Cell Significance Index: -8.1000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3188
    Cell Significance Index: -6.4000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3204
    Cell Significance Index: -9.1900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3309
    Cell Significance Index: -4.8900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3392
    Cell Significance Index: -8.4600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** * TUBG2 is a gamma subunit of microtubules, which is essential for the formation and stability of microtubule filaments. * The gene is highly expressed in cells that require rapid cell division, such as neurons and germ cells. * TUBG2 interacts with gamma-tubulin, a protein that plays a key role in microtubule nucleation and organization. * The protein encoded by TUBG2 is involved in the regulation of microtubule dynamics, including depolymerization and polymerization. * TUBG2 has been implicated in the regulation of cell cycle progression, particularly in the G2/M phase. **Pathways and Functions:** TUBG2 is involved in several cellular pathways, including: * Cell cycle regulation: TUBG2 interacts with other proteins to regulate microtubule dynamics and cell cycle progression, particularly in the G2/M phase. * Microtubule organization: TUBG2 interacts with gamma-tubulin to regulate microtubule nucleation and organization. * Microtubule dynamics: TUBG2 is involved in the regulation of microtubule depolymerization and polymerization. * Cytoskeleton organization: TUBG2 is involved in the organization of the cytoskeleton, particularly in the formation of microtubule filaments. * Meiotic spindle organization: TUBG2 is involved in the organization of the meiotic spindle, which is essential for proper meiosis. **Clinical Significance:** Dysregulation of TUBG2 has been implicated in various diseases, including: * Cancer: TUBG2 is overexpressed in several types of cancer, including breast, lung, and colon cancer. * Neurodegenerative disorders: TUBG2 has been implicated in the pathogenesis of neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. * Neurodevelopmental disorders: TUBG2 is involved in the regulation of neuronal development and function, and dysregulation of TUBG2 has been implicated in neurodevelopmental disorders, including autism spectrum disorder and schizophrenia. In conclusion, TUBG2 is a critical gene that plays a vital role in the regulation of microtubule dynamics and cell cycle progression. Dysregulation of TUBG2 has been implicated in various diseases, highlighting the importance of this gene in maintaining cellular homeostasis and preventing disease.

Genular Protein ID: 2223705650

Symbol: TBG2_HUMAN

Name: Tubulin gamma-2 chain

UniProtKB Accession Codes:

Q9NRH3 A6NDI4 Q32NB2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 GO 20 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10903841

Title: The gamma-tubulin gene family in humans.

PubMed ID: 10903841

DOI: 10.1006/geno.2000.6247

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 451
  • Mass: 51092
  • Checksum: FDE2CB5A33D92691
  • Sequence:
    • MPREIITLQL GQCGNQIGFE FWKQLCAEHG ISPEGIVEEF ATEGTDRKDV FFYQADDEHY 
IPRAVLLDLE PRVIHSILNS PYAKLYNPEN IYLSEHGGGA GNNWASGFSQ GEKIHEDIFD 
IIDREADGSD SLEGFVLCHS IAGGTGSGLG SYLLERLNDR YPKKLVQTYS VFPYQDEMSD 
VVVQPYNSLL TLKRLTQNAD CVVVLDNTAL NRIATDRLHI QNPSFSQINQ LVSTIMSAST 
TTLRYPGYMN NDLIGLIASL IPTPRLHFLM TGYTPLTTDQ SVASVRKTTV LDVMRRLLQP 
KNVMVSTGRD RQTNHCYIAI LNIIQGEVDP TQVHKSLQRI RERKLANFIP WGPASIQVAL 
SRKSPYLPSA HRVSGLMMAN HTSISSLFES SCQQFDKLRK RDAFLEQFRK EDMFKDNFDE 
MDRSREVVQE LIDEYHAATQ PDYISWGTQE Q

Genular Protein ID: 1098054501

Symbol: A0A1B4Z394_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A1B4Z394

Database IDs:

ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 13 Gene3D 3 InterPro 9 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 1 PeptideAtlas 1 Pfam 2 RefSeq 1 RuleBase 1 SMART 4 SMR 1 SUPFAM 2

Citations:

PubMed ID: 27015882

Title: Human TUBG2 gene is expressed as two splice variant mRNA and involved in cell growth.

PubMed ID: 27015882

DOI: 10.1002/1873-3468.12163

Sequence Information:

  • Length: 460
  • Mass: 52118
  • Checksum: 49F2E6A24D81767F
  • Sequence:
    • MPREIITLQL GQCGNQIGFE FWKQLCAEHG ISPEGIVEEF ATEGTDRKDV FFYQADDEHY 
IPRAVLLDLE PRVIHSILNS PYAKLYNPEN IYLSEHGGGA GNNWASGFSQ GEKIHEDIFD 
IIDREADGSD SLELQNSSRV IKGFVLCHSI AGGTGSGLGS YLLERLNDRY PKKLVQTYSV 
FPYQDEMSDV VVQPYNSLLT LKRLTQNADC VVVLDNTALN RIATDRLHIQ NPSFSQINQL 
VSTIMSASTT TLRYPGYMNN DLIGLIASLI PTPRLHFLMT GYTPLTTDQS VASVRKTTVL 
DVMRRLLQPK NVMVSTGRDR QTNHCYIAIL NIIQGEVDPT QVHKSLQRIR ERKLANFIPW 
GPASIQVALS RKSPYLPSAH RVSGLMMANH TSISSLFESS CQQFDKLRKR DAFLEQFRKE 
DMFKDNFDEM DRSREVVQEL IDEYHAATQP DYISWGTQEQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.