Details for: TUBGCP4

Gene ID: 27229

Symbol: TUBGCP4

Ensembl ID: ENSG00000137822

Description: tubulin gamma complex component 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 117.7792
    Cell Significance Index: -18.3200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 72.3851
    Cell Significance Index: -18.3600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 46.8099
    Cell Significance Index: -22.1000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 43.6177
    Cell Significance Index: -17.7200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 18.6019
    Cell Significance Index: -17.7600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.2188
    Cell Significance Index: -21.2300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.5667
    Cell Significance Index: -20.2700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.4916
    Cell Significance Index: -21.6700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1419
    Cell Significance Index: 15.5800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0468
    Cell Significance Index: 103.5600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.8571
    Cell Significance Index: 54.0200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.8407
    Cell Significance Index: 97.9800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8051
    Cell Significance Index: 161.5100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7657
    Cell Significance Index: 45.9700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7063
    Cell Significance Index: 637.7500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6757
    Cell Significance Index: 73.5000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6403
    Cell Significance Index: 127.0700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5364
    Cell Significance Index: 14.9900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4899
    Cell Significance Index: 79.6900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.4641
    Cell Significance Index: 11.9300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4639
    Cell Significance Index: 320.8600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4543
    Cell Significance Index: 12.3700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4514
    Cell Significance Index: 15.6900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3088
    Cell Significance Index: 13.6600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3023
    Cell Significance Index: 8.7100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3016
    Cell Significance Index: 11.4200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3008
    Cell Significance Index: 20.8000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2988
    Cell Significance Index: 41.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2917
    Cell Significance Index: 104.6400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.2777
    Cell Significance Index: 3.3100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2739
    Cell Significance Index: 14.3800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2554
    Cell Significance Index: 139.5000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2481
    Cell Significance Index: 12.8900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2474
    Cell Significance Index: 13.8900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2424
    Cell Significance Index: 29.8100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2351
    Cell Significance Index: 42.3800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2264
    Cell Significance Index: 5.6600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2055
    Cell Significance Index: 12.6300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1984
    Cell Significance Index: 12.8000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1939
    Cell Significance Index: 4.2000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1766
    Cell Significance Index: 78.0700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1635
    Cell Significance Index: 7.4100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1621
    Cell Significance Index: 10.9000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.1554
    Cell Significance Index: 3.3200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1295
    Cell Significance Index: 16.6000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1113
    Cell Significance Index: 5.1900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1049
    Cell Significance Index: 7.4200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0966
    Cell Significance Index: 1.6600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0672
    Cell Significance Index: 12.7900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0528
    Cell Significance Index: 4.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0528
    Cell Significance Index: 97.4400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0455
    Cell Significance Index: 70.0500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0371
    Cell Significance Index: 4.7900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0347
    Cell Significance Index: 4.0900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0199
    Cell Significance Index: 0.7000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0165
    Cell Significance Index: 31.0400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0131
    Cell Significance Index: 8.3000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0103
    Cell Significance Index: 0.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0048
    Cell Significance Index: 6.5600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0001
    Cell Significance Index: -0.0200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0101
    Cell Significance Index: -7.3900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0120
    Cell Significance Index: -0.3200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0143
    Cell Significance Index: -6.5100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0213
    Cell Significance Index: -16.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0217
    Cell Significance Index: -16.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0353
    Cell Significance Index: -19.8900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0379
    Cell Significance Index: -0.6400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0403
    Cell Significance Index: -25.1400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0504
    Cell Significance Index: -2.3700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0524
    Cell Significance Index: -0.6500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0538
    Cell Significance Index: -4.0100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0545
    Cell Significance Index: -2.8400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0580
    Cell Significance Index: -1.2700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0597
    Cell Significance Index: -6.1000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0607
    Cell Significance Index: -1.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0647
    Cell Significance Index: -18.6200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0806
    Cell Significance Index: -11.7200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0965
    Cell Significance Index: -2.0200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1090
    Cell Significance Index: -3.4900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1117
    Cell Significance Index: -2.6800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1125
    Cell Significance Index: -23.7100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1235
    Cell Significance Index: -14.1500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1245
    Cell Significance Index: -3.1800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1903
    Cell Significance Index: -5.0900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1927
    Cell Significance Index: -20.0600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2236
    Cell Significance Index: -1.5200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2261
    Cell Significance Index: -17.9100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2394
    Cell Significance Index: -14.6800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2588
    Cell Significance Index: -3.8200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2716
    Cell Significance Index: -5.3000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2816
    Cell Significance Index: -7.5500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3019
    Cell Significance Index: -3.1300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3583
    Cell Significance Index: -5.4000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3670
    Cell Significance Index: -9.6500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3879
    Cell Significance Index: -5.5600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3950
    Cell Significance Index: -12.5800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4184
    Cell Significance Index: -11.9400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4268
    Cell Significance Index: -13.9800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4288
    Cell Significance Index: -9.1000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4354
    Cell Significance Index: -10.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TUBGCP4 is a small protein, approximately 34 kDa in size, which is highly expressed in cells that require dynamic microtubule organization, such as neurons, germ cells, and intestinal epithelial cells. The protein is characterized by its ability to bind gamma-tubulin, a crucial component of the gamma-tubulin complex, and its involvement in the assembly and stabilization of microtubules. TUBGCP4 is also known for its role in the recruitment of other proteins to the microtubule plus-end, facilitating the formation of stable microtubule arrays. **Pathways and Functions** TUBGCP4 is involved in several key cellular pathways, including: 1. **Microtubule nucleation**: TUBGCP4 plays a crucial role in the assembly of microtubules from gamma-tubulin dimers, facilitating the nucleation of microtubules at the centrosome. 2. **Centrosome maturation**: TUBGCP4 is involved in the maturation of centrosomes, which are critical for the organization of the microtubule cytoskeleton. 3. **Cytoplasmic microtubule organization**: TUBGCP4 helps to regulate the organization and stabilization of microtubules in the cytoplasm, which is essential for cellular processes such as transport and signaling. 4. **Spindle assembly**: TUBGCP4 is involved in the assembly of the spindle apparatus during cell division, ensuring proper chromosome segregation. **Clinical Significance** Abnormalities in TUBGCP4 expression or function have been implicated in various diseases, including: 1. **Cancer**: Alterations in TUBGCP4 expression have been observed in various types of cancer, including breast, lung, and colon cancer. 2. **Neurodegenerative disorders**: TUBGCP4 has been implicated in neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. 3. **Infertility**: Abnormalities in TUBGCP4 expression have been observed in patients with infertility, highlighting its role in gamete development and fertilization. 4. **Neurodevelopmental disorders**: TUBGCP4 has been implicated in neurodevelopmental disorders such as autism spectrum disorder and schizophrenia. In conclusion, TUBGCP4 is a crucial component of the gamma-tubulin complex, which plays a pivotal role in the organization and dynamics of microtubules within cells. Abnormalities in TUBGCP4 expression or function have been implicated in various diseases, highlighting the importance of this gene in maintaining cellular homeostasis and preventing disease. Further research is necessary to fully elucidate the role of TUBGCP4 in various cellular processes and diseases.

Genular Protein ID: 2221127220

Symbol: GCP4_HUMAN

Name: Gamma-tubulin complex component 4

UniProtKB Accession Codes:

Q9UGJ1 B3KNK6 Q969X3 Q9NVF0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 23 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 23 PDBsum 23 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10562286

Title: Human 76p: a new protein member of the gamma-tubulin associated protein family.

PubMed ID: 10562286

DOI: 10.1083/jcb.147.4.857

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12852856

Title: Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation.

PubMed ID: 12852856

DOI: 10.1016/s1534-5807(03)00193-x

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25817018

Title: Mutations in TUBGCP4 alter microtubule organization via the gamma-tubulin ring complex in autosomal-recessive microcephaly with chorioretinopathy.

PubMed ID: 25817018

DOI: 10.1016/j.ajhg.2015.02.011

PubMed ID: 26213385

Title: ATF5 Connects the Pericentriolar Materials to the Proximal End of the Mother Centriole.

PubMed ID: 26213385

DOI: 10.1016/j.cell.2015.06.055

Sequence Information:

  • Length: 667
  • Mass: 76089
  • Checksum: 2030EEDF290F5FAC
  • Sequence:
    • MIHELLLALS GYPGSIFTWN KRSGLQVSQD FPFLHPSETS VLNRLCRLGT DYIRFTEFIE 
QYTGHVQQQD HHPSQQGQGG LHGIYLRAFC TGLDSVLQPY RQALLDLEQE FLGDPHLSIS 
HVNYFLDQFQ LLFPSVMVVV EQIKSQKIHG CQILETVYKH SCGGLPPVRS ALEKILAVCH 
GVMYKQLSAW MLHGLLLDQH EEFFIKQGPS SGNVSAQPEE DEEDLGIGGL TGKQLRELQD 
LRLIEEENML APSLKQFSLR VEILPSYIPV RVAEKILFVG ESVQMFENQN VNLTRKGSIL 
KNQEDTFAAE LHRLKQQPLF SLVDFEQVVD RIRSTVAEHL WKLMVEESDL LGQLKIIKDF 
YLLGRGELFQ AFIDTAQHML KTPPTAVTEH DVNVAFQQSA HKVLLDDDNL LPLLHLTIEY 
HGKEHKADAT QAREGPSRET SPREAPASGW AALGLSYKVQ WPLHILFTPA VLEKYNVVFK 
YLLSVRRVQA ELQHCWALQM QRKHLKSNQT DAIKWRLRNH MAFLVDNLQY YLQVDVLESQ 
FSQLLHQINS TRDFESIRLA HDHFLSNLLA QSFILLKPVF HCLNEILDLC HSFCSLVSQN 
LGPLDERGAA QLSILVKGFS RQSSLLFKIL SSVRNHQINS DLAQLLLRLD YNKYYTQAGG 
TLGSFGM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.