Details for: GNMT

Gene ID: 27232

Symbol: GNMT

Ensembl ID: ENSG00000124713

Description: glycine N-methyltransferase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 62.2447
    Cell Significance Index: 31.2600
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 20.8942
    Cell Significance Index: -3.2500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 12.6950
    Cell Significance Index: -3.2200
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 6.5316
    Cell Significance Index: 17.2300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 2.6481
    Cell Significance Index: -3.2700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3603
    Cell Significance Index: 61.5200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.3430
    Cell Significance Index: 3.5500
  • Cell Name: mucus secreting cell of tracheobronchial tree submucosal gland (CL4033037)
    Fold Change: 0.2516
    Cell Significance Index: 1.6800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.2078
    Cell Significance Index: 3.5000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1875
    Cell Significance Index: 35.6800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1367
    Cell Significance Index: 3.7200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1214
    Cell Significance Index: 9.0500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.1118
    Cell Significance Index: 1.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1029
    Cell Significance Index: 4.8000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0956
    Cell Significance Index: 18.9800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0691
    Cell Significance Index: 47.7700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0620
    Cell Significance Index: 55.9700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0548
    Cell Significance Index: 3.2900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0504
    Cell Significance Index: 0.8300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0362
    Cell Significance Index: 1.8800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0335
    Cell Significance Index: 4.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0334
    Cell Significance Index: 6.7100
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 0.0321
    Cell Significance Index: 0.6700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0317
    Cell Significance Index: 5.7100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0263
    Cell Significance Index: 2.8600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0221
    Cell Significance Index: 2.1900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0180
    Cell Significance Index: 2.0700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0147
    Cell Significance Index: 5.2900
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: 0.0127
    Cell Significance Index: 0.2100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0115
    Cell Significance Index: 0.1700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0114
    Cell Significance Index: 0.7900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0112
    Cell Significance Index: 1.8300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.0097
    Cell Significance Index: 0.0600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0086
    Cell Significance Index: 3.7900
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.0078
    Cell Significance Index: 0.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0042
    Cell Significance Index: 2.6400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0031
    Cell Significance Index: 2.3800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0006
    Cell Significance Index: 0.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0002
    Cell Significance Index: 0.0300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0002
    Cell Significance Index: 0.1800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0007
    Cell Significance Index: -1.3600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0012
    Cell Significance Index: -0.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0013
    Cell Significance Index: -0.6900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0015
    Cell Significance Index: -2.8000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0015
    Cell Significance Index: -2.3200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0022
    Cell Significance Index: -3.0400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0028
    Cell Significance Index: -0.0800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0028
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0038
    Cell Significance Index: -2.8000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0045
    Cell Significance Index: -2.5400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0048
    Cell Significance Index: -0.6200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0052
    Cell Significance Index: -0.1300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0056
    Cell Significance Index: -3.5200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0064
    Cell Significance Index: -2.9000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0089
    Cell Significance Index: -2.5600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0091
    Cell Significance Index: -0.9300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0094
    Cell Significance Index: -0.3000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0097
    Cell Significance Index: -1.1400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0100
    Cell Significance Index: -0.2800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0102
    Cell Significance Index: -0.7200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0112
    Cell Significance Index: -0.2800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0113
    Cell Significance Index: -1.4600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0149
    Cell Significance Index: -2.0400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0160
    Cell Significance Index: -3.3700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0179
    Cell Significance Index: -0.8100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0203
    Cell Significance Index: -0.5200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0223
    Cell Significance Index: -1.7700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0227
    Cell Significance Index: -1.7400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0248
    Cell Significance Index: -2.9300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0250
    Cell Significance Index: -0.5300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0250
    Cell Significance Index: -0.4200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0253
    Cell Significance Index: -1.5500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0257
    Cell Significance Index: -0.8400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0281
    Cell Significance Index: -1.1500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0327
    Cell Significance Index: -3.4100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0329
    Cell Significance Index: -2.2200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0343
    Cell Significance Index: -0.7300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0346
    Cell Significance Index: -1.7500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0351
    Cell Significance Index: -1.2300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0359
    Cell Significance Index: -0.7100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0361
    Cell Significance Index: -0.7800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0368
    Cell Significance Index: -2.3200
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: -0.0386
    Cell Significance Index: -0.3400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0417
    Cell Significance Index: -1.9600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0431
    Cell Significance Index: -0.8700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0453
    Cell Significance Index: -1.1900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0463
    Cell Significance Index: -1.2400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0473
    Cell Significance Index: -2.9100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0484
    Cell Significance Index: -2.5200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0503
    Cell Significance Index: -2.8200
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.0517
    Cell Significance Index: -0.6300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0518
    Cell Significance Index: -1.3900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0565
    Cell Significance Index: -2.5000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0585
    Cell Significance Index: -1.2800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0587
    Cell Significance Index: -3.0800
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.0626
    Cell Significance Index: -0.6700
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0629
    Cell Significance Index: -0.8100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0630
    Cell Significance Index: -0.9500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0651
    Cell Significance Index: -2.3900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0663
    Cell Significance Index: -2.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** GNMT is significantly expressed in various tissues, including pancreatic acinar cells, epithelial cells of the exocrine pancreas, colon goblet cells, and enterocytes of the small intestine. 2. **Enzymatic Activity:** GNMT catalyzes the transfer of a methyl group from S-adenosyl-l-methionine (SAMe) to glycine, resulting in the formation of sarcosine and S-adenosylhomocysteine (SAH). 3. **Subcellular Localization:** GNMT is primarily found in the cytosol, where it plays a critical role in regulating metabolic pathways. **Pathways and Functions:** 1. **Glycine Degradation:** GNMT is involved in the degradation of glycine, which is a critical amino acid in various metabolic pathways. 2. **Methionine Metabolism:** GNMT regulates the metabolism of methionine, an essential amino acid involved in various cellular processes, including DNA synthesis and methylation. 3. **One-Carbon Metabolism:** GNMT participates in one-carbon metabolism, which is a set of biochemical reactions that involve the transfer of one-carbon units. 4. **S-Adenosylhomocysteine Metabolism:** GNMT is involved in the metabolism of S-adenosylhomocysteine, a byproduct of methionine metabolism. **Clinical Significance:** 1. **Metabolic Disorders:** Alterations in GNMT expression or activity have been implicated in various metabolic disorders, including diabetes, obesity, and metabolic syndrome. 2. **Cancer:** GNMT has been shown to be overexpressed in certain types of cancer, including pancreatic cancer, and may play a role in tumorigenesis. 3. **Neurological Disorders:** GNMT has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease, where it may play a role in the regulation of methionine metabolism. 4. **Pharmacological Applications:** GNMT inhibitors have been explored as potential therapeutic agents for the treatment of various metabolic disorders and cancers. In conclusion, the GNMT gene plays a critical role in regulating metabolic pathways and maintaining cellular homeostasis. Its dysregulation has been implicated in various metabolic disorders, cancers, and neurological disorders, highlighting the importance of GNMT in human health and disease. Further research is needed to fully elucidate the functions of GNMT and its potential therapeutic applications.

Genular Protein ID: 3412903727

Symbol: GNMT_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q14749 Q5T8W2 Q9NNZ1 Q9NS24

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 21 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EC 1 EMBL 6 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 2 Rhea 2 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9495250

Title: Characterization of glycine-N-methyltransferase-gene expression in human hepatocellular carcinoma.

PubMed ID: 9495250

DOI: 10.1002/(sici)1097-0215(19980302)75:5<787::aid-ijc20>3.0.co;2-2

PubMed ID: 10843803

Title: Genomic structure, expression, and chromosomal localization of the human glycine N-methyltransferase gene.

PubMed ID: 10843803

DOI: 10.1006/geno.2000.6188

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8281755

Title: Mammalian glycine N-methyltransferases. Comparative kinetic and structural properties of the enzymes from human, rat, rabbit and pig livers.

PubMed ID: 8281755

DOI: 10.1016/0305-0491(93)90137-t

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 15340920

Title: Glycine N-methyltransferases: a comparison of the crystal structures and kinetic properties of recombinant human, mouse and rat enzymes.

PubMed ID: 15340920

DOI: 10.1002/prot.20209

PubMed ID: 17660255

Title: Destabilization of human glycine N-methyltransferase by H176N mutation.

PubMed ID: 17660255

DOI: 10.1110/ps.072921507

PubMed ID: 11810299

Title: Mutations in human glycine N-methyltransferase give insights into its role in methionine metabolism.

PubMed ID: 11810299

DOI: 10.1007/s00439-001-0648-4

PubMed ID: 14651980

Title: Effect of naturally occurring mutations in human glycine N-methyltransferase on activity and conformation.

PubMed ID: 14651980

DOI: 10.1016/j.bbrc.2003.11.037

PubMed ID: 14739680

Title: Glycine N-methyltransferase deficiency: a new patient with a novel mutation.

PubMed ID: 14739680

DOI: 10.1023/b:boli.0000009978.17777.33

Sequence Information:

  • Length: 295
  • Mass: 32742
  • Checksum: 34F4546136FD27ED
  • Sequence:
    • MVDSVYRTRS LGVAAEGLPD QYADGEAARV WQLYIGDTRS RTAEYKAWLL GLLRQHGCQR 
VLDVACGTGV DSIMLVEEGF SVTSVDASDK MLKYALKERW NRRHEPAFDK WVIEEANWMT 
LDKDVPQSAE GGFDAVICLG NSFAHLPDCK GDQSEHRLAL KNIASMVRAG GLLVIDHRNY 
DHILSTGCAP PGKNIYYKSD LTKDVTTSVL IVNNKAHMVT LDYTVQVPGA GQDGSPGLSK 
FRLSYYPHCL ASFTELLQAA FGGKCQHSVL GDFKPYKPGQ TYIPCYFIHV LKRTD

Genular Protein ID: 2832270516

Symbol: A0A0S2Z5F2_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z5F2

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 12 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 13 Gene3D 2 IntAct 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 1 PROSITE 1 PeptideAtlas 1 Pfam 2 RefSeq 1 Rhea 2 SUPFAM 1

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 276
  • Mass: 30664
  • Checksum: EAFE10C969E1B4D8
  • Sequence:
    • MVDSVYRTRS LGVAAEGLPD QYADGEAARV WQLYIGDTRS RTAEYKAWLL GLLRQHGCQR 
VLDVACGTGV DSIMLVEEGF SVTSVDASDK MLKYALKERW NRRHEPAFDK WVIEEANWMT 
LDKDVPQSAE GGFDAVICLG NSFAHLPDCK GGLLVIDHRN YDHILSTGCA PPGKNIYYKS 
DLTKDVTTSV LIVNNKAHMV TLDYTVQVPG AGQDGSPGLS KFRLSYYPHC LASFTELLQA 
AFGGKCQHSV LGDFKPYKPG QTYIPCYFIH VLKRTD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.