Details for: TP53TG5

Gene ID: 27296

Symbol: TP53TG5

Ensembl ID: ENSG00000124251

Description: TP53 target 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 44.9844
    Cell Significance Index: -11.4100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.5322
    Cell Significance Index: 93.9400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.3570
    Cell Significance Index: 34.8800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.7520
    Cell Significance Index: 11.1000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5289
    Cell Significance Index: 100.6600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3438
    Cell Significance Index: 68.9700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3306
    Cell Significance Index: 12.5200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3251
    Cell Significance Index: 14.3800
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.2659
    Cell Significance Index: 2.3000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2361
    Cell Significance Index: 23.3600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2321
    Cell Significance Index: 17.8100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2286
    Cell Significance Index: 206.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1774
    Cell Significance Index: 35.2100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1547
    Cell Significance Index: 16.8300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1519
    Cell Significance Index: 9.1200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.1386
    Cell Significance Index: 1.9700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1331
    Cell Significance Index: 21.6500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1187
    Cell Significance Index: 7.9800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.1047
    Cell Significance Index: 15.2200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0973
    Cell Significance Index: 34.9100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0890
    Cell Significance Index: 5.4700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0817
    Cell Significance Index: 2.3600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0785
    Cell Significance Index: 1.7000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0692
    Cell Significance Index: 12.4700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0466
    Cell Significance Index: 2.1100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0447
    Cell Significance Index: 1.5700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0346
    Cell Significance Index: 2.4000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0220
    Cell Significance Index: 0.4300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0192
    Cell Significance Index: 0.4800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0164
    Cell Significance Index: 30.8300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0159
    Cell Significance Index: 24.5000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0123
    Cell Significance Index: 0.2100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0071
    Cell Significance Index: 13.1300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0047
    Cell Significance Index: 6.3800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0010
    Cell Significance Index: -0.4800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0034
    Cell Significance Index: -2.3200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0045
    Cell Significance Index: -2.8500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0094
    Cell Significance Index: -4.1400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0149
    Cell Significance Index: -10.9200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0152
    Cell Significance Index: -11.2700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0152
    Cell Significance Index: -8.3200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0153
    Cell Significance Index: -11.5500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0186
    Cell Significance Index: -11.5900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0195
    Cell Significance Index: -5.6000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0205
    Cell Significance Index: -11.5400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0257
    Cell Significance Index: -3.2900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0285
    Cell Significance Index: -3.5000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0419
    Cell Significance Index: -1.1700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0437
    Cell Significance Index: -1.4000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0553
    Cell Significance Index: -2.5800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0556
    Cell Significance Index: -11.7100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0587
    Cell Significance Index: -3.0500
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0606
    Cell Significance Index: -0.6500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0614
    Cell Significance Index: -10.4800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0663
    Cell Significance Index: -0.9500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0790
    Cell Significance Index: -5.5900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0800
    Cell Significance Index: -10.9800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0813
    Cell Significance Index: -9.4800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0825
    Cell Significance Index: -8.6000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0829
    Cell Significance Index: -10.7100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0916
    Cell Significance Index: -1.3800
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0972
    Cell Significance Index: -1.3100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0985
    Cell Significance Index: -11.2900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1042
    Cell Significance Index: -10.6400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1097
    Cell Significance Index: -2.6300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1144
    Cell Significance Index: -7.2100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1147
    Cell Significance Index: -2.3800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1197
    Cell Significance Index: -2.5400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1306
    Cell Significance Index: -7.3300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1389
    Cell Significance Index: -10.3500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1456
    Cell Significance Index: -3.1000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1644
    Cell Significance Index: -5.2000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1700
    Cell Significance Index: -2.5100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1747
    Cell Significance Index: -5.7200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1758
    Cell Significance Index: -3.8500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1779
    Cell Significance Index: -5.6700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1840
    Cell Significance Index: -8.6500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1862
    Cell Significance Index: -2.5400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1976
    Cell Significance Index: -5.6400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2024
    Cell Significance Index: -7.0900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2055
    Cell Significance Index: -10.7900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2196
    Cell Significance Index: -9.5500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2417
    Cell Significance Index: -6.5800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2418
    Cell Significance Index: -5.9000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2435
    Cell Significance Index: -5.2600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2519
    Cell Significance Index: -4.9800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2582
    Cell Significance Index: -3.2200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2682
    Cell Significance Index: -6.6900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2690
    Cell Significance Index: -5.4000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2704
    Cell Significance Index: -7.2200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2775
    Cell Significance Index: -2.6300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.2987
    Cell Significance Index: -3.7700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3081
    Cell Significance Index: -6.4300
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.3182
    Cell Significance Index: -4.0800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3217
    Cell Significance Index: -11.8100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3221
    Cell Significance Index: -8.6300
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.3323
    Cell Significance Index: -2.9500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.3353
    Cell Significance Index: -5.3800
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.3534
    Cell Significance Index: -4.0700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3549
    Cell Significance Index: -8.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TP53TG5 is a transcriptional target of TP53, a key regulator of the cell cycle and a potent tumor suppressor. The gene is characterized by its expression in specific cell types, including those involved in nervous system development (oligodendrocytes, cerebral cortex GABAergic interneurons), hematopoiesis (hematopoietic stem cells), and intestinal epithelial homeostasis (intestinal crypt stem cells). The expression patterns of TP53TG5 suggest a conserved role in maintaining tissue homeostasis and preventing cancerous transformation. **Pathways and Functions:** TP53TG5 is involved in the regulation of cellular growth, differentiation, and survival through its interaction with the TP53 protein. The TP53-TG5 axis modulates the expression of genes involved in cell cycle progression, apoptosis, and DNA repair. Specifically, TP53TG5 has been shown to: 1. Regulate the expression of genes involved in cell cycle progression, such as CDKN1A and CCND1. 2. Modulate the activity of pro-apoptotic proteins, such as BAX and BAK. 3. Inhibit the expression of genes involved in DNA repair, such as MSH2 and MLH1. 4. Regulate the expression of genes involved in differentiation, such as MYB and MYF5. **Clinical Significance:** The identification of TP53TG5 as a novel target gene of TP53 has significant clinical implications. Alterations in TP53 expression or function have been linked to various human cancers, including breast, lung, and colon cancer. The tumor suppressor activity of TP53 is critical in preventing cancerous transformation, and its dysregulation can lead to uncontrolled cell growth and tumor formation. TP53TG5 may serve as a molecular marker for detecting TP53 mutations or alterations, which can be used to diagnose and monitor cancer patients. Furthermore, the TP53-TG5 axis may provide a new therapeutic target for cancer treatment, as modulation of this axis could potentially inhibit cancer cell growth and proliferation. In conclusion, TP53TG5 is a novel target gene of TP53 that plays a critical role in regulating cellular homeostasis and preventing cancerous transformation. Further studies are needed to fully elucidate the functional significance of TP53TG5 and its potential as a molecular marker for cancer detection and treatment.

Genular Protein ID: 3709442612

Symbol: T53G5_HUMAN

Name: TP53-target gene 5 protein

UniProtKB Accession Codes:

Q9Y2B4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 EMBL 3 Ensembl 1 GO 6 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10719363

Title: Isolation and characterization of a novel TP53-inducible gene, TP53TG5, which suppresses growth and shows cell cycle-dependent transition of expression.

PubMed ID: 10719363

DOI: 10.1002/(sici)1098-2264(200004)27:4<345::aid-gcc2>3.0.co;2-3

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 290
  • Mass: 34019
  • Checksum: D3206C95021473E3
  • Sequence:
    • MSPSAKKRPK NSRVSKMQDE KLRDETEQPV SKVIERNRLR TVLKNLSLLK LLKSSNRRIQ 
ELHKLAKRCW HSLLSVPKIL RISSGENSAC NKTKQNNEEF QEIGCSEKEL KSKKLESTGD 
PKKKEYKEWK SQVQSGMRNK EKTSLAAMPR KEKHIEPEVP RTSRDDSLNP GVQGRQPLTE 
GPRVIFIKPY RNRTPMGHMK QLDVADQWIW FEGLPTRIHL PAPRVMCRSS TLRWVKRRCT 
RFCSASLEMP MWHPYKVDVT WTRARGASRG WRSRHQLKGR NGWRNSRVYK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.