Details for: RPS6KA6

Gene ID: 27330

Symbol: RPS6KA6

Ensembl ID: ENSG00000072133

Description: ribosomal protein S6 kinase A6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 48.2586
    Cell Significance Index: -19.8800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 43.5069
    Cell Significance Index: -17.6800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 18.5285
    Cell Significance Index: -17.6900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.1344
    Cell Significance Index: 94.4100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.9875
    Cell Significance Index: 75.2600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.8766
    Cell Significance Index: 376.4400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1038
    Cell Significance Index: 50.0300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.0465
    Cell Significance Index: 70.3700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9649
    Cell Significance Index: 346.0900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.9253
    Cell Significance Index: 639.9900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.9045
    Cell Significance Index: 57.0100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8358
    Cell Significance Index: 754.6300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8050
    Cell Significance Index: 17.4400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.7855
    Cell Significance Index: 44.0800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.6727
    Cell Significance Index: 14.3800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.6709
    Cell Significance Index: 14.6900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6279
    Cell Significance Index: 68.3000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6243
    Cell Significance Index: 37.4800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.6138
    Cell Significance Index: 14.7200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5855
    Cell Significance Index: 35.9900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5747
    Cell Significance Index: 93.4800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.5614
    Cell Significance Index: 16.0200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3866
    Cell Significance Index: 11.1400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2954
    Cell Significance Index: 56.2200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2811
    Cell Significance Index: 19.4400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2568
    Cell Significance Index: 4.4000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2384
    Cell Significance Index: 23.5800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2175
    Cell Significance Index: 39.2000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1555
    Cell Significance Index: 8.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1317
    Cell Significance Index: 6.1400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1157
    Cell Significance Index: 14.2300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0858
    Cell Significance Index: 1.1700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0500
    Cell Significance Index: 76.9400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0389
    Cell Significance Index: 24.7000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0360
    Cell Significance Index: 67.8400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0312
    Cell Significance Index: 13.7800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0261
    Cell Significance Index: 11.8600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0178
    Cell Significance Index: 0.3800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0173
    Cell Significance Index: 31.9000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0156
    Cell Significance Index: 11.4200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0130
    Cell Significance Index: 17.6600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0099
    Cell Significance Index: 0.2700
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.0023
    Cell Significance Index: 0.0300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0022
    Cell Significance Index: -1.2000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0070
    Cell Significance Index: -0.4300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0076
    Cell Significance Index: -1.1100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0159
    Cell Significance Index: -0.5600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0169
    Cell Significance Index: -0.3400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0219
    Cell Significance Index: -0.3300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0252
    Cell Significance Index: -18.6300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0264
    Cell Significance Index: -19.9600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0297
    Cell Significance Index: -0.9500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0346
    Cell Significance Index: -19.5200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0358
    Cell Significance Index: -22.3800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0554
    Cell Significance Index: -1.1500
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0592
    Cell Significance Index: -0.7900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0594
    Cell Significance Index: -17.1100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0845
    Cell Significance Index: -8.6300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0916
    Cell Significance Index: -15.6400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0953
    Cell Significance Index: -13.0900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1006
    Cell Significance Index: -1.9900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1022
    Cell Significance Index: -20.2800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1065
    Cell Significance Index: -1.2700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1075
    Cell Significance Index: -22.6400
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.1354
    Cell Significance Index: -1.4100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1367
    Cell Significance Index: -17.6600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1379
    Cell Significance Index: -17.6800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1544
    Cell Significance Index: -16.0800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1545
    Cell Significance Index: -3.2800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1557
    Cell Significance Index: -17.8400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1582
    Cell Significance Index: -5.1800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1660
    Cell Significance Index: -11.7400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1728
    Cell Significance Index: -20.3800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1744
    Cell Significance Index: -1.9000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1865
    Cell Significance Index: -5.9400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1961
    Cell Significance Index: -15.0500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2037
    Cell Significance Index: -16.1300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2177
    Cell Significance Index: -11.4300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2349
    Cell Significance Index: -17.5100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2542
    Cell Significance Index: -3.1700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2560
    Cell Significance Index: -3.1800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2681
    Cell Significance Index: -12.6000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2681
    Cell Significance Index: -7.1600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2703
    Cell Significance Index: -5.8400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2795
    Cell Significance Index: -14.5600
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.2824
    Cell Significance Index: -2.5500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3246
    Cell Significance Index: -20.9400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3275
    Cell Significance Index: -4.6900
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.3384
    Cell Significance Index: -3.6000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3494
    Cell Significance Index: -8.7200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.3499
    Cell Significance Index: -4.4200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3514
    Cell Significance Index: -9.4200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.3555
    Cell Significance Index: -15.4600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3614
    Cell Significance Index: -12.6600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.3637
    Cell Significance Index: -4.5900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3993
    Cell Significance Index: -11.4500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.4191
    Cell Significance Index: -3.2300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4253
    Cell Significance Index: -14.7800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.4401
    Cell Significance Index: -13.9200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.4473
    Cell Significance Index: -4.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RPS6KA6 is a serine/threonine kinase that belongs to the RSK (Ribosomal S6 Kinase) family. It is highly expressed in neurons and other neural cells, where it is involved in the regulation of various cellular processes. RPS6KA6 is activated by the NMDA receptor, a glutamate receptor that plays a critical role in synaptic plasticity and learning. The kinase is also involved in the phosphorylation and activation of downstream targets, including CREB (cAMP response element-binding protein) and ERK (extracellular signal-regulated kinase). **Pathways and Functions:** RPS6KA6 is involved in several key pathways that regulate neural development and function. These include: 1. **Activation of NMDA receptors and postsynaptic events:** RPS6KA6 is activated by the NMDA receptor, leading to the phosphorylation and activation of downstream targets, including CREB and ERK. This pathway is critical for synaptic plasticity and learning. 2. **ATP binding and signal transduction:** RPS6KA6 interacts with ATP, a key energy source for cellular processes, and is involved in the regulation of signal transduction pathways. 3. **Axon guidance and central nervous system development:** RPS6KA6 plays a role in the regulation of axon guidance and central nervous system development, influencing the formation and function of neural circuits. 4. **Creb1 phosphorylation through NMDA receptor-mediated activation of Ras signaling:** RPS6KA6 is involved in the phosphorylation and activation of CREB, a transcription factor that regulates gene expression in response to neural activity. 5. **Negative regulation of embryonic development and mesoderm development:** RPS6KA6 is also involved in the negative regulation of embryonic development and mesoderm development, influencing the formation of neural and non-neural tissues. **Clinical Significance:** RPS6KA6 is involved in several neurological disorders, including: 1. **Neurodegenerative diseases:** RPS6KA6 has been implicated in neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, where it is involved in the regulation of synaptic plasticity and neuronal survival. 2. **Neuropsychiatric disorders:** RPS6KA6 is also involved in neuropsychiatric disorders such as schizophrenia and bipolar disorder, where it is involved in the regulation of neural circuit function and behavior. 3. **Cancer:** RPS6KA6 has been implicated in cancer, where it is involved in the regulation of cell growth and survival. 4. **Neurodevelopmental disorders:** RPS6KA6 is also involved in neurodevelopmental disorders such as autism spectrum disorder and attention-deficit/hyperactivity disorder (ADHD), where it is involved in the regulation of neural circuit function and behavior. In conclusion, RPS6KA6 is a key regulator of neural development and function, involved in various cellular processes such as cell growth, differentiation, and survival. Its dysregulation is implicated in several neurological disorders, highlighting the importance of this kinase in understanding the molecular mechanisms underlying these diseases.

Genular Protein ID: 723834808

Symbol: KS6A6_HUMAN

Name: Ribosomal protein S6 kinase alpha-6

UniProtKB Accession Codes:

Q9UK32 B2R854 B7ZL90 Q6FHX2 Q8WX28 Q9H4S6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CPTAC 2 CTD 1 ChEBI 15 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 3 EMBL 7 Ensembl 2 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIRSF 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 3 Rhea 6 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10644430

Title: A novel ribosomal S6-kinase (RSK4; RPS6KA6) is commonly deleted in patients with complex X-linked mental retardation.

PubMed ID: 10644430

DOI: 10.1006/geno.1999.6004

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15042092

Title: A large-scale RNAi screen in human cells identifies new components of the p53 pathway.

PubMed ID: 15042092

DOI: 10.1038/nature02371

PubMed ID: 15632195

Title: Functional characterization of human RSK4, a new 90-kDa ribosomal S6 kinase, reveals constitutive activation in most cell types.

PubMed ID: 15632195

DOI: 10.1074/jbc.m408194200

PubMed ID: 18813292

Title: The RSK family of kinases: emerging roles in cellular signalling.

PubMed ID: 18813292

DOI: 10.1038/nrm2509

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 745
  • Mass: 83872
  • Checksum: 5EC5AB2FA1C19DE8
  • Sequence:
    • MLPFAPQDEP WDREMEVFSG GGASSGEVNG LKMVDEPMEE GEADSCHDEG VVKEIPITHH 
VKEGYEKADP AQFELLKVLG QGSFGKVFLV RKKTGPDAGQ LYAMKVLKKA SLKVRDRVRT 
KMERDILVEV NHPFIVKLHY AFQTEGKLYL ILDFLRGGDV FTRLSKEVLF TEEDVKFYLA 
ELALALDHLH QLGIVYRDLK PENILLDEIG HIKLTDFGLS KESVDQEKKA YSFCGTVEYM 
APEVVNRRGH SQSADWWSYG VLMFEMLTGT LPFQGKDRNE TMNMILKAKL GMPQFLSAEA 
QSLLRMLFKR NPANRLGSEG VEEIKRHLFF ANIDWDKLYK REVQPPFKPA SGKPDDTFCF 
DPEFTAKTPK DSPGLPASAN AHQLFKGFSF VATSIAEEYK ITPITSANVL PIVQINGNAA 
QFGEVYELKE DIGVGSYSVC KRCIHATTNM EFAVKIIDKS KRDPSEEIEI LMRYGQHPNI 
ITLKDVFDDG RYVYLVTDLM KGGELLDRIL KQKCFSEREA SDILYVISKT VDYLHCQGVV 
HRDLKPSNIL YMDESASADS IRICDFGFAK QLRGENGLLL TPCYTANFVA PEVLMQQGYD 
AACDIWSLGV LFYTMLAGYT PFANGPNDTP EEILLRIGNG KFSLSGGNWD NISDGAKDLL 
SHMLHMDPHQ RYTAEQILKH SWITHRDQLP NDQPKRNDVS HVVKGAMVAT YSALTHKTFQ 
PVLEPVAASS LAQRRSMKKR TSTGL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.