Details for: SGSM3

Gene ID: 27352

Symbol: SGSM3

Ensembl ID: ENSG00000100359

Description: small G protein signaling modulator 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 120.2866
    Cell Significance Index: -18.7100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 75.7363
    Cell Significance Index: -19.2100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 47.5561
    Cell Significance Index: -19.3200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 46.6404
    Cell Significance Index: -22.0200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 42.4584
    Cell Significance Index: -21.8400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 32.8901
    Cell Significance Index: -22.0700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 20.2568
    Cell Significance Index: -19.3400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.1522
    Cell Significance Index: -19.9200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.6226
    Cell Significance Index: -20.4200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.5104
    Cell Significance Index: -16.9300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.1533
    Cell Significance Index: -20.3400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.5417
    Cell Significance Index: -9.9400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.1841
    Cell Significance Index: 818.9500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.1672
    Cell Significance Index: 31.2800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.0584
    Cell Significance Index: 14.4400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0329
    Cell Significance Index: 932.6300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9783
    Cell Significance Index: 106.4100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.9012
    Cell Significance Index: 42.0200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8306
    Cell Significance Index: 82.1600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.8106
    Cell Significance Index: 7.4700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7860
    Cell Significance Index: 96.6400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7751
    Cell Significance Index: 423.2900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7549
    Cell Significance Index: 136.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7366
    Cell Significance Index: 147.7700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.6489
    Cell Significance Index: 13.8700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.6337
    Cell Significance Index: 33.2700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.6224
    Cell Significance Index: 14.3800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5647
    Cell Significance Index: 91.8500
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.5238
    Cell Significance Index: 3.4200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4788
    Cell Significance Index: 13.3800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4561
    Cell Significance Index: 86.7900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4081
    Cell Significance Index: 56.0500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3482
    Cell Significance Index: 21.4000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3457
    Cell Significance Index: 23.9100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3125
    Cell Significance Index: 8.5100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3086
    Cell Significance Index: 8.8900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2689
    Cell Significance Index: 12.1900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2599
    Cell Significance Index: 5.6300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2583
    Cell Significance Index: 92.6300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1994
    Cell Significance Index: 23.5100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1982
    Cell Significance Index: 5.6800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1925
    Cell Significance Index: 10.0000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1879
    Cell Significance Index: 2.8200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1804
    Cell Significance Index: 6.2700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1334
    Cell Significance Index: 3.2000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1280
    Cell Significance Index: 6.0200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1136
    Cell Significance Index: 2.8400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1123
    Cell Significance Index: 14.4000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1112
    Cell Significance Index: 8.5300
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.1048
    Cell Significance Index: 1.0900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0549
    Cell Significance Index: 9.3700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0532
    Cell Significance Index: 6.8800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0209
    Cell Significance Index: 1.3200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0182
    Cell Significance Index: 8.0600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0041
    Cell Significance Index: 0.1100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0039
    Cell Significance Index: 2.9200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0047
    Cell Significance Index: -8.8200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0092
    Cell Significance Index: -16.9600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0111
    Cell Significance Index: -17.1600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0127
    Cell Significance Index: -0.2700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0142
    Cell Significance Index: -19.3000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0247
    Cell Significance Index: -18.2900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0262
    Cell Significance Index: -19.2000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0274
    Cell Significance Index: -17.3800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0283
    Cell Significance Index: -15.9600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0293
    Cell Significance Index: -2.9900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0319
    Cell Significance Index: -2.3800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0364
    Cell Significance Index: -22.7500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0382
    Cell Significance Index: -17.3400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0388
    Cell Significance Index: -1.1400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0466
    Cell Significance Index: -0.7800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0606
    Cell Significance Index: -17.4400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0640
    Cell Significance Index: -12.7100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0695
    Cell Significance Index: -3.9000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0754
    Cell Significance Index: -2.4200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1044
    Cell Significance Index: -21.9900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1074
    Cell Significance Index: -12.5200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1157
    Cell Significance Index: -1.4400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1183
    Cell Significance Index: -17.1900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1222
    Cell Significance Index: -4.3000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1248
    Cell Significance Index: -14.3000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1327
    Cell Significance Index: -3.3900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1700
    Cell Significance Index: -10.9700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1797
    Cell Significance Index: -7.9500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1832
    Cell Significance Index: -3.8000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1933
    Cell Significance Index: -20.1300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2039
    Cell Significance Index: -14.4200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2145
    Cell Significance Index: -2.2200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2290
    Cell Significance Index: -8.6700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2500
    Cell Significance Index: -2.8400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2518
    Cell Significance Index: -6.6200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2586
    Cell Significance Index: -20.4800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2840
    Cell Significance Index: -17.4100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2867
    Cell Significance Index: -19.2800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2943
    Cell Significance Index: -2.4000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3073
    Cell Significance Index: -9.0500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3181
    Cell Significance Index: -16.5700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3341
    Cell Significance Index: -7.0900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3537
    Cell Significance Index: -7.1000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3554
    Cell Significance Index: -11.3200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SGSM3 is a small GTPase-binding protein that modulates the activity of small GTPases, which are crucial regulators of cellular signaling pathways. The protein is highly expressed in various cell types, including bronchial goblet cells, pulmonary interstitial fibroblasts, and neurons. SGSM3 is also found in the plasma membrane and endosomes, where it interacts with other signaling molecules to regulate their activity. **Pathways and Functions:** SGSM3 is involved in several signaling pathways, including: 1. **Rap protein signal transduction:** SGSM3 modulates the activity of Rap GTPases, which are involved in regulating cell growth, differentiation, and survival. 2. **Regulation of cell cycle:** SGSM3 regulates the cell cycle by modulating the activity of cyclin-dependent kinases and other cell cycle regulators. 3. **Cytoskeleton dynamics:** SGSM3 regulates cytoskeleton dynamics by interacting with microtubule-associated proteins and modulating their activity. 4. **Gap junction regulation:** SGSM3 regulates the activity of connexin channels, which are essential for gap junction communication. **Clinical Significance:** SGSM3 has been implicated in various diseases, including: 1. **Respiratory diseases:** SGSM3 has been found to be overexpressed in bronchial goblet cells of patients with chronic obstructive pulmonary disease (COPD) and asthma. 2. **Neurological diseases:** SGSM3 has been implicated in the regulation of neuronal signaling pathways and has been found to be overexpressed in patients with Parkinson's disease and Huntington's disease. 3. **Cancer:** SGSM3 has been found to be overexpressed in certain types of cancer, including lung cancer and colon cancer. 4. **Neurodegenerative diseases:** SGSM3 has been implicated in the regulation of cilia assembly and has been found to be overexpressed in patients with primary ciliary dyskinesia. **Conclusion:** In conclusion, SGSM3 is a small G protein signaling modulator that plays a crucial role in regulating various cellular processes, including cell cycle, cytoskeleton dynamics, and signal transduction. Its clinical significance has been implicated in various diseases, including respiratory, neurological, and cancer diseases. Further studies are needed to fully understand the functions and clinical significance of SGSM3. **Recommendations:** 1. **Further research:** Further studies are needed to fully understand the functions of SGSM3 and its clinical significance in different diseases. 2. **Therapeutic targeting:** SGSM3 could be a potential therapeutic target for the treatment of various diseases, including respiratory, neurological, and cancer diseases. 3. **Immunological studies:** Immunological studies are needed to understand the role of SGSM3 in immune responses and its potential as a biomarker for disease diagnosis. **Limitations:** The study of SGSM3 is limited by the availability of reagents and the complexity of the signaling pathways involved. Further studies are needed to fully understand the functions and clinical significance of SGSM3. **Future Directions:** The study of SGSM3 has the potential to lead to the development of new therapeutic strategies for various diseases. Future studies should focus on the regulation of SGSM3 expression, its interaction with other signaling molecules, and its potential as a biomarker for disease diagnosis.

Genular Protein ID: 3089044358

Symbol: SGSM3_HUMAN

Name: Small G protein signaling modulator 3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15541357

Title: MAP, a protein interacting with a tumor suppressor, merlin, through the run domain.

PubMed ID: 15541357

DOI: 10.1016/j.bbrc.2004.10.095

PubMed ID: 15849434

Title: Identification of Rab GTPase-activating protein-like protein (RabGAPLP) as a novel Alix/AIP1-interacting protein.

PubMed ID: 15849434

DOI: 10.1271/bbb.69.861

PubMed ID: 17509819

Title: Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway.

PubMed ID: 17509819

DOI: 10.1016/j.ygeno.2007.03.013

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

Sequence Information:

  • Length: 749
  • Mass: 85354
  • Checksum: 3DA4F7961EF79056
  • Sequence:
  • MSGSHTPACG PFSALTPSIW PQEILAKYTQ KEESAEQPEF YYDEFGFRVY KEEGDEPGSS 
    LLANSPLMED APQRLRWQAH LEFTHNHDVG DLTWDKIAVS LPRSEKLRSL VLAGIPHGMR 
    PQLWMRLSGA LQKKRNSELS YREIVKNSSN DETIAAKQIE KDLLRTMPSN ACFASMGSIG 
    VPRLRRVLRA LAWLYPEIGY CQGTGMVAAC LLLFLEEEDA FWMMSAIIED LLPASYFSTT 
    LLGVQTDQRV LRHLIVQYLP RLDKLLQEHD IELSLITLHW FLTAFASVVD IKLLLRIWDL 
    FFYEGSRVLF QLTLGMLHLK EEELIQSENS ASIFNTLSDI PSQMEDAELL LGVAMRLAGS 
    LTDVAVETQR RKHLAYLIAD QGQLLGAGTL TNLSQVVRRR TQRRKSTITA LLFGEDDLEA 
    LKAKNIKQTE LVADLREAIL RVARHFQCTD PKNCSVELTP DYSMESHQRD HENYVACSRS 
    HRRRAKALLD FERHDDDELG FRKNDIITIV SQKDEHCWVG ELNGLRGWFP AKFVEVLDER 
    SKEYSIAGDD SVTEGVTDLV RGTLCPALKA LFEHGLKKPS LLGGACHPWL FIEEAAGREV 
    ERDFASVYSR LVLCKTFRLD EDGKVLTPEE LLYRAVQSVN VTHDAVHAQM DVKLRSLICV 
    GLNEQVLHLW LEVLCSSLPT VEKWYQPWSF LRSPGWVQIK CELRVLCCFA FSLSQDWELP 
    AKREAQQPLK EGVRDMLVKH HLFSWDVDG

Genular Protein ID: 654637181

Symbol: B4DVE3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 660
  • Mass: 75682
  • Checksum: 660FFF088CE04B7A
  • Sequence:
  • MSLVSVCTRK RLRWQAHLEF THNHDVGDLT WDKIAVSLPR SEKLRSLVLA GIPHGMRPQL 
    WMRLSGALQK KRNSELSYRE IVKNSSNDET IAAKQIEKDL LRTMPSNACF ASMGSIGVPR 
    LRRVLRALAW LYPEIGYCQG TGMVAACLLL FLEEEDAFWM MSAIIEDLLP ASYFSTTLLG 
    VQTDQRVLRH LIVQYLPRLD KLLQEHDIEL SLITLHWFLT AFASVVDIKL LLRIWDLFFY 
    EGSRVLFQLT LGMLHLKEEE LIQSENSASI FNTLSDIPSQ MEDAELLLGV AMRLAGSLTD 
    VAVETQRRKH LAYLIADQGQ LLGAGTLTNL SQVVRRRTQR RKSTITALLF GEDDLEALKA 
    KNIKQTELVA DLREAILRVA RHFQCTDPKN CSVELTPDYS MESHQRDHEN YVACSRSHRR 
    RAKALLDFER HDDDELGFRK NDIITIVSQK DEHCWVGELN GLRGWFPAKF VEVLDERSKE 
    ALFEHGLKKP SLLGGACHPW LFIEEAAGRE VERDFASVYS RLVLCKTFRL DEDGKVLTPE 
    ELLYRAVQSV NVTHDAVHAQ MDVKLRSLIC VGLNEQVLHL WLEVLCSSLP TVEKWYQPWS 
    FLRSPGWVQI KCELRVLCCF AFSLSQDWEL PAKREAQQPL KEGVRDMLVK HHLFSWDVDG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.