Details for: GPLD1

Gene ID: 2822

Symbol: GPLD1

Ensembl ID: ENSG00000112293

Description: glycosylphosphatidylinositol specific phospholipase D1

Associated with

  • Metabolism of proteins
    (R-HSA-392499)
  • Post-translational modification: synthesis of gpi-anchored proteins
    (R-HSA-163125)
  • Post-translational protein modification
    (R-HSA-597592)
  • Cell migration involved in sprouting angiogenesis
    (GO:0002042)
  • Cellular response to calcium ion
    (GO:0071277)
  • Cellular response to cholesterol
    (GO:0071397)
  • Cellular response to insulin stimulus
    (GO:0032869)
  • Cellular response to ph
    (GO:0071467)
  • Cellular response to triglyceride
    (GO:0071401)
  • Cellular response to xenobiotic stimulus
    (GO:0071466)
  • Chondrocyte differentiation
    (GO:0002062)
  • Complement receptor mediated signaling pathway
    (GO:0002430)
  • Cytoplasm
    (GO:0005737)
  • Extracellular exosome
    (GO:0070062)
  • Extracellular matrix
    (GO:0031012)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Glycosylphosphatidylinositol phospholipase d activity
    (GO:0004621)
  • Gpi anchor release
    (GO:0006507)
  • Hematopoietic stem cell migration
    (GO:0035701)
  • Hematopoietic stem cell migration to bone marrow
    (GO:0097241)
  • Insulin receptor signaling pathway
    (GO:0008286)
  • Intracellular membrane-bounded organelle
    (GO:0043231)
  • Lysosomal membrane
    (GO:0005765)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of triglyceride catabolic process
    (GO:0010897)
  • Ossification
    (GO:0001503)
  • Phosphatidylcholine metabolic process
    (GO:0046470)
  • Phospholipase d activity
    (GO:0004630)
  • Positive regulation of alkaline phosphatase activity
    (GO:0010694)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of endothelial cell migration
    (GO:0010595)
  • Positive regulation of glucose metabolic process
    (GO:0010907)
  • Positive regulation of high-density lipoprotein particle clearance
    (GO:0010983)
  • Positive regulation of insulin secretion involved in cellular response to glucose stimulus
    (GO:0035774)
  • Positive regulation of membrane protein ectodomain proteolysis
    (GO:0051044)
  • Positive regulation of secretion
    (GO:0051047)
  • Positive regulation of triglyceride biosynthetic process
    (GO:0010867)
  • Regulation of cellular response to insulin stimulus
    (GO:1900076)
  • Response to glucose
    (GO:0009749)
  • Sodium channel regulator activity
    (GO:0017080)
  • Transepithelial transport
    (GO:0070633)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 89.2988
    Cell Significance Index: -13.8900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 56.6938
    Cell Significance Index: -14.3800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.5657
    Cell Significance Index: -14.2600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.6822
    Cell Significance Index: -14.5300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.4547
    Cell Significance Index: 53.7500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.8937
    Cell Significance Index: 31.9000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.4949
    Cell Significance Index: 36.2100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.3342
    Cell Significance Index: -2.9200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3298
    Cell Significance Index: 266.7500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 1.2032
    Cell Significance Index: 17.2300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0024
    Cell Significance Index: 359.5300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.7244
    Cell Significance Index: 32.0400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.7117
    Cell Significance Index: 26.9500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5691
    Cell Significance Index: 35.8700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5210
    Cell Significance Index: 103.3900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5192
    Cell Significance Index: 26.9700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4484
    Cell Significance Index: 85.3300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3540
    Cell Significance Index: 23.8000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.3523
    Cell Significance Index: 51.2200
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.3156
    Cell Significance Index: 2.6100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2746
    Cell Significance Index: 189.9000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2650
    Cell Significance Index: 16.2900
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.2629
    Cell Significance Index: 3.3100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2485
    Cell Significance Index: 14.9200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2410
    Cell Significance Index: 4.1300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.1626
    Cell Significance Index: 2.4000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1587
    Cell Significance Index: 4.5300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1394
    Cell Significance Index: 15.1700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1318
    Cell Significance Index: 3.1600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1281
    Cell Significance Index: 9.8300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1145
    Cell Significance Index: 6.4300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1040
    Cell Significance Index: 10.2900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1017
    Cell Significance Index: 5.3400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1016
    Cell Significance Index: 91.7600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0777
    Cell Significance Index: 2.7300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0745
    Cell Significance Index: 13.4300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0678
    Cell Significance Index: 11.0400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0588
    Cell Significance Index: 7.2300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0533
    Cell Significance Index: 33.8400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0443
    Cell Significance Index: 83.4900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0327
    Cell Significance Index: 0.5500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0086
    Cell Significance Index: 13.2100
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.0054
    Cell Significance Index: 0.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0045
    Cell Significance Index: 8.2100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0022
    Cell Significance Index: 1.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0002
    Cell Significance Index: -0.2400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0008
    Cell Significance Index: -0.0200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0045
    Cell Significance Index: -0.1300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0046
    Cell Significance Index: -0.1000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0067
    Cell Significance Index: -0.4700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0107
    Cell Significance Index: -4.7500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0110
    Cell Significance Index: -0.2200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0115
    Cell Significance Index: -0.2500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0121
    Cell Significance Index: -0.5500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0148
    Cell Significance Index: -8.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0160
    Cell Significance Index: -11.8700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0178
    Cell Significance Index: -13.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0182
    Cell Significance Index: -13.7400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0190
    Cell Significance Index: -0.5300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0218
    Cell Significance Index: -12.2700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0252
    Cell Significance Index: -15.7100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0286
    Cell Significance Index: -0.3600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0292
    Cell Significance Index: -0.6200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0328
    Cell Significance Index: -2.0100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0400
    Cell Significance Index: -11.5200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0478
    Cell Significance Index: -6.1300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0500
    Cell Significance Index: -1.0800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0503
    Cell Significance Index: -6.9100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0506
    Cell Significance Index: -1.6200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0616
    Cell Significance Index: -10.5200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0691
    Cell Significance Index: -14.5600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0733
    Cell Significance Index: -1.4500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0873
    Cell Significance Index: -2.7800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0910
    Cell Significance Index: -2.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0984
    Cell Significance Index: -11.2800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0997
    Cell Significance Index: -7.0500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1006
    Cell Significance Index: -11.7200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1015
    Cell Significance Index: -11.9700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1018
    Cell Significance Index: -0.6900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1022
    Cell Significance Index: -2.1200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1094
    Cell Significance Index: -14.1400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1107
    Cell Significance Index: -11.5300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1179
    Cell Significance Index: -1.4700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1334
    Cell Significance Index: -13.6300
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: -0.1430
    Cell Significance Index: -0.1900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1654
    Cell Significance Index: -10.6700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1672
    Cell Significance Index: -3.4900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1700
    Cell Significance Index: -4.2400
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1703
    Cell Significance Index: -2.1500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1728
    Cell Significance Index: -12.8800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1747
    Cell Significance Index: -13.8400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1980
    Cell Significance Index: -8.6100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2052
    Cell Significance Index: -7.1900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2081
    Cell Significance Index: -5.3500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2134
    Cell Significance Index: -3.6900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2299
    Cell Significance Index: -2.7400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2300
    Cell Significance Index: -11.9800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2421
    Cell Significance Index: -11.2900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2477
    Cell Significance Index: -2.8900
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.2520
    Cell Significance Index: -3.7700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** GPLD1 is a member of the phospholipase D family, which is characterized by their ability to hydrolyze phosphatidylinositol-4,5-bisphosphate (PIP2) into phosphatidic acid and inositol 1,4,5-trisphosphate (IP3). GPLD1 is specifically involved in the release of GPI-anchored proteins from the cell surface, which is mediated by its phospholipase D activity. This enzyme is unique in that it is specifically activated by the hydrolysis of GPI-anchored proteins, allowing for their proper release and function. GPLD1 is also notable for its ability to regulate various cellular responses, including cell migration, differentiation, and signaling pathways. The enzyme has been implicated in the regulation of cellular responses to calcium, cholesterol, insulin, and xenobiotics, highlighting its importance in maintaining cellular homeostasis. **Pathways and Functions** GPLD1 is involved in several cellular pathways, including: 1. **Cell migration**: GPLD1 plays a crucial role in the regulation of cell migration, particularly in the context of angiogenesis and hematopoietic stem cell migration. 2. **Cellular response to calcium ion**: GPLD1 has been implicated in the regulation of cellular responses to calcium ions, which is essential for maintaining cellular homeostasis. 3. **Cellular response to cholesterol**: GPLD1 has been shown to regulate the cellular response to cholesterol, which is critical for maintaining lipid homeostasis. 4. **Insulin receptor signaling pathway**: GPLD1 is involved in the regulation of insulin receptor signaling, which is essential for glucose metabolism. 5. **GPI anchor release**: GPLD1 is specifically involved in the release of GPI-anchored proteins from the cell surface, which is mediated by its phospholipase D activity. **Clinical Significance** GPLD1 has been implicated in various diseases, including: 1. **Neurological disorders**: GPLD1 has been shown to play a crucial role in the regulation of neural development and function, and its dysregulation has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 2. **Cardiovascular disease**: GPLD1 has been implicated in the regulation of cellular responses to cholesterol and calcium ions, which is critical for maintaining cardiovascular health. 3. **Cancer**: GPLD1 has been shown to regulate cellular responses to insulin and xenobiotics, which is essential for maintaining cellular homeostasis and preventing cancer. 4. **Metabolic disorders**: GPLD1 has been implicated in the regulation of glucose metabolism, which is critical for maintaining metabolic homeostasis. In conclusion, GPLD1 is a critical enzyme that plays a crucial role in various cellular processes, including cell migration, differentiation, and signaling pathways. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms and functions of this enzyme.

Genular Protein ID: 3800186463

Symbol: PHLD_HUMAN

Name: Phosphatidylinositol-glycan-specific phospholipase D

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11072085

Title: Structure and expression of the human glycosylphosphatidylinositol phospholipase D1 (GPLD1) gene.

PubMed ID: 11072085

DOI: 10.1016/s0167-4781(00)00194-9

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1606959

Title: Phosphatidylinositol-glycan-specific phospholipase D is an amphiphilic glycoprotein that in serum is associated with high-density lipoproteins.

PubMed ID: 1606959

DOI: 10.1111/j.1432-1033.1992.tb16981.x

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

Sequence Information:

  • Length: 840
  • Mass: 92336
  • Checksum: 11369BAFEC3D6D38
  • Sequence:
  • MSAFRLWPGL LIMLGSLCHR GSPCGLSTHV EIGHRALEFL QLHNGRVNYR ELLLEHQDAY 
    QAGIVFPDCF YPSICKGGKF HDVSESTHWT PFLNASVHYI RENYPLPWEK DTEKLVAFLF 
    GITSHMAADV SWHSLGLEQG FLRTMGAIDF HGSYSEAHSA GDFGGDVLSQ FEFNFNYLAR 
    RWYVPVKDLL GIYEKLYGRK VITENVIVDC SHIQFLEMYG EMLAVSKLYP TYSTKSPFLV 
    EQFQEYFLGG LDDMAFWSTN IYHLTSFMLE NGTSDCNLPE NPLFIACGGQ QNHTQGSKMQ 
    KNDFHRNLTT SLTESVDRNI NYTERGVFFS VNSWTPDSMS FIYKALERNI RTMFIGGSQL 
    SQKHVSSPLA SYFLSFPYAR LGWAMTSADL NQDGHGDLVV GAPGYSRPGH IHIGRVYLIY 
    GNDLGLPPVD LDLDKEAHRI LEGFQPSGRF GSALAVLDFN VDGVPDLAVG APSVGSEQLT 
    YKGAVYVYFG SKQGGMSSSP NITISCQDIY CNLGWTLLAA DVNGDSEPDL VIGSPFAPGG 
    GKQKGIVAAF YSGPSLSDKE KLNVEAANWT VRGEEDFSWF GYSLHGVTVD NRTLLLVGSP 
    TWKNASRLGH LLHIRDEKKS LGRVYGYFPP NGQSWFTISG DKAMGKLGTS LSSGHVLMNG 
    TLKQVLLVGA PTYDDVSKVA FLTVTLHQGG ATRMYALTSD AQPLLLSTFS GDRRFSRFGG 
    VLHLSDLDDD GLDEIIMAAP LRIADVTSGL IGGEDGRVYV YNGKETTLGD MTGKCKSWIT 
    PCPEEKAQYV LISPEASSRF GSSLITVRSK AKNQVVIAAG RSSLGARLSG ALHVYSLGSD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.