Details for: GPLD1

Gene ID: 2822

Symbol: GPLD1

Ensembl ID: ENSG00000112293

Description: glycosylphosphatidylinositol specific phospholipase D1

Associated with

  • Metabolism of proteins
    (R-HSA-392499)
  • Post-translational modification: synthesis of gpi-anchored proteins
    (R-HSA-163125)
  • Post-translational protein modification
    (R-HSA-597592)
  • Cell migration involved in sprouting angiogenesis
    (GO:0002042)
  • Cellular response to calcium ion
    (GO:0071277)
  • Cellular response to cholesterol
    (GO:0071397)
  • Cellular response to insulin stimulus
    (GO:0032869)
  • Cellular response to ph
    (GO:0071467)
  • Cellular response to triglyceride
    (GO:0071401)
  • Cellular response to xenobiotic stimulus
    (GO:0071466)
  • Chondrocyte differentiation
    (GO:0002062)
  • Complement receptor mediated signaling pathway
    (GO:0002430)
  • Cytoplasm
    (GO:0005737)
  • Extracellular exosome
    (GO:0070062)
  • Extracellular matrix
    (GO:0031012)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Glycosylphosphatidylinositol phospholipase d activity
    (GO:0004621)
  • Gpi anchor release
    (GO:0006507)
  • Hematopoietic stem cell migration
    (GO:0035701)
  • Hematopoietic stem cell migration to bone marrow
    (GO:0097241)
  • Insulin receptor signaling pathway
    (GO:0008286)
  • Intracellular membrane-bounded organelle
    (GO:0043231)
  • Lysosomal membrane
    (GO:0005765)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of triglyceride catabolic process
    (GO:0010897)
  • Ossification
    (GO:0001503)
  • Phosphatidylcholine metabolic process
    (GO:0046470)
  • Phospholipase d activity
    (GO:0004630)
  • Positive regulation of alkaline phosphatase activity
    (GO:0010694)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of endothelial cell migration
    (GO:0010595)
  • Positive regulation of glucose metabolic process
    (GO:0010907)
  • Positive regulation of high-density lipoprotein particle clearance
    (GO:0010983)
  • Positive regulation of insulin secretion involved in cellular response to glucose stimulus
    (GO:0035774)
  • Positive regulation of membrane protein ectodomain proteolysis
    (GO:0051044)
  • Positive regulation of secretion
    (GO:0051047)
  • Positive regulation of triglyceride biosynthetic process
    (GO:0010867)
  • Regulation of cellular response to insulin stimulus
    (GO:1900076)
  • Response to glucose
    (GO:0009749)
  • Sodium channel regulator activity
    (GO:0017080)
  • Transepithelial transport
    (GO:0070633)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.62
    Marker Score: 59773
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.54
    Marker Score: 6396
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.54
    Marker Score: 11780
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.52
    Marker Score: 6186
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.51
    Marker Score: 92750
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.5
    Marker Score: 29924
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.48
    Marker Score: 22188
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.48
    Marker Score: 2281
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169484
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.48
    Marker Score: 56067
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.48
    Marker Score: 14015
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.47
    Marker Score: 5675
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.41
    Marker Score: 12139
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.39
    Marker Score: 8968
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.35
    Marker Score: 7258
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.34
    Marker Score: 12605
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.34
    Marker Score: 5767
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.32
    Marker Score: 13600
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.23
    Marker Score: 4538
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.18
    Marker Score: 860
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4812
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.13
    Marker Score: 3696
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.08
    Marker Score: 36526
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71821
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48046
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.95
    Marker Score: 398
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.95
    Marker Score: 643
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5327
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 371
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.91
    Marker Score: 378
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.81
    Marker Score: 17282
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8
    Marker Score: 12476
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 607
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.79
    Marker Score: 217
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1260
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 706
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.77
    Marker Score: 703
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.76
    Marker Score: 3500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.72
    Marker Score: 211
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.71
    Marker Score: 2971
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.63
    Marker Score: 1198
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.58
    Marker Score: 1356
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.57
    Marker Score: 609
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.55
    Marker Score: 355
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.55
    Marker Score: 175
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.55
    Marker Score: 476
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.55
    Marker Score: 373
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.54
    Marker Score: 1102
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 171
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.53
    Marker Score: 350
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.52
    Marker Score: 880
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.52
    Marker Score: 217
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.52
    Marker Score: 3104
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.51
    Marker Score: 633
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.51
    Marker Score: 1458
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5
    Marker Score: 192
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.43
    Marker Score: 109
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.41
    Marker Score: 239
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.4
    Marker Score: 238
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.38
    Marker Score: 832.5
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.37
    Marker Score: 120
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.36
    Marker Score: 207
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.35
    Marker Score: 229
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.33
    Marker Score: 187
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.33
    Marker Score: 398
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.32
    Marker Score: 1326
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.32
    Marker Score: 146
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.31
    Marker Score: 6981
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.31
    Marker Score: 98
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.31
    Marker Score: 150
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.31
    Marker Score: 105
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.29
    Marker Score: 667
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.29
    Marker Score: 107
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.28
    Marker Score: 694
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.27
    Marker Score: 86
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.27
    Marker Score: 371.5
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.27
    Marker Score: 157
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.26
    Marker Score: 884
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.26
    Marker Score: 125
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.26
    Marker Score: 920
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.25
    Marker Score: 177
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.25
    Marker Score: 251
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.25
    Marker Score: 65
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.25
    Marker Score: 303
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.25
    Marker Score: 1874
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.25
    Marker Score: 154
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.25
    Marker Score: 282
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.24
    Marker Score: 423
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.24
    Marker Score: 355
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.24
    Marker Score: 224

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * The GPLD1 gene is located on chromosome 17q21.1. * It is a large gene, with a length of approximately 2.3 kb. * It contains 15 exons and 13 intronic sequences. * The protein encoded by GPLD1 is a transmembrane protein with a molecular weight of approximately 800 kDa. **Pathways and functions:** * The GPLD1 gene is involved in cell migration by regulating the release of gpi-anchored proteins from the cell surface. * Gpi-anchored proteins are proteins that are attached to the cell surface by a glycosylphosphatidylinositol (GPi) linkage. * When GPi-anchored proteins are released from the cell surface, they can bind to receptors on other cells, which can then initiate signaling events that lead to cell migration. * The GPLD1 gene is also involved in the Complement receptor mediated signaling pathway, the Glycosylphosphatidylinositol phospholipase d activity, and the Positive regulation of endothelial cell migration. **Clinical significance:** * Mutations in the GPLD1 gene have been linked to several neurological disorders, including autism, schizophrenia, and Alzheimer's disease. * These mutations can lead to the loss of GPi-anchored proteins from the cell surface, which can disrupt cell migration and lead to neuronal dysfunction. * Therefore, GPLD1 is a promising target for the treatment of neurological disorders that are characterized by neuronal migration defects.

Genular Protein ID: 3800186463

Symbol: PHLD_HUMAN

Name: Phosphatidylinositol-glycan-specific phospholipase D

UniProtKB Accession Codes:

P80108 Q15127 Q15128 Q2M2F2 Q5T3Y0 Q7Z6T8 Q8TCV0 Q8WW82 Q96ID6 Q9H167 Q9H4M1 Q9UJC9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 1 CTD 1 ChEBI 5 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 18 Ensembl 1 GO 39 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SMART 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11072085

Title: Structure and expression of the human glycosylphosphatidylinositol phospholipase D1 (GPLD1) gene.

PubMed ID: 11072085

DOI: 10.1016/s0167-4781(00)00194-9

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1606959

Title: Phosphatidylinositol-glycan-specific phospholipase D is an amphiphilic glycoprotein that in serum is associated with high-density lipoproteins.

PubMed ID: 1606959

DOI: 10.1111/j.1432-1033.1992.tb16981.x

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

Sequence Information:

  • Length: 840
  • Mass: 92336
  • Checksum: 11369BAFEC3D6D38
  • Sequence:
    • MSAFRLWPGL LIMLGSLCHR GSPCGLSTHV EIGHRALEFL QLHNGRVNYR ELLLEHQDAY 
QAGIVFPDCF YPSICKGGKF HDVSESTHWT PFLNASVHYI RENYPLPWEK DTEKLVAFLF 
GITSHMAADV SWHSLGLEQG FLRTMGAIDF HGSYSEAHSA GDFGGDVLSQ FEFNFNYLAR 
RWYVPVKDLL GIYEKLYGRK VITENVIVDC SHIQFLEMYG EMLAVSKLYP TYSTKSPFLV 
EQFQEYFLGG LDDMAFWSTN IYHLTSFMLE NGTSDCNLPE NPLFIACGGQ QNHTQGSKMQ 
KNDFHRNLTT SLTESVDRNI NYTERGVFFS VNSWTPDSMS FIYKALERNI RTMFIGGSQL 
SQKHVSSPLA SYFLSFPYAR LGWAMTSADL NQDGHGDLVV GAPGYSRPGH IHIGRVYLIY 
GNDLGLPPVD LDLDKEAHRI LEGFQPSGRF GSALAVLDFN VDGVPDLAVG APSVGSEQLT 
YKGAVYVYFG SKQGGMSSSP NITISCQDIY CNLGWTLLAA DVNGDSEPDL VIGSPFAPGG 
GKQKGIVAAF YSGPSLSDKE KLNVEAANWT VRGEEDFSWF GYSLHGVTVD NRTLLLVGSP 
TWKNASRLGH LLHIRDEKKS LGRVYGYFPP NGQSWFTISG DKAMGKLGTS LSSGHVLMNG 
TLKQVLLVGA PTYDDVSKVA FLTVTLHQGG ATRMYALTSD AQPLLLSTFS GDRRFSRFGG 
VLHLSDLDDD GLDEIIMAAP LRIADVTSGL IGGEDGRVYV YNGKETTLGD MTGKCKSWIT 
PCPEEKAQYV LISPEASSRF GSSLITVRSK AKNQVVIAAG RSSLGARLSG ALHVYSLGSD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.