Details for: SLCO3A1

Gene ID: 28232

Symbol: SLCO3A1

Ensembl ID: ENSG00000176463

Description: solute carrier organic anion transporter family member 3A1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 336.6224
    Cell Significance Index: -52.3600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 201.2274
    Cell Significance Index: -51.0400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 103.4690
    Cell Significance Index: -42.0400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 95.1233
    Cell Significance Index: -48.9300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 44.1375
    Cell Significance Index: -42.1400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 42.4833
    Cell Significance Index: -52.3800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.8102
    Cell Significance Index: -50.3900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 15.4529
    Cell Significance Index: -33.8200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.0927
    Cell Significance Index: -43.2900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.2918
    Cell Significance Index: -52.4500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 3.9919
    Cell Significance Index: 111.5600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 3.5010
    Cell Significance Index: 2223.4700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 3.4493
    Cell Significance Index: 264.7000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 3.2501
    Cell Significance Index: 1165.7500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 2.6539
    Cell Significance Index: 178.4500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 2.6187
    Cell Significance Index: 74.7300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.5465
    Cell Significance Index: 49.7000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 2.4787
    Cell Significance Index: 35.6500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.2151
    Cell Significance Index: 444.3400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.1860
    Cell Significance Index: 1511.9100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.7731
    Cell Significance Index: 37.9000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9189
    Cell Significance Index: 165.6600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.8690
    Cell Significance Index: 12.8300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7956
    Cell Significance Index: 97.8300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7146
    Cell Significance Index: 116.2200
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.6675
    Cell Significance Index: 5.9300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.6654
    Cell Significance Index: 40.9000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6260
    Cell Significance Index: 35.1300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.5427
    Cell Significance Index: 20.5500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4851
    Cell Significance Index: 52.7600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4593
    Cell Significance Index: 20.3200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3859
    Cell Significance Index: 726.5500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3378
    Cell Significance Index: 149.3600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2731
    Cell Significance Index: 27.0200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2427
    Cell Significance Index: 46.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2329
    Cell Significance Index: 127.1900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2306
    Cell Significance Index: 11.9800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2177
    Cell Significance Index: 3.7300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2121
    Cell Significance Index: 326.5300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1984
    Cell Significance Index: 5.4000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1295
    Cell Significance Index: 17.7800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1226
    Cell Significance Index: 2.6100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1090
    Cell Significance Index: 21.6300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1063
    Cell Significance Index: 196.0400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0899
    Cell Significance Index: 6.2200
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.0856
    Cell Significance Index: 1.1100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0850
    Cell Significance Index: 9.9000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0406
    Cell Significance Index: 5.2000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0106
    Cell Significance Index: 0.4800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0123
    Cell Significance Index: -16.7100
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: -0.0261
    Cell Significance Index: -0.2700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0270
    Cell Significance Index: -0.9500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0375
    Cell Significance Index: -17.0300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0421
    Cell Significance Index: -30.8900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0455
    Cell Significance Index: -1.3100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0498
    Cell Significance Index: -37.7200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0551
    Cell Significance Index: -40.8000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0553
    Cell Significance Index: -8.0400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0580
    Cell Significance Index: -1.4900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0827
    Cell Significance Index: -46.6400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0840
    Cell Significance Index: -1.8200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0859
    Cell Significance Index: -2.0600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0916
    Cell Significance Index: -57.2200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1093
    Cell Significance Index: -1.5700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1246
    Cell Significance Index: -14.7000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1587
    Cell Significance Index: -45.6600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1883
    Cell Significance Index: -2.6800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2040
    Cell Significance Index: -23.3800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2529
    Cell Significance Index: -3.4500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2533
    Cell Significance Index: -32.7300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2607
    Cell Significance Index: -54.9100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2828
    Cell Significance Index: -28.8900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2967
    Cell Significance Index: -50.6700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3108
    Cell Significance Index: -3.8800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3334
    Cell Significance Index: -23.5800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4441
    Cell Significance Index: -20.8700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4510
    Cell Significance Index: -11.8600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4745
    Cell Significance Index: -49.4100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4959
    Cell Significance Index: -23.1200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5004
    Cell Significance Index: -10.6200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5227
    Cell Significance Index: -16.7400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5275
    Cell Significance Index: -9.7500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.5331
    Cell Significance Index: -7.6400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.5344
    Cell Significance Index: -5.7300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.5804
    Cell Significance Index: -7.3300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5826
    Cell Significance Index: -46.1400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5843
    Cell Significance Index: -35.8200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6165
    Cell Significance Index: -16.4900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6255
    Cell Significance Index: -32.5800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.6349
    Cell Significance Index: -47.3200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.6474
    Cell Significance Index: -13.4300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6683
    Cell Significance Index: -21.8800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6955
    Cell Significance Index: -22.1500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.7106
    Cell Significance Index: -14.0500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7226
    Cell Significance Index: -37.9400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.7407
    Cell Significance Index: -14.8700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.7592
    Cell Significance Index: -48.9800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.8146
    Cell Significance Index: -23.3500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.8530
    Cell Significance Index: -18.4300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.9167
    Cell Significance Index: -7.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transport Mechanism:** SO3A1 is a sodium-independent organic anion transporter, meaning it can transport organic anions across cell membranes without the need for sodium ions. 2. **Tissue Expression:** SLCO3A1 is expressed in various tissues, including the brain, heart, lungs, kidneys, and gastrointestinal tract, where it plays a crucial role in maintaining homeostasis. 3. **Function:** SO3A1 regulates the transport of organic anions, including vitamins, nucleosides, and related molecules, across cellular membranes. 4. **Regulation:** SO3A1 is subject to positive regulation by transcription factors, such as NF-κB, and protein kinases, which modulate its activity and expression. **Pathways and Functions:** The SLCO3A1 gene is involved in several biological pathways, including: 1. **Apical Plasma Membrane:** SO3A1 mediates the transport of organic anions across the apical plasma membrane of epithelial cells in the gut and kidneys. 2. **Basal Plasma Membrane:** SO3A1 is also expressed in the basal plasma membrane of epithelial cells, where it regulates the transport of organic anions. 3. **Monoatomic Ion Transport:** SO3A1 is involved in the transport of monoatomic ions, such as chloride and sulfate, across cellular membranes. 4. **Prostaglandin Transport:** SO3A1 regulates the transport of prostaglandins, which play a crucial role in inflammation and immune responses. 5. **Blood-Brain Barrier:** SO3A1 is expressed in the blood-brain barrier, where it regulates the transport of organic anions across this critical barrier. **Clinical Significance:** The SLCO3A1 gene has been implicated in several diseases, including: 1. **Neurological Disorders:** Variants in the SLCO3A1 gene have been associated with neurological disorders, such as epilepsy, Parkinson's disease, and Alzheimer's disease. 2. **Cardiovascular Conditions:** SO3A1 is involved in the regulation of blood pressure and cardiovascular function, making it a potential target for the treatment of cardiovascular diseases. 3. **Cancer:** SLCO3A1 is overexpressed in certain types of cancer, including breast and lung cancer, highlighting its potential as a therapeutic target. 4. **Pharmacogenomics:** Variants in the SLCO3A1 gene can affect the pharmacokinetics and pharmacodynamics of certain medications, making it an important gene for pharmacogenomic studies. In conclusion, the SLCO3A1 gene plays a crucial role in the transport of organic anions across cellular membranes, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the mechanisms by which SO3A1 regulates its functions and to explore its therapeutic potential in human disease.

Genular Protein ID: 1762874143

Symbol: SO3A1_HUMAN

Name: Solute carrier organic anion transporter family member 3A1

UniProtKB Accession Codes:

Q9UIG8 A8K4A7 B3KPY5 B3KUR7 C6G486 Q9BW73 Q9GZV2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 14 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 12 EMBL 13 Ensembl 2 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 28 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10873595

Title: Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family.

PubMed ID: 10873595

DOI: 10.1006/bbrc.2000.2922

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12409283

Title: Characterization and identification of steroid sulfate transporters of human placenta.

PubMed ID: 12409283

DOI: 10.1152/ajpendo.00257.2002

PubMed ID: 14631946

Title: Molecular characterization of human and rat organic anion transporter OATP-D.

PubMed ID: 14631946

DOI: 10.1152/ajprenal.00402.2002

PubMed ID: 16971491

Title: Characterization of two splice variants of human organic anion transporting polypeptide 3A1 isolated from human brain.

PubMed ID: 16971491

DOI: 10.1152/ajpcell.00597.2005

PubMed ID: 19129463

Title: Mechanisms of pH-gradient driven transport mediated by organic anion polypeptide transporters.

PubMed ID: 19129463

DOI: 10.1152/ajpcell.00436.2008

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 25732826

Title: An organellar nalpha-acetyltransferase, naa60, acetylates cytosolic N termini of transmembrane proteins and maintains Golgi integrity.

PubMed ID: 25732826

DOI: 10.1016/j.celrep.2015.01.053

PubMed ID: 30063921

Title: Solute Carrier Organic Anion Transporter Family Member 3A1 Is a Bile Acid Efflux Transporter in Cholestasis.

PubMed ID: 30063921

DOI: 10.1053/j.gastro.2018.07.031

PubMed ID: 35307651

Title: Localization of Xenobiotic Transporters Expressed at the Human Blood-Testis Barrier.

PubMed ID: 35307651

DOI: 10.1124/dmd.121.000748

Sequence Information:

  • Length: 710
  • Mass: 76553
  • Checksum: ED56724BA0998553
  • Sequence:
    • MQGKKPGGSS GGGRSGELQG DEAQRNKKKK KKVSCFSNIK IFLVSECALM LAQGTVGAYL 
VSVLTTLERR FNLQSADVGV IASSFEIGNL ALILFVSYFG ARGHRPRLIG CGGIVMALGA 
LLSALPEFLT HQYKYEAGEI RWGAEGRDVC AANGSGGDEG PDPDLICRNR TATNMMYLLL 
IGAQVLLGIG ATPVQPLGVS YIDDHVRRKD SSLYIGILFT MLVFGPACGF ILGSFCTKIY 
VDAVFIDTSN LDITPDDPRW IGAWWGGFLL CGALLFFSSL LMFGFPQSLP PHSEPAMESE 
QAMLSEREYE RPKPSNGVLR HPLEPDSSAS CFQQLRVIPK VTKHLLSNPV FTCIILAACM 
EIAVVAGFAA FLGKYLEQQF NLTTSSANQL LGMTAIPCAC LGIFLGGLLV KKLSLSALGA 
IRMAMLVNLV STACYVSFLF LGCDTGPVAG VTVPYGNSTA PGSALDPYSP CNNNCECQTD 
SFTPVCGADG ITYLSACFAG CNSTNLTGCA CLTTVPAENA TVVPGKCPSP GCQEAFLTFL 
CVMCICSLIG AMAQTPSVII LIRTVSPELK SYALGVLFLL LRLLGFIPPP LIFGAGIDST 
CLFWSTFCGE QGACVLYDNV VYRYLYVSIA IALKSFAFIL YTTTWQCLRK NYKRYIKNHE 
GGLSTSEFFA STLTLDNLGR DPVPANQTHR TKFIYNLEDH EWCENMESVL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.